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Volumn 122, Issue 4, 2015, Pages 565-576

Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer’s disease

Author keywords

Alzheimer; Brain; IDE; Insulin signalling; Streptozotocin; Tau

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR; INSULINASE; MESSENGER RNA; STREPTOZOCIN; TAU PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MAPT PROTEIN, RAT;

EID: 84926215322     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-014-1323-y     Document Type: Article
Times cited : (40)

References (60)
  • 1
    • 77649274672 scopus 로고    scopus 로고
    • Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat
    • COI: 1:CAS:528:DC%2BC3cXjt1Wmt7g%3D, PID: 20026275
    • Agrawal R, Mishra B, Tyagi E, Nath C, Shukla R (2010) Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat. Pharmacol Res 61:247–252
    • (2010) Pharmacol Res , vol.61 , pp. 247-252
    • Agrawal, R.1    Mishra, B.2    Tyagi, E.3    Nath, C.4    Shukla, R.5
  • 2
    • 79251628354 scopus 로고    scopus 로고
    • Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model
    • COI: 1:CAS:528:DC%2BC3MXhtlejtro%3D, PID: 21195590
    • Agrawal R, Tyagi E, Shukla R, Nath C (2011) Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model. Eur Neuropsychopharmacol 21:261–273
    • (2011) Eur Neuropsychopharmacol , vol.21 , pp. 261-273
    • Agrawal, R.1    Tyagi, E.2    Shukla, R.3    Nath, C.4
  • 3
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer’s disease: seminar
    • COI: 1:CAS:528:DC%2BD28XnsFymsbY%3D, PID: 16876668
    • Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer’s disease: seminar. Lancet 368:387–403
    • (2006) Lancet , vol.368 , pp. 387-403
    • Blennow, K.1    de Leon, M.J.2    Zetterberg, H.3
  • 5
    • 84889263487 scopus 로고    scopus 로고
    • A non-transgenic mouse model (icv-STZ mouse) of Alzheimer’s disease: similarities to and differences from the transgenic model (3xTg-AD mouse)
    • COI: 1:CAS:528:DC%2BC3sXjsFejsLc%3D, PID: 23150171
    • Chen Y, Liang Z, Blanchard J, Dai CL, Sun S, Lee MH, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX (2013) A non-transgenic mouse model (icv-STZ mouse) of Alzheimer’s disease: similarities to and differences from the transgenic model (3xTg-AD mouse). Mol Neurobiol 47:711–725
    • (2013) Mol Neurobiol , vol.47 , pp. 711-725
    • Chen, Y.1    Liang, Z.2    Blanchard, J.3    Dai, C.L.4    Sun, S.5    Lee, M.H.6    Grundke-Iqbal, I.7    Iqbal, K.8    Liu, F.9    Gong, C.X.10
  • 7
    • 0033593461 scopus 로고    scopus 로고
    • Signaling mechanisms that regulate glucose transport
    • COI: 1:CAS:528:DyaK1MXovVGjuw%3D%3D, PID: 9890935
    • Czech MP, Corvera S (1999) Signaling mechanisms that regulate glucose transport. J Biol Chem 274:1865–1868
    • (1999) J Biol Chem , vol.274 , pp. 1865-1868
    • Czech, M.P.1    Corvera, S.2
  • 8
    • 33748755428 scopus 로고    scopus 로고
    • Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease
    • PID: 16988486
    • de la Monte SM, Tong M, Lester-Coll N, Plater M Jr, Wands JR (2006) Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease. J Alzheimers Dis 10:89–109
    • (2006) J Alzheimers Dis , vol.10 , pp. 89-109
    • de la Monte, S.M.1    Tong, M.2    Lester-Coll, N.3    Plater, M.4    Wands, J.R.5
  • 9
    • 73649112749 scopus 로고    scopus 로고
