Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers

Journal of Pathology

Volumn 230, Issue 2, 2013, Pages 148-153

  Briggs, Sarah ^a   Tomlinson, Ian ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

colorectal adenomas; colorectal cancer; DNA polymerase; endometrial cancer; exonuclease; germline mutation; polyposis; proofreading; somatic mutation

Indexed keywords

DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE EPSILON; EXONUCLEASE; POLD1 PROTEIN; POLE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CANCER RISK; CARCINOGENESIS; COLORECTAL ADENOMA; COLORECTAL CANCER; COLORECTAL CARCINOMA; ENDOMETRIUM CANCER; EXONUCLEASE DOMAIN MUTATION; GENE MUTATION; GENE REPLICATION; INHERITANCE; PHENOTYPE; POLYMERASE PROOFREADING ASSOCIATED POLYPOSIS; POLYPOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SOMATIC MUTATION; SUBSTITUTION LINE;

ADENOCARCINOMA; ADENOMA; COLORECTAL NEOPLASMS; DNA POLYMERASE II; DNA POLYMERASE III; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; MALE; MICROSATELLITE INSTABILITY; MICROSATELLITE REPEATS; PEDIGREE;

EID: 84877769352     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4185     Document Type: Article

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