Natural grape extracts regulate colon cancer cells malignancy

Nutrition and Cancer

Volumn 67, Issue 3, 2015, Pages 494-503

  Signorelli, Paola ^a,b   Fabiani, Carlotta ^a   Brizzolari, Andrea ^a   Paroni, Rita ^a   Casas, Josefina ^c   Fabriàs, Gemma ^c   Rossi, Dario ^d   Ghidoni, Riccardo ^a,b   Caretti, Anna ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN PAOLO HOSPITAL   (Italy)

^c INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^d Immobiliare Ca Novella Srl   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHOCYANIN; CERAMIDE DERIVATIVE; DIHYDROCERAMIDE; ETOPOSIDE; FLAVONOID; GRAPEFRUIT EXTRACT; LIOFENOL; MARKER; POLYPHENOL; PROTEIN P21; PROTEIN P53; SPHINGOLIPID; TAMOXIFEN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UVOMORULIN; ANTIOXIDANT; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; NFE2L2 PROTEIN, HUMAN; PLANT EXTRACT;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL DIFFERENTIATION; CELL LYSATE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HCT116 CELL LINE; HUMAN; HUMAN CELL; MIGRATION INHIBITION; PROTEIN CONTENT; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPHINGOLIPID METABOLISM; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING; CELL MOTION; COLONIC NEOPLASMS; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; VITIS;

VITACEAE;

ANTIOXIDANTS; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HCT116 CELLS; HUMANS; NF-E2-RELATED FACTOR 2; PLANT EXTRACTS; SPHINGOLIPIDS; TUMOR SUPPRESSOR PROTEIN P53; VITIS;

EID: 84926518447     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2015.1004591     Document Type: Article

References (57)

