Demethoxycurcumin-carrying chitosan-antibody core-shell nanoparticles with multitherapeutic efficacy toward malignant a549 lung tumor: From in vitro characterization to in vivo evaluation

Molecular Pharmaceutics

Volumn 12, Issue 4, 2015, Pages 1242-1249

  Huang, Wei Ting ^a   Larsson, Mikael ^a,b   Wang, Yen Jen ^a   Chiou, Shih Hwa ^c,d   Lin, Hui Yi ^e   Liu, Dean Mo ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

amphiphilic chitosan; demethoxycurcumin; drug release; multidrug resistant; non small cell lung cancer cell

Indexed keywords

ANTIBODY; CHITOSAN NANOPARTICLE; DEMETHOXYCURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; CHITOSAN; CURCUMIN; DRUG CARRIER; EPIDERMAL GROWTH FACTOR RECEPTOR; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; COATED PARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG RELEASE; DYNAMIC LIGHT SCATTERING; ENDOCYTOSIS; ENDOSOME; EXPERIMENTAL MODEL; HYPOXIC CELL; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; LUNG CANCER; LYSOSOME; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CARCINOMA, NON-SMALL-CELL LUNG; CHEMISTRY; CYTOPLASM; DRUG DELIVERY SYSTEM; HUMAN; IC50; LIGHT; LUNG NEOPLASMS; METABOLISM; NANOMEDICINE; NUDE MOUSE; RADIATION SCATTERING; TUMOR CELL LINE;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CHITOSAN; CURCUMIN; CYTOPLASM; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; INHIBITORY CONCENTRATION 50; LIGHT; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NANOMEDICINE; NANOPARTICLES; NEOPLASM TRANSPLANTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SCATTERING, RADIATION;

EID: 84926472847     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500747w     Document Type: Article

References (58)

