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Volumn 26, Issue 4, 2015, Pages 624-644

A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage

Author keywords

Biomarkers; Cancer; Cancer staging; Esophageal; Genomic; Prognosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLEOMYCIN; CISPLATIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETOPOSIDE; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; FIBROBLAST GROWTH FACTOR 3; FLUOROURACIL; GEFITINIB; IRINOTECAN; MULTIDRUG RESISTANCE PROTEIN 1; PLATINUM DERIVATIVE; PROTEIN MDM2; PROTEIN P53; TAXANE DERIVATIVE; TUMOR MARKER; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 84926434070     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdu449     Document Type: Review
Times cited : (61)

References (192)
  • 1
    • 76049128595 scopus 로고    scopus 로고
    • Estimates of cancer incidence and mortality in Europe in 2008
    • Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 2010; 46: 765-781.
    • (2010) Eur J Cancer , vol.46 , pp. 765-781
    • Ferlay, J.1    Parkin, D.M.2    Steliarova-Foucher, E.3
  • 2
    • 55349095007 scopus 로고    scopus 로고
    • Continuing rapid increase in esophageal adenocarcinoma in England and Wales
    • Lepage C, Rachet B, Jooste V et al. Continuing rapid increase in esophageal adenocarcinoma in England and Wales. Am J Gastroenterol 2008; 103: 2694-2699.
    • (2008) Am J Gastroenterol , vol.103 , pp. 2694-2699
    • Lepage, C.1    Rachet, B.2    Jooste, V.3
  • 3
    • 0033580405 scopus 로고    scopus 로고
    • Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    • Lagergren J, Bergstrom R, Lindgren A et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825-831.
    • (1999) N Engl J Med , vol.340 , pp. 825-831
    • Lagergren, J.1    Bergstrom, R.2    Lindgren, A.3
  • 4
    • 34548725712 scopus 로고    scopus 로고
    • Case volume as a predictor of inpatient mortality after esophagectomy
    • Rodgers M, Jobe BA, O'Rourke RW et al. Case volume as a predictor of inpatient mortality after esophagectomy. Arch Surg 2007; 142: 829-839.
    • (2007) Arch Surg , vol.142 , pp. 829-839
    • Rodgers, M.1    Jobe, B.A.2    O'Rourke, R.W.3
  • 5
    • 84892478638 scopus 로고    scopus 로고
    • National Oesophago-Gastric Cancer Audit 2012
    • London: Royal College Of Surgeons of England
    • Unit RCoSCE. National Oesophago-Gastric Cancer Audit 2012. London: Royal College Of Surgeons of England 2012.
    • (2012)
  • 6
    • 84940450230 scopus 로고    scopus 로고
    • The effect of formalizing enhanced recovery after esophagectomy with a protocol
    • Epub ahead of print
    • Findlay JM, Tustian E, Millo J et al. The effect of formalizing enhanced recovery after esophagectomy with a protocol. Dis Esophagus 2014 [Epub ahead of print].
    • (2014) Dis Esophagus
    • Findlay, J.M.1    Tustian, E.2    Millo, J.3
  • 7
    • 84873749641 scopus 로고    scopus 로고
    • Health-related quality of life in patients with oesophageal cancer: analysis at different steps of the treatment pathway
    • Scarpa M, Saadeh LM, Fasolo A et al. Health-related quality of life in patients with oesophageal cancer: analysis at different steps of the treatment pathway. J Gastrointest Surg 2013; 17: 421-433.
    • (2013) J Gastrointest Surg , vol.17 , pp. 421-433
    • Scarpa, M.1    Saadeh, L.M.2    Fasolo, A.3
  • 8
    • 84896123032 scopus 로고    scopus 로고
    • Influence of co-morbidity on long-term quality of life after oesophagectomy for cancer
    • Djarv T, Derogar M, Lagergren P. Influence of co-morbidity on long-term quality of life after oesophagectomy for cancer. Br J Surg 2014; 101: 495-501.
    • (2014) Br J Surg , vol.101 , pp. 495-501
    • Djarv, T.1    Derogar, M.2    Lagergren, P.3
  • 9
    • 33847156303 scopus 로고    scopus 로고
    • Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis
    • Gebski V, Burmeister B, Smithers BM et al. Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncol 2007; 8: 226-234.
    • (2007) Lancet Oncol , vol.8 , pp. 226-234
    • Gebski, V.1    Burmeister, B.2    Smithers, B.M.3
  • 10
  • 11
    • 27744551934 scopus 로고    scopus 로고
    • Survival after surgery for oesophageal cancer: a population-based study
    • Rouvelas I, Zeng W, Lindblad M et al. Survival after surgery for oesophageal cancer: a population-based study. Lancet Oncol 2005; 6: 864-870.
    • (2005) Lancet Oncol , vol.6 , pp. 864-870
    • Rouvelas, I.1    Zeng, W.2    Lindblad, M.3
  • 12
    • 4043168433 scopus 로고    scopus 로고
    • Postoperative mortality following oesophagectomy and problems in reporting its rate
    • Jamieson GG, Mathew G, Ludemann R et al. Postoperative mortality following oesophagectomy and problems in reporting its rate. Br J Surg 2004; 91: 943-947.
    • (2004) Br J Surg , vol.91 , pp. 943-947
    • Jamieson, G.G.1    Mathew, G.2    Ludemann, R.3
  • 13
    • 84897024124 scopus 로고    scopus 로고
    • Factors associated with early recurrence and death after esophagectomy for cancer
    • Davies AR, Pillai A, Sinha P et al. Factors associated with early recurrence and death after esophagectomy for cancer. J Surg Oncol 2014; 109: 459-464.
    • (2014) J Surg Oncol , vol.109 , pp. 459-464
    • Davies, A.R.1    Pillai, A.2    Sinha, P.3
  • 14
    • 80053573654 scopus 로고    scopus 로고
    • Guidelines for the management of oesophageal and gastric cancer
    • Allum WH, Blazeby JM, Griffin SM et al. Guidelines for the management of oesophageal and gastric cancer. Gut 2011; 60: 1449-1472.
    • (2011) Gut , vol.60 , pp. 1449-1472
    • Allum, W.H.1    Blazeby, J.M.2    Griffin, S.M.3
  • 15
    • 84866565407 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the influence of HER2 expression and amplification in operable oesophageal cancer
    • Chan DS, Twine CP, Lewis WG. Systematic review and meta-analysis of the influence of HER2 expression and amplification in operable oesophageal cancer. J Gastrointest Surg 2012; 16: 1821-1829.
    • (2012) J Gastrointest Surg , vol.16 , pp. 1821-1829
    • Chan, D.S.1    Twine, C.P.2    Lewis, W.G.3
  • 16
    • 84878593111 scopus 로고    scopus 로고
    • Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
    • Dulak AM, Stojanov P, Peng S et al. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet 2013; 45: 478-486.
    • (2013) Nat Genet , vol.45 , pp. 478-486
    • Dulak, A.M.1    Stojanov, P.2    Peng, S.3
  • 17
    • 84867398217 scopus 로고    scopus 로고
    • Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
    • Agrawal N, Jiao Y, Bettegowda C et al. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov 2012; 2: 899-905.
    • (2012) Cancer Discov , vol.2 , pp. 899-905
    • Agrawal, N.1    Jiao, Y.2    Bettegowda, C.3
  • 18
    • 84892657781 scopus 로고    scopus 로고
    • Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett's esophagus
    • Streppel MM, Lata S, DelaBastide M et al. Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett's esophagus. Oncogene 2014; 33: 347-357.
    • (2014) Oncogene , vol.33 , pp. 347-357
    • Streppel, M.M.1    Lata, S.2    DelaBastide, M.3
  • 19
    • 79952267262 scopus 로고    scopus 로고
    • Novel chemosensitive single-nucleotide polymorphism markers to targeted regimens in metastatic colorectal cancer
    • Kim JC, Kim SY, Cho DH et al. Novel chemosensitive single-nucleotide polymorphism markers to targeted regimens in metastatic colorectal cancer. Clin Cancer Res 2011; 17: 1200-1209.
    • (2011) Clin Cancer Res , vol.17 , pp. 1200-1209
    • Kim, J.C.1    Kim, S.Y.2    Cho, D.H.3
  • 20
    • 84882644323 scopus 로고    scopus 로고
    • Implications of genome-wide association studies in cancer therapeutics
    • Patel JN, McLeod HL, Innocenti F. Implications of genome-wide association studies in cancer therapeutics. Br J Clin Pharmacol 2013; 76: 370-380.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 370-380
    • Patel, J.N.1    McLeod, H.L.2    Innocenti, F.3
  • 21
    • 77954952497 scopus 로고    scopus 로고
    • 7th edition of the AJCC Cancer Staging Manual: esophagus and esophagogastric junction
    • Rice TW, Blackstone EH, Rusch VW. 7th edition of the AJCC Cancer Staging Manual: esophagus and esophagogastric junction. Ann Surg Oncol 2010; 17: 1721-1724.
    • (2010) Ann Surg Oncol , vol.17 , pp. 1721-1724
    • Rice, T.W.1    Blackstone, E.H.2    Rusch, V.W.3
  • 22
    • 0034685429 scopus 로고    scopus 로고
    • Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group
    • Stroup DF, Berlin JA, Morton SC et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-2012.
    • (2000) JAMA , vol.283 , pp. 2008-2012
    • Stroup, D.F.1    Berlin, J.A.2    Morton, S.C.3
  • 24
    • 0028931857 scopus 로고
    • Multiple significance tests: the Bonferroni method
    • Bland JM, Altman DG. Multiple significance tests: the Bonferroni method. BMJ 1995; 310: 170.
    • (1995) BMJ , vol.310 , pp. 170
    • Bland, J.M.1    Altman, D.G.2
  • 25
    • 70449420123 scopus 로고    scopus 로고
    • Use of archived specimens in evaluation of prognostic and predictive biomarkers
    • Simon RM, Paik S, Hayes DF. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst 2009; 101: 1446-1452.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1446-1452
    • Simon, R.M.1    Paik, S.2    Hayes, D.F.3
  • 26
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • International HapMap C. The International HapMap Project. Nature 2003; 426: 789-796.
    • (2003) Nature , vol.426 , pp. 789-796
    • International HapMap, C.1
  • 27
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform metaanalyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform metaanalyses of the published literature for survival endpoints. Stat Med 1998; 17: 2815-2834.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 28
    • 0142250376 scopus 로고    scopus 로고
    • Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia
    • Miller CT, Moy JR, Lin L et al. Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. Clin Cancer Res 2003; 9: 4819-4825.
