Skewed Fc glycosylation profiles of anti-proteinase 3 immunoglobulin G1 autoantibodies from granulomatosis with polyangiitis patients show low levels of bisection, galactosylation, and sialylation

Journal of Proteome Research

Volumn 14, Issue 4, 2015, Pages 1657-1665

  Wuhrer, Manfred ^a,b,c   Stavenhagen, Kathrin ^a,b   Koeleman, Carolien A M ^a   Selman, Maurice H J ^a   Harper, Lorraine ^d   Jacobs, Bart C ^e   Savage, Caroline O S ^d   Jefferis, Roy ^d   Deelder, André M ^a   Morgan, Matthew ^d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

autoantibody; glycopeptide; glycosylation; immunoglobulin; mass spectrometry

Indexed keywords

CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; AUTOANTIBODY;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; BIRMINGHAM VASCULITIS ACTIVITY SCORE; BISECTION; CHEMICAL MODIFICATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; FUCOSYLATION; GALACTOSYLATION; GLYCOSYLATION; HUMAN; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; REMISSION; SCORING SYSTEM; SIALYLATION; WEGENER GRANULOMATOSIS; BLOOD; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; VASCULITIS;

ADULT; AUTOANTIBODIES; CYTOKINES; GLYCOSYLATION; GRANULOMATOSIS WITH POLYANGIITIS; HUMANS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MIDDLE AGED; MYELOBLASTIN; VASCULITIS;

EID: 84926432276     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500780a     Document Type: Article

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