Estrogenicity of food-associated estrogenic compounds in the fetuses of female transgenic mice upon oral and IP maternal exposure

Reproductive Toxicology

Volumn 27, Issue 2, 2009, Pages 133-139

  ter Veld, Marcel G R ^a   Zawadzka, E ^a   Rietjens, Ivonne M C M ^a   Murk, Albertinka J ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Endocrine disruption; Estrogen receptor; Fetus; Food packaging; Placental transfer; Plasticizer; Pseudo estrogen; Reporter gene mice

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 17 BETA ESTRADIOL 3,17 DIPROPIONATE; 4,4' ISOPROPYLIDENEDIPHENOL; ADIPIC ACID; DI (2 ETHYLHEXYL)ADIPATE; DI (2 ETHYLHEXYL)PHTHALATE; DIMETHYL SULFOXIDE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; LUCIFERASE; NONYLPHENOL; PHTHALIC ACID; PHTHALIC ACID BIS(5 METHYLHEXYL) ESTER; QUERCETIN; UNCLASSIFIED DRUG; VINYLIDENE CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENVIRONMENTAL EXPOSURE; ESTROGEN ACTIVITY; FEMALE; FEMUR; FETUS; GENE INDUCTION; LIVER; MALE; MOUSE; NONHUMAN; ORGANOGENESIS; PREGNANCY; REPORTER GENE; TIBIA; TRANSGENIC MOUSE;

ADMINISTRATION, ORAL; ANIMALS; ENDOCRINE DISRUPTORS; ESTROGENS; FEMALE; FETUS; FOOD CONTAMINATION; GENES, REPORTER; GESTATIONAL AGE; INJECTIONS, INTRAPERITONEAL; LUCIFERASES; MATERNAL-FETAL EXCHANGE; MICE; MICE, TRANSGENIC; ORGANOGENESIS; PHYTOESTROGENS; PREGNANCY; RECEPTORS, ESTROGEN; TIME FACTORS;

MUS; MUS MUSCULUS;

EID: 62549149830     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2009.01.010     Document Type: Article

References (51)

1. Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., and Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342 8878 (1993) 1007-1011
2. Knight D.C., and Eden J.A. A review of the clinical effects of phytoestrogens. Obstet Gynecol 87 5 Pt 2 (1996) 897-904
3. Van der Woude H., ter Veld M.G.R., Jacobs N., van der Saag P.T., Murk A.J., and Rietjens I.M.C.M. The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Mol Nutr Food Res 49 8 (2005) 763-771
4. Brotons J.A., Olea-Serrano M.F., Villalobos M., Pedraza V., and Olea N. Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect 103 6 (1995) 608-612
5. Stroheker T., Chagnon M.C., Pinnert M.F., Berges R., and Canivenc-Lavier M.C. Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. Reprod Toxicol 17 4 (2003) 421-432
6. ter Veld M.G.R., Schouten B., Louisse J., van Es D.S., van der Saag P.T., Rietjens I.M.C.M., et al. Estrogenic potency of food-packaging-associated plasticizers and antioxidants as detected in ERalpha and ERbeta reporter gene cell lines. J Agric Food Chem 54 12 (2006) 4407-4416
7. Lemmen J.G., Arends R.J., van Boxtel A.L., van der Saag P.T., and van der Burg B. Tissue- and time-dependent estrogen receptor activation in estrogen reporter mice. J Mol Endocrinol 32 3 (2004) 689-701
8. Lemmen J.G., Arends R.J., van der Saag P.T., and van der Burg B. In vivo imaging of activated estrogen receptors in utero by estrogens and bisphenol A. Environ Health Perspect 112 15 (2004) 1544-1549
9. ter Veld M.G.R., Zawadzka E., van den Berg J.H.J., van der Saag P.T., Rietjens I.M.C.M., and Murk A.J. Food associated estrogenic compounds induce estrogen receptor mediated luciferase gene expression in transgenic male mice. Chem Biol Int 174 (2008) 126
10. Miller K.P., Borgeest C., Greenfeld C., Tomic D., and Flaws J.A. In utero effects of chemicals on reproductive tissues in females. Toxicol Appl Pharmacol 198 2 (2004) 111-131
11. Takahashi O., and Oishi S. Disposition of orally administered 2,2-Bis(4-hydroxyphenyl) propane (Bisphenol A) in pregnant rats and the placental transfer to fetuses. Environ Health Perspect 108 10 (2000) 931-935
12. Hatch E.E., Palmer J.R., Titus-Ernstoff L., Noller K.L., Kaufman R.H., Mittendorf R., et al. Cancer risk in women exposed to diethylstilbestrol in utero. JAMA 280 7 (1998) 630-634
13. Zutphen L., Baumans V., and Beynen A.C. Proefdieren en dierproeven (Experimental animals and animal experiments) (2000), Maarssen:Elsevier/Bunge, The Netherlands
14. Tickner J.A., Schettler T., Guidotti T., McCally M., and Rossi M. Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review. Am J Ind Med 39 1 (2001) 100-111
15. Doull J., Cattley R., Elcombe C., Lake B.G., Swenberg J., Wilkinson C., et al. A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines. Regul Toxicol Pharmacol 29 3 (1999) 327-357
16. You L., Gazi E., Archibeque-Engle S., Casanova M., Conolly R.B., and Heck H.A. Transplacental and lactational transfer of p,p′-DDE in Sprague-Dawley rats. Toxicol Appl Pharmacol 157 2 (1999) 134-144
17. Van der Woude H. Mechanism of toxic action of the flavonoid quercetin and its phase II metabolites (2006), Wageningen University, Wageningen, The Netherlands
18. Claassen V. Neglected factors in pharmacology and neuroscience research (1994), Elsevier, Amsterdam, The Netherlands
19. Dötsch J., Dörr H.G., and Wildt L. Exposure to endogenous estrogens during lifetime (2001), Springer-Verslag, Germany, Berlin, Heidelberg
20. Poindexter A. The emerging use of the 20-microg oral contraceptive. Fertil Steril 75 3 (2001) 457-465
21. Legler J., Zeinstra L.M., Schuitemaker F., Lanser P.H., Bogerd J., Brouwer A., et al. Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activity. Environ Sci Technol 36 20 (2001) 4410-4415
22. Slikker Jr. W., Hill D.E., and Young J.F. Comparison of the transplacental pharmacokinetics of 17 beta-estradiol and diethylstilbestrol in the subhuman primate. J Pharmacol Exp Ther 221 1 (1982) 173-182
23. Pardridge W.M., Mietus L.J., Frumar A.M., Davidson B.J., and Judd H.J. Effects of human serum on transport of testosterone and estradiol into rat brain. Am J Physiol Endocrinol Metab 239 1 (1980) 103-108
24. Kabuto H., Amakawa M., and Shishibori T. Exposure to bisphenol A during embryonic/fetal life and infancy increases oxidative injury and causes underdevelopment of the brain and testis in mice. Life Sci 74 24 (2004) 2931-2940
25. Fisher J.S. Are all EDC effects mediated via steroid hormone receptors?. Toxicology 205 1-2 (2004) 33-41
