Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Little, Mark A ^a   Al Ani, Bahjat ^b,g   Ren, Shuyu ^c   Al Nuaimi, Hamad ^b   Leite, Maurilo ^c,d   Alpers, Charles E ^e   Savage, Caroline O ^b,f   Duffield, Jeremy S ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^e UNIVERSITY OF WASHINGTON   (United States)

^f GLAXOSMITHKLINE   (United Kingdom)

^g KING KHALID UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; HUMAN IMMUNOGLOBULIN; PROTEINASE 3 NEUTROPHIL CYTOPLASM AUTOANTIBODY; UNCLASSIFIED DRUG; INTERLEUKIN 2 RECEPTOR; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; GLOMERULOPATHY; HEMATOPOIETIC STEM CELL; HEMATURIA; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LEUKOCYTE; LUNG HEMORRHAGE; MOUSE; NONHUMAN; PATHOGENICITY; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEIN FUNCTION; RADIATION CHIMERA; SYSTEMIC VASCULITIS; ANCA ASSOCIATED VASCULITIS; ANIMAL; BLEEDING; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PATHOLOGY;

ANIMALIA; MURINAE; MUS; RODENTIA;

ANIMALS; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOANTIBODIES; FEMALE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HEMATURIA; HEMORRHAGE; HUMANS; IMMUNE SYSTEM; IMMUNOENZYME TECHNIQUES; LEUKOCYTES; MICE; MICE, INBRED NOD; MICE, SCID; MYELOBLASTIN; RECEPTORS, INTERLEUKIN-2;

EID: 84855674846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028626     Document Type: Article

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