    • Dysregulation of Insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: implication for Alzheimer’s Disease
    • COI: 1:CAS:528:DC%2BC3cXhslSjtb0%3D, PID: 19815707
    • Deng Y, Li B, Liu Ying, Iqbal K, Grundke-Iqbal I, Gong CX (2009) Dysregulation of Insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: implication for Alzheimer’s Disease. Am J Pathol 175:2089–2098
    • (2009) Am J Pathol , vol.175 , pp. 2089-2098
    • Deng, Y.1    Li, B.2    Liu, Y.3    Iqbal, K.4    Grundke-Iqbal, I.5    Gong, C.X.6
  • 10
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: tricks of the trade for a multi-tasking kinase
    • COI: 1:CAS:528:DC%2BD3sXivFWhtbc%3D, PID: 12615961
    • Doble BW, Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116:1175–1186
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 11
    • 0028598190 scopus 로고
    • Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats
    • COI: 1:CAS:528:DyaK2MXksVOgsrs%3D, PID: 7747600
    • Duelli R, Schrock H, Kuschinsky W, Hoyer S (1994) Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. Int J Dev Neurosci 12:737–743
    • (1994) Int J Dev Neurosci , vol.12 , pp. 737-743
    • Duelli, R.1    Schrock, H.2    Kuschinsky, W.3    Hoyer, S.4
  • 12
    • 0035094403 scopus 로고    scopus 로고
    • Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick’s disease, progressive supranuclear palsy and corticobasal degeneration
    • COI: 1:CAS:528:DC%2BD3MXitlCjurY%3D, PID: 11303790
    • Ferrer I, Blanco R, Carmona M, Ribera R, Goutan E, Puig B, Rey MJ, Cardozo A, Viñals F, Ribalta T (2001) Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick’s disease, progressive supranuclear palsy and corticobasal degeneration. Brain Pathol 11:144–158
    • (2001) Brain Pathol , vol.11 , pp. 144-158
    • Ferrer, I.1    Blanco, R.2    Carmona, M.3    Ribera, R.4    Goutan, E.5    Puig, B.6    Rey, M.J.7    Cardozo, A.8    Viñals, F.9    Ribalta, T.10
  • 14
    • 0142026832 scopus 로고    scopus 로고
    • Potential roles of insulin and IGF-1 in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD3sXlvFOrt7g%3D, PID: 12900169
    • Gasparini L, Xu H (2003) Potential roles of insulin and IGF-1 in Alzheimer’s disease. Trends Neurosci 26:404–406
    • (2003) Trends Neurosci , vol.26 , pp. 404-406
    • Gasparini, L.1    Xu, H.2
  • 15
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD28XhtFKit73K, PID: 17082447
    • Goedert M, Spillantini MG (2006) A century of Alzheimer’s disease. Science 314:777–781
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 16
    • 34247324303 scopus 로고    scopus 로고
    • Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
    • PID: 17448147
    • Grünblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101:757–770
    • (2007) J Neurochem , vol.101 , pp. 757-770
    • Grünblatt, E.1    Salkovic-Petrisic, M.2    Osmanovic, J.3    Riederer, P.4    Hoyer, S.5
  • 17
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
    • COI: 1:CAS:528:DyaL28XksFyqtrg%3D, PID: 3088567
    • Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A. 83:4913–4917
    • (1986) Proc Natl Acad Sci U S A. , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.C.3    Quinlan, M.4    Wisniewski, H.M.5    Binder, L.I.6
  • 18
    • 0029163166 scopus 로고
    • Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)?
