Dissociation between anti-porcine albumin and anti-Gal antibody responses in non-human primate recipients of intraportal porcine islet transplantation

Xenotransplantation

Volumn 22, Issue 2, 2015, Pages 124-134

  Kang, Hee Jung ^a   Lee, Haneulnari ^a   Park, Eun Mi ^a   Kim, Jong Min ^b   Shin, Jun Seop ^b   Kim, Jung Sik ^b   Park, Chung Gyu ^b   Park, Seong Hoe ^b   Kim, Sang Joon ^b  

^a Hallym University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

antibody; Gal; islets; non Gal; non human primate; pig; xenotransplantation

Indexed keywords

ALBUMIN; ALBUMIN ANTIBODY; ANTI PORCINE ANTIBODY; BOVINE SERUM ALBUMIN; HUMAN ALBUMIN; IMMUNOGLOBULIN G ANTIBODY; PORCINE ALBUMIN; UNCLASSIFIED DRUG; ALBUMINOID; ALPHA-1,3-GALACTOSYLTRANSFERASE 1, PORCINE; GALACTOSYLTRANSFERASE; HETEROPHILE ANTIBODY; IMMUNOGLOBULIN G;

ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT SURVIVAL; IMMUNOBLOTTING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PORCINE ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN BINDING; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; BLOOD; BOVINE; CELL LINE; DEFICIENCY; DIABETES MELLITUS, EXPERIMENTAL; GENE INACTIVATION; GENETICS; HUMAN; IMMUNOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MINIPIG; PIG; PORTAL VEIN; PROCEDURES; RHESUS MONKEY; TRANSGENIC ANIMAL; XENOGRAFT;

ALBUMINS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, HETEROPHILE; CATTLE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; GRAFT SURVIVAL; HUMANS; IMMUNOGLOBULIN G; INFUSIONS, INTRAVENOUS; ISLETS OF LANGERHANS TRANSPLANTATION; MACACA MULATTA; PORTAL VEIN; SWINE; SWINE, MINIATURE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84926508310     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12152     Document Type: Article

References (33)

1. Matsumoto S,. Islet cell transplantation for Type 1 diabetes. J Diabetes 2010; 2: 16-22.
2. van der Windt DJ, Bottino R, Kumar G, et al. Clinical islet xenotransplantation: how close are we? Diabetes 2012; 61: 3046-3055.
3. Cardona K, Korbutt GS, Milas Z, et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006; 12: 304-306.
4. Hering BJ, Wijkstrom M, Graham ML, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303.
5. Thompson P, Cardona K, Russell M, et al. CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. Am J Transplant 2011; 11: 947-957.
6. Graham ML, Schuurman HJ,. The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival. Xenotransplantation 2013; 20: 5-17.
7. Samy KP, Martin BM, Turgeon NA, Kirk AD,. Islet cell xenotransplantation: a serious look toward the clinic. Xenotransplantation 2014; 21: 221-229.
8. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29-31.
9. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295-1298.
10. Hisashi Y, Yamada K, Kuwaki K, et al. Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons. Am J Transplant 2008; 8: 2516-2526.
11. Kirchhof N, Shibata S, Wijkstrom M, et al. Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection. Xenotransplantation 2004; 11: 396-407.
12. Thompson P, Badell IR, Lowe M, et al. Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function. Am J Transplant 2011; 11: 2593-2602.
13. Thompson P, Badell IR, Lowe M, et al. Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival. Am J Transplant 2012; 12: 1765-1775.
14. Galili U,. Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits. Immunology 2013; 140: 1-11.
15. Cramer DV,. Natural antibodies and the host immune responses to xenografts. Xenotransplantation 2000; 7: 83-92.
16. Breimer ME,. Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO era. Xenotransplantation 2011; 18: 215-228.
17. Byrne GW, Stalboerger PG, Du Z, Davis TR, McGregor CG,. Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantation. Transplantation 2011; 91: 287-292.
18. Kang HJ, Lee H, Ha JM, et al. The role of the alternative complement pathway in early graft loss after intraportal porcine islet xenotransplantation. Transplantation 2014; 97: 999-1008.
19. Kim HI, Lee SY, Jin SM, et al. Parameters for successful pig islet isolation as determined using 68 specific-pathogen-free miniature pigs. Xenotransplantation 2009; 16: 11-18.
20. Jin SM, Shin JS, Kim KS, et al. Islet isolation from adult designated pathogen-free pigs: use of the newer bovine nervous tissue-free enzymes and a revised donor selection strategy would improve the islet graft function. Xenotransplantation 2011; 18: 369-379.
21. Jung KC, Park CG, Jeon YK, et al. In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates. J Exp Med 2011; 208: 2477-2488.
22. Liu CT, Higbee GA,. Determination of body surface area in the rhesus monkey. J Appl Physiol 1976; 40: 101-104.
23. Choi HJ, Kim MK, Lee HJ, et al. Efficacy of pig-to-rhesus lamellar corneal xenotransplantation. Invest Ophthalmol Vis Sci 2011; 52: 6643-6650.
24. Domenech N,. Xenoantibodies and complement activity determinations in pig-to-primate xenotransplantation. Methods Mol Biol 2012; 885: 57-69.
25. Takahagi Y, Fujimura T, Miyagawa S, et al. Production of alpha 1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N-acetylglucosaminyltransferase III. Mol Reprod Dev 2005; 71: 331-338.
26. Galili U,. Induced anti-non gal antibodies in human xenograft recipients. Transplantation 2012; 93: 11-16.
27. Buhler L, Deng S, O'Neil J, et al. Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade. Xenotransplantation 2002; 9: 3-13.
28. Buhler L, Xu Y, Li W, Zhu A, Cooper DK,. An investigation of the specificity of induced anti-pig antibodies in baboons. Xenotransplantation 2003; 10: 88-93.
29. Byrne GW, Stalboerger PG, Davila E, et al. Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation. Xenotransplantation 2008; 15: 268-276.
30. Noelle RJ, Snow EC,. Cognate interactions between helper T cells and B cells. Immunol Today 1990; 11: 361-368.
31. Mond JJ, Vos Q, Lees A, Snapper CM,. T cell independent antigens. Curr Opin Immunol 1995; 7: 349-354.
32. MacLennan IC,. Germinal centers. Annu Rev Immunol 1994; 12: 117-139.
33. Brokhof MM, Sollinger HW, Hager DR, et al. Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibodies in moderately sensitized renal transplant recipients. Transplantation 2014; 97: 612-617.