    • (2003) Clin Cancer Res , vol.9 , pp. 4819-4825
    • Miller, C.T.1    Moy, J.R.2    Lin, L.3
  • 29
    • 0030266901 scopus 로고    scopus 로고
    • Prognostic significance of the p53 mutation in esophageal cancer
    • Uchino S, Saito T, Inomata M et al. Prognostic significance of the p53 mutation in esophageal cancer. Jpn J Clin Oncol 1996; 26: 287-292.
    • (1996) Jpn J Clin Oncol , vol.26 , pp. 287-292
    • Uchino, S.1    Saito, T.2    Inomata, M.3
  • 30
    • 0028911999 scopus 로고
    • High amplification of the hst-1 gene correlates with haematogenous recurrence after curative resection of oesophageal carcinoma
    • Chikuba K, Saito T, Uchino S et al. High amplification of the hst-1 gene correlates with haematogenous recurrence after curative resection of oesophageal carcinoma. Br J Surg 1995; 82: 364-367.
    • (1995) Br J Surg , vol.82 , pp. 364-367
    • Chikuba, K.1    Saito, T.2    Uchino, S.3
  • 31
    • 0028023741 scopus 로고
    • Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic findings and DNA amplification
    • Itakura Y, Sasano H, Shiga C et al. Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic findings and DNA amplification. Cancer 1994; 74: 795-804.
    • (1994) Cancer , vol.74 , pp. 795-804
    • Itakura, Y.1    Sasano, H.2    Shiga, C.3
  • 32
    • 0033015159 scopus 로고    scopus 로고
    • Prognosis of esophageal squamous cell carcinoma: analysis of clinicopathological and biological factors
    • Wang LS, Chow KC, Chi KH et al. Prognosis of esophageal squamous cell carcinoma: analysis of clinicopathological and biological factors. Am J Gastroenterol 1999; 94: 1933-1940.
    • (1999) Am J Gastroenterol , vol.94 , pp. 1933-1940
    • Wang, L.S.1    Chow, K.C.2    Chi, K.H.3
  • 33
    • 70349435434 scopus 로고    scopus 로고
    • ERCC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer
    • Warnecke-Eberz U, Vallbohmer D, Alakus H et al. ERCC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer. J Gastrointest Surg 2009; 13: 1411-1421.
    • (2009) J Gastrointest Surg , vol.13 , pp. 1411-1421
    • Warnecke-Eberz, U.1    Vallbohmer, D.2    Alakus, H.3
  • 34
    • 79961238388 scopus 로고    scopus 로고
    • Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
    • Sterne JA, Sutton AJ, Ioannidis JP et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 2011; 343: d4002.
    • (2011) BMJ , vol.343 , pp. d4002
    • Sterne, J.A.1    Sutton, A.J.2    Ioannidis, J.P.3
  • 35
    • 84887346660 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions
    • Oxford: Wiley-Blackwell
    • Higgins J, Green SP. Cochrane Handbook for Systematic Reviews of Interventions. Oxford: Wiley-Blackwell 2008.
    • (2008)
    • Higgins, J.1    Green, S.P.2
  • 36
    • 0034631415 scopus 로고    scopus 로고
    • Empirical assessment of effect of publication bias on meta-analyses
    • Sutton AJ, Duval SJ, Tweedie RL et al. Empirical assessment of effect of publication bias on meta-analyses. BMJ 2000; 320: 1574-1577.
    • (2000) BMJ , vol.320 , pp. 1574-1577
    • Sutton, A.J.1    Duval, S.J.2    Tweedie, R.L.3
  • 37
    • 84863304598 scopus 로고    scopus 로고
    • R: A Language and Environment for Statistical Computing
    • Vienna, Austria: R Foundation for Statistical Computing
    • Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing 2013.
    • (2013)
  • 38
    • 0037674951 scopus 로고    scopus 로고
    • Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: results of a ten-year prospective study
    • Casson AG, Evans SC, Gillis A et al. Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: results of a ten-year prospective study. J Thorac Cardiovasc Surg 2003; 125: 1121-1131.
    • (2003) J Thorac Cardiovasc Surg , vol.125 , pp. 1121-1131
    • Casson, A.G.1    Evans, S.C.2    Gillis, A.3
  • 39
    • 0033875562 scopus 로고    scopus 로고
    • P53 mutational status improves estimation of prognosis in patients with curatively resected adenocarcinoma in Barrett's esophagus
    • Schneider PM, Stoeltzing O, Roth JA et al. P53 mutational status improves estimation of prognosis in patients with curatively resected adenocarcinoma in Barrett's esophagus. Clin Cancer Res 2000; 6: 3153-3158.
    • (2000) Clin Cancer Res , vol.6 , pp. 3153-3158
    • Schneider, P.M.1    Stoeltzing, O.2    Roth, J.A.3
  • 40
    • 77952585707 scopus 로고    scopus 로고
    • Prognostic value of p53 mutations in oesophageal adenocarcinoma: final results of a 15-year prospective study
    • Madani K, Zhao R, Lim HJ et al. Prognostic value of p53 mutations in oesophageal adenocarcinoma: final results of a 15-year prospective study. Eur J Cardiothorac Surg 2010; 37: 1427-1432.
    • (2010) Eur J Cardiothorac Surg , vol.37 , pp. 1427-1432
    • Madani, K.1    Zhao, R.2    Lim, H.J.3
  • 41
    • 77149145188 scopus 로고    scopus 로고
    • p53 genotype predicts response to chemotherapy in patients with squamous cell carcinoma of the esophagus
    • Yamasaki M, Miyata H, Fujiwara Y et al. p53 genotype predicts response to chemotherapy in patients with squamous cell carcinoma of the esophagus. Ann Surg Oncol 2010; 17: 634-642.
    • (2010) Ann Surg Oncol , vol.17 , pp. 634-642
    • Yamasaki, M.1    Miyata, H.2    Fujiwara, Y.3
  • 42
    • 0032789413 scopus 로고    scopus 로고
    • The p53 gene mutation is of prognostic value in esophageal squamous cell carcinoma patients in unified stages of curability
    • Kobayashi S, Koide Y, Endo M et al. The p53 gene mutation is of prognostic value in esophageal squamous cell carcinoma patients in unified stages of curability. Am J Surg 1999; 177: 497-502.
    • (1999) Am J Surg , vol.177 , pp. 497-502
    • Kobayashi, S.1    Koide, Y.2    Endo, M.3
  • 43
    • 2642655267 scopus 로고    scopus 로고
    • p53 sequence analysis predicts treatment response and outcome of patients with esophageal carcinoma
    • Ribeiro U, Jr, Finkelstein SD, Safatle-Ribeiro AV et al. p53 sequence analysis predicts treatment response and outcome of patients with esophageal carcinoma. Cancer 1998; 83: 7-18.
    • (1998) Cancer , vol.83 , pp. 7-18
    • Ribeiro, U.1    Finkelstein, S.D.2    Safatle-Ribeiro, A.V.3
  • 44
    • 84911004896 scopus 로고    scopus 로고
    • The biomarker TP53 divides patients with neoadjuvantly treated esophageal cancer into 2 subgroups with markedly different outcomes. A p53 Research Group study
    • Epub ahead of print
    • Kandioler D, Schoppmann SF, Zwrtek R et al. The biomarker TP53 divides patients with neoadjuvantly treated esophageal cancer into 2 subgroups with markedly different outcomes. A p53 Research Group study. J Thorac Cardiovasc Surg 2014 [Epub ahead of print].
    • (2014) J Thorac Cardiovasc Surg
    • Kandioler, D.1    Schoppmann, S.F.2    Zwrtek, R.3
  • 45
    • 33646752806 scopus 로고    scopus 로고
    • Lack of prognostic impact of p53 gene mutation and p53 phosphorylation at serine 15 in multimodally treated adenocarcinomas of the gastroesophageal junction
    • Puhringer-Oppermann F, Stahl M, Keller G et al. Lack of prognostic impact of p53 gene mutation and p53 phosphorylation at serine 15 in multimodally treated adenocarcinomas of the gastroesophageal junction. J Cancer Res Clin Oncol 2006; 132: 433-438.
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 433-438
    • Puhringer-Oppermann, F.1    Stahl, M.2    Keller, G.3
  • 46
    • 0033393711 scopus 로고    scopus 로고
    • TP53 gene mutation status in pretreatment biopsies of oesophageal adenocarcinoma has no prognostic value
    • Soontrapornchai P, Elsaleh H, Joseph D et al. TP53 gene mutation status in pretreatment biopsies of oesophageal adenocarcinoma has no prognostic value. Eur J Cancer 1999; 35: 1683-1687.
    • (1999) Eur J Cancer , vol.35 , pp. 1683-1687
    • Soontrapornchai, P.1    Elsaleh, H.2    Joseph, D.3
  • 47
    • 77149150924 scopus 로고    scopus 로고
    • p53 Mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer
    • Makino T, Yamasaki M, Miyata H et al. p53 Mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer. Ann Surg Oncol 2010; 17: 804-811.
    • (2010) Ann Surg Oncol , vol.17 , pp. 804-811
    • Makino, T.1    Yamasaki, M.2    Miyata, H.3
  • 48
    • 0031470550 scopus 로고    scopus 로고
    • Genetic alterations in patients with esophageal cancer with short- and long-term survival rates after curative esophagectomy
    • Shimada Y, Imamura M, Shibagaki I et al. Genetic alterations in patients with esophageal cancer with short- and long-term survival rates after curative esophagectomy. Ann Surg 1997; 226: 162-168.
    • (1997) Ann Surg , vol.226 , pp. 162-168
    • Shimada, Y.1    Imamura, M.2    Shibagaki, I.3
  • 49
    • 79959933173 scopus 로고    scopus 로고
    • Loss of p53 in esophageal squamous cell carcinoma and the correlation with survival: analyses of gene mutations, protein expression, and loss of heterozygosity in Japanese patients
    • Egashira A, Morita M, Yoshida R et al. Loss of p53 in esophageal squamous cell carcinoma and the correlation with survival: analyses of gene mutations, protein expression, and loss of heterozygosity in Japanese patients. J Surg Oncol 2011; 104: 169-175.
    • (2011) J Surg Oncol , vol.104 , pp. 169-175
    • Egashira, A.1    Morita, M.2    Yoshida, R.3
  • 50
    • 0034987331 scopus 로고    scopus 로고
    • Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy
    • Ito T, Kaneko K, Makino R et al. Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy. J Gastroenterol 2001; 36: 303-311.
