Effects of puerarin on lipid accumulation and metabolism in high-fat diet-fed mice

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Zheng, Guodong ^a   Lin, Lezhen ^a   Zhong, Shusheng ^a   Zhang, Qingfeng ^a   Li, Dongming ^a  

^a JIANGXI AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE ACYLTRANSFERASE; FATTY ACID SYNTHASE; HORMONE SENSITIVE LIPASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PUERARIN; TRIACYLGLYCEROL; CHOLESTEROL ESTERASE; FAS ANTIGEN; FAS PROTEIN, MOUSE; ISOFLAVONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG DOSE COMPARISON; FEMALE; FOOD INTAKE; GENE EXPRESSION; LIPID DIET; LIPID STORAGE; LIVER WEIGHT; METABOLISM; MOUSE; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT REDUCTION; ADVERSE EFFECTS; ANIMAL; BODY WEIGHT; CHEMISTRY; DRUG EFFECTS; EATING; ENZYMOLOGY; FECES; GENE EXPRESSION REGULATION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID METABOLISM; LIVER; ORGAN SIZE; PHOSPHORYLATION;

MUS; PUERARIA MONTANA VAR. LOBATA;

ADIPOSE TISSUE; ANIMALS; ANTIGENS, CD95; BODY WEIGHT; DIET, HIGH-FAT; EATING; FECES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISOFLAVONES; LIPID METABOLISM; LIVER; MICE; MICE, INBRED ICR; ORGAN SIZE; PHOSPHORYLATION; PPAR GAMMA; RNA, MESSENGER; STEROL ESTERASE;

EID: 84926432212     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122925     Document Type: Article

References (40)

