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Volumn 295, Issue , 2015, Pages 139-150

The protein L-isoaspartyl (D-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells

Author keywords

Apoptosis; Dopamine; Oxidative stress; Parkinson's disease; PIMT; Protein l isoaspartyl (d aspartyl) methyltransferase

Indexed keywords

CASPASE 3; DOPAMINE; METHYLTRANSFERASE; PROTEIN DEXTRO ASPARTATE METHYLTRANSFERASE; PROTEIN ISOASPARTYL METHYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CASPASE; PCMT1 PROTEIN, HUMAN;

EID: 84926431643     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.03.026     Document Type: Article
Times cited : (21)

References (58)
  • 1
    • 66249140251 scopus 로고    scopus 로고
    • Behavioural adverse effects of dopaminergic treatments in Parkinson's disease: incidence, neurobiological basis, management and prevention
    • Antonini A., Cilia R. Behavioural adverse effects of dopaminergic treatments in Parkinson's disease: incidence, neurobiological basis, management and prevention. Drug Saf 2009, 32:475-488.
    • (2009) Drug Saf , vol.32 , pp. 475-488
    • Antonini, A.1    Cilia, R.2
  • 2
    • 0022370732 scopus 로고
    • Protein-O-carboxylmethyltransferase in the rat brain: high regional levels in the substantia nigra, locus coeruleus and paraventricular nucleus
    • Billingsley M.L., Balaban C.D. Protein-O-carboxylmethyltransferase in the rat brain: high regional levels in the substantia nigra, locus coeruleus and paraventricular nucleus. Brain Res 1985, 358:96-103.
    • (1985) Brain Res , vol.358 , pp. 96-103
    • Billingsley, M.L.1    Balaban, C.D.2
  • 3
    • 84881071322 scopus 로고    scopus 로고
    • Paracrine control of tissue regeneration and cell proliferation by Caspase-3
    • Boland K., Flanagan L., Prehn J.H.M. Paracrine control of tissue regeneration and cell proliferation by Caspase-3. Cell Death Dis 2013, 4:e725.
    • (2013) Cell Death Dis , vol.4 , pp. e725
    • Boland, K.1    Flanagan, L.2    Prehn, J.H.M.3
  • 6
    • 0021891879 scopus 로고
    • Protein carboxyl methyltransferases: two distinct classes of enzymes
    • Clarke S. Protein carboxyl methyltransferases: two distinct classes of enzymes. Annu Rev Biochem 1985, 54:479-506.
    • (1985) Annu Rev Biochem , vol.54 , pp. 479-506
    • Clarke, S.1
  • 7
    • 0348099030 scopus 로고    scopus 로고
    • Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair
    • Clarke S. Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair. Ageing Res Rev 2003, 2:263-285.
    • (2003) Ageing Res Rev , vol.2 , pp. 263-285
    • Clarke, S.1
  • 9
    • 79958792815 scopus 로고    scopus 로고
    • Damaged proteins bearing l-isoaspartyl residues and aging: a dynamic equilibium between generation of isomerized forms and repair by PIMT
    • Desrosiers R.R., Fanélus I. Damaged proteins bearing l-isoaspartyl residues and aging: a dynamic equilibium between generation of isomerized forms and repair by PIMT. Curr Aging Sci 2011, 4:8-18.
    • (2011) Curr Aging Sci , vol.4 , pp. 8-18
    • Desrosiers, R.R.1    Fanélus, I.2
  • 10
    • 43049173731 scopus 로고    scopus 로고
    • Reactive oxygen species generated by thiol-modifying phenylarsine oxide stimulate the expression of protein l-isoaspartyl methyltransferase
    • Fanélus I., Desrosiers R.R. Reactive oxygen species generated by thiol-modifying phenylarsine oxide stimulate the expression of protein l-isoaspartyl methyltransferase. Biochem Biophys Res Commun 2008, 371:203-208.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 203-208
    • Fanélus, I.1    Desrosiers, R.R.2
  • 11
    • 84878911829 scopus 로고    scopus 로고
    • Mitochondrial uncoupler carbonyl cyanide M-chlorophenylhydrazone induces the multimer assembly and activity of repair enzyme protein l-isoaspartyl methyltransferase
    • Fanélus I., Desrosiers R.R. Mitochondrial uncoupler carbonyl cyanide M-chlorophenylhydrazone induces the multimer assembly and activity of repair enzyme protein l-isoaspartyl methyltransferase. J Mol Neurosci 2013, 50:411-423.