    • (2001) J Gastroenterol , vol.36 , pp. 303-311
    • Ito, T.1    Kaneko, K.2    Makino, R.3
  • 51
    • 0030997699 scopus 로고    scopus 로고
    • Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients
    • Lam KY, Tsao SW, Zhang D et al. Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients. Int J Cancer 1997; 74: 212-219.
    • (1997) Int J Cancer , vol.74 , pp. 212-219
    • Lam, K.Y.1    Tsao, S.W.2    Zhang, D.3
  • 52
    • 0029033840 scopus 로고
    • p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma
    • Shibagaki I, Tanaka H, Shimada Y et al. p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma. Clin Cancer Res 1995; 1: 769-773.
    • (1995) Clin Cancer Res , vol.1 , pp. 769-773
    • Shibagaki, I.1    Tanaka, H.2    Shimada, Y.3
  • 53
    • 23944512803 scopus 로고    scopus 로고
    • Deregulated p21(WAF1) overexpression impacts survival of surgically resected esophageal squamous cell carcinoma patients
    • Goan YG, Hsu HK, Chang HC et al. Deregulated p21(WAF1) overexpression impacts survival of surgically resected esophageal squamous cell carcinoma patients. Ann Thorac Surg 2005; 80: 1007-1016.
    • (2005) Ann Thorac Surg , vol.80 , pp. 1007-1016
    • Goan, Y.G.1    Hsu, H.K.2    Chang, H.C.3
  • 54
    • 3543135337 scopus 로고    scopus 로고
    • Mutational spectra of p53 in geographically localized esophageal squamous cell carcinoma groups in China
    • Cao W, Chen X, Dai H et al. Mutational spectra of p53 in geographically localized esophageal squamous cell carcinoma groups in China. Cancer 2004; 101: 834-844.
    • (2004) Cancer , vol.101 , pp. 834-844
    • Cao, W.1    Chen, X.2    Dai, H.3
  • 55
    • 0346963103 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy
    • Gibson MK, Abraham SC, Wu TT et al. Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy. Clin Cancer Res 2003; 9: 6461-6468.
    • (2003) Clin Cancer Res , vol.9 , pp. 6461-6468
    • Gibson, M.K.1    Abraham, S.C.2    Wu, T.T.3
  • 56
    • 0031028551 scopus 로고    scopus 로고
    • p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations
    • Coggi G, Bosari S, Roncalli M et al. p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations. Cancer 1997; 79: 425-432.
    • (1997) Cancer , vol.79 , pp. 425-432
    • Coggi, G.1    Bosari, S.2    Roncalli, M.3
  • 57
    • 33947611435 scopus 로고    scopus 로고
    • Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma
    • Izzo JG, Wu TT, Wu X et al. Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma. J Clin Oncol 2007; 25: 698-707.
    • (2007) J Clin Oncol , vol.25 , pp. 698-707
    • Izzo, J.G.1    Wu, T.T.2    Wu, X.3
  • 58
    • 84877091712 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma
    • Shigaki H, Baba Y, Watanabe M et al. PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma. Clin Cancer Res 2013; 19: 2451-2459.
    • (2013) Clin Cancer Res , vol.19 , pp. 2451-2459
    • Shigaki, H.1    Baba, Y.2    Watanabe, M.3
  • 59
    • 77956626969 scopus 로고    scopus 로고
    • Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis
    • Marx AH, Zielinski M, Kowitz CM et al. Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis. Histopathology 2010; 57: 418-426.
    • (2010) Histopathology , vol.57 , pp. 418-426
    • Marx, A.H.1    Zielinski, M.2    Kowitz, C.M.3
  • 60
    • 0029974391 scopus 로고    scopus 로고
    • Further evidence for prognostic significance of epidermal growth factor receptor gene amplification in patients with esophageal squamous cell carcinoma
    • Kitagawa Y, Ueda M, Ando N et al. Further evidence for prognostic significance of epidermal growth factor receptor gene amplification in patients with esophageal squamous cell carcinoma. Clin Cancer Res 1996; 2: 909-914.
    • (1996) Clin Cancer Res , vol.2 , pp. 909-914
    • Kitagawa, Y.1    Ueda, M.2    Ando, N.3
  • 61
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, Kwak EL, Ackerman A et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol 2011; 29: 4803-4810.
    • (2011) J Clin Oncol , vol.29 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3
  • 62
    • 82755167862 scopus 로고    scopus 로고
    • Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophagogastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • Luber B, Deplazes J, Keller G et al. Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophagogastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). BMC Cancer 2011; 11: 509.
    • (2011) BMC Cancer , vol.11 , pp. 509
    • Luber, B.1    Deplazes, J.2    Keller, G.3
  • 63
    • 33645734242 scopus 로고    scopus 로고
    • Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients
    • Janmaat ML, Gallegos-Ruiz MI, Rodriguez JA et al. Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients. J Clin Oncol 2006; 24: 1612-1619.
    • (2006) J Clin Oncol , vol.24 , pp. 1612-1619
    • Janmaat, M.L.1    Gallegos-Ruiz, M.I.2    Rodriguez, J.A.3
  • 64
    • 13244298108 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma
    • Sunpaweravong P, Sunpaweravong S, Puttawibul P et al. Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma. J Cancer Res Clin Oncol 2005; 131: 111-119.
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 111-119
    • Sunpaweravong, P.1    Sunpaweravong, S.2    Puttawibul, P.3
  • 65
    • 84877137684 scopus 로고    scopus 로고
    • The significance of the HER-2 status in esophageal adenocarcinoma for survival: an immunohistochemical and an in situ hybridization study
    • Prins MJ, Ruurda JP, van Diest PJ et al. The significance of the HER-2 status in esophageal adenocarcinoma for survival: an immunohistochemical and an in situ hybridization study. Ann Oncol 2013; 24: 1290-1297.
    • (2013) Ann Oncol , vol.24 , pp. 1290-1297
    • Prins, M.J.1    Ruurda, J.P.2    van Diest, P.J.3
  • 66
    • 34548835771 scopus 로고    scopus 로고
    • Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissues
    • Rauser S, Weis R, Braselmann H et al. Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissues. Clin Cancer Res 2007; 13: 5115-5123.
    • (2007) Clin Cancer Res , vol.13 , pp. 5115-5123
    • Rauser, S.1    Weis, R.2    Braselmann, H.3
  • 67
    • 0033963379 scopus 로고    scopus 로고
    • HER-2/neu gene amplification by FISH predicts poor survival in Barrett's esophagus-associated adenocarcinoma
    • Brien TP, Odze RD, Sheehan CE et al. HER-2/neu gene amplification by FISH predicts poor survival in Barrett's esophagus-associated adenocarcinoma. Hum Pathol 2000; 31: 35-39.
    • (2000) Hum Pathol , vol.31 , pp. 35-39
    • Brien, T.P.1    Odze, R.D.2    Sheehan, C.E.3
  • 68
    • 84866297340 scopus 로고    scopus 로고
    • Analysis of HER2 gene amplification and protein expression in esophageal squamous cell carcinoma
    • Zhan N, Dong WG, Tang YF et al. Analysis of HER2 gene amplification and protein expression in esophageal squamous cell carcinoma. Med Oncol 2012; 29: 933-940.
    • (2012) Med Oncol , vol.29 , pp. 933-940
    • Zhan, N.1    Dong, W.G.2    Tang, Y.F.3
  • 69
    • 61849109966 scopus 로고    scopus 로고
    • Evaluation of gene amplification and protein expression of HER-2/neu in esophageal squamous cell carcinoma using Fluorescence in situ Hybridization (FISH) and immunohistochemistry
    • Sato-Kuwabara Y, Neves JI, Fregnani JH et al. Evaluation of gene amplification and protein expression of HER-2/neu in esophageal squamous cell carcinoma using Fluorescence in situ Hybridization (FISH) and immunohistochemistry. BMC Cancer 2009; 9: 6.
    • (2009) BMC Cancer , vol.9 , pp. 6
    • Sato-Kuwabara, Y.1    Neves, J.I.2    Fregnani, J.H.3
  • 70
    • 18044376819 scopus 로고    scopus 로고
    • Frequencies of HER-2/neu expression and gene amplification in patients with oesophageal squamous cell carcinoma
    • Mimura K, Kono K, Hanawa M et al. Frequencies of HER-2/neu expression and gene amplification in patients with oesophageal squamous cell carcinoma. Br J Cancer 2005; 92: 1253-1260.
    • (2005) Br J Cancer , vol.92 , pp. 1253-1260
    • Mimura, K.1    Kono, K.2    Hanawa, M.3
  • 71
    • 84869466016 scopus 로고    scopus 로고
    • Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma
    • Yoon HH, Shi Q, Sukov WR et al. Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma. J Clin Oncol 2012; 30: 3932-3938.
    • (2012) J Clin Oncol , vol.30 , pp. 3932-3938
    • Yoon, H.H.1    Shi, Q.2    Sukov, W.R.3
  • 72
    • 80051549783 scopus 로고    scopus 로고
    • Her-2/neu gene amplification in esophageal adenocarcinoma and its influence on survival
    • Thompson SK, Sullivan TR, Davies R et al. Her-2/neu gene amplification in esophageal adenocarcinoma and its influence on survival. Ann Surg Oncol 2011; 18: 2010-2017.
    • (2011) Ann Surg Oncol , vol.18 , pp. 2010-2017
    • Thompson, S.K.1    Sullivan, T.R.2    Davies, R.3
  • 73
    • 84891368159 scopus 로고    scopus 로고
    • Concordance of HER2 status in primary tumour and lymph node metastases in patients with esophageal carcinoma
    • Konig AM, Reeh M, Dancau AM et al. Concordance of HER2 status in primary tumour and lymph node metastases in patients with esophageal carcinoma. Anticancer Res 2013; 33: 4975-4982.
    • (2013) Anticancer Res , vol.33 , pp. 4975-4982
    • Konig, A.M.1    Reeh, M.2    Dancau, A.M.3
  • 74
    • 0030853587 scopus 로고    scopus 로고
    • Gene amplification of int-2 and erbB in human esophageal cancer: relationship to clinicopathological variables
    • Suzuki H, Abo S, Kitamura M et al. Gene amplification of int-2 and erbB in human esophageal cancer: relationship to clinicopathological variables. Cancer Invest 1997; 15: 411-415.