1. Zhang A, Sun H, Wang X (2013) Power of metabolomics in biomarker discovery and mining mechanisms of obesity. Obes Rev 14: 344-349. doi: 10.1111/obr.12011 PMID: 23279162
2. Abete I, Astrup A, Martinez JA, Thorsdottir I, Zulet MA (2010) Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance. Nutr Rev 68: 214-231. doi: 10.1111/j.1753-4887.2010.00280.x PMID: 20416018
3. Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, et al. (2014) Novel insights of dietary polyphenols and obesity. J Nutr Biochem 25: 1-18. doi: 10.1016/j.jnutbio.2013.09.001 PMID: 24314860
4. MarrelliM, Loizzo MR, Nicoletti M,Menichini F, Conforti F (2014) In vitro investigation of the potential health benefits of wild Mediterranean dietary plants as anti-obesity agents with alpha-amylase and pancreatic lipase inhibitory activities. J Sci Food Agric 94: 2217-2224. doi: 10.1002/jsfa.6544 PMID: 24535986
5. Zhang Z, Lam TN, Zuo Z (2013) Radix Puerariae: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 53: 787-811. doi: 10.1002/jcph.96 PMID: 23677886
6. Liang YZ, Chen HM, Su ZQ, Hou SZ, Chen XY, et al. (2014) White pepper and piperine have different effects on pharmacokinetics of puerarin in rats. Evid Based Complement Alternat Med 2014: 796890. doi: 10.1155/2014/796890 PMID: 24991227
7. Yan LP, Chan SW, Chan AS, Chen SL, Ma XJ, et al. (2006) Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sci 79: 324-330. PMID: 16472823
8. Zhang S, Chen S, Shen Y, Yang D, Liu X, et al. (2006) Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. Biol Pharm Bull 29: 945-950. PMID: 16651724
9. Chen G, Pan SQ, Shen C, Pan SF, Zhang XM, et al. (2014) Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-kappaB pathways. Acta Pharmacol Sin 35: 463-475. doi: 10.1038/aps.2013.185 PMID: 24608673
10. LiuM, Liao K, Yu C, Li X, Liu S, et al. (2014) Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord.Mediators Inflamm 2014: 485927. doi: 10.1155/2014/485927 PMID: 25089076
11. Guerra MC, Speroni E, Broccoli M, Cangini M, Pasini P, et al. (2000) Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. Life Sci 67: 2997-3006. PMID: 11133012
12. Liang XL, Zhao LJ, Liao ZG, Zhao GW, Zhang J, et al. (2012) Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. J Ethnopharmacol 144: 677-682. doi: 10.1016/j.jep.2012.10.011 PMID: 23085309
13. Wang L, Cui Y, Tang M, Hu X, Luo H, et al. (2014) Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 34: 383-392. doi: 10.1159/000363007 PMID: 25059232
14. Chen X, Li R, Liang T, Zhang K, Gao Y, et al. (2013) Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats. Phytomedicine 20: 849-852. doi: 10.1016/j.phymed.2013.04.001 PMID: 23669266
15. Peng JH, Cui T, Huang F, Chen L, Zhao Y, et al. (2013) Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. J Pharmacol Exp Ther 344: 646-654. doi: 10.1124/jpet.112.201137 PMID: 23277536
16. Li R, Liang T, He Q, Guo C, Xu L, et al. (2013) Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3beta/NF-kappaB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. Int Immunopharmacol 17: 71-78. doi: 10.1016/j.intimp.2013.05.023 PMID: 23751897
17. Song XP, Chen PP, Chai XS (1988) [Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats]. Zhongguo Yao Li Xue Bao 9: 55-58. PMID: 3055814
18. Meezan E, Meezan EM, Jones K, Moore R, Barnes S, et al. (2005) Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. J Agric Food Chem 53: 8760-8767. PMID: 16248582
19. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509. PMID: 13428781
20. Zheng G, Qiu Y, Zhang Q, Li D (2014) Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice. Brit J Nutr 112: 1034-1040. doi: 10.1017/S0007114514001652 PMID: 25201308
21. Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I (2002) Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord 26: 1459-1464. PMID: 12439647
22. Li M, Shi Y, TianW(1999) Factors influencing the levels of fatty acid synthase complex activity in fowl. Biochem Mol Biol Int 47: 63-69. PMID: 10092945
23. Ma JQ, Ding J, Zhao H, Liu CM (2014) Puerarin Attenuates Carbon Tetrachloride-Induced Liver Oxidative Stress and Hyperlipidaemia in Mouse by JNK/c-Jun/CYP7A1 Pathway. Basic Clin Pharmacol Toxicol.
24. She S, Liu W, Li T, Hong Y (2014) Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. Food Funct 5: 944-950. doi: 10.1039/c3fo60565e PMID: 24595557
25. Zhu W, Chen S, Li Z, Zhao X, Li W, et al. (2014) Effects and mechanisms of resveratrol on the amelioration of oxidative stress and hepatic steatosis in KKAy mice. Nutr Metab (Lond) 11: 35. doi: 10.1186/1743-7075-11-35 PMID: 25140191
26. Klein S, Coppack SW, Mohamed-Ali V, Landt M (1996) Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45: 984-987. PMID: 8666153
27. Janeckova R (2001) The role of leptin in human physiology and pathophysiology. Physiol Res 50: 443-459. PMID: 11702849
28. Lee CE, Hur HJ, Hwang JT, Sung MJ, Yang HJ, et al. (2012) Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways. Evid Based Complement Alternat Med 2012: 759143. doi: 10.1155/2012/759143 PMID: 22829857
29. Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D (2007) Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 403: 139-148. PMID: 17147517
30. Zhang BB, Zhou G, Li C (2009) AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 9: 407-416. doi: 10.1016/j.cmet.2009.03.012 PMID: 19416711
31. Winder WW, Hardie DG (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 277: E1-10. PMID: 10409121
32. Gaidhu MP, Fediuc S, Anthony NM, So M, Mirpourian M, et al. (2009) Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL. J Lipid Res 50: 704-715. doi: 10.1194/jlr.M800480-JLR200 PMID: 19050316
33. Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, et al. (2008) Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem 283: 13087-13099. doi: 10.1074/jbc.M800533200 PMID: 18337240
34. Lord CC, Brown JM (2012) Distinct roles for alpha-beta hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling. Adipocyte 1: 123-131. PMID: 23145367
35. Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, et al. (2006) Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-737. PMID: 16675698
36. Tontonoz P, Spiegelman BM (2008) Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 77: 289-312. doi: 10.1146/annurev.biochem.77.061307.091829 PMID: 18518822
37. Christodoulides C, Vidal-Puig A (2010) PPARs and adipocyte function. Mol Cell Endocrinol 318: 61-68. doi: 10.1016/j.mce.2009.09.014 PMID: 19772894
38. Goto T, Kim YI (2013) Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors. Mol Nutr Food Res 57:20-33. doi: 10.1002/mnfr.201200522 PMID: 23180608
39. Otto TC, Lane MD (2005) Adipose development: from stem cell to adipocyte. Crit Rev Biochem Mol Biol 40: 229-242. PMID: 16126487
40. Gustafson B, Smith U (2006) Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281: 9507-9516. PMID: 16464856