The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer

Cellular Oncology

Volumn 34, Issue 4, 2011, Pages 281-288

  Vashist, Yogesh Kumar ^a   Kutup, Asad ^a   Musici, Safije ^a   Yekebas, Emre F ^a   Mina, Sormeh ^a   Uzunoglu, Guentac ^a   Zehler, Oliver ^a   Koenig, Alexandra ^a   Cataldegirmen, Guelle ^a   Bockhorn, Maximillian ^a   Effenberger, Katharina ^a   Kalinin, Viacheslav ^a   Pantel, Klaus ^a   Izbicki, Jakob R ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Esophageal cancer; GNAS1; Polymorphism; Prognostic marker

Indexed keywords

GENOMIC DNA; GNAS1 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; GNAS PROTEIN, HUMAN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CANCER CELL; CANCER SURGERY; DNA EXTRACTION; ESOPHAGUS CANCER; ESOPHAGUS RESECTION; FEMALE; GENOTYPE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; DISEASE COURSE; ESOPHAGUS TUMOR; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PROGNOSIS; RECURRENT DISEASE; TREATMENT OUTCOME;

AGED; DISEASE PROGRESSION; ESOPHAGEAL NEOPLASMS; FEMALE; GENOTYPE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RECURRENCE; TREATMENT OUTCOME;

EID: 84865340450     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-011-0016-x     Document Type: Article

References (43)

