PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis

Diabetologia

Volumn 57, Issue 12, 2014, Pages 2576-2585

  Kim, Don Kyu ^a   Kim, Yong Hoon ^b   Hynx, Debby ^c   Wang, Yanning ^d   Yang, Keum Jin ^e   Ryu, Dongryeol ^f   Kim, Kyung Seok ^a   Yoo, Eun Kyung ^g   Kim, Jeong Sun ^a   Koo, Seung Hoi ^f   Lee, In Kyu ^g   Chae, Ho Zoon ^a   Park, Jongsun ^e   Lee, Chul Ho ^b   Biddinger, Sudha B ^d   Hemmings, Brian A ^c   Choi, Hueng Sik ^a  

^a Chonnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e Chungnam National University   (South Korea)

^f Korea University   (South Korea)

^g Kyungpook National University School of Medicine   (South Korea)

Author keywords

Akt PKB; Hepatic gluconeogenesis; Insulin receptor signalling; Nuclear hormone receptor; Phosphorylation

Indexed keywords

CELL NUCLEUS RECEPTOR; ESTROGEN RELATED RECEPTOR GAMMA; GLUCOSE; INSULIN; MUTANT PROTEIN; PROTEIN 14 3 3; PROTEIN KINASE B; UNCLASSIFIED DRUG; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR GAMMA; INSULIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; INSULIN; LIVER; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION;

EID: 84926656626     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3366-x     Document Type: Article

References (27)

1. Saltiel AR (2001) New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104:517–529
2. Pilkis SJ, Granner DK (1992) Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54:885–909
3. Yabaluri N, Bashyam MD (2010) Hormonal regulation of gluconeogenic gene transcription in the liver. J Biosci 35:473–484
4. Kim DH, Perdomo G, Zhang T et al (2011) FoxO6 integrates insulin signaling with gluconeogenesis in the liver. Diabetes 60:2763–2774
5. Dentin R, Liu Y, Koo S-H et al (2007) Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449:366–369
6. Li X, Monks B, Ge Q, Birnbaum MJ (2007) Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447:1012–1016
7. Tremblay AM, Giguere V (2007) The NR3B subgroup: an ovERRview. Nucl Recept Signal 5:e009
8. Kim DK, Kim YH, Jang HH et al (2013) Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. Gut 62:1044–1054
9. Kim DK, Jeong JH, Lee JM et al (2014) Inverse agonist of estrogen-related receptor gamma controls Salmonella typhimurium infection by modulating host iron homeostasis. Nat Med 20:419–424
10. Kim DK, Ryu D, Koh M et al (2012) Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis. J Biol Chem 287:21628–21639
11. Kim DK, Gang GT, Ryu D et al (2013) Inverse agonist of nuclear receptor ERRgamma mediates antidiabetic effect through inhibition of hepatic gluconeogenesis. Diabetes 62:3093–3102
12. Kim DK, Kim JR, Koh M et al (2011) Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling. J Biol Chem 286:38035–38042
13. Fisher SJ, Kahn CR (2003) Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J Clin Invest 111:463–468
14. Dummler B, Tschopp O, Hynx D, Yang ZZ, Dirnhofer S, Hemmings BA (2006) Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol 26:8042–8051
15. Woo HA, Kang SW, Kim HK, Yang KS, Chae HZ, Rhee SG (2003) Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence. J Biol Chem 278:47361–47364
16. Yang KJ, Shin S, Piao L et al (2008) Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. J Biol Chem 283:1480–1491
17. Sanyal S, Kim JY, Kim HJ et al (2002) Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem 277:1739–1748
18. Tzivion G, Shen YH, Zhu J (2001) 14-3-3 proteins; bringing new definitions to scaffolding. Oncogene 20:6331–6338
19. Tremblay AM, Wilson BJ, Yang XJ, Giguere V (2008) Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif. Mol Endocrinol 22:570–584
20. Hirata Y, Kiuchi K, Chen HC, Milbrandt J, Guroff G (1993) The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B. J Biol Chem 268:24808–24812
21. Zhang Y, Ma K, Sadana P et al (2006) Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem 281:39897–39906
22. Dufour CR, Wilson BJ, Huss JM et al (2007) Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab 5:345–356
23. Herzog B, Cardenas J, Hall RK et al (2006) Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 281:99–106
24. Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguere V (2010) An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha. Mol Endocrinol 24:1349–1358
25. Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D (2007) Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 6:208–216
26. Haeusler RA, Kaestner KH, Accili D (2010) FoxOs function synergistically to promote glucose production. J Biol Chem 285:35245–35248
27. Lu M, Wan M, Leavens KF et al (2012) Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med 18:388–395