Organic aerosols associated with the generation of reactive oxygen species (ROS) by water-soluble PM2.5

Environmental Science and Technology

Volumn 49, Issue 7, 2015, Pages 4646-4656

  Verma, Vishal ^a   Fang, Ting ^a   Xu, Lu ^b   Peltier, Richard E ^c   Russell, Armistead G ^b   Ng, Nga Lee ^b   Weber, Rodney J ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b Georgia Institute of Technology   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHILICITY; OXIDATION; OXYGEN; URBAN GROWTH;

AEROSOL MASS SPECTROMETERS; HYDROPHOBIC AND HYDROPHILIC; LINEAR REGRESSION TECHNIQUES; ORGANIC AEROSOL COMPOSITIONS; POSITIVE MATRIX FACTORIZATION; REACTIVE OXYGEN SPECIES; SECONDARY ORGANIC AEROSOLS; WATER SOLUBLE FRACTION;

AEROSOLS;

AMMONIUM SULFATE; CADMIUM; CHROMIUM; COBALT; CUPRIC ION; DITHIOTHREITOL; HYDROCARBON; IRON; ISOPRENE; LEAD; LEVOGLUCOSAN; MANGANESE; NICKEL; NITRATE; ORGANIC CARBON; REACTIVE OXYGEN METABOLITE; SULFUR; TERPENE; VANADIUM; VOLATILE ORGANIC COMPOUND; ZINC; AEROSOL; AIR POLLUTANT; ORGANIC COMPOUND;

AEROSOL COMPOSITION; BIOMASS BURNING; MASS SPECTROMETRY; REACTION KINETICS; SOLUBILITY;

AEROSOL; ARTICLE; BIOMASS; BIOMASS BURNING AEROSOL; CHEMICAL COMPOSITION; CONTROLLED STUDY; HYDROPHILICITY; HYDROPHOBICITY; OXIDATION REDUCTION POTENTIAL; PARTICULATE MATTER; RURAL AREA; SEASONAL VARIATION; SECONDARY ORGANIC AEROSOL; SOLID PHASE EXTRACTION; SUMMER; URBAN AREA; WINTER; AIR POLLUTANT; CHEMISTRY; CITY; GEORGIA; MASS SPECTROMETRY; SOLUBILITY; THEORETICAL MODEL; TOXICITY; UNITED STATES;

UNITED STATES;

AEROSOLS; AIR POLLUTANTS; ALABAMA; CITIES; DITHIOTHREITOL; GEORGIA; MASS SPECTROMETRY; MODELS, THEORETICAL; ORGANIC CHEMICALS; REACTIVE OXYGEN SPECIES; SOLUBILITY;

EID: 84926444196     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es505577w     Document Type: Article

References (70)

