Beyond gastric acid reduction: Proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells

Biochemical and Biophysical Research Communications

Volumn 345, Issue 3, 2006, Pages 1014-1021

  Becker, Jan C ^a   Grosser, Nina ^b   Waltke, Christian ^a   Schulz, Stephanie ^b   Erdmann, Kati ^b   Domschke, Wolfram ^a   Schröder, Henning ^b   Pohle, Thorsten ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Gastroprotection; Heme oxygenase 1; NSAID; Proton pump inhibitors; Reactive oxygen species; Vasoprotection

Indexed keywords

ANTIOXIDANT; CYCLOHEXIMIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DACTINOMYCIN; FREE RADICAL; HEME OXYGENASE 1; HEME OXYGENASE INHIBITOR; LANSOPRAZOLE; MESSENGER RNA; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTON PUMP INHIBITOR; REACTIVE OXYGEN METABOLITE; ROFECOXIB;

ANIMAL CELL; ARTICLE; CELL LEVEL; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ACID; STOMACH DISEASE; STOMACH PROTECTION; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ANIMALS; CELL LINE, TUMOR; CYCLOOXYGENASE 1; DEUTEROPORPHYRINS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GASTRIC ACID; HEME OXYGENASE-1; HUMANS; OMEPRAZOLE; OXIDATIVE STRESS; RATS; STOMACH;

EID: 33646853281     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.04.170     Document Type: Article

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