PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation

PLoS Pathogens

Volumn 11, Issue 3, 2015, Pages 1-26

  Li, Zexing ^a   Liu, Ge ^b   Sun, Liwei ^a   Teng, Yan ^c   Guo, Xuejiang ^d   Jia, Jianhang ^e   Sha, Jiahao ^d   Yang, Xiao ^c   Chen, Dahua ^b   Sun, Qinmiao ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b INSTITUTE OF ZOOLOGY   (China)

^c BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON; INTERFERON REGULATORY FACTOR; INTERFERON STIMULATED RESPONSE ELEMENT; PROTEIN KINASE; PROTEIN PHOSPHATASE 1A (MAGNESIUM MANGANESE); RANTES; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; MPYS PROTEIN, MOUSE; PHOSPHOPROTEIN PHOSPHATASE; PPM1A PROTEIN, HUMAN; PPM1A PROTEIN, MOUSE; PROTEIN PHOSPHATASE 2C; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN; TBK1 PROTEIN, MOUSE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DEPHOSPHORYLATION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; ANIMAL; CHLOROCEBUS AETHIOPS; GENETICS; HEK293 CELL LINE; HELA CELL LINE; IMMUNOLOGY; KNOCKOUT MOUSE; MOUSE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; VERO CELL LINE;

ANIMALS; CERCOPITHECUS AETHIOPS; HEK293 CELLS; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2C; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; VERO CELLS;

EID: 84926450646     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004783     Document Type: Article

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