Influence of phthalates on glucose homeostasis and atherosclerosis in hyperlipidemic mice

BMC Endocrine Disorders

Volumn 15, Issue 1, 2015, Pages

  Zhou, Wei ^a,b   Chen, Mei Hua ^a   Shi, Weibin ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Department of Endocrinology of Jianghuai Hospital ^*  (China)

Author keywords

Atherosclerosis; Dyslipidemia; Mice; Phthalates; Type 2 diabetes

Indexed keywords

DRINKING WATER; GLUCOSE; INSULIN; PHTHALIC ACID; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; TRIACYLGLYCEROL; APOLIPOPROTEIN E; ENDOCRINE DISRUPTOR; GLUCOSE BLOOD LEVEL; PHTHALIC ACID DERIVATIVE; POLLUTANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ROOT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HYPERLIPIDEMIA; HYPERLIPOPROTEINEMIA TYPE 3; INSULIN TOLERANCE TEST; MOUSE; NONHUMAN; PHENOTYPE; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN DIET; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; COMPLICATION; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GENETICS; HOMEOSTASIS; KNOCKOUT MOUSE; METABOLISM; PHARMACOLOGY; POLLUTANT; RISK FACTOR;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; FEMALE; HOMEOSTASIS; HYPERLIPIDEMIAS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHTHALIC ACIDS; RISK FACTORS;

EID: 84926312811     PISSN: None     EISSN: 14726823     Source Type: Journal    
DOI: 10.1186/s12902-015-0015-4     Document Type: Article

References (39)