    • COI: 1:CAS:528:DyaK2MXnsVClsrs%3D, PID: 15374226
    • Henneberg N, Hoyer S (1995) Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)? Arch Gerontol Geriatr 21:63–74
    • (1995) Arch Gerontol Geriatr , vol.21 , pp. 63-74
    • Henneberg, N.1    Hoyer, S.2
  • 19
    • 79960787962 scopus 로고    scopus 로고
    • Spatial distribution of glucose hypometabolism induced by intracerebroventricular streptozotocin in monkeys
    • PID: 21471644
    • Heo JH, Lee SR, Lee ST, Lee KM, Oh JH, Jang DP, Chang KT, Cho ZH (2011) Spatial distribution of glucose hypometabolism induced by intracerebroventricular streptozotocin in monkeys. J Alzheimers Dis 25:517–523
    • (2011) J Alzheimers Dis , vol.25 , pp. 517-523
    • Heo, J.H.1    Lee, S.R.2    Lee, S.T.3    Lee, K.M.4    Oh, J.H.5    Jang, D.P.6    Chang, K.T.7    Cho, Z.H.8
  • 20
    • 0030868557 scopus 로고    scopus 로고
    • Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
    • COI: 1:CAS:528:DyaK2sXms1eht70%3D, PID: 9312151
    • Hong M, Chen DC, Klein PS, Lee VM (1997) Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem 272:25326–25332
    • (1997) J Biol Chem , vol.272 , pp. 25326-25332
    • Hong, M.1    Chen, D.C.2    Klein, P.S.3    Lee, V.M.4
  • 21
    • 0027967549 scopus 로고
    • Neurodegeneration, Alzheimer’s disease, and beta-amyloid toxicity
    • COI: 1:CAS:528:DyaK2MXitlSlurk%3D, PID: 7997056
    • Hoyer S (1994) Neurodegeneration, Alzheimer’s disease, and beta-amyloid toxicity. Life Sci 55:1977–1983
    • (1994) Life Sci , vol.55 , pp. 1977-1983
    • Hoyer, S.1
  • 22
    • 0031928535 scopus 로고    scopus 로고
    • Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
    • COI: 1:STN:280:DyaK1czosF2htw%3D%3D, PID: 9720971
    • Hoyer S (1998) Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. J Neural Transm 105:415–422
    • (1998) J Neural Transm , vol.105 , pp. 415-422
    • Hoyer, S.1
  • 23
    • 0036205701 scopus 로고    scopus 로고
    • The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update
    • COI: 1:CAS:528:DC%2BD38XktF2gsrg%3D, PID: 11956956
    • Hoyer S (2002) The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update. J Neural Transm 109:341–360
    • (2002) J Neural Transm , vol.109 , pp. 341-360
    • Hoyer, S.1
  • 24
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • COI: 1:CAS:528:DC%2BD2cXjt1Shsbs%3D, PID: 15094078
    • Hoyer S (2004) Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol 490:115–125
    • (2004) Eur J Pharmacol , vol.490 , pp. 115-125
    • Hoyer, S.1
  • 25
    • 0027255817 scopus 로고
    • Glycogen synthase kinase 3 beta is identical to tau protein kinase I generation several epitopes of paired helical filaments
    • COI: 1:CAS:528:DyaK3sXlsFCmtr4%3D
    • Ishiguro K, Shiratsuchi A, Sato S, Omori A, Arioka M, Kobayashi S, Uchida T, Imahori K (1993) Glycogen synthase kinase 3 beta is identical to tau protein kinase I generation several epitopes of paired helical filaments. FEBS Letter 325:167–172
    • (1993) FEBS Letter , vol.325 , pp. 167-172
    • Ishiguro, K.1    Shiratsuchi, A.2    Sato, S.3    Omori, A.4    Arioka, M.5    Kobayashi, S.6    Uchida, T.7    Imahori, K.8
  • 26
    • 0021745904 scopus 로고
    • Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats
    • COI: 1:CAS:528:DyaL2cXmtVylsr0%3D, PID: 6389544
    • Kadowaki T, Kasuga M, Akanuma Y, Ezaki O, Takaku F (1984) Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats. J Biol Chem 259:14208–14216
    • (1984) J Biol Chem , vol.259 , pp. 14208-14216
    • Kadowaki, T.1    Kasuga, M.2    Akanuma, Y.3    Ezaki, O.4    Takaku, F.5
  • 27
    • 0031797937 scopus 로고    scopus 로고
    • Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
    • COI: 1:CAS:528:DyaK1cXnsleis7g%3D, PID: 9829797