1. Venkatachari, P.; Hopke, P. K. Development and laboratory testing of an automated monitor for the measurement of atmospheric particle-bound reactive oxygen species (ROS) Aerosol Sci. Technol. 2008, 42 (8) 629-635
2. Evelson, P.; Martin, S.; Mandalunis, P.; Dawidowski, L.; Tasat, D. R. Lung oxidative stress by exposure to air pollution particles Free Radical Biol. Med. 2004, 36, S92-S92
3. Gurgueira, S. A.; Lawrence, J.; Coull, B.; Murthy, G. G. K.; Gonzalez-Flecha, B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation Environ. Health Perspect. 2002, 110 (8) 749-755
4. Ghio, A. J.; Stonehuerner, J.; Dailey, L. A.; Carter, J. D. Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress Inhalation Toxicol. 1999, 11 (1) 37-49
5. Li, N.; Wang, M. Y.; Bramble, L. A.; Schmitz, D. A.; Schauer, J. J.; Sioutas, C.; Harkema, J. R.; Nel, A. E. The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential Environ. Health Perspect. 2009, 117 (7) 1116-1123
6. Li, N.; Wang, M. Y.; Oberley, T. D.; Sempf, J. M.; Nel, A. E. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages J. Immunol. 2002, 169 (8) 4531-4541
7. Akhtar, U. S.; McWhinney, R. D.; Rastogi, N.; Abbatt, J. P. D.; Evans, G. J.; Scott, J. A. Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles Inhalation Toxicol. 2010, 22, 37-47
8. Tao, F.; Gonzalez-Flecha, B.; Kobzik, L. Reactive oxygen species in pulmonary inflammation by ambient particulates Free Radical Biol. Med. 2003, 35 (4) 327-340
9. Shukla, A.; Timblin, C.; BeruBe, K.; Gordon, T.; McKinney, W.; Driscoll, K.; Vacek, P.; Mossman, B. T. Inhaled particulate matter causes expression of nuclear factor (NF)-kappa B-related genes and oxidant-dependent NF-kappa B activation in vitro Am. J. Resp Cell Mo 2000, 23 (2) 182-187
10. Donaldson, K.; Brown, D.; Clouter, A.; Duffin, R.; MacNee, W.; Renwick, L.; Tran, L.; Stone, V. The pulmonary toxicology of ultrafine particles J. Aerosol Med. 2002, 15 (2) 213-220
11. Mudway, I. S.; Stenfors, N.; Duggan, S. T.; Roxborough, H.; Zielinski, H.; Marklund, S. L.; Blomberg, A.; Frew, A. J.; Sandstrom, T.; Kelly, F. J. An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants Arch. Biochem. Biophys. 2004, 423 (1) 200-212
12. 2.5 in the European Community Respiratory Health Survey (ECRHS) Epidemiology 2004, 15 (4) S43-S43
13. Kunzli, N.; Mudway, I. S.; Gotschi, T.; Shi, T. M.; Kelly, F. J.; Cook, S.; Burney, P.; Forsberg, B.; Gauderman, J. W.; Hazenkamp, M. E.; Heinrich, J.; Jarvis, D.; Norback, D.; Payo-Losa, F.; Poli, A.; Sunyer, J.; Borm, P. J. A. Comparison of oxidative properties, light absorbance, and total and elemental mass concentration of ambient PM2.5 collected at 20 European sites Environ. Health Perspect. 2006, 114 (5) 684-690
14. Soukup, J. M.; Ghio, A. J.; Becker, S. Soluble components of Utah Valley particulate pollution alter alveolar macrophage function in vivo and in vitro Inhalation Toxicol. 2000, 12 (5) 401-414
15. Esposito, S.; Tenconi, R.; Lelii, M.; Preti, V.; Nazzari, E.; Consolo, S.; Patria, M. F., Possible molecular mechanisms linking air pollution and asthma in children. BMC Pulm. Med. 2014, 14.
16. Schoonen, M. A. A.; Cohn, C. A.; Roemer, E.; Laffers, R.; Simon, S. R.; ORiordan, T. Mineral-induced formation of reactive oxygen species Med. Mineral. Geochem. 2006, 64, 179-221