    • (2013) J Mol Neurosci , vol.50 , pp. 411-423
    • Fanélus, I.1    Desrosiers, R.R.2
  • 12
    • 23844547049 scopus 로고    scopus 로고
    • Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice
    • Farrar C.E., Houser C.R., Clarke S.G. Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice. Aging Cell 2005, 4:1-12.
    • (2005) Aging Cell , vol.4 , pp. 1-12
    • Farrar, C.E.1    Houser, C.R.2    Clarke, S.G.3
  • 13
    • 79955041511 scopus 로고    scopus 로고
    • Deep brain stimulation: a review of the procedure and the complications
    • Farris S., Giroux M. Deep brain stimulation: a review of the procedure and the complications. JAAPA 2011, 24(39-40):42-45.
    • (2011) JAAPA , vol.24 , Issue.39-40 , pp. 42-45
    • Farris, S.1    Giroux, M.2
  • 14
    • 66149143952 scopus 로고    scopus 로고
    • Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons
    • Guillot S.T., Miller G.W. Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons. Mol Neurobiol 2009, 39:149-170.
    • (2009) Mol Neurobiol , vol.39 , pp. 149-170
    • Guillot, S.T.1    Miller, G.W.2
  • 15
    • 76949108822 scopus 로고    scopus 로고
    • The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease
    • Hastings T.G. The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease. J Bioenerg Biomembr 2009, 41:469-472.
    • (2009) J Bioenerg Biomembr , vol.41 , pp. 469-472
    • Hastings, T.G.1
  • 16
    • 84888592766 scopus 로고    scopus 로고
    • RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis
    • Heman-Ackah S.M., Hallegger M., Rao M.S., Wood M.J.A. RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis. Front Mol Neurosci 2013, 6:40.
    • (2013) Front Mol Neurosci , vol.6 , pp. 40
    • Heman-Ackah, S.M.1    Hallegger, M.2    Rao, M.S.3    Wood, M.J.A.4
  • 17
    • 0033926856 scopus 로고    scopus 로고
    • Increased methyl esterification of altered aspartyl residues in erythrocyte membrane proteins in response to oxidative stress
    • Ingrosso D., D'angelo S., di Carlo E., Perna A.F., Zappia V., Galletti P. Increased methyl esterification of altered aspartyl residues in erythrocyte membrane proteins in response to oxidative stress. Eur J Biochem 2000, 267:4397-4405.
    • (2000) Eur J Biochem , vol.267 , pp. 4397-4405
    • Ingrosso, D.1    D'angelo, S.2    di Carlo, E.3    Perna, A.F.4    Zappia, V.5    Galletti, P.6
  • 18
    • 84871089477 scopus 로고    scopus 로고
    • Neurobiology of cognitive impairment in Parkinson's disease
    • Jellinger K.A. Neurobiology of cognitive impairment in Parkinson's disease. Expert Rev Neurother 2012, 12:1451-1466.
    • (2012) Expert Rev Neurother , vol.12 , pp. 1451-1466
    • Jellinger, K.A.1
  • 19
    • 0022203606 scopus 로고
    • Identification and topography of substrates for protein carboxyl methyltransferase in synaptic membrane and myelin-enriched fractions of bovine and rat brain
    • Johnson B.A., Aswad D.W. Identification and topography of substrates for protein carboxyl methyltransferase in synaptic membrane and myelin-enriched fractions of bovine and rat brain. J Neurochem 1985, 45:1119-1127.
    • (1985) J Neurochem , vol.45 , pp. 1119-1127
    • Johnson, B.A.1    Aswad, D.W.2
  • 20
    • 70349411509 scopus 로고    scopus 로고
    • Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans
    • Khare S., Gomez T., Linster C.L., Clarke S.G. Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans. Mech Ageing Dev 2009, 130:670-680.
    • (2009) Mech Ageing Dev , vol.130 , pp. 670-680
    • Khare, S.1    Gomez, T.2    Linster, C.L.3    Clarke, S.G.4
  • 22
    • 80054994567 scopus 로고    scopus 로고
    • Neuroprotective effects of 3α-acetoxyeudesma-1,4(15),11(13)-trien-12,6α-olide against dopamine-induced apoptosis in the human neuroblastoma SH-SY5Y cell line
    • Koo U., Nam K.W., Ham A., Lyu D., Kim B., Lee S.J., Kim K.H., Oh K.B., Mar W., Shin J. Neuroprotective effects of 3α-acetoxyeudesma-1,4(15),11(13)-trien-12,6α-olide against dopamine-induced apoptosis in the human neuroblastoma SH-SY5Y cell line. Neurochem Res 2011, 36:1991-2001.
