Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

Nature Communications

Volumn 5, Issue , 2014, Pages

  Pritchard, Colin C ^a   Morrissey, Colm ^b   Kumar, Akash ^a   Zhang, Xiaotun ^b   Smith, Christina ^a   Coleman, Ilsa ^c   Salipante, Stephen J ^a   Milbank, Jennifer ^a   Yu, Ming ^c   Grady, William M ^c   Tait, Jonathan F ^a   Corey, Eva ^b   Vessella, Robert L ^b   Walsh, Tom ^b   Shendure, Jay ^a   Nelson, Peter S ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MSH2; PROTEIN MSH6; DNA BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; MSH2 PROTEIN, HUMAN; PROTEIN BINDING;

CANCER; DISEASE INCIDENCE; GENE EXPRESSION; GENETIC DIFFERENTIATION; MICROSTRUCTURE; MUTATION;

ADVANCED CANCER; ARTICLE; AUTOPSY; BIOINFORMATICS; CANCER GROWTH; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE ASSESSMENT; DISEASE ASSOCIATION; DNA REPAIR; FRAMESHIFT MUTATION; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; PROSTATE CANCER; PROTEIN EXPRESSION; ENZYMOLOGY; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; PROSTATE TUMOR;

DNA MISMATCH REPAIR; DNA-BINDING PROTEINS; HUMANS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; PROSTATIC NEOPLASMS; PROTEIN BINDING;

EID: 84923354398     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5988     Document Type: Article

References (22)

1. Kumar, A. et al. Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers. Proc. Natl Acad. Sci. USA 108, 17087-17092 (2011
2. Barbieri, C. E. et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat. Genet. 44, 685-689 (2012
3. Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012
4. Kandoth, C. et al. Integrated genomic characterization of endometrial carcinoma. Nature 497, 67-73 (2013
5. Pritchard, C. C. et al. ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing. J. Mol. Diagn. 14, 357-366 (2012
6. Walsh, T. et al. Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. Proc. Natl Acad. Sci. USA 107, 12629-12633 (2010
7. Pritchard, C. C. et al. Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens. J. Mol. Diagn. 16, 56-67 (2014
8. Jarzen, J., Diamanduros, A. & Scarpinato, K. D. Mismatch repair proteins in recurrent prostate cancer. Adv. Clin. Chem. 60, 65-84 (2013
9. Burger, M. et al. Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer. Eur. Urol. 50, 770-775 (2006
10. Chen, Y. et al. Defects of DNA mismatch repair in human prostate cancer. Cancer Res. 61, 4112-4121 (2001
11. Velasco, A. et al. Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrence. Cancer 94, 690-699 (2002
12. Sun, X., Chen, C., Vessella, R. L. & Dong, J. T. Microsatellite instability and mismatch repair target gene mutations in cell lines and xenografts of prostate cancer. Prostate 66, 660-666 (2006
13. Chen, Y. et al. Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer. Int. J. Oncol. 22, 1033-1043 (2003
14. Dahiya, R. et al. High frequency of genetic instability of microsatellites in human prostatic adenocarcinoma. Int. J. Cancer 72, 762-767 (1997
15. Watanabe, M. et al. Microsatellite instability in human prostate cancer. Br. J. Cancer 72, 562-564 (1995
16. Baca, S. C. et al. Punctuated evolution of prostate cancer genomes. Cell 153, 666-677 (2013
17. White, N. M., Feng, F. Y. & Maher, C. A. Recurrent rearrangements in prostate cancer: causes and therapeutic potential. Curr. Drug Targets 14, 450-459 (2013
18. Wu, D., Zhang, C., Shen, Y., Nephew, K. P. & Wang, Q. Androgen receptordriven chromatin looping in prostate cancer. Trends Endocrinol. Metab. 22, 474-480 (2011
19. Petko, Z. et al. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin. Cancer Res. 11, 1203-1209 (2005
20. O'Roak, B. J. et al. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations. Nat. Genet. 43, 585-589 (2011
21. Pritchard, C. C. et al. Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens. J. Mol. Diagn. 16, 56-67 (2014
22. Salipante, S. J., Scroggins, S. M., Hampel, H. L., Turner, E. H. & Pritchard, C. C. Microsatellite instability detection by next-generation sequencing. Clin. Chem. 24987110 (2014).