1. Siegel, R.; DeSantis, C.; Virgo, K.; Stein, K.; Mariotto, A.; Smith, T.; Cooper, D.; Gansler, T.; Lerro, C.; Fedewa, S.; Lin, C.; Leach, C.; Cannady, R. S.; Cho, H.; Scoppa, S.; Hachey, M.; Kirch, R.; Jemal, A.; Ward, E. Cancer Treatment and Survivorship Statistics, 2012 Ca-Cancer J. Clin. 2012, 62 (4) 220-241
2. Siegel, R.; Naishadham, D.; Jemal, A. Cancer Statistics, 2013 Ca-Cancer J. Clin. 2013, 63 (1) 11-30
3. Quoix, E.; Westeel, V.; Zalcman, G.; Milleron, B. Chemotherapy in Elderly Patients with Advanced Non-Small Cell Lung Cancer Lung Cancer 2011, 74 (3) 364-368
4. Pallis, A. G.; Scarci, M. Are We Treating Enough Elderly Patients with Early Stage Non-Small Cell Lung Cancer? Lung Cancer 2011, 74 (2) 149-154
5. Reck, M.; Heigener, D. F.; Mok, T.; Soria, J. C.; Rabe, K. F. Management of Non-Small-Cell Lung Cancer: Recent Developments Lancet 2013, 382 (9893) 709-719
6. Blinman, P.; Alam, M.; Duric, V.; McLachlan, S. A.; Stockler, M. R. Patients' Preferences for Chemotherapy in Non-Small-Cell Lung Cancer: A Systematic Review Lung Cancer 2010, 69 (2) 141-147
7. Kelly, R. J.; Sharon, E.; Hassan, R. Chemotherapy and Targeted Therapies for Unresectable Malignant Mesothelioma Lung Cancer 2011, 73 (3) 256-263
8. Younes, R. N.; Pereira, J. R.; Fares, A. L.; Gross, J. Chemotherapy Beyond First-Line in Stage IV Metastatic Non-Small Cell Lung Cancer Rev. Assoc. Med. Bras. (Engl. Ed.) 2011, 57 (6) 672-677
9. Chang, A. Chemotherapy, Chemoresistance and the Changing Treatment Landscape for NSCLC Lung Cancer 2011, 71 (1) 3-10
10. Krishna, R.; Mayer, L. D. Multidrug Resistance (MDR) in Cancer: Mechanisms, Reversal Using Modulators of MDR and the Role of MDR Modulators in Influencing the Pharmacokinetics of Anticancer Drugs Eur. J. Pharm. Sci. 2000, 11 (4) 265-283
11. DeVita, V. T.; Chu, E. A History of Cancer Chemotherapy Cancer Res. 2008, 68 (21) 8643-8653
12. Rademakers, S. E.; Span, P. N.; Kaanders, J. H. A. M.; Sweep, F. C. G. J.; van der Kogel, A. J.; Bussink, J. Molecular Aspects of Tumour Hypoxia Mol. Oncol. 2008, 2 (1) 41-53
13. Meng, X.; Kong, F. M.; Yu, J. Implementation of Hypoxia Measurement into Lung Cancer Therapy Lung Cancer 2012, 75 (2) 146-150
14. Milane, L.; Duan, Z.; Amiji, M. Role of Hypoxia and Glycolysis in the Development of Multi-Drug Resistance in Human Tumor Cells and the Establishment of an Orthotopic Multi-Drug Resistant Tumor Model in Nude Mice Using Hypoxic Pre-Conditioning Cancer Cell Int. 2011, 11 (1) 3
15. Hsu, P. P.; Sabatini, D. M. Cancer Cell Metabolism: Warburg and Beyond Cell 2008, 134 (5) 703-707
16. Kibria, G.; Hatakeyama, H.; Harashima, H. Cancer Multidrug Resistance: Mechanisms Involved and Strategies for Circumvention Using a Drug Delivery System Arch. Pharmacal Res. 2014, 37 (1) 4-15
17. Song, X.; Liu, X.; Chi, W.; Liu, Y.; Wei, L.; Wang, X.; Yu, J. Hypoxia-Induced Resistance to Cisplatin and Doxorubicin in Non-Small Cell Lung Cancer Is Inhibited by Silencing of HIF-1a Gene Cancer Chemother. Pharmacol. 2006, 58 (6) 776-784
18. Lee, S. H.; Koo, K. H.; Park, J. W.; Kim, H. J.; Ye, S. K.; Park, J. B.; Park, B. K.; Kim, Y. N. HIF-1 Is Induced via EGFR Activation and Mediates Resistance to Anoikis-Like Cell Death under Lipid Rafts/Caveolae-Disrupting Stress Carcinogenesis 2009, 30 (12) 1997-2004
19. Xue, X.; Yu, J. L.; Sun, D. Q.; Zou, W.; Kong, F.; Wu, J.; Liu, H. p.; Qu, X. j.; Wang, R. M. Curcumin as a Multidrug Resistance Modulator-A Quick Review Biomed. Prev. Nutr. 2013, 3 (2) 173-176
20. Shehzad, A.; Wahid, F.; Lee, Y. S. Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials Arch. Pharm. 2010, 343 (9) 489-499
21. Blakely, C. M.; Bivona, T. G. Roles of NF-kappaB Signaling in EGFR Oncogene Dependence in Non-Small Cell Lung Cancer Cancer Hallmarks 2013, 1 (1) 18-27