    • (1997) Cancer Invest , vol.15 , pp. 411-415
    • Suzuki, H.1    Abo, S.2    Kitamura, M.3
  • 75
    • 0030248050 scopus 로고    scopus 로고
    • Meanings of c-erbB and int-2 amplification in superficial esophageal squamous cell carcinomas
    • Ikeda Y, Ozawa S, Ando N et al. Meanings of c-erbB and int-2 amplification in superficial esophageal squamous cell carcinomas. Ann Thorac Surg 1996; 62: 835-838.
    • (1996) Ann Thorac Surg , vol.62 , pp. 835-838
    • Ikeda, Y.1    Ozawa, S.2    Ando, N.3
  • 76
    • 84866294247 scopus 로고    scopus 로고
    • Prognostic significance of cyclinD1 amplification and the co-alteration of cyclinD1/pRb/ppRb in patients with esophageal squamous cell carcinoma
    • Wang MT, Chen G, An SJ et al. Prognostic significance of cyclinD1 amplification and the co-alteration of cyclinD1/pRb/ppRb in patients with esophageal squamous cell carcinoma. Dis Esophagus 2012; 25: 664-670.
    • (2012) Dis Esophagus , vol.25 , pp. 664-670
    • Wang, M.T.1    Chen, G.2    An, S.J.3
  • 77
    • 77951667933 scopus 로고    scopus 로고
    • Prediction of CCND1 amplification using plasma DNA as a prognostic marker in oesophageal squamous cell carcinoma
    • Takeshita H, Ichikawa D, Komatsu S et al. Prediction of CCND1 amplification using plasma DNA as a prognostic marker in oesophageal squamous cell carcinoma. Br J Cancer 2010; 102: 1378-1383.
    • (2010) Br J Cancer , vol.102 , pp. 1378-1383
    • Takeshita, H.1    Ichikawa, D.2    Komatsu, S.3
  • 78
    • 0029888123 scopus 로고    scopus 로고
    • Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information
    • Shinozaki H, Ozawa S, Ando N et al. Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information. Clin Cancer Res 1996; 2: 1155-1161.
    • (1996) Clin Cancer Res , vol.2 , pp. 1155-1161
    • Shinozaki, H.1    Ozawa, S.2    Ando, N.3
  • 79
    • 84902259347 scopus 로고    scopus 로고
    • Clinical impact of predicting CCND1 amplification using plasma DNA in superficial esophageal squamous cell carcinoma
    • Komatsu S, Ichikawa D, Hirajima S et al. Clinical impact of predicting CCND1 amplification using plasma DNA in superficial esophageal squamous cell carcinoma. Dig Dis Sci 2014; 59: 1152-1159.
    • (2014) Dig Dis Sci , vol.59 , pp. 1152-1159
    • Komatsu, S.1    Ichikawa, D.2    Hirajima, S.3
  • 80
    • 0028109892 scopus 로고
    • Differential polymerase chain reaction assay of cyclin D1 gene amplification in esophageal carcinoma
    • Gramlich TL, Fritsch CR, Maurer D et al. Differential polymerase chain reaction assay of cyclin D1 gene amplification in esophageal carcinoma. Diagn Mol Pathol 1994; 3: 255-259.
    • (1994) Diagn Mol Pathol , vol.3 , pp. 255-259
    • Gramlich, T.L.1    Fritsch, C.R.2    Maurer, D.3
  • 81
    • 43449107706 scopus 로고    scopus 로고
    • Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer
    • Carneiro A, Isinger A, Karlsson A et al. Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer. BMC Cancer 2008; 8: 98.
    • (2008) BMC Cancer , vol.8 , pp. 98
    • Carneiro, A.1    Isinger, A.2    Karlsson, A.3
  • 82
    • 0026607048 scopus 로고
    • Association between chromosome 11q13 amplification and prognosis of patients with oesophageal carcinomas
    • Mori M, Tokino T, Yanagisawa A et al. Association between chromosome 11q13 amplification and prognosis of patients with oesophageal carcinomas. Eur J Cancer 1992; 28A: 755-757.
    • (1992) Eur J Cancer , vol.28 A , pp. 755-757
    • Mori, M.1    Tokino, T.2    Yanagisawa, A.3
  • 83
    • 84876797906 scopus 로고    scopus 로고
    • Clinical significance of combined detection of human papilloma virus infection and human telomerase RNA component gene amplification in patients with squamous cell carcinoma of the esophagus in northern China
    • Wang YF, Wang XS, Gao SG et al. Clinical significance of combined detection of human papilloma virus infection and human telomerase RNA component gene amplification in patients with squamous cell carcinoma of the esophagus in northern China. Eur J Med Res 2013; 18: 11.
    • (2013) Eur J Med Res , vol.18 , pp. 11
    • Wang, Y.F.1    Wang, X.S.2    Gao, S.G.3
  • 84
    • 79955674914 scopus 로고    scopus 로고
    • Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization
    • Shi ZZ, Liang JW, Zhan T et al. Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization. Genes Chromosomes Cancer 2011; 50: 518-526.
    • (2011) Genes Chromosomes Cancer , vol.50 , pp. 518-526
    • Shi, Z.Z.1    Liang, J.W.2    Zhan, T.3
  • 85
    • 43049132485 scopus 로고    scopus 로고
    • Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma
    • Gertler R, Doll D, Maak M et al. Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma. Cancer 2008; 112: 2173-2180.
    • (2008) Cancer , vol.112 , pp. 2173-2180
    • Gertler, R.1    Doll, D.2    Maak, M.3
  • 86
    • 0032587544 scopus 로고    scopus 로고
    • Detection of loss of heterozygosityat microsatellite loci in esophageal squamous-cell carcinoma
    • Ikeguchi M, Unate H, Maeta M et al. Detection of loss of heterozygosityat microsatellite loci in esophageal squamous-cell carcinoma. Oncology 1999; 56: 164-168.
    • (1999) Oncology , vol.56 , pp. 164-168
    • Ikeguchi, M.1    Unate, H.2    Maeta, M.3
  • 87
    • 63449140431 scopus 로고    scopus 로고
    • Frequent loss of heterozygosity of chromosome 1q in esophageal adenocarcinoma: loss of chromosome 1q21.3 is associated with shorter overall survival
    • Maru DM, Luthra R, Correa AM et al. Frequent loss of heterozygosity of chromosome 1q in esophageal adenocarcinoma: loss of chromosome 1q21.3 is associated with shorter overall survival. Cancer 2009; 115: 1576-1585.
    • (2009) Cancer , vol.115 , pp. 1576-1585
    • Maru, D.M.1    Luthra, R.2    Correa, A.M.3
  • 88
    • 0027185925 scopus 로고
    • Prognostic value of DNA ploidy in squamous cell carcinoma of esophagus. Analyzed with improved flow cytometric measurement
    • Doki Y, Shiozaki H, Tahara H et al. Prognostic value of DNA ploidy in squamous cell carcinoma of esophagus. Analyzed with improved flow cytometric measurement. Cancer 1993; 72: 1813-1818.
    • (1993) Cancer , vol.72 , pp. 1813-1818
    • Doki, Y.1    Shiozaki, H.2    Tahara, H.3
  • 89
    • 0026495587 scopus 로고
    • A flow cytometric analysis of DNA content in primary and metastatic lesions of esophageal squamous cell carcinoma
    • Tsutsui S, Kuwano H, Mori M et al. A flow cytometric analysis of DNA content in primary and metastatic lesions of esophageal squamous cell carcinoma. Cancer 1992; 70: 2586-2591.
    • (1992) Cancer , vol.70 , pp. 2586-2591
    • Tsutsui, S.1    Kuwano, H.2    Mori, M.3
  • 90
    • 0024371955 scopus 로고
    • Flow cytometric analysis of nuclear DNA content in esophageal cancer. Aneuploidy as an index for highly malignant potential
    • Kaketani K, Saito T, Kobayashi M. Flow cytometric analysis of nuclear DNA content in esophageal cancer. Aneuploidy as an index for highly malignant potential. Cancer 1989; 64: 887-891.
    • (1989) Cancer , vol.64 , pp. 887-891
    • Kaketani, K.1    Saito, T.2    Kobayashi, M.3
  • 91
    • 0024574101 scopus 로고
    • DNA aneuploidy assessment of the effectiveness of hyperthermo-chemo-radiotherapy for esophageal carcinoma
    • Ohno S, Korenaga D, Kuwano H et al. DNA aneuploidy assessment of the effectiveness of hyperthermo-chemo-radiotherapy for esophageal carcinoma. Cancer 1989; 63: 1951-1955.
    • (1989) Cancer , vol.63 , pp. 1951-1955
    • Ohno, S.1    Korenaga, D.2    Kuwano, H.3
  • 92
    • 0029117430 scopus 로고
    • The prognostic significance of the cytophotometric DNA content and its relationship with the argyrophilic nucleolar organizer regions (AgNOR) and proliferating cell nuclear antigen (PCNA) in oesophageal cancer
    • Kuwano H, Sumiyoshi K, Nozoe T et al. The prognostic significance of the cytophotometric DNA content and its relationship with the argyrophilic nucleolar organizer regions (AgNOR) and proliferating cell nuclear antigen (PCNA) in oesophageal cancer. Eur J Surg Oncol 1995; 21: 368-373.
    • (1995) Eur J Surg Oncol , vol.21 , pp. 368-373
    • Kuwano, H.1    Sumiyoshi, K.2    Nozoe, T.3
  • 93
    • 0024432399 scopus 로고
    • Ploidy as a prognostic indicator in oesophageal squamous carcinoma and its relationship to various histological criteria
    • Edwards JM, Jones DJ, Wilkes SJ et al. Ploidy as a prognostic indicator in oesophageal squamous carcinoma and its relationship to various histological criteria. J Pathol 1989; 159: 35-41.
    • (1989) J Pathol , vol.159 , pp. 35-41
    • Edwards, J.M.1    Jones, D.J.2    Wilkes, S.J.3
  • 94
    • 0027674606 scopus 로고
    • Intratumoral heterogeneity of DNA ploidy and regional differences in epidermal growth factor and epidermal growth factor receptor of esophageal carcinoma
    • Deguchi S, Muto Y, Kusano T et al. Intratumoral heterogeneity of DNA ploidy and regional differences in epidermal growth factor and epidermal growth factor receptor of esophageal carcinoma. Tohoku J Exp Med 1993; 171: 107-118.
