Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway

Enzyme and Microbial Technology

Volumn 49, Issue 1, 2011, Pages 17-24

  Tang, Zhenyu ^a   Xiao, Ciying ^a   Zhuang, Yingping ^a   Chu, Ju ^a   Zhang, Siliang ^a   Herron, Paul R ^b   Hunter, Iain S ^b   Guo, Meijin ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Glucose 6 phosphate dehydrogenase; Malonyl CoA; NADPH generation; Oxytetracycline biosynthesis; Streptomyces rimosus M4018

Indexed keywords

GLUCOSE-6-PHOSPHATE DEHYDROGENASE; MALONYL-COA; NADPH GENERATION; OXYTETRACYCLINE BIOSYNTHESIS; STREPTOMYCES RIMOSUS;

AMIDES; ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; BIOMOLECULES; ENZYMES; GENE EXPRESSION; GLUCOSE; INTERNET PROTOCOLS; METABOLITES; PHYSIOLOGY;

METABOLISM;

ADENOSINE TRIPHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MALONYL COENZYME A; OXYTETRACYCLINE; PENTOSE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BIOSYNTHESIS; ENZYME ACTIVITY; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITE; MUTANT; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; STREPTOMYCES; STREPTOMYCES RIMOSUS;

BASE SEQUENCE; BIOMASS; BIOREACTORS; CARBON CYCLE; DNA, BACTERIAL; FERMENTATION; GENES, BACTERIAL; GLUCOSEPHOSPHATE DEHYDROGENASE; METABOLIC ENGINEERING; MUTATION; OXYTETRACYCLINE; PENTOSE PHOSPHATE PATHWAY; STREPTOMYCES;

STREPTOMYCES RIMOSUS; STREPTOMYCINEAE;

EID: 79957577939     PISSN: 01410229     EISSN: 18790909     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2011.04.002     Document Type: Article

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