1. R.A. Malthaner, R.K. Wong, R.B. Rumble, L. Zuraw, Neoadjuvant or adjuvant therapy for resectable esophageal cancer: A clinical practice guideline. BMC Cancer 4, 67 (2004)
2. R.A. Malthaner, R.K. Wong, R.B. Rumble, L. Zuraw, Neoadjuvant or adjuvant therapy for resectable esophageal cancer: A systematic review and meta-analysis. BMC Med. 2, 35 (2004)
3. C.G. Peyre, J.A. Hagen, S.R. DeMeester, J.J. Van Lanschot, A. Holscher et al., Predicting systemic disease in patients with esophageal cancer after esophagectomy: A multinational study on the significance of the number of involved lymph nodes. Ann. Surg. 248, 979-985 (2008)
4. E. Adjadj, M. Schlumberger, F. de Vathaire, Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer. Lancet Oncol. 10, 181-190 (2009)
5. D.F. Easton, K.A. Pooley, A.M. Dunning, P.D. Pharoah, D. Thompson et al., Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447, 1087-1093 (2007) (Pubitemid 47014426)
6. K.W. Hunter, Host genetics and tumour metastasis. Br. J. Cancer 90, 752-755 (2004) (Pubitemid 38406581)
7. M.R. Koelle, Heterotrimeric G protein signaling: Getting inside the cell. Cell 126, 25-27 (2006)
8. L.S. Weinstein, S. Yu, D.R. Warner, J. Liu, Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. Endocr. Rev. 22, 675-705 (2001) (Pubitemid 32955250)
9. J. Lyons, C.A. Landis, G. Harsh, L. Vallar, K. Grunewald et al., Two G protein oncogenes in human endocrine tumors. Science 249, 655-659 (1990) (Pubitemid 20259082)
10. A. Lania, G. Mantovani, A. Spada, Genetics of pituitary tumors: Focus on G-protein mutations. Exp. Biol. Med. (Maywood) 228, 1004-1017 (2003) (Pubitemid 37222168)
11. Y. Daaka, L.M. Luttrell, R.J. Lefkowitz, Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature 390, 88-91 (1997) (Pubitemid 27494762)
12. X. Yang, F.Y. Lee Sr., G.S. Wand, Increased expression of Gs (alpha) enhances activation of the adenylyl cyclase signal transduction cascade. Mol. Endocrinol. 11, 1053-1061 (1997) (Pubitemid 27278828)
13. U.H. Frey, H. Alakus, J. Wohlschlaeger, K.J. Schmitz, G. Winde et al., GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer. Clin. Cancer Res. 11, 5071-5077 (2005) (Pubitemid 41003689)
14. U.H. Frey, A. Eisenhardt, G. Lummen, H. Rubben, K.H. Jockel et al., The T393C polymorphism of the G alpha s gene (GNAS1) is a novel prognostic marker in bladder cancer. Cancer Epidemiol. Biomark. Prev. 14, 871-877 (2005) (Pubitemid 40478550)
15. K. Pantel, C. Alix-Panabieres, S. Riethdorf, Cancer micrometastases. Nat Rev Clin Oncol 6, 339-351 (2009)
16. K. Pantel, R.H. Brakenhoff, B. Brandt, Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat. Rev. Cancer 8, 329-340 (2008) (Pubitemid 351596394)
17. E. Borgen, B. Naume, J.M. Nesland, G. Kvalheim, K. Beiske et al., Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. Establishment of objective criteria for the evaluation of immunostained cells. Cytotherapy 1, 377-388 (1999)
18. T. Fehm, S. Braun, V. Muller, W. Janni, G. Gebauer et al., A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer 107, 885-892 (2006) (Pubitemid 44291136)
19. U.H. Frey, G. Lummen, T. Jager, K.H. Jockel, K.W. Schmid et al., The GNAS1 T393C polymorphism predicts survival in patients with clear cell renal cell carcinoma. Clin. Cancer Res. 12, 759-763 (2006) (Pubitemid 43259855)
20. U.H. Frey, H. Nuckel, L. Sellmann, D. Siemer, R. Kuppers et al., The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia. Clin. Cancer Res. 12, 5686-5692 (2006) (Pubitemid 44629596)
21. G.F. Lehnerdt, P. Franz, S. Winterhoff, A. Bankfalvi, S. Grehl et al., The GNAS1 T393C polymorphism predicts survival in patients with advanced squamous cell carcinoma of the larynx. Laryngoscope 118, 2172-2176 (2008)
22. G.F. Lehnerdt, P. Franz, A. Zaqoul, K.J. Schmitz, S. Grehl et al., Overall and relapse-free survival in oropharyngeal and hypopharyngeal squamous cell carcinoma are associated with genotypes of T393C polymorphism of the GNAS1 gene. Clin. Cancer Res. 14, 1753-1758 (2008) (Pubitemid 351469460)
23. L.S. Weinstein, J. Liu, A. Sakamoto, T. Xie, M. Chen, Minireview: GNAS: Normal and abnormal functions. Endocrinology 145, 5459-5464 (2004) (Pubitemid 39564584)
24. F. Capon, M.H. Allen, M. Ameen, A.D. Burden, D. Tillman et al., A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups. Hum. Mol. Genet. 13, 2361-2368 (2004) (Pubitemid 39377840)
25. J. Duan, M.S. Wainwright, J.M. Comeron, N. Saitou, A.R. Sanders et al., Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum. Mol. Genet. 12, 205-216 (2003) (Pubitemid 36204418)
26. M.J. Tierney, R.L. Medcalf, Plasminogen activator inhibitor type 2 contains mRNA instability elements within exon 4 of the coding region. Sequence homology to coding region instability determinants in other mRNAs. J. Biol. Chem. 276, 13675-13684 (2001)
27. F. Otterbach, R. Callies, U.H. Frey, K.J. Schmitz, C. Wreczycki et al., The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma. Breast Cancer Res. Treat. 105, 311-317 (2007) (Pubitemid 47596451)
28. K.J. Schmitz, H. Lang, U.H. Frey, G.C. Sotiropoulos, J.Wohlschlaeger et al., GNAS1 T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma. Neoplasia 9, 159-165 (2007)
29. H. Alakus, U. Warnecke-Eberz, E. Bollschweiler, S.P. Monig, D. Vallbohmer et al., GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer. Pharmacogenomics J. 9, 202-207 (2009)
30. E.J. Neer, Heterotrimeric G proteins: Organizers of transmembrane signals. Cell 80, 249-257 (1995)
31. L.S. Weinstein, T. Xie, Q.H. Zhang, M. Chen, Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology. Pharmacol. Ther. 115, 271-291 (2007) (Pubitemid 47042911)
32. A. Harry, Y. Chen, R. Magnusson, R. Iyengar, G. Weng, Differential regulation of adenylyl cyclases by Galphas. J. Biol. Chem. 272, 19017-19021 (1997) (Pubitemid 27318257)
33. 2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J. Biol. Chem. 279, 46497-46508 (2004) (Pubitemid 39518293)
34. S. Kiermayer, R.M. Biondi, J. Imig, G. Plotz, J. Haupenthal et al., Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells. Mol. Biol. Cell 16, 5639-5648 (2005) (Pubitemid 41752214)
35. C. Peyssonnaux, A. Eychene, The Raf/MEK/ERK pathway: New concepts of activation. Biol. Cell 93, 53-62 (2001) (Pubitemid 33040860)
36. B.C. Visser, A.P. Venook, M.G. Patti, Adjuvant and neoadjuvant therapy for esophageal cancer: A critical reappraisal. Surg. Oncol. 12, 1-7 (2003) (Pubitemid 36411665)
37. J. Zhang, H.Q. Chen, Y.W. Zhang, J.Q. Xiang, Adjuvant chemotherapy in oesophageal cancer: A meta-analysis and experience from the Shanghai Cancer Hospital. J. Int. Med. Res. 36, 875-882 (2008)
38. A. DeMichele, R. Aplenc, J. Botbyl, T. Colligan, L. Wray et al., Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort. J. Clin. Oncol. 23, 5552-5559 (2005)
39. F. Innocenti, L. Iyer, M.J. Ratain, Pharmacogenetics: A tool for individualizing antineoplastic therapy. Clin. Pharmacokinet. 39, 315-325 (2000)
40. F. Innocenti, S.D. Undevia, L. Iyer, P.X. Chen, S. Das et al., Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J. Clin. Oncol. 22, 1382-1388 (2004) (Pubitemid 41103619)
41. P.E. Huijts, M.P. Vreeswijk, K.H. Kroeze-Jansema, C.E. Jacobi, C. Seynaeve et al., Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases. Breast Cancer Res. 9, R78 (2007)
42. P. Kraft, P. Pharoah, S.J. Chanock, D. Albanes, L.N. Kolonel et al., Genetic variation in the HSD17B1 gene and risk of prostate cancer. PLoS Genet. 1, e68 (2005)
43. U.H. Frey, A. Fritz, S. Rotterdam, K.W. Schmid, A. Potthoff et al., GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma. Eur. J. Med. Res. 15, 422-427 (2010)