Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles

Inhalation Toxicology

Volumn 22, Issue SUPPL. 2, 2010, Pages 37-47

  Akhtar, Umme S ^a,b   McWhinney, Robert D ^a,b   Rastogi, Neeraj ^a,b   Abbatt, Jonathan P D ^a,b   Evans, Greg J ^a,b   Scott, Jeremy A ^a,b,c,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Biological toxicological effects; Chemical composition; Cytotoxicity; IL 8 adsorption; Inflammation; Oxidative stress; Particulate matter; PM2.5; Redox activity; Standard reference materials

Indexed keywords

CYTOKINE; DITHIOTHREITOL; FERROUS ION; INTERLEUKIN 8; REACTIVE OXYGEN METABOLITE; TRANSITION ELEMENT;

ADSORPTION; AIRBORNE PARTICLE; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOKINE RELEASE; CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS CELL; OXIDATION REDUCTION REACTION; PARTICULATE MATTER; PRIORITY JOURNAL; UPREGULATION;

ADSORPTION; AIR POLLUTANTS; CANADA; CELL LINE; ENVIRONMENTAL MONITORING; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-8; LUNG; OXIDATION-REDUCTION; PARTICULATE MATTER; REACTIVE OXYGEN SPECIES; VEHICLE EMISSIONS;

EID: 78650218719     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2010.518377     Document Type: Article

References (49)

