Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways

Acta Pharmacologica Sinica

Volumn 35, Issue 4, 2014, Pages 463-475

  Chen, Gang ^a   Pan, Shi Qi ^b   Shen, Cong ^a   Pan, Shi Fen ^c   Zhang, Xiu Min ^a   He, Qi Yang ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin II; Cardiac hypertrophy; ERK1 2; Isoflavone; Kudzu root; NF B; p38; Puerarin; ROS; Valsartan

Indexed keywords

ANGIOTENSIN II; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUCINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PUERARIN; VALSARTAN; ANTIOXIDANT; ISOFLAVONE DERIVATIVE; MAPK1 PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TETRAZOLE DERIVATIVE; VALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BODY WEIGHT; CONTROLLED STUDY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HEART HYPERTROPHY; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE WALL; HEART MUSCLE CELL; HEART WEIGHT; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PROTEIN SYNTHESIS; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ECHOGRAPHY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEART VENTRICLE REMODELING; HYPERTROPHY, LEFT VENTRICULAR; METABOLISM; ORAL DRUG ADMINISTRATION; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION;

ADMINISTRATION, ORAL; ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HYPERTROPHY, LEFT VENTRICULAR; ISOFLAVONES; MALE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; NF-KAPPA B; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TETRAZOLES; VALINE; VENTRICULAR REMODELING;

EID: 84898716109     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.185     Document Type: Article

References (42)