22. Anand, P.; Sundaram, C.; Jhurani, S.; Kunnumakkara, A. B.; Aggarwal, B. B. Curcumin and Cancer: An "Old-Age" Disease with an "Age-Old" Solution Cancer Lett. 2008, 267 (1) 133-164
23. Guo, L.; Cai, X.; Lee, J.; Kang, S.; Shin, E.; Zhou, H.; Jung, J.; Kim, Y. Comparison of Suppressive Effects of Demethoxycurcumin and Bisdemethoxycurcumin on Expressions of Inflammatory Mediators In Vitro and In Vivo Arch. Pharmacal Res. 2008, 31 (4) 490-496
24. Luthra, P. M.; Kumar, R.; Prakash, A. Demethoxycurcumin Induces Bcl-2 Mediated G2/M Arrest and Apoptosis in Human Glioma U87 Cells Biochem. Biophys. Res. Commun. 2009, 384 (4) 420-425
25. Wu, S. H.; Hang, L. W.; Yang, J. S.; Chen, H. Y.; Lin, H. Y.; Chiang, J. H.; Lu, C. C.; Yang, J. L.; Lai, T. Y.; Ko, Y. C.; Chung, J. G. Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways Anticancer Res. 2010, 30 (6) 2125-2133
26. Prakobwong, S.; Gupta, S. C.; Kim, J. H.; Sung, B.; Pinlaor, P.; Hiraku, Y.; Wongkham, S.; Sripa, B.; Pinlaor, S.; Aggarwal, B. B. Curcumin Suppresses Proliferation and Induces Apoptosis in Human Biliary Cancer Cells through Modulation of Multiple Cell Signaling Pathways Carcinogenesis 2011, 32 (9) 1372-1380
27. Sharma, R. A.; Gescher, A. J.; Steward, W. P. Curcumin: The Story so Far Eur. J. Cancer 2005, 41 (13) 1955-1968
28. Syng-ai, C.; Kumari, A. L.; Khar, A. Effect of Curcumin on Normal and Tumor Cells: Role of Glutathione and Bcl-2 Mol. Cancer Ther. 2004, 3 (9) 1101-1108
29. Sandur, S. K.; Pandey, M. K.; Sung, B.; Ahn, K. S.; Murakami, A.; Sethi, G.; Limtrakul, P.; Badmaev, V.; Aggarwal, B. B. Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin, Tetrahydrocurcumin and Turmerones Differentially Regulate Anti-Inflammatory and Anti-Proliferative Responses through a ROS-Independent Mechanism Carcinogenesis 2007, 28 (8) 1765-1773
30. Li, R.; Qiao, X.; Li, Q.; He, R.; Ye, M.; Xiang, C.; Lin, X.; Guo, D. Metabolic and Pharmacokinetic Studies of Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin in Mice Tumor after Intragastric Administration of Nanoparticle Formulations by Liquid Chromatography Coupled with Tandem Mass Spectrometry J. Chromatogr. B 2011, 879 (26) 2751-2758
31. Quitschke, W. Differential Solubility of Curcuminoids in Serum and Albumin Solutions: Implications for Analytical and Therapeutic Applications BMC Biotechnol. 2008, 8 (1) 84
32. Hsu, C. H.; Cheng, A. L. Clinical Studies with Curcumin. In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease; Aggarwal, B.; Surh, Y. J.; Shishodia, S., Eds.; Springer: New York, 2007; Vol. 595, pp 471-480.
33. Li, C. A Targeted Approach to Cancer Imaging and Therapy Nat. Mater. 2014, 13 (2) 110-115
34. Patel, N. R.; Pattni, B. S.; Abouzeid, A. H.; Torchilin, V. P. Nanopreparations to Overcome Multidrug Resistance in Cancer Adv. Drug Delivery Rev. 2013, 65 (13-14) 1748-1762
35. Alexis, F.; Pridgen, E.; Langer, R.; Farokhzad, O. Nanoparticle Technologies for Cancer Therapy. In Drug Delivery; Schäfer-Korting, M., Ed.; Springer: Berlin, Heidelberg; 2010; Vol. 197, pp 55-86.
36. Vinogradov, S.; Wei, X. Cancer Stem Cells and Drug Resistance: The Potential of Nanomedicine Nanomedicine 2012, 7 (4) 597-615
37. Larsson, M.; Huang, W. C.; Hsiao, M. H.; Wang, Y. J.; Nydén, M.; Chiou, S. H.; Liu, D. M. Biomedical Applications and Colloidal Properties of Amphiphilically Modified Chitosan Hybrids Prog. Polym. Sci. 2013, 38 (9) 1307-1328
38. Malatesta, M.; Galimberti, V.; Cisterna, B.; Costanzo, M.; Biggiogera, M.; Zancanaro, C. Chitosan Nanoparticles Are Efficient Carriers for Delivering Biodegradable Drugs to Neuronal Cells Histochem. Cell Biol. 2014, 141 (5) 551-558
39. Kumari, A.; Yadav, S. K.; Yadav, S. C. Biodegradable Polymeric Nanoparticles Based Drug Delivery Systems Colloids Surf., B 2010, 75 (1) 1-18
40. Wang, A. Z.; Langer, R.; Farokhzad, O. C. Nanoparticle Delivery of Cancer Drugs Annu. Rev. Med. 2012, 63 (1) 185-198
