The role of the alternative complement pathway in early graft loss after intraportal porcine islet xenotransplantation

Transplantation

Volumn 97, Issue 10, 2014, Pages 999-1008

  Kang, Hee Jung ^a   Lee, Haneulnari ^a   Ha, Jeong Mi ^a   Lee, Jae Il ^b,c   Shin, Jun Seop ^c   Kim, Ki Yong ^d   Park, Ji Yoon ^d   Kim, Jung Sik ^c   Min, Sang Il ^c   Park, Chung Gyu ^b,c   Park, Seong Hoe ^b   Kim, Sang Joon ^c  

^a Hallym University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d Green Cross Company   (South Korea)

Author keywords

Complement; Islets; Monkey; Pig; Xenotransplantation

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; C PEPTIDE; CD40 LIGAND MONOCLONAL ANTIBODY; COBROTOXIN; COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C4D; COMPLEMENT FACTOR H; D DIMER; FACTOR B ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; MONOCLONAL ANTIBODY; THROMBIN ANTITHROMBIN COMPLEX; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CHEMOPROPHYLAXIS; COMPARATIVE STUDY; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; FEASIBILITY STUDY; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; IMMUNOLOGICAL MONITORING; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INSTANT BLOOD MEDIATED INFLAMMATORY REACTION; INSULIN DEPENDENT DIABETES MELLITUS; INTRAPORTAL ISLET TRANSPLANTATION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN SECRETION; RHESUS MONKEY; SWINE; XENOTRANSPLANTATION;

ANIMALS; COMPLEMENT PATHWAY, ALTERNATIVE; DIABETES MELLITUS, EXPERIMENTAL; GRAFT REJECTION; GRAFT SURVIVAL; HETEROGRAFTS; HUMANS; INFLAMMATION; ISLETS OF LANGERHANS TRANSPLANTATION; SWINE;

EID: 84901265105     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000069     Document Type: Article

References (35)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230.
2. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355: 1318.
3. Matsumoto S. Islet cell transplantation for type 1 diabetes. J Diabetes 2010; 2: 16.
4. Hering BJ, Cooper DK, Cozzi E, et al. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetesVexecutive summary. Xenotransplantation 2009; 16: 196.
5. Hering BJ, Wijkstrom M, Graham ML, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301.
6. Cardona K, Korbutt GS, Milas Z, et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006; 12: 304.
7. van der Windt DJ, Bottino R, Casu A, et al. Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant 2009; 9: 2716.
8. Paraskevas S, Maysinger D, Wang R, et al. Cell loss in isolated human islets occurs by apoptosis. Pancreas 2000; 20: 270.
9. Bottino R, Balamurugan AN, Tse H, et al. Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 2004; 53: 2559.
10. Carlsson PO, Palm F, Andersson A, et al. Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes 2001; 50: 489.
11. Moberg L, Johansson H, Lukinius A, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360: 2039.
12. van der Windt DJ, Bottino R, Casu A, et al. Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies. Xenotransplantation 2007; 14: 288.
13. Davalli AM, Ogawa Y, Ricordi C, et al. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation 1995; 59: 817.
14. Davalli AM, Ogawa Y, Scaglia L, et al. Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes 1995; 44: 104.
15. Korsgren O, Nilsson B, Berne C, et al. Current status of clinical islet transplantation. Transplantation 2005; 79: 1289.
16. Titus TT, Horton PJ, Badet L, et al. Adverse outcome of human isletallogeneic blood interaction. Transplantation 2003; 75: 1317.
17. Tjernberg J, Ekdahl KN, Lambris JD, et al. Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation 2008; 85: 1193.
18. Goto M, Tjernberg J, Dufrane D, et al. Dissecting the instant bloodmediated inflammatory reaction in islet xenotransplantation. Xenotransplantation 2008; 15: 225.
19. Lee KG, Lee H, Ha JM, et al. Increased human tumor necrosis factoralpha levels induce procoagulant change in porcine endothelial cells in vitro. Xenotransplantation 2012; 19: 186.
20. Kirchhof N, Shibata S,Wijkstrom M, et al. Reversal of diabetes in nonimmunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection. Xenotransplantation 2004; 11: 396.
21. van der Windt DJ, Marigliano M, He J, et al. Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated? Cell Transplant 2012; 21: 1791.
22. Rood PP, Bottino R, Balamurugan AN, et al. Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation 2007; 83: 202.
23. Bennet W, Sundberg B, Lundgren T, et al. Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation 2000; 69: 711.
24. Thurman JM, Kraus DM, Girardi G, et al. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibodyinduced pregnancy loss in mice. Mol Immunol 2005; 42: 87.
25. Kim SJ, Kim J, Lee J, et al. Intravitreal human complement factor H in a rat model of laser-induced choroidal neovascularisation. Br J Ophthalmol 2013; 97: 367.
26. Komoda H, Miyagawa S, Kubo T, et al. A study of the xenoantigenicity of adult pig islets cells. Xenotransplantation 2004; 11: 237.
27. Rayat GR, Rajotte RV, Hering BJ, et al. In vitro and in vivo expression of Galalpha-(1,3)Gal on porcine islet cells is age dependent. J Endocrinol 2003; 177: 127.
28. Ferreira VP, Pangburn MK, Cortes C. Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol 2010; 47: 2187.
29. van Denderen BJ, Salvaris E, RomanellaM, et al. Combination of decayaccelerating factor expression and alpha1,3-galactosyltransferase knockout affords added protection fromhuman complement-mediated injury. Transplantation 1997; 64: 882.
30. Bennet W, Bjorkland A, Sundberg B, et al. Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs. Transplantation 2001; 72: 312.
31. Kim HI, Lee SY, Jin SM, et al. Parameters for successful pig islet isolation as determined using 68 specific-pathogen-free miniature pigs. Xenotransplantation 2009; 16: 11.
32. Lee JI, Shin JS, Lee JE, et al. Reference values of hematology, chemistry, electrolytes, blood gas, coagulation time, and urinalysis in the Chinese rhesus macaques (Macaca mulatta). Xenotransplantation 2012; 19: 244.
33. Jin SM, Shin JS, Kim KS, et al. Islet isolation from adult designated pathogen-free pigs: use of the newer bovine nervous tissue-free enzymes and a revised donor selection strategy would improve the islet graft function. Xenotransplantation 2011; 18: 369.
34. Jung KC, Park CG, Jeon YK, et al. In situ induction of dendritic cellbased T cell tolerance in humanized mice and nonhuman primates. J Exp Med 2011; 208: 2477.
35. Kang HJ, Ki CS, Kim YS, et al. Two mutations of the C7 gene, c.1424G 9 A and c.281-1G 9 T, in two Korean families. J Clin Immunol 2006; 26: 186.