1. Nakajima S, Doi R, Toyoda T, Tsuji S, and Wada M: N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res, 10, 4125-4133, 2004.
2. Signorelli P, Munoz-Olaya JM, Gagliostro V, Casas J, and Ghidoni R: Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett 282, 238-243, 2009.
3. Gonzalez-Gallego J, Garcia-Mediavilla MV, Sanchez-Campos S, and Tuñ-on MJ: Fruit polyphenols, immunity and inflammation. Br J Nutr 104, S15-S27,, 2010.
4. Granci V, Dupertuis YM, and Pichard C: Angiogenesis as a potential target of pharmaconutrients in cancer therapy. Curr Opin Clin Nutr Metab Care 13, 417-422, 2010.
5. Yang CS, Wang X, and Lu G: Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9, 429-439, 2009.
6. Signorelli P and Ghidoni R: Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem 16, 449-466, 2005.
7. Scarlatti F, Sala G, Ricci C, et al.: Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase. Cancer Lett 253, 124-130, 2007.
8. Tyagi AK, Singh RP, Agarwal C, et al.: Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis. Clin Cancer Res 8, 3512-3519, 2002.
9. Lea MA, Ibeh C, Han L, et al.: Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Res 30, 311-318, 2010.
10. Lemos T, Verdoorn KS, Nogaroli L, et al.: Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: Cross talk between glycero-And sphingolipids in the kidney. Biochim Biophys Acta, 1838, 1003-1009, 2014.
11. Sukocheva OA and Wadham C: Role of sphingolipids in estrogen signalling in breast cancer cells: an update. J Endocrinol, 220, R22-35, 2014.
12. Scarlatti F, Sala G, Somenzi G, et al.: Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 17, 2339-2341, 2003.
13. Park K, Lee S, and Lee YM: Sphingolipids and antimicrobial peptides: function and roles in atopic dermatitis. Biomol Ther (Seoul) 21, 251-257, 2013.
14. Ernst AM and Brugger B: Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta, 1841, 665-670, 2014.
15. Schulze H and Sandhoff K: Sphingolipids and lysosomal pathologies. Biochim Biophys Acta, 134(5), 1359-1368, 2014.
16. Dolfini E, Roncoroni L, Dogliotti E, et al.: Resveratrol impairs the formation of MDA-MB-231 multicellular tumor spheroids concomitant with ceramide accumulation. Cancer Lett 249, 143-147, 2007.
17. Delmas D, Solary E, and Latruffe N: Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe. Curr Med Chem 18, 1100-1121, 2011.
18. Fremont L: Biological effects of resveratrol. Life Sci 66, 663-673, 2000.
19. Pervaiz S: Resveratrol: from grapevines to mammalian biology. FASEB J 17, 1975-1985, 2003.
20. Kang NJ, Shin SH, Lee H J, et al.: Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis. Pharmacol Ther 130, 310-324, 2011.
21. Danilenko M, Wang Q, Wang X, et al.: Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium. Cancer Res 63, 1325-1332, 2003.
22. Sharabani H, Izumchenko E, Wang Q, et al.: Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. Int J Cancer 118, 3012-3021, 2006.
23. Shabtay A, Sharabani H, Barvish Z, et al.: Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia. Oncol 75, 203-214, 2008.
24. Zhang J, Harrison JS, Uskokovic M, et al.: Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors. Hematol Oncol 28, 124-132, 2010.
25. Iida K, Itoh K, Kumagai Y, et al.: Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 64, 6424-6431, 2004.
26. Rangasamy T, Guo J, Mitzner WA, et al.: Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 202, 47-59, 2005.
27. Fahey JW, Haristoy X, Dolan PM, et al.: Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA;99, 7610-7615, May 28, 2002.
28. Khor TO, Huang MT, Kwon KH, et al.: Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res 66, 11580-11584, 2006.
29. Chen W, Sun Z, Wang XJ, et al.: Direct interaction between Nrf2 and p21 (Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell 34, 663-673, 2009.
30. Villeneuve NF, Sun Z, Chen W, et al.: and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle 8, 3255-3256, 2009.
31. Zhao F, Wu T, Lau A, et al.: Nrf2 promotes neuronal cell differentiation Free Radic Biol Med 47, 867-879, 2009.
32. Kosaka K, Mimura J, Itoh K, et al.: Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J Biochem 147, 73-81, Jan, 2010.
33. Pi J, Leung L, Xue P, et al.: Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem 285, 9292-9300, 2010.
34. Bobilev I, Novik V, Levi I, et al.: The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells. Cancer Biol Ther 11, 317-329, 2011.
35. Perletti G, Marras E, Dondi D, et al.: p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. Int J Cancer 113, 42-53, 2005.
36. Li Y, Paonessa JD, and Zhang Y: Mechanism of chemical activation of Nrf2. PLoS One 7, e35122, 2012.
37. Kensler TW, Curphey TJ, Maxiutenko Y, et al.: Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metabol Drug Interact 17(1-4), 3-22, 2000.
38. Balogun E, Hoque M, Gong P, et al.: Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 371, 887-895, 2003.
39. Garg R, Gupta S, and Maru GB: Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrenetreated mice: mechanism of its anti-initiating action. Carcinogenesis; 29, 1022-1032, 2008.
40. Kode A, Rajendrasozhan S., Caito S, et al.: Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smokemediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 294, L478-L488, 2008.
41. Chen CY, Jang JH, Li MH, et al.: Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem Biophys Res Commun 331, 993-1000, 2005.
42. Shu L, Cheung KL, Khor TO, et al.: Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev 29, 483-502, 2010.
43. Iiizumi M, Liu W, Pai K, et al.: Drug development against metastasisrelated genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta 1786, 87-104, 2008.
44. Canals D and Hannun YA: Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol, 215, 211-238, 2013.
45. Kraveka JM, Li L, Szulc ZM, et al.: Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem 282, 16718-16728, 2007.
46. Benzie IF and Strain JJ: The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 239, 70-76, 1996.
47. Zarban A, Taheri F, Chahkandi T, et al.: Antioxidant and radical scavenging activity of human colostrum, transitional and mature milk. J Clin Biochem Nutr. 45, 150-154, 2009.
48. Aruoma OI: Nutrition and health aspects of free radicals and antioxidants. Food Chem Toxicol 32, 671-683, 1994.
49. Munoz-Olaya JM, Matabosch X, Bedia C, et al.: Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMed-Chem 3, 946-953, 2008.
50. Nautiyal J, Kanwar SS, Yu Y, et al.: Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. J Mol Signal 6, 7, 2011.
51. Arocho A, Chen B, Ladanyi M, et al.: Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol 15, 56-61, 2006.
52. Gagliostro V, Casas J, Caretti A, et al.: Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy. Int J Biochem Cell Biol 44, 2135-2143, 2012.
53. Taguchi K, Motohashi H, and Yamamoto M: Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 16, 123-140, 2011.
54. Zhang M, Liu Y, Feng H, et al.: CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2. Am J Pathol 182, 565-576, 2013.
55. Peinado H, Olmeda D, and Cano A: Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7, 415-428, 2007.
56. Uchikado Y, Natsugoe S, Okumura H, et al.: Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma. Clin Cancer Res 11, 1174-1180, 2005.
57. Connor KM, Hempel N, Nelson KK, et al.: Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Cancer Res 67, 10260-10267, 2007.