    • (2011) Neurochem Res , vol.36 , pp. 1991-2001
    • Koo, U.1    Nam, K.W.2    Ham, A.3    Lyu, D.4    Kim, B.5    Lee, S.J.6    Kim, K.H.7    Oh, K.B.8    Mar, W.9    Shin, J.10
  • 23
    • 0033119372 scopus 로고    scopus 로고
    • BCL-2 gene family and the regulation of programmed cell death
    • Korsmeyer S.J. BCL-2 gene family and the regulation of programmed cell death. Cancer Res 1999, 59(7 Suppl.):1693s-1700s.
    • (1999) Cancer Res , vol.59 , Issue.7 , pp. 1693s-1700s
    • Korsmeyer, S.J.1
  • 24
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 25
    • 33846286501 scopus 로고    scopus 로고
    • Regulation of protein l-isoaspartyl methyltransferase by cell-matrix interactions: involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome
    • Lanthier J., Desrosiers R.R. Regulation of protein l-isoaspartyl methyltransferase by cell-matrix interactions: involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome. Biochem Cell Biol 2006, 84:684-694.
    • (2006) Biochem Cell Biol , vol.84 , pp. 684-694
    • Lanthier, J.1    Desrosiers, R.R.2
  • 26
    • 77952326081 scopus 로고    scopus 로고
    • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
    • Lee J.Y., Nagano Y., Taylor J.P., Lim K.L., Yao T.P. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol 2010, 189:671-679.
    • (2010) J Cell Biol , vol.189 , pp. 671-679
    • Lee, J.Y.1    Nagano, Y.2    Taylor, J.P.3    Lim, K.L.4    Yao, T.P.5
  • 28
    • 84867704444 scopus 로고    scopus 로고
    • Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis
    • Li F., Tian X., Zhou Y., Zhu L., Wang B., Ding M., Pang H.J. Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis. Neurosci Res 2012, 90:2237-2246.
    • (2012) Neurosci Res , vol.90 , pp. 2237-2246
    • Li, F.1    Tian, X.2    Zhou, Y.3    Zhu, L.4    Wang, B.5    Ding, M.6    Pang, H.J.7
  • 29
    • 84880832520 scopus 로고    scopus 로고
    • PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2
    • Li X.L., Li B.Y., Cheng M., Yu F., Yin W.B., Cai Q., Zhang Z., Zhang J.H., Wang J.F., Zhou R.H., Gao H.Q. PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. PLoS One 2013, 8:e69979.
    • (2013) PLoS One , vol.8 , pp. e69979
    • Li, X.L.1    Li, B.Y.2    Cheng, M.3    Yu, F.4    Yin, W.B.5    Cai, Q.6    Zhang, Z.7    Zhang, J.H.8    Wang, J.F.9    Zhou, R.H.10    Gao, H.Q.11
  • 30
    • 0036797552 scopus 로고    scopus 로고
    • Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
    • Lotharius J., Brundin P. Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. Hum Mol Genet 2002, 11:2395-2407.
    • (2002) Hum Mol Genet , vol.11 , pp. 2395-2407
    • Lotharius, J.1    Brundin, P.2
  • 31
    • 84867148645 scopus 로고    scopus 로고
    • Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice
    • MacKay K.B., Lowenson J.D., Clarke S.G. Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice. PLoS One 2012, 7:e46719.
    • (2012) PLoS One , vol.7 , pp. e46719
    • MacKay, K.B.1    Lowenson, J.D.2    Clarke, S.G.3
  • 33
    • 0028157699 scopus 로고
    • Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis
    • Mizobuchi M., Murao K., Takeda R., Kakimoto Y. Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis. J Neurochem 1994, 62:322-328.