    • Lannert H, Hoyer S (1998) Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav Neurosci 112:1199–1208
    • (1998) Behav Neurosci , vol.112 , pp. 1199-1208
    • Lannert, H.1    Hoyer, S.2
  • 28
    • 84889607139 scopus 로고    scopus 로고
    • Insulin/IGF signaling-related gene expression in the brain of a sporadic Alzheimer’s disease monkey model induced by intracerebroventricular injection of streptozotocin
    • PID: 23948941
    • Lee Y, Kim YH, Park SJ, Huh JW, Kim SH, Kim SU, Kim JS, Jeong KJ, Lee KM, Hong Y, Lee SR, Chang KT (2014) Insulin/IGF signaling-related gene expression in the brain of a sporadic Alzheimer’s disease monkey model induced by intracerebroventricular injection of streptozotocin. J Alzheimers Dis 38:251–267
    • (2014) J Alzheimers Dis , vol.38 , pp. 251-267
    • Lee, Y.1    Kim, Y.H.2    Park, S.J.3    Huh, J.W.4    Kim, S.H.5    Kim, S.U.6    Kim, J.S.7    Jeong, K.J.8    Lee, K.M.9    Hong, Y.10    Lee, S.R.11    Chang, K.T.12
  • 29
    • 33645960672 scopus 로고    scopus 로고
    • Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD28Xjs1Kltb0%3D, PID: 16627931
    • Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM (2006) Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer’s disease. J Alzheimers Dis 9:13–33
    • (2006) J Alzheimers Dis , vol.9 , pp. 13-33
    • Lester-Coll, N.1    Rivera, E.J.2    Soscia, S.J.3    Doiron, K.4    Wands, J.R.5    de la Monte, S.M.6
  • 31
    • 84877138257 scopus 로고    scopus 로고
    • Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats
    • COI: 1:CAS:528:DC%2BC3sXmtVantbo%3D, PID: 23562514
    • Liu P, Zou L, Jiao Q, Chi T, Ji X, Qi Y, Xu Q, Wang L (2013) Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. Neurosci Lett 543:115–120
    • (2013) Neurosci Lett , vol.543 , pp. 115-120
    • Liu, P.1    Zou, L.2    Jiao, Q.3    Chi, T.4    Ji, X.5    Qi, Y.6    Xu, Q.7    Wang, L.8
  • 33
    • 64049098761 scopus 로고    scopus 로고
    • Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship
    • COI: 1:CAS:528:DC%2BD1MXhsFGlsrw%3D, PID: 19104448
    • Nelson PT, Braak H, Markesbery WR (2009) Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol 68:1–14
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 1-14
    • Nelson, P.T.1    Braak, H.2    Markesbery, W.R.3
  • 34
    • 0025737376 scopus 로고
    • Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex
    • COI: 1:CAS:528:DyaK3MXltlehs7c%3D, PID: 1834965
    • Nitsch R, Hoyer S (1991) Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex. Neurosci Lett 128:199–202
    • (1991) Neurosci Lett , vol.128 , pp. 199-202
    • Nitsch, R.1    Hoyer, S.2
  • 35
    • 0014052767 scopus 로고
    • A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the ratbrain
    • COI: 1:CAS:528:DyaF2sXnt12hsg%3D%3D, PID: 6071872
    • Noble EP, Wurtman RJ, Axelrod J (1967) A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the ratbrain. Life Sci 6:281–291
    • (1967) Life Sci , vol.6 , pp. 281-291
    • Noble, E.P.1    Wurtman, R.J.2    Axelrod, J.3
  • 36
    • 84874009086 scopus 로고    scopus 로고
    • Selection of appropriate reference genes for RT-qPCR analysis in a streptozotocin-induced Alzheimer’s disease model of cynomolgus monkeys (Macaca fascicularis)
    • COI: 1:CAS:528:DC%2BC3sXjtl2qurs%3D, PID: 23457495
    • Park SJ, Kim YH, Lee Y, Kim KM, Kim HS, Lee SR, Kim SU, Kim SH, Kim JS, Jeong KJ, Lee KM, Huh JW, Chang KT (2013) Selection of appropriate reference genes for RT-qPCR analysis in a streptozotocin-induced Alzheimer’s disease model of cynomolgus monkeys (Macaca fascicularis). PLoS One 8:e56034
    • (2013) PLoS One , vol.8 , pp. 56034
    • Park, S.J.1    Kim, Y.H.2    Lee, Y.3    Kim, K.M.4    Kim, H.S.5    Lee, S.R.6    Kim, S.U.7    Kim, S.H.8    Kim, J.S.9    Jeong, K.J.10    Lee, K.M.11    Huh, J.W.12    Chang, K.T.13
