HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress

Carcinogenesis

Volumn 30, Issue 12, 2009, Pages 1997-2004

  Lee, Seong Hee ^a   Koo, Kyung Hee ^a   Park, Jong Wan ^b   Kim, Hee Jung ^a   Ye, Sang Kyu ^b   Park, Jong Bae ^a   Park, Byung Kiu ^a   Kim, Yong Nyun ^a  

^a National Cancer Center   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLODEXTRIN; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; VASCULOTROPIN; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; VASCULOTROPIN A;

ANOIKIS; ARTICLE; CAVEOLA; CELLULAR STRESS RESPONSE; CHOLESTEROL SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; LIPID RAFT; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RNA INTERFERENCE; UPREGULATION; ANOXIA; CELL DEATH; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY; HELA CELL; METABOLISM; TUMOR CELL LINE;

ANOIKIS; ANOXIA; CAVEOLAE; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; LIPIDS; MEMBRANE MICRODOMAINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 73949152978     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp233     Document Type: Article

References (35)

1. Hancock, J.F. (2006) Lipid rafts: contentious only from simplistic standpoints. Nat. Rev. Mol. Cell Biol., 7, 456-462.
2. Jacobson, K. et al. (2007) Lipid rafts: at a crossroad between cell biology and physics. Nat. Cell Biol., 9, 7-14.
3. Patra, S.K. (2008) Dissecting lipid raft facilitated cell signaling pathways in cancer. Biochim. Biophys. Acta, 1785, 182-206.
4. Li, Y.C. et al. (2006) Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesteroldepleting agents. Am. J. Pathol., 168, 1107-1118; quiz 1404-1405.
5. Magura, L. et al. (2008) Hypercholesterolemia and prostate cancer: a hospitalbased case-control study. Cancer Causes Control, 19, 1259-1266.
6. Freeman, M.R. et al. (2007) Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids, 72, 210-217.
7. Summons, R.E. et al. (2006) Steroids, triterpenoids and molecular oxygen. Philos. Trans. R. Soc. Lond. B Biol. Sci., 361, 951-968.
8. Nguyen, A.D. et al. (2007) Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. J. Biol. Chem., 282, 27436-27446.
9. Maynard, M.A. et al. (2007) The role of hypoxia-inducible factors in cancer. Cell. Mol. Life Sci., 64, 2170-2180.
10. Dery, M.A. et al. (2005) Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int. J. Biochem. Cell Biol., 37, 535-540.
11. Peng, X.H. et al. (2006) Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. J. Biol. Chem., 281, 25903-25914.
12. Semenza, G.L. (2008) Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life, 60, 591-597.
13. Zhong, H. et al. (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/Akt/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res., 60, 1541-1545.
14. Chen, X. et al. (2002) Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J. Biol. Chem., 277, 49631-49637.
15. Park, E.K. et al. (2009) Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization. J. Pathol., 218, 337-349.
16. Kim, Y.N. et al. (2000) Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status. J. Biol. Chem., 275, 7481-7491.
17. Hwang, J.I. et al. (2005) Silencing the expression of multiple Gbetasubunits eliminates signaling mediated by all four families of G proteins. Proc. Natl Acad. Sci. USA, 102, 9493-9498.
18. Chiche, J. et al. (2009) Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res., 69, 358-368.
19. Pedersen, M. et al. (2008) Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells. Biochem. Biophys. Res. Commun., 377, 98-103.
20. Song, G. et al. (2008) Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1alpha expression through the PI3-K/Akt pathway. Cancer Sci., 99, 1901-1907.
21. Fedida-Metula, S. et al. (2008) Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells. Carcinogenesis, 29, 1546-1554.
22. Diebold, I. et al. (2008) Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription. Thromb. Haemost., 100, 1021-1028.
23. Niu, G. et al. (2008) Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells. Mol. Cancer Res., 6, 1099-1105.
24. Bellot, G. et al. (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol., 29, 2570-2581.
25. Shin, D.H. et al. (2008) CITED2 mediates the paradoxical responses of HIF-1alpha to proteasome inhibition. Oncogene, 27, 1939-1944.
26. Mitra, S.K. et al. (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol., 18, 516-523.
27. Koike, T. et al. (2004) Hypoxia induces adhesion molecules on cancer cells: a missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc. Natl Acad. Sci. USA, 101, 8132-8137.
28. Indovina, P. et al. (2008) Hypoxia increases adhesion and spreading of MG-63 three-dimensional tumor spheroids. Anticancer Res., 28, 1013-1022.
29. Rohwer, N. et al. (2008) Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin. Cancer Res., 68, 10113-10120.
30. Kilic, M. et al. (2007) Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance. Oncogene, 26, 2027-2038.
31. Laura, B. et al. (2008) Hypoxia-induced modifications in plasma membranes and lipid microdomains in A549 cells and primary human alveolar cells. J. Cell. Biochem., 105, 503-513.
32. Gauthaman, K. et al. (2009) Statins, stem cells, and cancer. J. Cell. Biochem., 106, 975-983.
33. Zhuang, L. et al. (2005) Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J. Clin. Invest., 115, 959-968.
34. Chen, S.D. et al. (2005) Pravastatin attenuates ceramide-induced cytotoxicity in mouse cerebral endothelial cells with HIF-1 activation and VEGF upregulation. Ann. N.Y. Acad. Sci., 1042, 357-364.
35. Nishimoto-Hazuku, A. et al. (2008) Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J. Cardiovasc. Pharmacol., 51, 267 273.