    • (1994) J Neurochem , vol.62 , pp. 322-328
    • Mizobuchi, M.1    Murao, K.2    Takeda, R.3    Kakimoto, Y.4
  • 34
    • 84897467873 scopus 로고    scopus 로고
    • Dopamine down-regulation of protein l-isoaspartyl methyltransferase is dependent of reactive oxygen species in SH-SY5Y cells
    • Ouazia D., Levros L.-C., Rassart E., Desrosiers R.R. Dopamine down-regulation of protein l-isoaspartyl methyltransferase is dependent of reactive oxygen species in SH-SY5Y cells. Neuroscience 2014, 267:263-276.
    • (2014) Neuroscience , vol.267 , pp. 263-276
    • Ouazia, D.1    Levros, L.-C.2    Rassart, E.3    Desrosiers, R.R.4
  • 35
    • 84867397192 scopus 로고    scopus 로고
    • Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson's disease - Resemblance to the effect of amphetamine drugs of abuse
    • Perfeito R., Cunha-Oliveira T., Cristina Rego A. Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson's disease - Resemblance to the effect of amphetamine drugs of abuse. Free Radic Biol Med 2012, 53:1791-1806.
    • (2012) Free Radic Biol Med , vol.53 , pp. 1791-1806
    • Perfeito, R.1    Cunha-Oliveira, T.2    Cristina, R.A.3
  • 36
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed J.C. Double identity for proteins of the Bcl-2 family. Nature 1997, 387:773-776.
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 37
    • 3142514201 scopus 로고    scopus 로고
    • Protein aggregation and neurodegenerative disease
    • Ross C.A., Poirier M.A. Protein aggregation and neurodegenerative disease. Nat Med 2004, 10(Suppl.):S10-S17.
    • (2004) Nat Med , vol.10 , pp. S10-S17
    • Ross, C.A.1    Poirier, M.A.2
  • 38
    • 84896546430 scopus 로고    scopus 로고
    • Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells
    • Pišlar A.H., Zidar N., Kikelj D., Kos J. Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells. Neuropharmacology 2014, 82:121-131.
    • (2014) Neuropharmacology , vol.82 , pp. 121-131
    • Pišlar, A.H.1    Zidar, N.2    Kikelj, D.3    Kos, J.4
  • 39
    • 83755162590 scopus 로고    scopus 로고
    • The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation
    • Sambri I., Capasso R., Pucci P., Perna A.F., Ingrosso D. The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation. J Biol Chem 2011, 286:43690-43700.
    • (2011) J Biol Chem , vol.286 , pp. 43690-43700
    • Sambri, I.1    Capasso, R.2    Pucci, P.3    Perna, A.F.4    Ingrosso, D.5
  • 40
    • 33745847479 scopus 로고    scopus 로고
    • Diagnosis and treatment of Parkinson disease: molecules to medicine
    • Savitt J.M., Dawson V.L., Dawson T.M. Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest 2006, 116:1744-1754.
    • (2006) J Clin Invest , vol.116 , pp. 1744-1754
    • Savitt, J.M.1    Dawson, V.L.2    Dawson, T.M.3
  • 41
    • 84886526775 scopus 로고    scopus 로고
    • Deamidation of asparagine to aspartate destabilizes Cu, Zn superoxide dismutase, accelerates fibrillization, and mirrors ALS-linked mutations
    • Shi Y., Rhodes N.R., Abdolvahabi A., Kohn T., Cook N.P., Marti A.A., Shaw B.F. Deamidation of asparagine to aspartate destabilizes Cu, Zn superoxide dismutase, accelerates fibrillization, and mirrors ALS-linked mutations. J Am Chem Soc 2013, 135:15897-15908.
    • (2013) J Am Chem Soc , vol.135 , pp. 15897-15908
    • Shi, Y.1    Rhodes, N.R.2    Abdolvahabi, A.3    Kohn, T.4    Cook, N.P.5    Marti, A.A.6    Shaw, B.F.7
  • 42
    • 0032914318 scopus 로고    scopus 로고
    • Monoamine oxidase: from genes to behavior
    • Shih J.C., Chen K., Ridd M.J. Monoamine oxidase: from genes to behavior. Annu Rev Neurosci 1999, 22:197-217.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 197-217
    • Shih, J.C.1    Chen, K.2    Ridd, M.J.3
  • 43
  • 44
    • 0032416062 scopus 로고    scopus 로고
    • Death by a thousand cuts: an ever increasing list of caspase substrates
    • Stroh C., Schulze-Osthoff K. Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ 1998, 5:997-1000.