  • 37
    • 0029924172 scopus 로고    scopus 로고
    • Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis
    • COI: 1:CAS:528:DyaK28XhvVyit7s%3D, PID: 8636129
    • Paz K, Voliovitch H, Hadari YR, Roberts CT Jr, LeRoith D, Zick Y (1996) Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis. J Biol Chem 271:6998–7003
    • (1996) J Biol Chem , vol.271 , pp. 6998-7003
    • Paz, K.1    Voliovitch, H.2    Hadari, Y.R.3    Roberts, C.T.4    LeRoith, D.5    Zick, Y.6
  • 38
    • 0030635495 scopus 로고    scopus 로고
    • Distribution, levels, and activity of glycogen synthase kinase 3 in the Alzheimer disease brain
    • COI: 1:STN:280:DyaK2s7ksVelsQ%3D%3D, PID: 8990130
    • Pei JJ, Tanaka T, Tung YC, Braak E, Iqbala K, Grundke-Iqbala I (1997) Distribution, levels, and activity of glycogen synthase kinase 3 in the Alzheimer disease brain. J Neuropathol Exp Neurol 56:70–78
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 70-78
    • Pei, J.J.1    Tanaka, T.2    Tung, Y.C.3    Braak, E.4    Iqbala, K.5    Grundke-Iqbala, I.6
  • 39
    • 0027304893 scopus 로고
    • Action of the diabetogenic drug streptozotocin on glycolytic metabolism in adult rat brain cortex and hippocampus
    • Plasche K, Hoyer S (1993) Action of the diabetogenic drug streptozotocin on glycolytic metabolism in adult rat brain cortex and hippocampus. Int J Dev Neurosci 11:477–483
    • (1993) Int J Dev Neurosci , vol.11 , pp. 477-483
    • Plasche, K.1    Hoyer, S.2
  • 40
    • 33748752882 scopus 로고    scopus 로고
    • The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
    • COI: 1:CAS:528:DC%2BD28XoslKlsb0%3D, PID: 16803897
    • Plattner F, Angelo M, Giese KP (2006) The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J Biol Chem 281:25457–25465
    • (2006) J Biol Chem , vol.281 , pp. 25457-25465
    • Plattner, F.1    Angelo, M.2    Giese, K.P.3
  • 41
    • 29844432266 scopus 로고    scopus 로고
    • Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer’s disease: review and hypothesis
    • COI: 1:CAS:528:DC%2BD28XitFClsg%3D%3D, PID: 16399206
    • Qiu WQ, Folstein MF (2006) Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer’s disease: review and hypothesis. Neurobiol Aging 27:190–198
    • (2006) Neurobiol Aging , vol.27 , pp. 190-198
    • Qiu, W.Q.1    Folstein, M.F.2
  • 42
    • 2342558065 scopus 로고    scopus 로고
    • Akt activity in Alzheimer’s disease and other neurodegenerative disorders
    • COI: 1:CAS:528:DC%2BD2cXkvFajuro%3D
    • Rickle A, Bogdanovic N, Volkman I, Winblad B, Ravid R, Cowburn RF (2004) Akt activity in Alzheimer’s disease and other neurodegenerative disorders. Neuro Rep 15:955–959
    • (2004) Neuro Rep , vol.15 , pp. 955-959
    • Rickle, A.1    Bogdanovic, N.2    Volkman, I.3    Winblad, B.4    Ravid, R.5    Cowburn, R.F.6
  • 43
    • 33645100144 scopus 로고    scopus 로고
    • Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway
    • COI: 1:CAS:528:DC%2BD28XivFWjsr8%3D, PID: 16412093
    • Salkovic-Petrisic M, Tribl F, Schmidt M, Hoyer S, Riederer P (2006) Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. J Neurochem 96:1005–1015
    • (2006) J Neurochem , vol.96 , pp. 1005-1015
    • Salkovic-Petrisic, M.1    Tribl, F.2    Schmidt, M.3    Hoyer, S.4    Riederer, P.5
  • 44
    • 79956215794 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study
    • COI: 1:CAS:528:DC%2BC3MXlvFSqs70%3D, PID: 21533606
    • Salkovic-Petrisic M, Osmanovic-Barilar J, Brückner MK, Hoyer S, Arendt T, Riederer P (2011) Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study. J Neural Transm 118:765–772
    • (2011) J Neural Transm , vol.118 , pp. 765-772
    • Salkovic-Petrisic, M.1    Osmanovic-Barilar, J.2    Brückner, M.K.3    Hoyer, S.4    Arendt, T.5    Riederer, P.6
  • 45