26. Moore R.W., Rudy T.A., Lin T.M., Ko K., and Peterson R.E. Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer Di(2-ethylhexyl) phthalate. Environ Health Perspect 109 3 (2001) 229-237
27. Takeuchi S., Iida M., Kobayashi S., Jin K., Matsuda T., and Kojima H. Differential effects of phthalate esters on transcriptional activities via human estrogen receptors [alpha] and [beta], and androgen receptor. Toxicology 210 2-3 (2005) 223-233
28. Lovekamp T., and Swan B.J. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect 111 2 (2003) 139-146
29. Bulun S.E., Noble L.S., Takayama K., Michael M.D., Agarwal V., Fisher C., et al. Endocrine disorders associated with inappropriately high aromatase expression. J Steroid Biochem Mol Biol 61 3-6 (1997) 133-139
30. Lee H.J., Chattopadhyay S., Gong E.-Y., Ahn R.S., and Lee K. Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor. Toxicol Sci 75 (2003) 40-46
31. Sohoni P., and Sumpter J.P. Several environmental oestrogens are also anti-androgens. J Endocrinol 158 (1998) 327-339
32. Simpson E.R., Clyne C., Rubin G., Boon W.C., Robertson K., Britt K., et al. Aromatase-a brief overview. Annu Rev Physiol 64 (2002) 93-127
33. Akinola L.A., Poutanen M., Vihko R., and Vikho P. Expression of 17β-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase and 20α-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats. Endocrinology 138 7 (1997) 2886-2892
34. Frasor J., Danes J.M., Komm B., Chang K.C.N., Lyttle R., and Katzenellenbogen B.S. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144 10 (2003) 4562-4574
35. Dalgaard M., Hass U., Vinggaard A.M., Jarfelt K., Lam H.R., Sorensen I.K., et al. Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats. Reprod Toxicol 17 2 (2003) 163-170
36. ow) data for hydrophobic organic compounds: DDT and DDE as a case study. US geological survey; Water-Resources investigations report 01-4201. Reston, Virginia, USA; 2001.
37. Savu L., Nunez E., and Jayle M.F. Plasma diethylstilbestrol binding proteins of rat, mouse and man in the course of development. Steroids 25 6 (1975) 717-728
38. Cheek A.O., Vonier P.M., Oberdorster E., Collins Burow B., and McLachlan J.A. Environmental signalling: a biological context for endocrine disruption. Environ Health Perspect 106 s1 (1998) 5-10
39. Gordon J.D., Chu A.C., Chu M.D., Denison M.S., and Clark G.C. Detection of estrogen receptor endocrine disruptor potency of commonly used organochlorine pesticides using the LUMI-CELL™ bioassay. Organohalogen Compd 66 (2004) 169-174
40. Laws S.C., Carey S.A., Ferrell J.M., Bodman G.J., and Cooper R.L. Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol Sci 54 1 (2000) 154-167
41. Tinwell H., Haseman J., Lefevre P.A., Wallis N., and Ashby J. Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A. Toxicol Sci 68 2 (2002) 339-348
42. Tyl R.W., Myers C.B., Marr M.C., Thomas B.F., Keimowitz A.R., Brine D.R., et al. Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Toxicol Sci 68 1 (2002) 121-146
43. Honma S., Suzuki A., Buchanan D.L., Katsu Y., Watanabe H., and Iguchi T. Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. Reprod Toxicol 16 2 (2002) 117-122
44. Tinwell H., Joiner R., Pate I., Soames A., Foster J., and Ashby J. Uterotrophic activity of bisphenol A in the immature mouse. Regul Toxicol Pharmacol 32 1 (2000) 118-126
45. Takagi H., Shibutani M., Masutomi N., Uneyama C., Takahashi N., Mitsumori K., et al. Lack of maternal dietary exposure effects of bisphenol A and nonylphenol during the critical period for brain sexual differentiation on the reproductive/endocrine systems in later life. Arch Toxicol 78 2 (2004) 97-105
46. Markey C.M., Luque E.H., Munoz De Toro M., Sonnenschein C., and Soto A.M. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol Reprod 65 4 (2001) 1215-1223
47. Shelby M.D., Newbold R.R., Tully D.B., Chae K., and Davis V.L. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect 104 12 (1996) 1296-1300
48. Chapin R.E., Delaney J., Wang Y., Lanning L., Davis B., Collins B., et al. The effects of 4-nonylphenol in rats: a multigeneration reproduction study. Toxicol Sci 52 1 (1999) 80-91
49. Doerge D.R., Twaddle N.C., Churchwell M.I., Chang H.C., Newbold R.R., and Delclos K.B. Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats. Reprod Toxicol 16 1 (2002) 45-56
50. Tyl R.W., Myers C.B., Marr M.C., Castillo N.P., Seely J.C., Sloan C.S., et al. Three-generation evaluation of dietary para-nonylphenol in CD (Sprague-Dawley) rats. Toxicol Sci 92 1 (2006) 295-310
51. Zacharewski T.R., Meek M.D., Clemons J.H., Wu Z.F., Fielden M.R., and Matthews J.B. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol Sci 46 2 (1998) 282-293