17. Kumagai, Y.; Koide, S.; Taguchi, K.; Endo, A.; Nakai, Y.; Yoshikawa, T.; Shimojo, N. Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles Chem. Res. Toxicol. 2002, 15 (4) 483-489
18. Li, Q. F.; Wyatt, A.; Kamens, R. M. Oxidant generation and toxicity enhancement of aged-diesel exhaust Atmos. Environ. 2009, 43 (5) 1037-1042
19. Charrier, J. G.; Anastasio, C. Impacts of antioxidants on hydroxyl radical production from individual and mixed transition metals in a surrogate lung fluid Atmos. Environ. 2011, 45 (40) 7555-7562
20. McWhinney, R. D.; Badali, K.; Liggio, J.; Li, S. M.; Abbatt, J. P. D. Filterable redox cycling activity: A comparison between diesel exhaust particles and secondary organic aerosol constituents Environ. Sci. Technol. 2013, 47 (7) 3362-3369
21. Li, Q.; Shang, J.; Zhu, T. Physicochemical characteristics and toxic effects of ozone-oxidized black carbon particles Atmos. Environ. 2013, 81, 68-75
22. Cho, A. K.; Sioutas, C.; Miguel, A. H.; Kumagai, Y.; Schmitz, D. A.; Singh, M.; Eiguren-Fernandez, A.; Froines, J. R. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin Environ. Res. 2005, 99 (1) 40-47
23. DiStefano, E.; Eiguren-Fernandez, A.; Delfino, R. J.; Sioutas, C.; Froines, J. R.; Cho, A. K. Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles Inhalation Toxicol. 2009, 21 (9) 731-738
24. Shen, H. Y.; Anastasio, C. A comparison of hydroxyl radical and hydrogen peroxide generation in ambient particle extracts and laboratory metal solutions Atmos. Environ. 2012, 46, 665-668
25. Shi, T. M.; Schins, R. P. F.; Knaapen, A. M.; Kuhlbusch, T.; Pitz, M.; Heinrich, J.; Borm, P. J. A. Hydroxyl radical generation by electron paramagnetic resonance as a new method to monitor ambient particulate matter composition J. Environ. Monit. 2003, 5 (4) 550-556
26. Rodrigueza, C. E.; Fukutoa, J. M.; Taguchic, K.; Froines, J.; Cho, A. K. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions Chem.-Biol. Interact. 2005, 155, 97-110
27. Shinyashiki, M.; Eiguren-Fernandez, A.; Schmitz, D. A.; Di Stefano, E.; Li, N.; Linak, W. P.; Cho, S. H.; Froines, J. R.; Cho, A. K. Electrophilic and redox properties of diesel exhaust particles Environ. Res. 2009, 109 (3) 239-244
28. Li, N.; Sioutas, C.; Cho, A.; Schmitz, D.; Misra, C.; Sempf, J.; Wang, M. Y.; Oberley, T.; Froines, J.; Nel, A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage Environ. Health Perspect. 2003, 111 (4) 455-460
29. Ayres, J. G.; Borm, P.; Cassee, F. R.; Castranova, V.; Donaldson, K.; Ghio, A.; Harrison, R. M.; Hider, R.; Kelly, F.; Kooter, I. M.; Marano, F.; Maynard, R. L.; Mudway, I.; Nel, A.; Sioutas, C.; Smith, S.; Baeza-Squiban, A.; Cho, A.; Duggan, S.; Froines, J. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential-A workshop report and consensus statement Inhalation Toxicol. 2008, 20 (1) 75-99
30. Steenhof, M.; Gosens, I.; Strak, M.; Godri, K. J.; Hoek, G.; Cassee, F. R.; Mudway, I. S.; Kelly, F. J.; Harrison, R. M.; Lebret, E.; Brunekreef, B.; Janssen, N. A. H.; Pieters, R. H. H., In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential-the RAPTES project. Part. Fibre Toxicol. 2011, 8.
31. Delfino, R. J.; Staimer, N.; Tjoa, T.; Gillen, D. L.; Schauer, J. J.; Shafer, M. M. Airway inflammation and oxidative potential of air pollutant particles in a pediatric asthma panel J. Exposure Sci. Environ. Epidemiol. 2013, 23 (5) 466-473
