Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 285, Issue 1 48-1, 2003, Pages

  Moon, Byoung ^a   Kwan, Jamie Jun Mae ^b   Duddy, Noreen ^a   Sweeney, Gary ^b   Begum, Najma ^a,c  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c YORK UNIVERSITY   (Canada)

Author keywords

Glucose transporter 4; Skeletal muscle

Indexed keywords

DEOXYGLUCOSE; GENE PRODUCT; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; RESISTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSFECTION; GLUCOSE TRANSPORT; INCUBATION TIME; INSULIN RELEASE; INSULIN RESISTANCE; MUSCLE CELL; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0038339561     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00457.2002     Document Type: Article

References (33)

1. Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, and Saltiel AR. CAP defines a second signaling pathway required for insulin-stimulated glucose transport. Nature 407: 202-207, 2000.
2. Begum N. Phenylarsine oxide inhibits insulin-stimulated protein phosphatase 1 activity and GLUT-4 translocation. Am J Physiol Endocrinol Metab 267: E14-E23, 1994.
3. Begum N, Sandu OA, Ito M, Lohmann SM, and Smolenski A. Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. J Biol Chem 277: 6214-6222, 2002.
4. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
5. Chiang SH, Baumann CA, Kanzaki M, Thurmond DC, Watson RT, Neudauer CL, Macara IG, Pessin JE, and Saltiel AR. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature 410: 944-948, 2001.
6. Cushman SW and Wardzala LJ. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J Biol Chem 255: 4758-4762, 1980.
7. Dietze D, Koenen M, Rohrig K, Horikoshi H, Haunen H, and Eckel J. Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes. Diabetes 51: 2369-2376, 2002.
8. Hansen PA, Wang W, Marshall BA, Holloszy JO, and Mueckler M. Dissociation of GLUT4 translocation and insulin-stimulated glucose transport in transgenic mice overexpressing GLUT1 in skeletal muscle. J Biol Chem 273: 18173-18179, 1998.
9. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, Nelson C, Lowman HB, Wright BD, Skelton NJ, Frantz GD, Tumas DB, Peale FV Jr, Shelton DL, and Hebert CC. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 19: 4046-4055, 2000.
10. Kim KH, Lee K, Moon YS, and Sul HS. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276: 11252-11256, 2001.
11. Lin KH and Cheng SY. An efficient method to purify active eukaryotic proteins from the inclusion bodies in E. coli. Biotechniques 11: 748-752, 1991.
12. Makimura H, Mizuno TM, Bergen H, and Mobbs CV. Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA. Am J Physiol Endocrinol Metab 283: E1266-E1271, 2002.
13. Nagaev I and Smith U. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 285: 561-564, 2001.
14. Ragolia L and Begum N. The effect of modulating the glycogen-associated regulatory subunit of protein phosphatase-1 on insulin action in rat skeletal muscle cells. Endocrinology 138: 2398-2404, 1997.
15. Rajala MW, Obici S, Scherer PE, and Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecule-B selectively impair insulin action on glucose production. J Clin Invest 111: 225-230, 2003.
16. Ribon V, Printen JA, Hoffman NG, Kay BK, and Saltiel AR. A novel, multifunctional c-Cb1 binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18: 872-879, 1998.
17. Ribon V and Saltiel AR. Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cb1 in 3T3-L1 adipocytes. Biochem J 324: 839-845, 1997.
18. Sandu OA, Ragolia L, and Begum N. Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation. Diabetes 49: 2178-2189, 2000.
19. Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV, and O'Rahilly S. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 50: 2199-2202, 2001.
20. Shepherd PR, Withers DJ, and Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signaling. Biochem J 333: 471-490, 19986.
21. Simpson F, Whitehead JP, and James DE. GLUT4-at the cross roads between membrane trafficking and signal transduction. Traffic 2: 2-11, 2001.
22. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartnber FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, and Klenk D. Measurement of proteins using bicinchoninic acid. Anal Biochem 150: 76-85, 1985.
23. Somwar R, Kim DY, Sweeney G, Huang C, Niu W, Lador C, Ramlal T, and Klip A. GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase. Biochem J 359: 639-649, 2001.
24. Somwar R, Niu W, Kim DY, Sweeney G, Randhawa VK, Huang C, Ramlal T, and Klip A. Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport. J Biol Chem 276: 46079-46087, 2001.
25. Somwar R, Perreault M, Kapur S, Taha C, Sweeney G, Ramlal T, Kim DY, Keen J, Cote CH, Klip A, and Marette A. Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport. Diabetes 49: 1794-1800, 2000.
26. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, and Lazar MA. The hormone resistin links obesity to diabetes. Nature 409: 307-312, 2001.
27. Sweeney G, Keen J, Somwar R, Konrad D, Garg R, and Klip A. High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in L6 rat skeletal muscle cells. Endocrinology 142: 4806-4812, 2001.
28. Sweeney G, Somwar R, Ramlal T, Volchuk A, Ueyama A, and Klip A. An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. J Biol Chem 274: 10071-10078, 1999.
29. Ueyama A, Yaworsky KL, Wang Q, Ebina Y, and Klip A. GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity. Am J Physiol Endocrinol Metab 277: E572-E578, 1999.
30. Wang H, Chu WS, Hemphill C, and Elbein S. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab 87: E2520-E2524, 2002.
31. Wang Q, Khayat, Z Kishi, K Ebina Y, and Klip A. GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay. FEBS Lett 427: 193-197, 1998.
32. Watson RT and Pessin JE. Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, Glut-4. Exp Cell Res 271: 75-83, 2001.
33. Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, and Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 276: 25651-25653, 2001.