Kinetically-Defined Component Actions in Gene Repression

PLoS Computational Biology

Volumn 11, Issue 3, 2015, Pages

  Chow, Carson C ^a   Finn, Kelsey K ^a,b   Storchan, Geoffery B ^a   Lu, Xinping ^a   Sheng, Xiaoyan ^a,c   Simons, S Stoney ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KINETICS; PHYSIOLOGICAL MODELS;

ACTIVITY CLASSIFICATIONS; COFACTORS; DOSE-RESPONSE CURVES; GENE PRODUCTS; GENE REPRESSION; GENES INDUCTION; GLUCOCORTICOID RECEPTOR; HILL COEFFICIENT; NON-COOPERATIVE; PHYSIOLOGICAL RESPONSE;

TRANSCRIPTION;

CHEMICAL COMPOUND; GLUCOCORTICOID RECEPTOR; LUCIFERASE; NU 6027; NUCLEAR RECEPTOR COACTIVATOR 2; PHENANTHROLINE; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG; 4-CYCLOHEXYLMETHOXY-5-NITROSOPYRIMIDINE-2,6-DIAMINE; NITROSO DERIVATIVE; PHENANTHROLINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRANSCRIPTION FACTOR;

ARTICLE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; GENE ACTIVITY; GENE DOSAGE; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; IC50; INHIBITION KINETICS; MASS ACTION; MATHEMATICAL ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; U2OS CELL LINE; BIOLOGICAL MODEL; BIOLOGY; EPIGENETIC REPRESSION; GENETICS; HUMAN; KINETICS; REPRODUCIBILITY;

COMPUTATIONAL BIOLOGY; EPIGENETIC REPRESSION; HUMANS; KINETICS; MODELS, GENETIC; NITROSO COMPOUNDS; PHENANTHROLINES; PYRIMIDINES; RECEPTORS, GLUCOCORTICOID; REPRODUCIBILITY OF RESULTS; TRANSCRIPTION FACTORS;

EID: 84926331737     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004122     Document Type: Article

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