32. Fang, T.; Verma, V.; Guo, H.; King, L. E.; Edgerton, E. S.; Weber, R. J. A semi-Automated system for quantifying the oxidative potential of ambient particles in aqueous extracts using the dithiothreitol (DTT) assay: Results from the Southeastern Center for Air Pollution and Epidemiology (SCAPE) Atmos. Mea. Tech. Discuss. 2014, 7, 7245-7279
33. 2.5 in the southeastern United States: Spatiotemporal trends and source apportionment Atmos Chem. Phys. 2014, 14 (23) 12915-12930
34. Ulbrich, I. M.; Canagaratna, M. R.; Zhang, Q.; Worsnop, D. R.; Jimenez, J. L. Interpretation of organic components from Positive Matrix Factorization of aerosol mass spectrometric data Atmos Chem. Phys. 2009, 9 (9) 2891-2918
35. Verma, V.; Rico-Martinez, R.; Kotra, N.; King, L.; Liu, J.; Snell, T. W.; Weber, R. J. Contribution of water-soluble and insoluble components and their hydrophobic/hydrophilic sub-fractions to the reactive oxygen species-generating potential of fine ambient aerosols Environ. Sci. Technol. 2012, 46 (20) 11384-11392
36. Lin, P.; Yu, J. Z. Generation of reactive oxygen species mediated by humic-like substances in atmospheric aerosols Environ. Sci. Technol. 2011, 45 (24) 10362-10368
37. 2.5 in the southeastern United States: Spatiotemporal trends and source apportionment Atmos Chem. Phys. 2014, 14, 19625-19672
38. Canagaratna, M. R.; Jayne, J. T.; Jimenez, J. L.; Allan, J. D.; Alfarra, M. R.; Zhang, Q.; Onasch, T. B.; Drewnick, F.; Coe, H.; Middlebrook, A.; Delia, A.; Williams, L. R.; Trimborn, A. M.; Northway, M. J.; DeCarlo, P. F.; Kolb, C. E.; Davidovits, P.; Worsnop, D. R. Chemical and microphysical characterization of ambient aerosols with the aerodyne aerosol mass spectrometer Mass Spectrom Rev. 2007, 26 (2) 185-222
39. DeCarlo, P. F.; Kimmel, J. R.; Trimborn, A.; Northway, M. J.; Jayne, J. T.; Aiken, A. C.; Gonin, M.; Fuhrer, K.; Horvath, T.; Docherty, K. S.; Worsnop, D. R.; Jimenez, J. L. Field-deployable, high-resolution, time-of-flight aerosol mass spectrometer Anal. Chem. 2006, 78 (24) 8281-8289
40. Graber, E. R.; Rudich, Y. Atmospheric HULIS: How humic-like are they? A comprehensive and critical review Atmos Chem. Phys. 2006, 6, 729-753
41. Mayol-Bracero, O. L.; Guyon, P.; Graham, B.; Roberts, G.; Andreae, M. O.; Decesari, S.; Facchini, M. C.; Fuzzi, S.; Artaxo, P., Water-soluble organic compounds in biomass burning aerosols over Amazonia-2. Apportionment of the chemical composition and importance of the polyacidic fraction. J. Geophys. Res.: Atmos. 2002, 107, (D20), DOI 10.1029/2001jd000522.
42. Varga, B.; Kiss, G.; Ganszky, I.; Gelencser, A.; Krivacsy, Z. Isolation of water-soluble organic matter from atmospheric aerosol Talanta 2001, 55 (3) 561-572
43. Sullivan, A. P.; Weber, R. J., Chemical characterization of the ambient organic aerosol soluble in water: 2. Isolation of acid, neutral, and basic fractions by modified size-exclusion chromatography. J. Geophys. Res.: Atmos. 2006, 111, (D05315), DOI: 10.1029/2005JD006486.
44. Christensen, J. B.; Christensen, T. H. The effect of pH on the complexation of Cd, Ni and Zn by dissolved organic carbon from leachate-polluted groundwater Water Res. 2000, 34 (15) 3743-3754
45. Fujii, M.; Imaoka, A.; Yoshimura, C.; Waite, T. D. Effects of molecular composition of natural organic matter on ferric iron complexation at circumneutral pH Environ. Sci. Technol. 2014, 48 (8) 4414-4424
