Pathophysiology of ANCA-associated vasculitides: Are ANCA really pathogenic?

Kidney International

Volumn 65, Issue 5, 2004, Pages 1564-1567

  Heeringa, P ^a   Cohen Tervaert, J W ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

ANCA; Microscopic polyangiitis; Vasculitis

Indexed keywords

CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 8; LYSOSOME ENZYME; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTROPHIL CYTOPLASMIC ANTIBODY; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

CELLULAR IMMUNITY; CONFERENCE PAPER; CYTOKINE PRODUCTION; DATA ANALYSIS; GLOMERULONEPHRITIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE ACTIVATION; MONOCYTE; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECRETION; SMALL VESSEL VASCULITIS; VASCULITIS;

EID: 2342570287     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.05412.x     Document Type: Conference Paper

References (26)

1. CSERNOK E: Anti-neutrophil cytoplasmic antibodies and pathogenesis of small vessel vasculitides. Autoimmun Rev 2:158-164, 2003
2. RAROK AA, LIMBURG PC, KALLENBERG CG: Neutrophil-activating potential of antineutrophil cytoplasm autoantibodies. J Leukoc Biol 74:3-15, 2003
3. SAVAGE CO, POTTINGER BE, GASKIN G, et al: Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am J Pathol 141:335-342, 1992
4. EWERT BH, BECKER ME, JENNETTE JC, FALK RJ: Antimyeloperoxidase antibodies induce neutrophil adherence to cultured human endothelial cells. Ren Fail 17:125-133, 1995
5. BROOKS CJ, KING WJ, RADFORD DJ, et al: IL-1 beta production by human polymorphonuclear leucocytes stimulated by anti-neutrophil cytoplasmic autoantibodies: Relevance to systemic vasculitis. Clin Exp Immunol 106:273-279, 1996
6. HATTAR K, BICKENBACH A, CSERNOK E, et al: Wegener's granulomatosis: Antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activation. J Leuko Biol 71:996-1004, 2002
7. CASSELMAN BL, KILGORE KS, MILLER BF, WARREN JS: Antibodies to neutrophil cytoplasmic antigens induce monocyte chemoattractant protein-1 secretion from human monocytes. J Lab Clin Med 126:495-502, 1995
8. CONDLIFFE AM, CHILVERS ER, HASLETT C, DRANSFIELD I: Priming differentially regulates neutrophil adhesion molecule expression/function. Immunology 89:105-111, 1996
9. WARD RA, NAKAMURA M, MCLEISH KR: Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules. J Biol Chem 275:36713-36719, 2000
10. CSERNOK E, ERNST M, SCHMITT W, et al: Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo. Clin Exp Immunol 95:244-250, 1994
11. FALK RJ, TERRELL RS, CHARLES LA, JENNETTE JC: Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 87:4115-4119, 1990
12. MULDER AH, HEERINGA P, BROUWER E, et al: Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): A Fc gamma RII-dependent process. Clin Exp Immunol 98:270-278, 1994
13. PORGES AJ, REDECHA PB, KIMBERLY WT, et al: Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa. J Immunol 153:1271-1280, 1994
14. KETTRITZ R, JENNETTE JC, FALK RJ: Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils. J Am Soc Nephrol 8:386-394, 1997
15. BEN-SMITH A, DOVE SK, MARTIN A, et al: Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: Comparison with conventional Fc gamma receptor ligation. Blood 98:1448-1455, 2001
16. KETTRITZ R, CHOI M, BUTT W, et al: Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils. J Am Soc Nephrol 13:1740-1749, 2002
17. KETTRITZ R, SCHREIBER A, LUFT FC, HALLER H: Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. J Am Soc Nephrol 12:37-46, 2001
18. YANG JJ, PRESTON GA, ALCORTA DA, et al: Expression profile of leukocyte genes activated by anti-neutrophil cytoplasmic autoantibodies (ANCA). Kidney Int 62:1638-1649, 2002
19. HARPER JM, THIRU S, LOCKWOOD CM, COOKE A: Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti-neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp-lpr/lpr mice: A spontaneous model for human microscopic angiitis. Eur J Immunol 28:2217-2226, 1998
20. KINJOH K, KYOGOKU M, GOOD RA: Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis. Proc Natl Acad Sci USA 90:3413-3417, 1993
21. NEUMANN I, BIRCK R, NEWMAN M, et al: SCG/Kinjoh mice: A model of ANCA-associated crescentic glomerulonephritis with immune deposits. Kidney Int 64:140-148, 2003
22. BROUWER E, HUITEMA MG, KLOK PA, et al: Antimyeloperoxidase-associated proliferative glomerulonephritis: An animal model. J Exp Med 177:905-914, 1993
23. 2 in myeloperoxidase- immunized rats leads to necrotizing vasculitis in the lungs and gut. Am J Pathol 151:131-140, 1997
24. HEERINGA P, BROUWER E, KLOK PA, et al: Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat. Am J Pathol 149:1695-1706, 1996
25. XIAO H, HEERINGA P, HU P, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 110:955-963, 2002
26. FRANSSEN CF, GANS RO, ARENDS B, et al: Differences between antimyeloperoxidase- and anti-proteinase 3-associated renal disease. Kidney Int 47:193-199, 1995