Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 942-948

  Hsiao, Meng Hsuan ^a   Larsson, Mikael ^a,b   Larsson, Anette ^b   Evenbratt, Hanne ^b   Chen, Ying Yu ^c   Chen, You Yin ^d   Liu, Dean Mo ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Amphiphilic chitosan; Drug delivery; In vivo; Nano capsules; Thermo responsive

Indexed keywords

AMPHIPHILICS; BURST RELEASE; DRUG DELIVERY SYSTEM; EPITHELIUM CELLS; ETHOSUXIMIDE; GEL STRUCTURES; GLYCEROPHOSPHATE; IN-VITRO; IN-VIVO; MODIFIED CHITOSAN; MTT ASSAYS; NANOGELS; NETWORK STRUCTURES; RAT MODEL; SELF-ASSEMBLED; THERAPEUTIC EFFECTS; THERMO-RESPONSIVE; TWO PHOTON MICROSCOPY;

CHITOSAN; DRUG DELIVERY; GELATION; GELS; GLYCEROL; NANOSTRUCTURED MATERIALS; PHOSPHOLIPIDS;

NANOCAPSULES;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMPHOPHILE; CARBOXYMETHYLHEXANOYLCHITOSAN; CHITOSAN; ETHOSUXIMIDE; GENIPIN; GLYCEROL; GLYCEROL 2 PHOSPHATE; NANOCAPSULE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; GELATION; HUMAN; HUMAN CELL; HYDROGEL; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; LONG EVANS RAT; MICROSCOPY; MONITORING; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; TRANSMISSION ELECTRON MICROSCOPY; TWO PHOTON MICROSCOPY;

ANIMALS; ANTICONVULSANTS; CELL LINE; CELL SURVIVAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; ETHOSUXIMIDE; GELS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NANOCAPSULES; RATS; RATS, LONG-EVANS; SEIZURES;

EID: 84864600729     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.038     Document Type: Article

References (34)