    • (1993) Tohoku J Exp Med , vol.171 , pp. 107-118
    • Deguchi, S.1    Muto, Y.2    Kusano, T.3
  • 95
    • 68849129048 scopus 로고    scopus 로고
    • Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes
    • Bradbury PA, Kulke MH, Heist RS et al. Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes. Pharmacogenet Genomics 2009; 19: 613-625.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 613-625
    • Bradbury, P.A.1    Kulke, M.H.2    Heist, R.S.3
  • 96
    • 79952228118 scopus 로고    scopus 로고
    • Genetic polymorphisms of ERCC1 and their effects on the efficacy of cisplatin-based chemotherapy in advanced esophageal carcinoma
    • Wang Y, Chen J, Li X et al. Genetic polymorphisms of ERCC1 and their effects on the efficacy of cisplatin-based chemotherapy in advanced esophageal carcinoma. Oncol Rep 2011; 25: 1047-1052.
    • (2011) Oncol Rep , vol.25 , pp. 1047-1052
    • Wang, Y.1    Chen, J.2    Li, X.3
  • 97
    • 84886589969 scopus 로고    scopus 로고
    • ERCC1 C8092A (rs3212986) polymorphism as a predictive marker in esophageal cancer patients treated with cisplatin/5-FU-based neoadjuvant therapy
    • Rumiato E, Cavallin F, Boldrin E et al. ERCC1 C8092A (rs3212986) polymorphism as a predictive marker in esophageal cancer patients treated with cisplatin/5-FU-based neoadjuvant therapy. Pharmacogenet Genomics 2013; 23: 597-604.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 597-604
    • Rumiato, E.1    Cavallin, F.2    Boldrin, E.3
  • 98
    • 80052741618 scopus 로고    scopus 로고
    • DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy
    • Ott K, Rachakonda PS, Panzram B et al. DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy. Ann Surg Oncol 2011; 18: 2688-2698.
    • (2011) Ann Surg Oncol , vol.18 , pp. 2688-2698
    • Ott, K.1    Rachakonda, P.S.2    Panzram, B.3
  • 99
    • 84896035464 scopus 로고    scopus 로고
    • Prognostic role of microRNA polymorphisms in patients with advanced esophageal squamous cell carcinoma receiving platinum-based chemotherapy
    • Wu C, Li M, Hu C et al. Prognostic role of microRNA polymorphisms in patients with advanced esophageal squamous cell carcinoma receiving platinum-based chemotherapy. Cancer Chemother Pharmacol 2014; 73: 335-341.
    • (2014) Cancer Chemother Pharmacol , vol.73 , pp. 335-341
    • Wu, C.1    Li, M.2    Hu, C.3
  • 100
    • 84939873467 scopus 로고    scopus 로고
    • Association of miRNA-related genetic polymorphisms and prognosis in patients with esophageal squamous cell carcinoma
    • Epub ahead of print
    • Yang PW, Huang YC, Hsieh CY et al. Association of miRNA-related genetic polymorphisms and prognosis in patients with esophageal squamous cell carcinoma. Ann Surg Oncol, 2014 [Epub ahead of print].
    • (2014) Ann Surg Oncol
    • Yang, P.W.1    Huang, Y.C.2    Hsieh, C.Y.3
  • 101
    • 84899559735 scopus 로고    scopus 로고
    • EGFR intron-1 CA repeat polymorphism is a predictor of relapse and survival in complete resected only surgically treated esophageal cancer
    • Vashist YK, Trump F, Gebauer F et al. EGFR intron-1 CA repeat polymorphism is a predictor of relapse and survival in complete resected only surgically treated esophageal cancer. Target Oncol 2014; 9: 43-52.
    • (2014) Target Oncol , vol.9 , pp. 43-52
    • Vashist, Y.K.1    Trump, F.2    Gebauer, F.3
  • 102
    • 84861819712 scopus 로고    scopus 로고
    • Interleukin-6-634G>C genetic polymorphism is associated with prognosis following surgery for advanced thoracic esophageal squamous cell carcinoma
    • Motoyama S, Nakatsu T, Miura M et al. Interleukin-6-634G>C genetic polymorphism is associated with prognosis following surgery for advanced thoracic esophageal squamous cell carcinoma. Dig Surg 2012; 29: 194-201.
    • (2012) Dig Surg , vol.29 , pp. 194-201
    • Motoyama, S.1    Nakatsu, T.2    Miura, M.3
  • 103
    • 79954467237 scopus 로고    scopus 로고
    • Genetic variants in DNA repair predicts the survival of patients with esophageal cancer
    • Lee JM, Yang PW, Yang SY et al. Genetic variants in DNA repair predicts the survival of patients with esophageal cancer. Ann Surg 2011; 253: 918-927.
    • (2011) Ann Surg , vol.253 , pp. 918-927
    • Lee, J.M.1    Yang, P.W.2    Yang, S.Y.3
  • 104
    • 84878826073 scopus 로고    scopus 로고
    • The survival impact of XPA and XPC genetic polymorphisms on patients with esophageal squamous cell carcinoma
    • Yang PW, Hsieh CY, Kuo FT et al. The survival impact of XPA and XPC genetic polymorphisms on patients with esophageal squamous cell carcinoma. Ann Surg Oncol 2013; 20: 562-571.
    • (2013) Ann Surg Oncol , vol.20 , pp. 562-571
    • Yang, P.W.1    Hsieh, C.Y.2    Kuo, F.T.3
  • 105
    • 79955000494 scopus 로고    scopus 로고
    • TS gene tandem repeats in esophageal cancer patients receiving chemoradiotherapy
    • Kaneko K, Nagai M, Murakami Y et al. TS gene tandem repeats in esophageal cancer patients receiving chemoradiotherapy. Front Biosci 2011; 16: 1036-1043.
    • (2011) Front Biosci , vol.16 , pp. 1036-1043
    • Kaneko, K.1    Nagai, M.2    Murakami, Y.3
  • 106
    • 34249983464 scopus 로고    scopus 로고
    • Favorable genetic polymorphisms predictive of clinical outcome of chemoradiotherapy for stage II/III esophageal squamous cell carcinoma in Japanese
    • Okuno T, Tamura T, Yamamori M et al. Favorable genetic polymorphisms predictive of clinical outcome of chemoradiotherapy for stage II/III esophageal squamous cell carcinoma in Japanese. Am J Clin Oncol 2007; 30: 252-257.
    • (2007) Am J Clin Oncol , vol.30 , pp. 252-257
    • Okuno, T.1    Tamura, T.2    Yamamori, M.3
  • 107
    • 31444452927 scopus 로고    scopus 로고
    • The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma
    • Sarbia M, Stahl M, von Weyhern C et al. The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma. Br J Cancer 2006; 94: 203-207.
    • (2006) Br J Cancer , vol.94 , pp. 203-207
    • Sarbia, M.1    Stahl, M.2    von Weyhern, C.3
  • 108
    • 84897619011 scopus 로고    scopus 로고
    • Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma
    • Renouf DJ, Zhai R, Sun B et al. Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. J Gastroenterol Hepatol 2013; 28: 1482-1488.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 1482-1488
    • Renouf, D.J.1    Zhai, R.2    Sun, B.3
  • 109
    • 78751572765 scopus 로고    scopus 로고
    • Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus
    • Boonstra JJ, van Marion R, Tilanus HW et al. Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus. J Gastrointest Surg 2011; 15: 48-56.
    • (2011) J Gastrointest Surg , vol.15 , pp. 48-56
    • Boonstra, J.J.1    van Marion, R.2    Tilanus, H.W.3
  • 110
    • 65649089824 scopus 로고    scopus 로고
    • p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis
    • Cescon DW, Bradbury PA, Asomaning K et al. p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis. Clin Cancer Res 2009; 15: 3103-3109.
    • (2009) Clin Cancer Res , vol.15 , pp. 3103-3109
    • Cescon, D.W.1    Bradbury, P.A.2    Asomaning, K.3
  • 111
    • 84865315597 scopus 로고    scopus 로고
    • Association of Aurora-A (STK15) kinase polymorphisms with clinical outcome of esophageal cancer treated with preoperative chemoradiation
    • Pan JY, Ajani JA, Gu J et al. Association of Aurora-A (STK15) kinase polymorphisms with clinical outcome of esophageal cancer treated with preoperative chemoradiation. Cancer 2012; 118: 4346-4353.
    • (2012) Cancer , vol.118 , pp. 4346-4353
    • Pan, J.Y.1    Ajani, J.A.2    Gu, J.3
  • 112
    • 84869050797 scopus 로고    scopus 로고
    • VEGF -634C/G genotype is predictive of long-term survival after treatment with a definitive 5-fluorouracil/cisplatinbased chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma
    • Tamura T, Kuwahara A, Yamamori M et al. VEGF -634C/G genotype is predictive of long-term survival after treatment with a definitive 5-fluorouracil/cisplatinbased chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma. Int J Med Sci 2012; 9: 833-837.
    • (2012) Int J Med Sci , vol.9 , pp. 833-837
    • Tamura, T.1    Kuwahara, A.2    Yamamori, M.3
  • 113
    • 84903310194 scopus 로고    scopus 로고
    • Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma
    • Yang PW, Hsieh MS, Huang YC et al. Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma. PLoS One 2014; 9: e100326.
    • (2014) PLoS One , vol.9 , pp. e100326
    • Yang, P.W.1    Hsieh, M.S.2    Huang, Y.C.3
  • 114
    • 79551579334 scopus 로고    scopus 로고
    • Association of the VEGF 936C>T polymorphism with FDG uptake, clinical, histopathological, and metabolic response in patients with adenocarcinomas of the esophagogastric junction
    • Lorenzen S, Panzram B, Keller G et al. Association of the VEGF 936C>T polymorphism with FDG uptake, clinical, histopathological, and metabolic response in patients with adenocarcinomas of the esophagogastric junction. Mol Imaging Biol 2011; 13: 178-186.
    • (2011) Mol Imaging Biol , vol.13 , pp. 178-186
    • Lorenzen, S.1    Panzram, B.2    Keller, G.3
  • 115
    • 68049091121 scopus 로고    scopus 로고
    • Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis
    • Bradbury PA, Zhai R, Ma C et al. Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis. Clin Cancer Res 2009; 15: 4680-4685.