46. Henshaw, J. M.; Heithmar, E. M.; Hinners, T. A. Inductively coupled plasma mass-spectrometric determination of trace-elements in surface waters subject to acidic deposition Anal. Chem. 1989, 61 (4) 335-342
47. Xu, L.; Guo, H.; Boyd, C.; Klein, M.; Bougiatioti, A.; Cerully, K.; Hite, J.; Isaacman-VanWertz, G.; Kreisberg, N. M.; Knote, C.; Olson, K.; Koss, A.; Goldstein, A.; Hering, S. V.; de Gouw, J.; Baumann, K.; Lee, S. H.; Nenes, A.; Weber, R. J.; Ng, N. L. Effects of anthropogenic emissions on aerosol formation from isoprene and monoterpenes in the southeastern United States Proc. Natl. Acad. Sci. U. S. A. 2014, 112 (1) 37-42
48. Zhang, Q.; Jimenez, J. L.; Canagaratna, M. R.; Ulbrich, I. M.; Ng, N. L.; Worsnop, D. R.; Sun, Y. L. Understanding atmospheric organic aerosols via factor analysis of aerosol mass spectrometry: A review Anal. Bioanal. Chem. 2011, 401 (10) 3045-3067
49. Setyan, A.; Zhang, Q.; Merkel, M.; Knighton, W. B.; Sun, Y.; Song, C.; Shilling, J. E.; Onasch, T. B.; Herndon, S. C.; Worsnop, D. R.; Fast, J. D.; Zaveri, R. A.; Berg, L. K.; Wiedensohler, A.; Flowers, B. A.; Dubey, M. K.; Subramanian, R. Characterization of submicron particles influenced by mixed biogenic and anthropogenic emissions using high-resolution aerosol mass spectrometry: Results from CARES Atmos. Chem. Phys. 2012, 12 (17) 8131-8156
50. Budisulistiorini, S. H.; Canagaratna, M. R.; Croteau, P. L.; Marth, W. J.; Baumann, K.; Edgerton, E. S.; Shaw, S. L.; Knipping, E. M.; Worsnop, D. R.; Jayne, J. T.; Gold, A.; Surratt, J. D. Real-time continuous characterization of secondary organic aerosol derived from isoprene epoxydiols in downtown Atlanta, Georgia, using the Aerodyne aerosol chemical speciation monitor Environ. Sci. Technol. 2013, 47 (11) 5686-5694
51. Lin, Y. H.; Zhang, Z. F.; Docherty, K. S.; Zhang, H. F.; Budisulistiorini, S. H.; Rubitschun, C. L.; Shaw, S. L.; Knipping, E. M.; Edgerton, E. S.; Kleindienst, T. E.; Gold, A.; Surratt, J. D. Isoprene epoxydiols as precursors to secondary organic aerosol formation: Acid-catalyzed reactive uptake studies with authentic compounds Environ. Sci. Technol. 2012, 46 (1) 250-258
52. Robinson, N. H.; Hamilton, J. F.; Allan, J. D.; Langford, B.; Oram, D. E.; Chen, Q.; Docherty, K.; Farmer, D. K.; Jimenez, J. L.; Ward, M. W.; Hewitt, C. N.; Barley, M. H.; Jenkin, M. E.; Rickard, A. R.; Martin, S. T.; McFiggans, G.; Coe, H. Evidence for a significant proportion of secondary organic aerosol from isoprene above a maritime tropical forest Atmos Chem. Phys. 2011, 11 (3) 1039-1050
53. Chen, Q.; Farmer, D. K.; Rizzo, L. V.; Rauliquevis, T.; Kuwata, M.; Karl, T.; Guenther, A.; Allan, J.; Coe, H.; Andreae, M. O.; Poschl, U.; Jimenez, J.; Artaxo, P.; Martin, S. T. Fine-mode organic mass concentrations and sources in the Amazonian wet season (AMAZE-08) Atmos. Chem. Phys. Discuss. 2014, 14, 16151-16186
54. Ng, N. L.; Canagaratna, M. R.; Zhang, Q.; Jimenez, J. L.; Tian, J.; Ulbrich, I. M.; Kroll, J. H.; Docherty, K. S.; Chhabra, P. S.; Bahreini, R.; Murphy, S. M.; Seinfeld, J. H.; Hildebrandt, L.; Donahue, N. M.; DeCarlo, P. F.; Lanz, V. A.; Prevot, A. S. H.; Dinar, E.; Rudich, Y.; Worsnop, D. R. Organic aerosol components observed in Northern Hemispheric datasets from aerosol mass spectrometry Atmos Chem. Phys. 2010, 10 (10) 4625-4641