41. Maya, S.; Sarmento, B.; Lakshmanan, V. K.; Menon, D.; Seabra, V.; Jayakumar, R. Chitosan Cross-Linked Docetaxel Loaded EGF Receptor Targeted Nanoparticles for Lung Cancer Cells Int. J. Biol. Macromol. 2014, 69 (0) 532-541
42. Deepagan, V. G.; Sarmento, B.; Menon, D.; Nascimento, A.; Jayasree, A.; Sreeranganathan, M.; Koyakutty, M.; Nair, S. V.; Rangasamy, J. In Vitro Targeted Imaging and Delivery of Camptothecin Using Cetuximab-Conjugated Multifunctional PLGA-Zns Nanoparticles Nanomedicine 2012, 7 (4) 507-519
43. Maya, S.; Sarmento, B.; Lakshmanan, V. K.; Menon, D.; Jayakumar, R. Actively Targeted Cetuximab Conjugated γ-Poly(glutamic acid)-Docetaxel Nanomedicines for Epidermal Growth Factor Receptor over Expressing Colon Cancer Cells J. Biomed. Nanotechnol. 2014, 10 (8) 1416-1428
44. Maya, S.; Kumar, L. G.; Sarmento, B.; Sanoj Rejinold, N.; Menon, D.; Nair, S. V.; Jayakumar, R. Cetuximab Conjugated O-Carboxymethyl Chitosan Nanoparticles for Targeting EGFR Overexpressing Cancer Cells Carbohydr. Polym. 2013, 93 (2) 661-669
45. Wang, Y. J.; Lin, H. Y.; Wu, C. H.; Liu, D. M. Forming of Demethoxycurcumin Nanocrystallite-Chitosan Nanocarrier for Controlled Low Dose Cellular Release for Inhibition of the Migration of Vascular Smooth Muscle Cells Mol. Pharmaceutics 2012, 9 (8) 2268-2279
46. Wang, Y. J.; Chien, Y. C.; Wu, C. H.; Liu, D. M. Magnolol-Loaded Core-Shell Hydrogel Nanoparticles: Drug Release, Intracellular Uptake, and Controlled Cytotoxicity for the Inhibition of Migration of Vascular Smooth Muscle Cells Mol. Pharmaceutics 2011, 8 (6) 2339-2349
47. Chien, Y.; Liao, Y. W.; Liu, D. M.; Lin, H. L.; Chen, S. J.; Chen, H. L.; Peng, C. H.; Liang, C. M.; Mou, C. Y.; Chiou, S. H. Corneal Repair by Human Corneal Keratocyte-Reprogrammed iPSCs and Amphiphatic Carboxymethyl-Hexanoyl Chitosan Hydrogel Biomaterials 2012, 33 (32) 8003-8016
48. Hsiao, M. H.; Larsson, M.; Larsson, A.; Evenbratt, H.; Chen, Y. Y.; Chen, Y. Y.; Liu, D. M. Design and Characterization of a Novel Amphiphilic Chitosan Nanocapsule-Based Thermo-Gelling Biogel with Sustained In Vivo Release of the Hydrophilic Anti-Epilepsy Drug Ethosuximide J. Controlled Release 2012, 161 (3) 942-948
49. Lin, L. J.; Larsson, M.; Liu, D. M. A Novel Dual-Structure, Self-Healable, Polysaccharide Based Hybrid Nanogel for Biomedical Uses Soft Matter 2011, 7 (12) 5816-5825
50. Orth, J. D.; Krueger, E. W.; Weller, S. G.; McNiven, M. A. A Novel Endocytic Mechanism of Epidermal Growth Factor Receptor Sequestration and Internalization Cancer Res. 2006, 66 (7) 3603-3610
51. Yue, T.; Zhang, X. Cooperative Effect in Receptor-Mediated Endocytosis of Multiple Nanoparticles ACS Nano 2012, 6 (4) 3196-3205
52. Albanese, A.; Tang, P. S.; Chan, W. C. W. The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems Annu. Rev. Biomed. Eng. 2012, 14 (1) 1-16
53. Canton, I.; Battaglia, G. Endocytosis at the Nanoscale Chem. Soc. Rev. 2012, 41 (7) 2718-2739
54. Hsiao, M. H.; Chiou, S. H.; Larsson, M.; Hung, K. H.; Wang, Y. L.; Liu, C. J. L.; Liu, D. M. A Temperature-Induced and Shear-Reversible Assembly of Latanoprost-Loaded Amphiphilic Chitosan Colloids: Characterization and In Vivo Glaucoma Treatment Acta Biomater. 2014, 10 (7) 3188-3196
55. Azarmi, S.; Roa, W. H.; Löbenberg, R. Targeted Delivery of Nanoparticles for the Treatment of Lung Diseases Adv. Drug Delivery Rev. 2008, 60 (8) 863-875
56. Rosenzweig, S. A. Acquired Resistance to Drugs Targeting Receptor Tyrosine Kinases Biochem. Pharmacol. 2012, 83 (8) 1041-1048
57. Ritger, P. L.; Peppas, N. A. A Simple Equation for Description of Solute Release I. Fickian and Non-Fickian Release from Non-Swellable Devices in the Form of Slabs, Spheres, Cylinders or Discs J. Controlled Release 1987, 5 (1) 23-36
58. Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Long-Circulating and Target-Specific Nanoparticles: Theory to Practice Pharmacol. Rev. 2001, 53 (2) 283-318