    • (2009) Clin Cancer Res , vol.15 , pp. 4680-4685
    • Bradbury, P.A.1    Zhai, R.2    Ma, C.3
  • 116
    • 80051544018 scopus 로고    scopus 로고
    • Interleukin-2-330T>G genetic polymorphism associates with prognosis following surgery for thoracic esophageal squamous cell cancer
    • Motoyama S, Miura M, Hinai Y et al. Interleukin-2-330T>G genetic polymorphism associates with prognosis following surgery for thoracic esophageal squamous cell cancer. Ann Surg Oncol 2011; 18: 1995-2002.
    • (2011) Ann Surg Oncol , vol.18 , pp. 1995-2002
    • Motoyama, S.1    Miura, M.2    Hinai, Y.3
  • 117
    • 84868628845 scopus 로고    scopus 로고
    • Polymorphisms of transforming growth factor beta 1 (RS#1800468 and RS#1800471) and esophageal squamous cell carcinoma among Zhuangese population, China
    • Tang RG, Huang YZ, Yao LM et al. Polymorphisms of transforming growth factor beta 1 (RS#1800468 and RS#1800471) and esophageal squamous cell carcinoma among Zhuangese population, China. Gene 2013; 512: 1-5.
    • (2013) Gene , vol.512 , pp. 1-5
    • Tang, R.G.1    Huang, Y.Z.2    Yao, L.M.3
  • 118
    • 84878698619 scopus 로고    scopus 로고
    • Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamouscell carcinoma
    • Wu C, Li D, Jia W et al. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamouscell carcinoma. Nat Genet 2013; 45: 632-638.
    • (2013) Nat Genet , vol.45 , pp. 632-638
    • Wu, C.1    Li, D.2    Jia, W.3
  • 119
    • 78649316052 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the mitochondrial displacement loop and outcome of esophageal squamous cell carcinoma
    • Zhang R, Wang R, Zhang F et al. Single nucleotide polymorphisms in the mitochondrial displacement loop and outcome of esophageal squamous cell carcinoma. J Exp Clin Cancer Res 2010; 29: 155.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 155
    • Zhang, R.1    Wang, R.2    Zhang, F.3
  • 120
    • 79955474495 scopus 로고    scopus 로고
    • CASP8-652 6N del and CASP8 IVS12-19G>A gene polymorphisms and susceptibility/prognosis of ESCC: a case control study in northern Indian population
    • Umar M, Upadhyay R, Kumar S et al. CASP8-652 6N del and CASP8 IVS12-19G>A gene polymorphisms and susceptibility/prognosis of ESCC: a case control study in northern Indian population. J Surg Oncol 2011; 103: 716-723.
    • (2011) J Surg Oncol , vol.103 , pp. 716-723
    • Umar, M.1    Upadhyay, R.2    Kumar, S.3
  • 121
    • 27644551365 scopus 로고    scopus 로고
    • Association of GSTP1 polymorphism and survival for esophageal cancer
    • Lee JM, Wu MT, Lee YC et al. Association of GSTP1 polymorphism and survival for esophageal cancer. Clin Cancer Res 2005; 11: 4749-4753.
    • (2005) Clin Cancer Res , vol.11 , pp. 4749-4753
    • Lee, J.M.1    Wu, M.T.2    Lee, Y.C.3
  • 122
    • 33747344251 scopus 로고    scopus 로고
    • Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
    • Wu X, Gu J, Wu TT et al. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer. J Clin Oncol 2006; 24: 3789-3798.
    • (2006) J Clin Oncol , vol.24 , pp. 3789-3798
    • Wu, X.1    Gu, J.2    Wu, T.T.3
  • 123
    • 80051550539 scopus 로고    scopus 로고
    • Polymorphism in epidermal growth factor receptor intron 1 predicts prognosis of patients with esophageal cancer after chemoradiation and surgery
    • Lee JM, Yang SY, Yang PW et al. Polymorphism in epidermal growth factor receptor intron 1 predicts prognosis of patients with esophageal cancer after chemoradiation and surgery. Ann Surg Oncol 2011; 18: 2066-2073.
    • (2011) Ann Surg Oncol , vol.18 , pp. 2066-2073
    • Lee, J.M.1    Yang, S.Y.2    Yang, P.W.3
  • 124
    • 84911980036 scopus 로고    scopus 로고
    • Homozygous GNAS 393C-allele carriers with locally advanced esophageal cancer fail to benefit from platinumbased preoperative chemoradiotherapy
    • Epub ahead of print
    • Alakus H, Bollschweiler E, Holscher AH et al. Homozygous GNAS 393C-allele carriers with locally advanced esophageal cancer fail to benefit from platinumbased preoperative chemoradiotherapy. Ann Surg Oncol, 2014 [Epub ahead of print].
    • (2014) Ann Surg Oncol
    • Alakus, H.1    Bollschweiler, E.2    Holscher, A.H.3
  • 125
    • 84865340450 scopus 로고    scopus 로고
    • The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer
    • Vashist YK, Kutup A, Musici S et al. The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer. Cell Oncol (Dordr) 2011; 34: 281-288.
    • (2011) Cell Oncol (Dordr) , vol.34 , pp. 281-288
    • Vashist, Y.K.1    Kutup, A.2    Musici, S.3
  • 126
    • 67349280683 scopus 로고    scopus 로고
    • GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    • Alakus H, Warnecke-Eberz U, Bollschweiler E et al. GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer. Pharmacogenomics J 2009; 9: 202-207.
    • (2009) Pharmacogenomics J , vol.9 , pp. 202-207
    • Alakus, H.1    Warnecke-Eberz, U.2    Bollschweiler, E.3
  • 127
    • 34547678014 scopus 로고    scopus 로고
    • Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancer
    • Kaifi JT, Rawnaq T, Schurr PG et al. Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancer. Am J Surg 2007; 194: 380-384.
    • (2007) Am J Surg , vol.194 , pp. 380-384
    • Kaifi, J.T.1    Rawnaq, T.2    Schurr, P.G.3
  • 128
    • 79952196661 scopus 로고    scopus 로고
    • Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma
    • Lu C, Xie H, Wang F et al. Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma. BMC Cancer 2011; 11: 91.
    • (2011) BMC Cancer , vol.11 , pp. 91
    • Lu, C.1    Xie, H.2    Wang, F.3
  • 129
    • 77955004111 scopus 로고    scopus 로고
    • Evaluation of MTHFR677C>T polymorphism in prediction and prognosis of esophageal squamous cell carcinoma: a case-control study in a northern Indian population
    • Umar M, Upadhyay R, Khurana R et al. Evaluation of MTHFR677C>T polymorphism in prediction and prognosis of esophageal squamous cell carcinoma: a case-control study in a northern Indian population. Nutr Cancer 2010; 62: 743-749.
    • (2010) Nutr Cancer , vol.62 , pp. 743-749
    • Umar, M.1    Upadhyay, R.2    Khurana, R.3
  • 130
    • 79951918192 scopus 로고    scopus 로고
    • Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer
    • Narumiya K, Metzger R, Bollschweiler E et al. Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer. Pharmacogenomics 2011; 12: 205-214.
    • (2011) Pharmacogenomics , vol.12 , pp. 205-214
    • Narumiya, K.1    Metzger, R.2    Bollschweiler, E.3
  • 131
    • 77951693104 scopus 로고    scopus 로고
    • Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus
    • Lurje G, Leers JM, Pohl A et al. Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg 2010; 251: 857-864.
    • (2010) Ann Surg , vol.251 , pp. 857-864
    • Lurje, G.1    Leers, J.M.2    Pohl, A.3
  • 132
    • 0028284682 scopus 로고
    • Allelotype analysis of esophageal squamous cell carcinoma
    • Shibagaki I, Shimada Y, Wagata T et al. Allelotype analysis of esophageal squamous cell carcinoma. Cancer Res 1994; 54: 2996-3000.
    • (1994) Cancer Res , vol.54 , pp. 2996-3000
    • Shibagaki, I.1    Shimada, Y.2    Wagata, T.3
  • 133
    • 60849109531 scopus 로고    scopus 로고
    • Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy
    • Hildebrandt MA, Yang H, Hung MC et al. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. J Clin Oncol 2009; 27: 857-871.
    • (2009) J Clin Oncol , vol.27 , pp. 857-871
    • Hildebrandt, M.A.1    Yang, H.2    Hung, M.C.3
  • 134
    • 34347334610 scopus 로고    scopus 로고
    • Genetic polymorphisms and the risk of infection following esophagectomy. Positive association with TNF-alpha gene -308 genotype
    • Azim K, McManus R, Brophy K et al. Genetic polymorphisms and the risk of infection following esophagectomy. Positive association with TNF-alpha gene -308 genotype. Ann Surg 2007; 246: 122-128.
    • (2007) Ann Surg , vol.246 , pp. 122-128
    • Azim, K.1    McManus, R.2    Brophy, K.3
  • 135
    • 15444370455 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme insertion/deletion polymorphism with serum level and development of pulmonary complications following esophagectomy
    • Lee JM, Lo AC, Yang SY et al. Association of angiotensin-converting enzyme insertion/deletion polymorphism with serum level and development of pulmonary complications following esophagectomy. Ann Surg 2005; 241: 659-665.
    • (2005) Ann Surg , vol.241 , pp. 659-665
    • Lee, J.M.1    Lo, A.C.2    Yang, S.Y.3
  • 136
    • 70349767910 scopus 로고    scopus 로고
    • Interferon-gamma 874A>T genetic polymorphism is associated with infectious complications following surgery in patients with thoracic esophageal cancer
    • Motoyama S, Miura M, Hinai Y et al. Interferon-gamma 874A>T genetic polymorphism is associated with infectious complications following surgery in patients with thoracic esophageal cancer. Surgery 2009; 146: 931-938.
    • (2009) Surgery , vol.146 , pp. 931-938
    • Motoyama, S.1    Miura, M.2    Hinai, Y.3
  • 137
    • 84855351500 scopus 로고    scopus 로고
    • Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis
    • discussion
    • Metzger R, Warnecke-Eberz U, Alakus H et al. Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis. J Gastrointest Surg 2012; 16: 26-34; discussion 34.
    • (2012) J Gastrointest Surg , vol.16 , pp. 26-34+34
    • Metzger, R.1    Warnecke-Eberz, U.2    Alakus, H.3
  • 138
    • 0347285535 scopus 로고    scopus 로고
    • Mutation of the p53 gene predicts lymph node metastases in Japanese patients with esophageal carcinoma: DNA and immunohistochemical analyses
    • Hattori K, Kajiyama Y, Tsurumaru M. Mutation of the p53 gene predicts lymph node metastases in Japanese patients with esophageal carcinoma: DNA and immunohistochemical analyses. Dis Esophagus 2003; 16: 301-306.