55. Bougiatioti, A.; Stavroulas, I.; Kostenidou, E.; Zarmpas, P.; Theodosi, C.; Kouvarakis, G.; Canonaco, F.; Prévôt, A. S. H.; Nenes, A.; Pandis, S. N.; Mihalopoulos, N. Processing of biomass-burning aerosol in the eastern Mediterranean during summertime Atmos. Chem. Phys. 2014, 14, 4793-4807
56. 2.5 Atmos. Pollut. Res. 2013, 4 (1) 14-21
57. 2.5 over the southeastern US during 2007: Integrating chemically speciated FRM filter measurements, MODIS fire counts and PMF analysis Atmos Chem. Phys. 2010, 10 (14) 6839-6853
58. Charrier, J. G.; Anastasio, C. On dithiothreitol (DTT) as a measure of oxidative potential for ambient particles: Evidence for the importance of soluble transition metals Atmos Chem. Phys. 2012, 12 (19) 9321-9333
59. Duscio, D.; Proietti, L.; Giarrusso, S.; Fantauzzo, R.; Rapisarda, V.; Calandra, C. Health effects of diesel exhaust Adv. Air Pollut. Ser. 2003, 13, 387-399
60. Garshick, E.; Laden, F.; Hart, J. E.; Smith, T. J.; Rosner, B. Smoking imputation and lung cancer in railroad workers exposed to diesel exhaust Am. J. Ind. Med. 2006, 49 (9) 709-718
61. Kagawa, J. Health effects of diesel exhaust emissions-A mixture of air pollutants of worldwide concern Toxicology 2001, 164 (1-3) 27-27
62. Pandya, R. J.; Solomon, G.; Kinner, A.; Balmes, J. R. Diesel exhaust and asthma: Hypotheses and molecular mechanisms of action Environ. Health Perspect. 2002, 110, 103-112
63. Sydbom, A.; Blomberg, A.; Parnia, S.; Stenfors, N.; Sandstrom, T.; Dahlen, S. E. Health effects of diesel exhaust emissions Eur. Respir. J. 2001, 17 (4) 733-746
64. Rattanavaraha, W.; Rosen, E.; Zhang, H. F.; Li, Q. F.; Pantong, K.; Kamens, R. M. The reactive oxidant potential of different types of aged atmospheric particles: An outdoor chamber study Atmos. Environ. 2011, 45 (23) 3848-3855
65. Sannigrahi, P.; Sullivan, A. P.; Weber, R. J.; Ingall, E. D. Characterization of water-soluble organic carbon in urban atmospheric aerosols using solid-state C-13 NMR spectroscopy Environ. Sci. Technol. 2006, 40 (3) 666-672
66. Sullivan, A. P.; Weber, R. J., Chemical characterization of the ambient organic aerosol soluble in water: 1. Isolation of hydrophobic and hydrophilic fractions with a XAD-8 resin. J. Geophys Res-Atmos 2006, 111, (D5).
67. Verma, V.; Ning, Z.; Cho, A. K.; Schauer, J. J.; Shafer, M. M.; Sioutas, C. Redox activity of urban quasi-ultrafine particles from primary and secondary sources Atmos. Environ. 2009, 43 (40) 6360-6368
68. Verma, V.; Pakbin, P.; Cheung, K. L.; Cho, A. K.; Schauer, J. J.; Shafer, M. M.; Kleinman, M. T.; Sioutas, C. Physicochemical and oxidative characteristics of semi-volatile components of quasi-ultrafine particles in an urban atmosphere Atmos. Environ. 2011, 45 (4) 1025-1033
69. Biswas, S.; Verma, V.; Schauer, J. J.; Cassee, F. R.; Cho, A. K.; Sioutas, C. Oxidative potential of semi-volatile and non-volatile particulate matter (PM) from heavy-duty vehicles retrofitted with emission control technologies Environ. Sci. Technol. 2009, 43 (10) 3905-3912
70. Hu, S.; Polidori, A.; Arhami, M.; Shafer, M. M.; Schauer, J. J.; Cho, A.; Sioutas, C. Redox activity and chemical speciation of size fractioned PM in the communities of the Los Angeles-Long Beach harbor Atmos Chem. Phys. 2008, 8 (21) 6439-6451