Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells

Molecular Medicine Reports

Volumn 12, Issue 1, 2015, Pages 937-944

  Jeong, Sun Oh ^a   Son, Yong ^a   Lee, Ju Hwan ^a   Cheong, Yong Kwan ^a   Park, Seong Hoon ^a   Chung, Hun Taeg ^b   Pae, Hyun Ock ^a  

^a Wonkwang University School of Medicine   (South Korea)

^b University of Ulsan   (South Korea)

Author keywords

Endothelial dysfunction; Endothelial nitric oxide synthase; Heme oxygenase 1; Insulin resistance; Palmitic acid; Piceatannol

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE 1; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; PALMITIC ACID; PICEATANNOL; REACTIVE OXYGEN METABOLITE; RESVERATROL; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; 3,3',4,5'-TETRAHYDROXYSTILBENE; ANTIOXIDANT; HMOX1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; METALLOPORPHYRIN; NFE2L2 PROTEIN, HUMAN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; NOS3 PROTEIN, HUMAN; OXIDIZING AGENT; PROTOPORPHYRIN; PROTOPORPHYRIN TIN; STILBENE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA BINDING; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RESISTANCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INTERLEUKIN-6; METALLOPORPHYRINS; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDANTS; OXIDATIVE STRESS; PALMITIC ACID; PROTOPORPHYRINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STILBENES;

EID: 84926645022     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3553     Document Type: Article

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