    • (1998) Cell Death Differ , vol.5 , pp. 997-1000
    • Stroh, C.1    Schulze-Osthoff, K.2
  • 46
    • 0033756901 scopus 로고    scopus 로고
    • Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease
    • Tatton N.A. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp Neurol 2000, 166:29-43.
    • (2000) Exp Neurol , vol.166 , pp. 29-43
    • Tatton, N.A.1
  • 47
    • 39749182234 scopus 로고    scopus 로고
    • Apoptosis: controlled demolition at the cellular level
    • Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008, 9:231-241.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 231-241
    • Taylor, R.C.1    Cullen, S.P.2    Martin, S.J.3
  • 48
    • 37349004102 scopus 로고    scopus 로고
    • Parkinson's disease
    • Thomas B., Beal M.F. Parkinson's disease. Hum Mol Genet 2007, 16 Spec No. 2:R183-R194.
    • (2007) Hum Mol Genet , pp. R183-R194
    • Thomas, B.1    Beal, M.F.2
  • 49
    • 0035964190 scopus 로고    scopus 로고
    • Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation
    • Ura S., Masuyama N., Graves J.D., Gotoh Y. Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. Proc Natl Acad Sci U S A 2001, 98:10148-10153.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10148-10153
    • Ura, S.1    Masuyama, N.2    Graves, J.D.3    Gotoh, Y.4
  • 51
    • 77949772436 scopus 로고    scopus 로고
    • Protein l-isoaspartyl methyltransferase1 (CaPIMT1) from chickpea mitigates oxidative stress-induced growth inhibition of Escherichia coli
    • Verma P., Singh A., Kaur H., Majee M. Protein l-isoaspartyl methyltransferase1 (CaPIMT1) from chickpea mitigates oxidative stress-induced growth inhibition of Escherichia coli. Planta 2010, 231:329-336.
    • (2010) Planta , vol.231 , pp. 329-336
    • Verma, P.1    Singh, A.2    Kaur, H.3    Majee, M.4
  • 53
    • 0035894881 scopus 로고    scopus 로고
    • Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
    • Viswanath V., Wu Y., Boonplueang R., Chen S., Stevenson F.F., Yantiri F., Yang L., Beal M.F., Andersen J.K. Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci 2001, 21:9519-9528.
    • (2001) J Neurosci , vol.21 , pp. 9519-9528
    • Viswanath, V.1    Wu, Y.2    Boonplueang, R.3    Chen, S.4    Stevenson, F.F.5    Yantiri, F.6    Yang, L.7    Beal, M.F.8    Andersen, J.K.9
  • 54
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: the growing complexity of p53
    • Vousden K.H., Prives C. Blinded by the light: the growing complexity of p53. Cell 2009, 137:413-431.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 55
    • 84886292106 scopus 로고    scopus 로고
    • Protein-l-isoaspartate (d-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1
    • Yan G., Qin Q., Yi B., Chuprun K., Sun H., Huang S., Sun J. Protein-l-isoaspartate (d-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol 2013, 168:3291-3299.
    • (2013) Int J Cardiol , vol.168 , pp. 3291-3299
    • Yan, G.1    Qin, Q.2    Yi, B.3    Chuprun, K.4    Sun, H.5    Huang, S.6    Sun, J.7
  • 56
    • 53849113943 scopus 로고    scopus 로고
    • Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose
    • Yang Z., Mo X., Gong Q., Pan Q., Yang X., Cai W., Li C., Ma J.X., He Y., Gao G. Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose. Apoptosis 2008, 13:1331-1343.
    • (2008) Apoptosis , vol.13 , pp. 1331-1343
    • Yang, Z.1    Mo, X.2    Gong, Q.3    Pan, Q.4    Yang, X.5    Cai, W.6    Li, C.7    Ma, J.X.8    He, Y.9    Gao, G.10
  • 58
    • 33845918167 scopus 로고    scopus 로고
    • Protein repair in the brain, proteomic analysis of endogenous substrates for protein l-isoaspartyl methyltransferase in mouse brain
    • Zhu J.X., Doyle H.A., Mamula M.J., Aswad D.W. Protein repair in the brain, proteomic analysis of endogenous substrates for protein l-isoaspartyl methyltransferase in mouse brain. J Biol Chem 2006, 281:33802-33813.
    • (2006) J Biol Chem , vol.281 , pp. 33802-33813
    • Zhu, J.X.1    Doyle, H.A.2    Mamula, M.J.3    Aswad, D.W.4


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