    • (2003) Dis Esophagus , vol.16 , pp. 301-306
    • Hattori, K.1    Kajiyama, Y.2    Tsurumaru, M.3
  • 139
    • 58649121716 scopus 로고    scopus 로고
    • Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma
    • Wang XC, Wu YP, Ye B et al. Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma. Mol Cancer Res 2009; 7: 12-22.
    • (2009) Mol Cancer Res , vol.7 , pp. 12-22
    • Wang, X.C.1    Wu, Y.P.2    Ye, B.3
  • 140
    • 38049074935 scopus 로고    scopus 로고
    • Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma
    • Yang YL, Chu JY, Luo ML et al. Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma. Genes Chromosomes Cancer 2008; 47: 127-136.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 127-136
    • Yang, Y.L.1    Chu, J.Y.2    Luo, M.L.3
  • 141
    • 33845689934 scopus 로고    scopus 로고
    • Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus
    • Reichelt U, Duesedau P, Tsourlakis M et al. Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus. Mod Pathol 2007; 20: 120-129.
    • (2007) Mod Pathol , vol.20 , pp. 120-129
    • Reichelt, U.1    Duesedau, P.2    Tsourlakis, M.3
  • 142
    • 0027294912 scopus 로고
    • Amplification and over-expression of the EGFR and erbB-2 genes in human esophageal adenocarcinomas
    • al-Kasspooles M, Moore JH, Orringer MB et al. Amplification and over-expression of the EGFR and erbB-2 genes in human esophageal adenocarcinomas. Int J Cancer 1993; 54: 213-219.
    • (1993) Int J Cancer , vol.54 , pp. 213-219
    • al-Kasspooles, M.1    Moore, J.H.2    Orringer, M.B.3
  • 143
    • 84863067226 scopus 로고    scopus 로고
    • Correlation of epidermal growth factor receptor overexpression with increased epidermal growth factor receptor gene copy number in esophageal squamous cell carcinomas
    • Yang YL, Xu KL, Zhou Y et al. Correlation of epidermal growth factor receptor overexpression with increased epidermal growth factor receptor gene copy number in esophageal squamous cell carcinomas. Chin Med J (Engl) 2012; 125: 450-454.
    • (2012) Chin Med J (Engl) , vol.125 , pp. 450-454
    • Yang, Y.L.1    Xu, K.L.2    Zhou, Y.3
  • 144
    • 47049116137 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma
    • Qin YR, Fu L, Sham PC et al. Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma. Int J Cancer 2008; 123: 826-830.
    • (2008) Int J Cancer , vol.123 , pp. 826-830
    • Qin, Y.R.1    Fu, L.2    Sham, P.C.3
  • 145
    • 0037044572 scopus 로고    scopus 로고
    • Allelic loss on 13q in esophageal squamous cell carcinomas from northern China
    • Huang XP, Wei F, Liu XY et al. Allelic loss on 13q in esophageal squamous cell carcinomas from northern China. Cancer Lett 2002; 185: 87-94.
    • (2002) Cancer Lett , vol.185 , pp. 87-94
    • Huang, X.P.1    Wei, F.2    Liu, X.Y.3
  • 146
    • 0033179516 scopus 로고    scopus 로고
    • Lymph node metastasis is associated with allelic loss on chromosome 13q12-13 in esophageal squamous cell carcinoma
    • Harada H, Tanaka H, Shimada Y et al. Lymph node metastasis is associated with allelic loss on chromosome 13q12-13 in esophageal squamous cell carcinoma. Cancer Res 1999; 59: 3724-3729.
    • (1999) Cancer Res , vol.59 , pp. 3724-3729
    • Harada, H.1    Tanaka, H.2    Shimada, Y.3
  • 147
    • 0024394528 scopus 로고
    • Flow cytometric analysis DNA content in esophageal carcinoma. Correlation with histologic and clinical features
    • Yu JM, Yang LH, Guo Q et al. Flow cytometric analysis DNA content in esophageal carcinoma. Correlation with histologic and clinical features. Cancer 1989; 64: 80-82.
    • (1989) Cancer , vol.64 , pp. 80-82
    • Yu, J.M.1    Yang, L.H.2    Guo, Q.3
  • 148
    • 38449118000 scopus 로고    scopus 로고
    • Microsatellite instability and clinicopathological features in esophageal squamous cell cancer
    • Matsumoto Y, Nagasaka T, Kambara T et al. Microsatellite instability and clinicopathological features in esophageal squamous cell cancer. Oncol Rep 2007; 18: 1123-1127.
    • (2007) Oncol Rep , vol.18 , pp. 1123-1127
    • Matsumoto, Y.1    Nagasaka, T.2    Kambara, T.3
  • 149
    • 84868613310 scopus 로고    scopus 로고
    • MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis
    • Wang K, Li J, Guo H et al. MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis. Carcinogenesis 2012; 33: 2147-2154.
    • (2012) Carcinogenesis , vol.33 , pp. 2147-2154
    • Wang, K.1    Li, J.2    Guo, H.3
  • 150
    • 84897672026 scopus 로고    scopus 로고
    • Modification of risk, but not survival of esophageal cancer patients by esophageal cancer-related gene 1 Arg290Gln polymorphism: a case-control study and meta-analysis
    • Umar M, Upadhyay R, Kumar S et al. Modification of risk, but not survival of esophageal cancer patients by esophageal cancer-related gene 1 Arg290Gln polymorphism: a case-control study and meta-analysis. J Gastroenterol Hepatol 2013; 28: 1717-1724.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 1717-1724
    • Umar, M.1    Upadhyay, R.2    Kumar, S.3
  • 151
    • 8444221622 scopus 로고    scopus 로고
    • Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma
    • Miao X, Sun T, Wang Y et al. Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. Cancer Res 2004; 64: 2680-2683.
    • (2004) Cancer Res , vol.64 , pp. 2680-2683
    • Miao, X.1    Sun, T.2    Wang, Y.3
  • 152
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 153
    • 0037098178 scopus 로고    scopus 로고
    • How should meta-regression analyses be undertaken and interpreted?
    • Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med 2002; 21: 1559-1573.
    • (2002) Stat Med , vol.21 , pp. 1559-1573
    • Thompson, S.G.1    Higgins, J.P.2
  • 154
    • 84865140093 scopus 로고    scopus 로고
    • Comparison of the 6th and 7th Editions of the UICC-AJCC TNM Classification for Esophageal Cancer
    • Talsma K, van Hagen P, Grotenhuis BA et al. Comparison of the 6th and 7th Editions of the UICC-AJCC TNM Classification for Esophageal Cancer. Ann Surg Oncol 2012; 19: 2142-2148.
    • (2012) Ann Surg Oncol , vol.19 , pp. 2142-2148
    • Talsma, K.1    van Hagen, P.2    Grotenhuis, B.A.3
  • 155
    • 33644772215 scopus 로고    scopus 로고
    • The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
    • Olivier M, Langerod A, Carrieri P et al. The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer. Clin Cancer Res 2006; 12: 1157-1167.
    • (2006) Clin Cancer Res , vol.12 , pp. 1157-1167
    • Olivier, M.1    Langerod, A.2    Carrieri, P.3
  • 156
    • 19944368439 scopus 로고    scopus 로고
    • P53 abnormalities and outcomes in colorectal cancer: a systematic review
    • Smith FM, Stephens RB, Kennedy MJ et al. P53 abnormalities and outcomes in colorectal cancer: a systematic review. Br J Cancer 2005; 92: 1813.
    • (2005) Br J Cancer , vol.92 , pp. 1813
    • Smith, F.M.1    Stephens, R.B.2    Kennedy, M.J.3
  • 157
    • 79955054710 scopus 로고    scopus 로고
    • Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
    • Xu J, Reumers J, Couceiro JR et al. Gain of function of mutant p53 by coaggregation with multiple tumor suppressors. Nat Chem Biol 2011; 7: 285-295.
    • (2011) Nat Chem Biol , vol.7 , pp. 285-295
    • Xu, J.1    Reumers, J.2    Couceiro, J.R.3
  • 158
    • 84867615093 scopus 로고    scopus 로고
    • Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
    • Lehmann S, Bykov VJ, Ali D et al. Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. J Clin Oncol 2012; 30: 3633-3639.
    • (2012) J Clin Oncol , vol.30 , pp. 3633-3639
    • Lehmann, S.1    Bykov, V.J.2    Ali, D.3
  • 159
    • 84866082525 scopus 로고    scopus 로고
    • Alterations of the TP53 gene in gastric and esophageal carcinogenesis
    • Bellini MF, Cadamuro AC, Succi M et al. Alterations of the TP53 gene in gastric and esophageal carcinogenesis. J Biomed Biotechnol 2012; 2012: 891961.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 891961
    • Bellini, M.F.1    Cadamuro, A.C.2    Succi, M.3
  • 160
    • 33846497262 scopus 로고    scopus 로고
    • Different levels of p53 induced either apoptosis or cell cycle arrest in a doxycycline-regulated hepatocellular carcinoma cell line in vitro
    • Lai PB, Chi TY, Chen GG. Different levels of p53 induced either apoptosis or cell cycle arrest in a doxycycline-regulated hepatocellular carcinoma cell line in vitro. Apoptosis 2007; 12: 387-393.
    • (2007) Apoptosis , vol.12 , pp. 387-393
    • Lai, P.B.1    Chi, T.Y.2    Chen, G.G.3
  • 161
    • 84863311924 scopus 로고    scopus 로고
    • Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
    • Coffill CR, Muller PA, Oh HK et al. Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep 2012; 13: 638-644.
    • (2012) EMBO Rep , vol.13 , pp. 638-644
    • Coffill, C.R.1    Muller, P.A.2    Oh, H.K.3
  • 162
    • 84887167098 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer
    • Chen M, Huang J, Zhu Z et al. Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer. BMC Cancer 2013; 13: 539.
    • (2013) BMC Cancer , vol.13 , pp. 539
    • Chen, M.1    Huang, J.2    Zhu, Z.3
  • 163
    • 84878875938 scopus 로고    scopus 로고
    • Correlation of p53 status with the response to chemotherapy-based treatment in esophageal cancer: a meta-analysis
    • Zhang SS, Huang QY, Yang H et al. Correlation of p53 status with the response to chemotherapy-based treatment in esophageal cancer: a meta-analysis. Ann Surg Oncol 2013; 20: 2419-2427.