1. Balakrishna S, Lomnicki S, McAvey KM, Cole RB, Dellinger B, Cormier SA. 2009. Environmentally persistent free radicals amplify ultrafine particle mediated cellular oxidative stress and cytotoxicity. Part Fibre Toxicol 6:11.
2. Becker S, Soukup JM, Sioutas C, Cassee FR. 2003. Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles. Exp Lung Res 29:29-44.
3. Becker S, Dailey LA, Soukup JM, Grambow SC, Devlin RB, Huang YC. 2005. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ Health Perspect 113:1032-1038.
4. Boland S, Baeza-Squiban A, Fournier T, Houcine O, Gendron MC, Chévrier M, Jouvenot G, Coste A, Aubier M, Marano F. 1999. Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production. Am J Physiol 276:L604-L613.
5. Boland S, Baeza-Squiban A, Bonvallot V, Houcine O, Pain C, Meyer M, Marano F. 2001. Similar cellular effects induced by diesel exhaust particles from a representative diesel vehicle recovered from filters and Standard Reference Material 1650. Toxicol In Vitro 15:379-385.
6. Brauer M, Hoek G, Van Vliet P, Meliefste K, Fischer PH, Wijga A, Koopman LP, Neijens HJ, Gerritsen J, Kerkhof M, Heinrich J, Bellander T, Brunekreef B. 2002. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med 166:1092-1098.
7. Brook RD, Brook JR, Rajagopalan S. 2003. Air pollution: The "Heart" of the problem. Curr Hypertens Rep 5:32-39.
8. Canadian Medical Association (CMA). (2008). No breathing room National illness costs of air pollution. [Online] Available at: Accessed on 17 May 2010
9. Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren- Fernandez A, Froines JR. 2005. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environ Res 99:40-47.
10. DiStefano E, Eiguren-Fernandez A, Delfino RJ, Sioutas C, Froines JR, Cho AK. 2009. Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles. Inhal Toxicol 21:731-738.
11. Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE. 1993. An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753-1759.
12. Frampton MW, Ghio AJ, Samet JM, Carson JL, Carter JD, Devlin RB. 1999. Effects of aqueous extracts of PM(10) filters from the Utah valley on human airway epithelial cells. Am J Physiol 277:L960-L967.
13. Fujii T, Hayashi S, Hogg JC, Vincent R, Van Eeden SF. 2001. Particulate matter induces cytokine expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol 25:265-271.
14. Ghio AJ, Stonehuerner J, Dailey LA, Carter JD. 1999. Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress. Inhal Toxicol 11:37-49.
15. Ghio AJ. 2004. Biological effects of Utah Valley ambient air particles in humans: A review. J Aerosol Med 17:157-164.
16. Gualtieri M, Mantecca P, Corvaja V, Longhin E, Perrone MG, Bolzacchini E, Camatini M. 2009. Winter fine particulate matter from Milan induces morphological and functional alterations in human pulmonary epithelial cells (A549). Toxicol Lett 188:52-62.
17. Hetland RB, Cassee FR, Refsnes M, Schwarze PE, Låg M, Boere AJ, Dybing E. 2004. Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions. Toxicol In Vitro 18:203-212.
18. Huang YC, Li Z, Harder SD, Soukup JM. 2004. Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. Inhal Toxicol 16:863-878.
19. Jeong CH, McGuire M, Herod D, Dann T, Dabek-Zlotorzynska E, Wang D, Ding L, Celo V, Mathieu D, Evans G. (2010). Receptor model based identification of the sources of PM2.5 in Canadian cities. Atm Pollut Res. In Press.
20. Kelly FJ. 2003. Oxidative stress: Its role in air pollution and adverse health effects. Occup Environ Med 60:612-616.
21. Knaapen AM, Shi T, Borm PJ, Schins RP. 2002. Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter. Mol Cell Biochem 234-235:317-326.
22. Kocbach A, Totlandsdal AI, Låg M, Refsnes M, Schwarze PE. 2008. Differential binding of cytokines to environmentally relevant particles: A possible source for misinterpretation of in vitro results? Toxicol Lett 176: 131-137.
23. Kunkel SL, Standiford T, Kasahara K, Strieter RM. 1991. Interleukin-8 (IL-8): The major neutrophil chemotactic factor in the lung. Exp Lung Res 17:17-23.
24. Laden F, Neas LM, Dockery DW, Schwartz J. 2000. Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ Health Perspect 108:941-947.
25. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455-460.
26. Li N, Xia T, Nel AE. 2008. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 44:1689-1699.
27. Medalia AI, Rivin D, Sanders DR. 1983. A comparison of carbon black with soot. Sci Total Environ 31:1-22.
28. Mills NL, Robinson SD, Fokkens PH, Leseman DL, Miller MR, Anderson D, Freney EJ, Heal MR, Donovan RJ, Blomberg A, Sandström T, MacNee W, Boon NA, Donaldson K, Newby DE, Cassee FR. 2008. Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease. Environ Health Perspect 116:709-715.
29. Ntziachristos L, Froines JR, Cho AK, Sioutas C. 2007. Relationship between redox activity and chemical speciation of size-fractionated particulate matter. Part Fibre Toxicol 4:5.
30. Pope CA 3rd. 1991. Respiratory hospital admissions associated with PM10 pollution in Utah, Salt Lake, and Cache Valleys. Arch Environ Health 46:90-97.
31. Pope CA 3rd, Schwartz J, Ransom MR. 1992. Daily mortality and PM10 pollution in Utah Valley. Arch Environ Health 47:211-217.
32. Pope CA 3rd, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 287:1132-1141.
33. Quinlan GJ, Evans TW, Gutteridge JM. 2002. Iron and the redox status of the lungs. Free Radic Biol Med 33:1306-1313.
34. Ramgolam K, Favez O, Cachier H, Gaudichet A, Marano F, Martinon L, Baeza- Squiban A. 2009. Size-partitioning of an urban aerosol to identify particle determinants involved in the proinflammatory response induced in airway epithelial cells. Part Fibre Toxicol 6:10.
35. Reiss R, Anderson EL, Cross CE, Hidy G, Hoel D, McClellan R, Moolgavkar S. 2007. Evidence of health impacts of sulfate-and nitrate-containing particles in ambient air. Inhal Toxicol 19:419-449.
36. Riley MR, Boesewetter DE, Kim AM, Sirvent FP. 2003. Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells. Toxicology 190:171-184.
37. Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, Diaz E, Koutrakis P, Suh H, Tsuda A, Godleski JJ. 2002. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am J Respir Crit Care Med 165:1610-1617.
38. Sánchez-Pérez Y, Chirino YI, Osornio-Vargas AR, Morales-Bárcenas R, Gutiérrez-Ruíz C, Vázquez- López I, García-Cuellar CM. 2009. DNA damage response of A549 cells treated with particulate matter (PM10) of urban air pollutants. Cancer Lett 278:192-200.
39. Schins RPF, Hei TK. (2007). Genotoxic effects of particles. In: Donaldson K, Borm P (eds) Particle Toxicology, 1st edn. CRC Press, New York
40. Schlesinger RB. 2007. The health impact of common inorganic components of fine particulate matter (PM2.5) in ambient air: A critical review. Inhal Toxicol 19:811-832.
41. Schwarze PE, Ovrevik J, Låg M, Refsnes M, Nafstad P, Hetland RB, Dybing E. 2006. Particulate matter properties and health effects: Consistency of epidemiological and toxicological studies. Hum Exp Toxicol 25:559-579.
42. Seagrave J, Knall C, McDonald JD, Mauderly JL. 2004. Diesel particulate material binds and concentrates a proinflammatory cytokine that causes neutrophil migration. Inhal Toxicol 16 Suppl 1:93-98.
43. Seagrave J. 2008. Mechanisms and implications of air pollution particle associations with chemokines. Toxicol Appl Pharmacol 232:469-477.
44. Shinyashiki M, Eiguren-Fernandez A, Schmitz DA, Di Stefano E, Li N, Linak WP, Cho SH, Froines JR, Cho AK. 2009. Electrophilic and redox properties of diesel exhaust particles. Environ Res 109:239-244.
45. Squadrito GL, Cueto R, Dellinger B, Pryor WA. 2001. Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter. Free Radic Biol Med 31:1132-1138.
46. Urch B, Silverman F, Corey P, Brook JR, Lukic KZ, Rajagopalan S, Brook RD. 2005. Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ Health Perspect 113:1052-1055.
47. Utah Bureau of Air Quality. (1990). Draft Utah State Implementation Plan, Utah State Department of Health, Salt Lake City.
48. Veranth JM, Moss TA, Chow JC, Labban R, Nichols WK, Walton JC, Watson JG, Yost GS. 2006. Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter. Environ Health Perspect 114:341-349.
49. World Health Organization (WHO). (2006). Air quality guidelines global update 2005. [Online] Available at: Www.cepis.org.pe/bvsea/fulltext/ guidelines05. pdf. Accessed on 2 July 2009