1. Bendall JK, Cave AC, Heymes C, Gall N, Shah AM. Pivotal role of a gp91 (phox)-containing NAD(P)H oxidase in angiotensinII-induced cardiac hypertrophy in mice. Circulation 2002; 105: 293-6
2. Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci 2003; 24: 471-8
3. Frank GD, Eguchi S, Yamakawa T, Tanaka S, Inagami T, Motley ED. Involvement of reactive oxygen species in the activation of tyrosine kinase and extracellular signal-regulated kinase by angiotensinII. Endocrinology 2000; 141: 3120-6
4. Garrido AM, Griendling KK. NADPH oxidases and angiotensinII receptor signaling. Mol Cell Endocrinol 2009; 302: 148-58
5. Li YQ, Li XB, Guo SJ, Chu SL, Gao PJ, Zhu DL, et al. Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensinII-induced cardiac diastolic dysfunction in mice. Acta Pharmacol Sin 2013; 34: 352-9
6. Koichi T, Masaaki H, Toshikazu T. Redox regulation of MAPK pathways and cardiac hypertrophy in adult rat cardiac myocyte. J Am Coll Cardiol 2001; 37: 676-85
7. Freund C, Schmidt-Ullrich R, Baurand A, Dunger S, Schneider W, Loser P, et al. Requirement of nuclear factor-kappaB in angiotensinII-And isoproterenol-induced cardiac hypertrophy in vivo. Circulation 2005; 111: 2319-25
8. Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, et al. Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-Alpha induced cardiomyocyte hypertrophy. J Mol Cell Cardiol 2002; 34: 233-240
9. Yue HW, Hu XQ. Pharmacologic value of radix Puerariae and puerarine on cardiovascular system. Zhongguo Zhong Xi Yi Jie He Za Zhi 1996; 16: 382-84. Chinese
10. Zhang Z, Lam TN, Zuo Z. Radix puerariae: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 2013; 53: 787-11
11. Lu XR, Gao E, Xu LZ, Li HZ, Kang B, Chen WN, et al. Blocking effect of puerarin on beta-Adrenoceptors of isolated organs and the whole animal. Acta Pharmacol Sin 1986; 7: 537-9
12. Chai XS, Wang ZX, Chen PP, Wang LY, Lv XR, Kang B. Anti-Arrhythmic action of puerarin. Acta Pharmacol Sin 1985; 6: 166-8
13. Song XP, Chen PP, Chai XS. Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats. Acta Pharmacol Sin 1988; 9: 55-8
14. Zhang GQ, Hao XM, Dai DZ, Fu Y, Zhou PA, Wu CH. Puerarin blocks Na+ current in rat ventricular myocytes. Acta Pharmacol Sin 2003; 24: 1212-6
15. Dai WJ, Chen HY, Jiang JD, Kong WJ, Wang YG. Silencing MR-1 attenuates inflammatory damage in mice heart induced by Ang II. Biochem Biophys Res Commun 2010; 391: 1573-8
16. Shiomi T, Tsutsui H, Ikeuchi M, Matsusaka H, Hayashidani S, Suematsu N, et al. Streptozotocin-induced hyperglycemia exacerbates left ventricular remodeling and failure after experimental myocardial infarction. J Am Coll Cardiol 2003; 42: 165-72
17. Whitesall SE, Hoff JB, Vollmer AP, D'Alecy LG. Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods. Am J Physiol 2004; 286: H2408-15
18. Fei AH, Cao Q, Chen SY, Wang HR, Wang FL, Pan SM, et al. Salvianolate inhibits reactive oxygen species production in H2O2-Treated mouse cardiomyocytes in vitro via the TGFβ pathway. Acta Pharmacol Sin 2013; 34: 496-500
19. Kim JM, Heo HS, Ha YM, Ye BH, Lee EK, Choi YJ, et al. Mechanism of Ang II involvement in activation of NF-κB through phosphorylation of p65 during aging. AGE 2012; 34: 11-25
20. Finco TS, Beg AA, Baldwin AS Jr. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors. Proc Natl Acad Sci U S A 1994; 91: 11884-8
21. Lu QM, Liu ZY. Effects of glucose flunctuation on cardiomyocyte hypertrophy in neonatal rats. Chin J Histochem Cytochem 2011; 20: 334-8
22. Nakamura K, Fushimi K, Kouchi H, Mihara K, Miyazaki M, Ohe T. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor alpha and angiotensin II. Circulation 1998; 98: 794-9
23. Nozato T, Ito H, Tamamori M, Adachi S, Abe S, Marumo F, et al. G1 cyclins are involved in the mechanism of cardiac myocyte hypertrophy induced by angiotensin II. Jpn Circ J 2000; 64: 595-601
24. Das S, Otani H, Maulik N, Das DK. Redox regulation of angiotensinII preconditioning of the myocardium requires MAP kinase signaling. J Mol Cell Cardiol 2006; 41: 248-55
25. Hirotani S, Otsu K, Nishida K, Higuchi Y, Morita T, Nakayama H, et al. Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 2002; 105: 509-15
26. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 2000; 19: 6341-50
27. Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, et al. The in vivo role of p38 MAP kinases in cardiac remodeling and restrict tive cardiomyopathy. Proc Natl Acad Sci U S A 2001; 98: 12283-8
28. Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A. Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci U S A 2001; 98: 6668-73
29. Kawano S, Kubota T, Monden Y, Kawamura N, Tsutsui H, Takeshita A, et al. Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II. Cardiovasc Res 2005; 67: 689-98
30. Shih NL, Cheng TH, Loh SH, Cheng PY, Wang DL, Chen YS, et al. Reactive oxygen species modulate angiotensin II-induced beta-myosin heavy chain gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in neonatal rat cardiomyocytes. Biochem Biophys Res Commun 2001; 283: 143-48
31. Sano M, Fukuda K, Sato T, Kawaguchi H, Suematsu M, Matsuda S, et al. ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts. Circ Res 2001; 89: 661-9
32. Meng Z, Yan C, Deng Q, Gao DF, Niu XL. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacol Sin 2013; 34: 901-11
33. Chung MJ, Sung NJ, Park CS, Kweon DK, Mantovani A, Moon TW, et al. Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 Bcl/6J mice. Eur J Pharmacol 2008; 578: 159-70
34. Liu CM, Ma JQ, Sun YZ. Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. Exp Toxicol Pathol 2012; 64: 575-82
35. Xiong FL, Sun XH, Gan L, Yang XL, Xu HB. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. Eur J Pharmacol 2006; 529: 1-7
36. Li YQ, Zhang ZX, Xu YJ, Ni W, Chen SX, Yang Z, et al. N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms. Acta Pharmacol Sin 2006; 27: 339-46
37. Nakamura K, Fushimi K, Kouchi H, Mihara K, Miyazaki M, Ohe T. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-Alpha and angiotensinII. Circulation 1998; 98: 794-9
38. Zou XJ, Yang L, Yao SL. Propofol depresses angiotensinII-induced cardiomyocyte hypertrophy in vitro. Exp Biol Med 2008; 233: 200-8
39. Shen DF, Tang QZ, Yan L, Zhang Y, Zhu LH, Wang L, et al. Tetrandrine blocks cardiac hypertrophy by disrupting reactive oxygen species-dependent ERK1/2 signalling. Br J Pharmacol 2010; 159: 970-81
40. Wang JX, Hou LF, Yang Y, Tang W, Li Y, Zuo JP. SM905, an artemisinin derivative, inhibited NO and pro-inflammatory cytokine production by suppressing MAPK and NF-kappaB pathways in RAW 264.7 macrophages. Acta Pharmacol Sin 2009; 30: 1428-35
41. Yang XS, Liu SA, Liu JW, Yan Q. Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2, p38, and NF-κB pathways in A431 cells. Asian Pac J Cancer Prev 2012; 13: 1657-62
42. Sée V, Rajala NK, Spiller DG, White MR. Calcium-dependent regulation of the cell cycle via a novel MAPK-NF-κB pathway in Swiss 3T3 cells. J Cell Biol 2004; 166: 661-72.