    • (2013) Ann Surg Oncol , vol.20 , pp. 2419-2427
    • Zhang, S.S.1    Huang, Q.Y.2    Yang, H.3
  • 164
    • 0033953130 scopus 로고    scopus 로고
    • Discordance of p53 mutations of synchronous colorectal carcinomas
    • Eguchi K, Yao T, Konomoto T et al. Discordance of p53 mutations of synchronous colorectal carcinomas. Mod Pathol 2000; 13: 131-139.
    • (2000) Mod Pathol , vol.13 , pp. 131-139
    • Eguchi, K.1    Yao, T.2    Konomoto, T.3
  • 165
    • 84864430562 scopus 로고    scopus 로고
    • SIFT web server: predicting effects of amino acid substitutions on proteins
    • Sim NL, Kumar P, Hu J et al. SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Res 2012; 40: W452-W457.
    • (2012) Nucleic Acids Res , vol.40 , pp. W452-W457
    • Sim, N.L.1    Kumar, P.2    Hu, J.3
  • 166
    • 77951640946 scopus 로고    scopus 로고
    • A method and server for predicting damaging missense mutations
    • Adzhubei IA, Schmidt S, Peshkin L et al. A method and server for predicting damaging missense mutations. Nat Methods 2010; 7: 248-249.
    • (2010) Nat Methods , vol.7 , pp. 248-249
    • Adzhubei, I.A.1    Schmidt, S.2    Peshkin, L.3
  • 167
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376: 687-697.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 168
    • 84865680221 scopus 로고    scopus 로고
    • A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261
    • Bible KC, Peethambaram PP, Oberg AL et al. A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261. Gynecol Oncol 2012; 127: 55-62.
    • (2012) Gynecol Oncol , vol.127 , pp. 55-62
    • Bible, K.C.1    Peethambaram, P.P.2    Oberg, A.L.3
  • 169
    • 84860512314 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial
    • Luke JJ, D'Adamo DR, Dickson MA et al. The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial. Clin Cancer Res 2012; 18: 2638-2647.
    • (2012) Clin Cancer Res , vol.18 , pp. 2638-2647
    • Luke, J.J.1    D'Adamo, D.R.2    Dickson, M.A.3
  • 170
    • 70349641356 scopus 로고    scopus 로고
    • Cetuximab plus cisplatin-5-fluorouracil versus cisplatin-5-fluorouracil alone in first-line metastatic squamous cell carcinoma of the esophagus: a randomized phase II study of the Arbeitsgemeinschaft Internistische Onkologie
    • Lorenzen S, Schuster T, Porschen R et al. Cetuximab plus cisplatin-5-fluorouracil versus cisplatin-5-fluorouracil alone in first-line metastatic squamous cell carcinoma of the esophagus: a randomized phase II study of the Arbeitsgemeinschaft Internistische Onkologie. Ann Oncol 2009; 20: 1667-1673.
    • (2009) Ann Oncol , vol.20 , pp. 1667-1673
    • Lorenzen, S.1    Schuster, T.2    Porschen, R.3
  • 171
    • 77649085714 scopus 로고    scopus 로고
    • A phase II study of perioperative concurrent chemotherapy, gefitinib, and hyperfractionated radiation followed by maintenance gefitinib in locoregionally advanced esophagus and gastroesophageal junction cancer
    • Rodriguez CP, Adelstein DJ, Rice TW et al. A phase II study of perioperative concurrent chemotherapy, gefitinib, and hyperfractionated radiation followed by maintenance gefitinib in locoregionally advanced esophagus and gastroesophageal junction cancer. J Thorac Oncol 2010; 5: 229-235.
    • (2010) J Thorac Oncol , vol.5 , pp. 229-235
    • Rodriguez, C.P.1    Adelstein, D.J.2    Rice, T.W.3
  • 172
    • 84864583237 scopus 로고    scopus 로고
    • Prospective phase II study of neoadjuvant therapy with cisplatin, 5-fluorouracil, and bevacizumab for locally advanced resectable esophageal cancer
    • Idelevich E, Kashtan H, Klein Y et al. Prospective phase II study of neoadjuvant therapy with cisplatin, 5-fluorouracil, and bevacizumab for locally advanced resectable esophageal cancer. Onkologie 2012; 35: 427-431.
    • (2012) Onkologie , vol.35 , pp. 427-431
    • Idelevich, E.1    Kashtan, H.2    Klein, Y.3
  • 173
    • 79551583770 scopus 로고    scopus 로고
    • A multicenter phase II study of induction chemotherapy with FOLFOX-4 and cetuximab followed by radiation and cetuximab in locally advanced oesophageal cancer
    • De Vita F, Orditura M, Martinelli E et al. A multicenter phase II study of induction chemotherapy with FOLFOX-4 and cetuximab followed by radiation and cetuximab in locally advanced oesophageal cancer. Br J Cancer 2011; 104: 427-432.
    • (2011) Br J Cancer , vol.104 , pp. 427-432
    • De Vita, F.1    Orditura, M.2    Martinelli, E.3
  • 174
    • 46349086833 scopus 로고    scopus 로고
    • Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis
    • Walther A, Houlston R, Tomlinson I. Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut 2008; 57: 941-950.
    • (2008) Gut , vol.57 , pp. 941-950
    • Walther, A.1    Houlston, R.2    Tomlinson, I.3
  • 175
    • 4143051317 scopus 로고    scopus 로고
    • Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
    • Zhou W, Gurubhagavatula S, Liu G et al. Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res 2004; 10: 4939-4943.
    • (2004) Clin Cancer Res , vol.10 , pp. 4939-4943
    • Zhou, W.1    Gurubhagavatula, S.2    Liu, G.3
  • 176
    • 79952728697 scopus 로고    scopus 로고
    • ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis
    • Yin M, Yan J, Martinez-Balibrea E et al. ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis. Clin Cancer Res 2011; 17: 1632-1640.
    • (2011) Clin Cancer Res , vol.17 , pp. 1632-1640
    • Yin, M.1    Yan, J.2    Martinez-Balibrea, E.3
  • 177
    • 82255193117 scopus 로고    scopus 로고
    • Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy
    • Giovannetti E, Pacetti P, Reni M et al. Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy. Pharmacogenomics 2011; 12: 1641-1652.
    • (2011) Pharmacogenomics , vol.12 , pp. 1641-1652
    • Giovannetti, E.1    Pacetti, P.2    Reni, M.3
  • 178
    • 84897353693 scopus 로고    scopus 로고
    • ERCC1 and ERCC2 variants predict survival in gastric cancer patients
    • Li Y, Liu Z, Liu H et al. ERCC1 and ERCC2 variants predict survival in gastric cancer patients. PLoS One 2013; 8: e71994.
    • (2013) PLoS One , vol.8 , pp. e71994
    • Li, Y.1    Liu, Z.2    Liu, H.3
  • 179
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S, Burk O, von Richter O et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000; 97: 3473-3478.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    von Richter, O.3
  • 180
    • 84878856110 scopus 로고    scopus 로고
    • Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis
    • Wu H, Kang H, Liu Y et al. Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis. Pharmacogenomics 2013; 14: 897-911.
    • (2013) Pharmacogenomics , vol.14 , pp. 897-911
    • Wu, H.1    Kang, H.2    Liu, Y.3
  • 181
    • 8844278362 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    • Bond GL, Hu W, Bond EE et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 2004; 119: 591-602.
    • (2004) Cell , vol.119 , pp. 591-602
    • Bond, G.L.1    Hu, W.2    Bond, E.E.3
  • 182
    • 84874524584 scopus 로고    scopus 로고
    • MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis
    • Ma Y, Bian J, Cao H. MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis. PLoS One 2013; 8: e56918.
    • (2013) PLoS One , vol.8 , pp. e56918
    • Ma, Y.1    Bian, J.2    Cao, H.3
  • 183
    • 0029435028 scopus 로고
    • Functional structure of the promoter region of the human thymidylate synthase gene and nuclear factors that regulate the expression of the gene
    • Horie N, Takeishi K. Functional structure of the promoter region of the human thymidylate synthase gene and nuclear factors that regulate the expression of the gene. Nucleic Acids Symp Ser 1995; 0: 77-78.
    • (1995) Nucleic Acids Symp Ser , vol.0 , pp. 77-78
    • Horie, N.1    Takeishi, K.2
  • 184
    • 84905716777 scopus 로고    scopus 로고
    • Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
    • Lima A, Seabra V, Martins S et al. Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Mol Biol Rep 2014; 41: 3349-3357.
    • (2014) Mol Biol Rep , vol.41 , pp. 3349-3357
    • Lima, A.1    Seabra, V.2    Martins, S.3
  • 185
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 186
    • 40049103754 scopus 로고    scopus 로고
    • Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review
    • Boccia S, Hung R, Ricciardi G et al. Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol 2008; 167: 505-516.
    • (2008) Am J Epidemiol , vol.167 , pp. 505-516
    • Boccia, S.1    Hung, R.2    Ricciardi, G.3
  • 187
    • 0034676239 scopus 로고    scopus 로고
    • The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK
    • Abdel-Rahman SZ, El-Zein RA. The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK. Cancer Lett 2000; 159: 63-71.
    • (2000) Cancer Lett , vol.159 , pp. 63-71
    • Abdel-Rahman, S.Z.1    El-Zein, R.A.2
  • 188
    • 84862817592 scopus 로고    scopus 로고
    • Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis
    • Cui Z, Yin Z, Li X et al. Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis. BMC Cancer 2012; 12: 71.
    • (2012) BMC Cancer , vol.12 , pp. 71
    • Cui, Z.1    Yin, Z.2    Li, X.3
  • 189
    • 0034145656 scopus 로고    scopus 로고
    • Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene
    • Yu JJ, Lee KB, Mu C et al. Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene. Int J Oncol 2000; 16: 555-560.
    • (2000) Int J Oncol , vol.16 , pp. 555-560
    • Yu, J.J.1    Lee, K.B.2    Mu, C.3
  • 190
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366: 883-892.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 191
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction?
    • Baylin SB, Ohm JE. Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 2006; 6: 107-116.
    • (2006) Nat Rev Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 192
    • 84877278637 scopus 로고    scopus 로고
    • Implementing personalized cancer genomics in clinical trials
    • Simon R, Roychowdhury S. Implementing personalized cancer genomics in clinical trials. Nat Rev Drug Discov 2013; 12: 358-369.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 358-369
    • Simon, R.1    Roychowdhury, S.2


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