1. H.T. Ta, C.R. Dass, and D.E. Dunstan Injectable chitosan hydrogels for localised cancer therapy J. Control. Release 126 2008 205 216
2. X. Li, X. Kong, J. Zhang, Y. Wang, Y. Wang, S. Shi, G. Guo, F. Luo, X. Zhao, Y. Wei, and Z. Qian A novel composite hydrogel based on chitosan and inorganic phosphate for local drug delivery of camptothecin nanocolloids J. Pharm. Sci. 100 2011 232 241
3. J.F. Mano Stimuli-responsive polymeric systems for biomedical applications Adv. Eng. Mater. 10 2008 515 527
4. E. Ruel-Gariépy, and J.-C. Leroux In situ-forming hydrogels - review of temperature-sensitive systems Eur. J. Pharm. Biopharm. 58 2004 409 426 (Pubitemid 39037244)
5. A. Hatefi, and B. Amsden Biodegradable injectable in situ forming drug delivery systems J. Control. Release 80 2002 9 28 (Pubitemid 34273745)
6. E. Ruel-Gariépy, G. Leclair, P. Hildgen, A. Gupta, and J.C. Leroux Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules J. Control. Release 82 2002 373 383 (Pubitemid 34880191)
7. X.-Z. Zhang, P. Jo Lewis, and C.-C. Chu Fabrication and characterization of a smart drug delivery system: microsphere in hydrogel Biomaterials 26 2005 3299 3309 (Pubitemid 39647263)
8. L. Yu, and J. Ding Injectable hydrogels as unique biomedical materials Chem. Soc. Rev. 37 2008 1473 1481
9. M. Dash, F. Chiellini, R.M. Ottenbrite, and E. Chiellini Chitosan-a versatile semi-synthetic polymer in biomedical applications Prog. Polym. Sci. 36 2011 981 1014
10. E. Khor, and L.Y. Lim Implantable applications of chitin and chitosan Biomaterials 24 2003 2339 2349 (Pubitemid 36434054)
11. V. Dodane, and V.D. Vilivalam Pharmaceutical applications of chitosan Pharm. Sci. Technol. Today 1 1998 246 253 (Pubitemid 28439296)
12. M. Prabaharan, and J.F. Mano Chitosan-based particles as controlled drug delivery systems Drug Deliv. 12 2004 41 57
13. D. Filion, M. Lavertu, and M.D. Buschmann Ionization and solubility of chitosan solutions related to thermosensitive chitosan/glycerol-phosphate systems Biomacromolecules 8 2007 3224 3234 (Pubitemid 350011646)
14. A. Chenite, M. Buschmann, D. Wang, C. Chaput, and N. Kandani Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions Carbohydr. Polym. 46 2001 39 47 (Pubitemid 32487087)
15. H.J. Chung, and T.G. Park Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering Nano Today 4 2009 429 437
16. X. Li, X. Kong, X. Wang, S. Shi, G. Guo, F. Luo, X. Zhao, Y. Wei, and Z. Qian Gel-sol-gel thermo-gelation behavior study of chitosan-inorganic phosphate solutions Eur. J. Pharm. Biopharm. 75 2010 388 392
17. L.S. Nair, T. Starnes, J.-W.K. Ko, and C.T. Laurencin Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications Biomacromolecules 8 2007 3779 3785
18. T.-Y. Liu, S.-Y. Chen, Y.-L. Lin, and D.-M. Liu Synthesis and characterization of amphiphatic carboxymethyl-hexanoyl chitosan hydrogel: water-retention ability and drug encapsulation Langmuir 22 2006 9740 9745 (Pubitemid 44826388)
19. K.-H. Liu, S.-Y. Chen, D.-M. Liu, and T.-Y. Liu Self-assembled hollow nanocapsule from amphiphatic carboxymethyl-hexanoyl chitosan as drug carrier Macromolecules 41 2008 6511 6516
20. K.-H. Liu, B.-R. Chen, S.-Y. Chen, and D.-M. Liu Self-assembly behavior and doxorubicin-loading capacity of acylated carboxymethyl chitosans J. Phys. Chem. B 113 2009 11800 11807
21. L.-J. Lin, M. Larsson, and D.-M. Liu A novel dual-structure, self-healable, polysaccharide based hybrid nanogel for biomedical uses Soft Matter 7 2011 5816 5825
22. T.-Y. Liu, T.-Y. Liu, S.-Y. Chen, S.-C. Chen, and D.-M. Liu Effect of hydroxyapatite nanoparticles on ibuprofen release from carboxymethyl-hexanoyl chitosan/o-hexanoyl chitosan hydrogel J. Nanosci. Nanotechnol. 6 2006 2929 2935 (Pubitemid 44579964)
23. R. Jin, L.S.M. Teixeira, P.J. Dijkstra, M. Karperien, C.A. van Blitterswijk, Z.Y. Zhong, and J. Feijen Injectable chitosan-based hydrogels for cartilage tissue engineering Biomaterials 30 2009 2544 2551
24. S. Kim, S.K. Nishimoto, J.D. Bumgardner, W.O. Haggard, M.W. Gaber, and Y.Z. Yang A chitosan/beta-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer Biomaterials 31 2010 4157 4166
25. R.A.A. Muzzarelli Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids Carbohydr. Polym. 77 2009 1 9
26. F.Z. Shaw, S.H. Chuang, K.R. Shieh, and Y.J. Wang Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges Neuroscience 160 2009 382 393
27. I. Serbanescu, M.A. Ryan, R. Shukla, M.A. Cortez, O.C. Snead, and S.C. Cunnane Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols J. Lipid Res. 45 2004 2038 2043 (Pubitemid 40990898)
28. P.-O. Polack, and S. Charpier Intracellular activity of cortical and thalamic neurones during high-voltage rhythmic spike discharge in long-evans rats in vivo J. Physiol. 571 2006 461 476
29. F.-Z. Shaw Is spontaneous high-voltage rhythmic spike discharge in long evans rats an absence-like seizure activity? J. Neurophysiol. 91 2004 63 77 (Pubitemid 38084354)
30. J. Siepmann, and N.A. Peppas Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (hpmc) Adv. Drug. Deliv. Rev. 48 2001 139 157 (Pubitemid 32434400)
31. P.L. Ritger, and N.A. Peppas A simple equation for description of solute release ii. Fickian and anomalous release from swellable devices J. Control. Release 5 1987 37 42 (Pubitemid 17106644)
32. R. Ahmadi, and J.D. de Bruijn Biocompatibility and gelation of chitosan-glycerol phosphate hydrogels J. Biomed. Mater. Res. A 86A 2008 824 832
33. A. Chenite, C. Chaput, D. Wang, C. Combes, M.D. Buschmann, C.D. Hoemann, J.C. Leroux, B.L. Atkinson, F. Binette, and A. Selmani Novel injectable neutral solutions of chitosan form biodegradable gels in situ Biomaterials 21 2000 2155 2161 (Pubitemid 30612386)
34. W.-C. Huang, S.-H. Hu, K.-H. Liu, S.-Y. Chen, and D.-M. Liu A flexible drug delivery chip for the magnetically-controlled release of anti-epileptic drugs J. Control. Release 139 2009 221 228