1. Wittassek M, Koch HM, Angerer J, Bruning T. Assessing exposure to phthalates - the human biomonitoring approach. Mol Nutr Food Res. 2011;55(1):7-31.
2. Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP, et al. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect. 2004;112(3):331-8.
3. Meeker JD, Calafat AM, Hauser R. Urinary phthalate metabolites and their biotransformation products: predictors and temporal variability among men and women. J Expo Sci Environ Epidemiol. 2012;22(4):376-85.
4. Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect. 2007;115(6):876-82.
5. Hatch EE, Nelson JW, Qureshi MM, Weinberg J, Moore LL, Singer M, et al. Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Environ Health. 2008;7:27.
6. Svensson K, Hernandez-Ramirez RU, Burguete-Garcia A, Cebrian ME, Calafat AM, Needham LL, et al. Phthalate exposure associated with self-reported diabetes among Mexican women. Environ Res. 2011;111(6):792-6.
7. James-Todd T, Stahlhut R, Meeker JD, Powell SG, Hauser R, Huang T, et al. Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008. Environ Health Perspect 2012; 120(9):1307-13.
8. Kim JH, Park HY, Bae S, Lim YH, Hong YC. Diethylhexyl phthalates is associated with insulin resistance via oxidative stress in the elderly: a panel study. PLoS ONE. 2013;8(8):e71392.
9. Lind PM, Zethelius B, Lind L. Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderly. Diabetes Care. 2012;35(7):1519-24.
10. Sun Q, Cornelis MC, Townsend MK, Tobias DK, Eliassen AH, Franke AA, et al. Association of Urinary Concentrations of Bisphenol A and Phthalate Metabolites with Risk of Type 2 Diabetes: A Prospective Investigation in the Nurses' Health Study (NHS) and NHSII Cohorts. Environ Health Perspect. 2014;122(6):616-23.
11. Martinelli MI, Mocchiutti NO, Bernal CA. Dietary di(2-ethylhexyl)phthalate-impaired glucose metabolism in experimental animals. Hum Exp Toxicol. 2006;25(9):531-8.
12. Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, et al. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab. 2011;301(3):E527-38.
13. Rajesh P, Sathish S, Srinivasan C, Selvaraj J, Balasubramanian K. Phthalate is associated with insulin resistance in adipose tissue of male rat: role of antioxidant vitamins. J Cell Biochem. 2013;114(3):558-69.
14. Sun W, Ban JB, Zhang N, Zu YK, Sun WX. Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol. 2014;29(5):596-603.
15. Nakane F, Kunieda M, Shimizu S, Kobayashi Y, Akane H, Akie Y, et al. Twenty-six-week oral toxicity of diheptyl phthalate with special emphasis on its induction of liver proliferative lesions in male F344 rats. J Toxicol Sci. 2012;37(3):527-37.
16. Feige JN, Gerber A, Casals-Casas C, Yang Q, Winkler C, Bedu E, et al. The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Environ Health Perspect. 2010;118(2):234-41.
17. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14(1):133-40.
18. Shi W, Wang NJ, Shih DM, Sun VZ, Wang X, Lusis AJ. Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism. Circ Res. 2000;86(10):1078-84.
19. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258(5081):468-71.
20. Su Z, Li Y, James JC, Matsumoto AH, Helm GA, Lusis AJ, et al. Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Hum Mol Genet. 2006;15(10):1650-8.
21. Paigen B, Holmes PA, Mitchell D, Albee D. Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H. Atherosclerosis. 1987;64(2-3):215-21.
22. Li J, Wang Q, Chai W, Chen MH, Liu Z, Shi W. Hyperglycemia in apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility. Cardiovasc Diabetol. 2011;10(1):117.
23. Li J, Lu Z, Wang Q, Su Z, Bao Y, Shi W. Characterization of Bglu3, a mouse fasting glucose locus, and identification of Apcs as an underlying candidate gene. Physiol Genomics. 2012;44(6):345-51.
24. Manichaikul A, Wang Q, Shi YL, Zhang Z, Leitinger N, Shi W. Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression. Am J Physiol Heart Circ Physiol. 2011;301(3):H1056-61.
25. Lu Z, Yuan Z, Miyoshi T, Wang Q, Su Z, Chang CC, et al. Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia. PLoS ONE. 2011;6(10):e25344.
26. Ter Veld MG, Zawadzka E, Rietjens IM, Murk AJ. Estrogenicity of food-associated estrogenic compounds in the fetuses of female transgenic mice upon oral and IP maternal exposure. Reprod Toxicol. 2009;27(2):133-9.
27. Zhang Z, Rowlan JS, Wang Q, Shi W. Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012;5(2):190-201.
28. Tian J, Pei H, James JC, Li Y, Matsumoto AH, Helm GA, et al. Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility. Biochem Biophys Res Commun. 2005;329(3):1102-7.
29. Rowlan JS, Zhang Z, Wang Q, Fang Y, Shi W. New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. Physiol Genomics. 2013;45(8):332-42.
30. Su Z, Li Y, James JC, McDuffie M, Matsumoto AH, Helm GA, et al. Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene. Genetics. 2006;172(3):1799-807.
31. Zhang Y, Kundu B, Zhong M, Huang T, Li J, Chordia MD, et al. PET imaging detection of macrophages with a formyl peptide receptor antagonist. Nucl Med Biol. 2015;42(4):381-6.
32. Clee SM, Attie AD. The genetic landscape of type 2 diabetes in mice. Endocr Rev. 2007;28(1):48-83.
33. Gayathri NS, Dhanya CR, Indu AR, Kurup PA. Changes in some hormones by low doses of di (2-ethyl hexyl) phthalate (DEHP), a commonly used plasticizer in PVC blood storage bags & medical tubing. Indian J Med Res. 2004;119(4):139-44.
34. Lake BG, Rijcken WR, Gray TJ, Foster JR, Gangolli SD. Comparative studies of the hepatic effects of di- and mono-n-octyl phthalates, di-(2-ethylhexyl) phthalate and clofibrate in the rat. Acta Pharmacol Toxicol (Copenh). 1984;54(3):167-76.
35. Song Y, Hauser R, Hu FB, Franke A, Liu S, Sun Q. Urinary concentrations of bisphenol a and phthalate metabolites and weight change: a prospective investigation in US women. Int J Obes (Lond). 2014; 38(12):1532-7.
36. Trasande L, Attina TM, Sathyanarayana S, Spanier AJ, Blustein J. Race/ethnicity-specific associations of urinary phthalates with childhood body mass in a nationally representative sample. Environ Health Perspect. 2013;121(4):501-6.
37. Lind PM, Roos V, Ronn M, Johansson L, Ahlstrom H, Kullberg J, et al. Serum concentrations of phthalate metabolites are related to abdominal fat distribution two years later in elderly women. Environ Health. 2012;11:21. 069X-11-21.
38. Wang H, Zhou Y, Tang C, He Y, Wu J, Chen Y, et al. Urinary phthalate metabolites are associated with body mass index and waist circumference in Chinese school children. PLoS ONE. 2013;8(2):e56800.
39. Teupser D, Pavlides S, Tan M, Gutierrez-Ramos JC, Kolbeck R, Breslow JL. Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci U S A. 2004;101(51):17795-800.