    • 0036470213 scopus 로고    scopus 로고
    • Insulin signaling pathways in time and space
    • COI: 1:CAS:528:DC%2BD38XhtFyrtbY%3D, PID: 11849969
    • Saltiel AR, Pessin JE (2002) Insulin signaling pathways in time and space. Trends Cell Biol 12:65–71
    • (2002) Trends Cell Biol , vol.12 , pp. 65-71
    • Saltiel, A.R.1    Pessin, J.E.2
  • 46
    • 84867237785 scopus 로고    scopus 로고
    • Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin
    • COI: 1:CAS:528:DC%2BC38XhslCkurfJ, PID: 22921433
    • Santos TO, Mazucanti CH, Xavier GF, Torrão AS (2012) Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin. Physiol Behav 107:401–413
    • (2012) Physiol Behav , vol.107 , pp. 401-413
    • Santos, T.O.1    Mazucanti, C.H.2    Xavier, G.F.3    Torrão, A.S.4
  • 47
    • 0025809079 scopus 로고
    • Luminography—a new, highly sensitive visualization method for electrophoresis
    • Schneppenheim R, Budde U, Dahlmann N, Rautenberg P (1991) Luminography—a new, highly sensitive visualization method for electrophoresis. Electrophoresis 1:367–372
    • (1991) Electrophoresis , vol.1 , pp. 367-372
    • Schneppenheim, R.1    Budde, U.2    Dahlmann, N.3    Rautenberg, P.4
  • 48
    • 84857783229 scopus 로고    scopus 로고
    • Cognitive decline in STZ-3 V rats is largely due to dysfunctional insulin signalling through the dentate gyrus
    • COI: 1:CAS:528:DC%2BC38Xjs1antbg%3D, PID: 22289199
    • Shingo AS, Kanabayashi T, Murase T, Kito S (2012) Cognitive decline in STZ-3 V rats is largely due to dysfunctional insulin signalling through the dentate gyrus. Behav Brain Res 229:378–383
    • (2012) Behav Brain Res , vol.229 , pp. 378-383
    • Shingo, A.S.1    Kanabayashi, T.2    Murase, T.3    Kito, S.4
  • 50
    • 84867902245 scopus 로고    scopus 로고
    • All-trans retinoic acid rescues memory deficits and neuropathological changes in mouse model of streptozotocin-induced dementia of Alzheimer’s type
    • COI: 1:CAS:528:DC%2BC38XhvVCkt7vP, PID: 23044340
    • Sodhi RK, Singh N (2013) All-trans retinoic acid rescues memory deficits and neuropathological changes in mouse model of streptozotocin-induced dementia of Alzheimer’s type. Prog Neuropsychopharmacol Biol Psychiatry 40:38–46
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.40 , pp. 38-46
    • Sodhi, R.K.1    Singh, N.2
  • 51
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer′s disease-is this type 3 diabetes?
    • COI: 1:CAS:528:DC%2BD2MXhvVSrtL8%3D
    • Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM (2005) Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer′s disease-is this type 3 diabetes? J Alzheimer′s Dis 7:63–80
    • (2005) J Alzheimer′s Dis , vol.7 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3    Cannon, J.L.4    Neely, T.R.5    Tavares, R.6    Xu, X.J.7    Wands, J.R.8    de la Monte, S.M.9
  • 52
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in B cell of the rat pancreas
    • COI: 1:CAS:528:DC%2BD38Xhslartb0%3D, PID: 11829314
    • Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in B cell of the rat pancreas. Physiol Res 50:537–546
    • (2001) Physiol Res , vol.50 , pp. 537-546
    • Szkudelski, T.1
  • 53
    • 0033987059 scopus 로고    scopus 로고
    • Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains
    • COI: 1:CAS:528:DC%2BD3cXotFam, PID: 10620662
    • Takahashi M, Iseki E, Kosaka K (2000) Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains. J Neurol Sci 172:63–69
    • (2000) J Neurol Sci , vol.172 , pp. 63-69
    • Takahashi, M.1    Iseki, E.2    Kosaka, K.3
  • 55
    • 85027936190 scopus 로고    scopus 로고
    • mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice
    • COI: 1:CAS:528:DC%2BC2cXhtlarsb%2FN, PID: 24682776
    • Wang S, Zhou SL, Min FY, Ma JJ, Shi XJ, Bereczki E, Wu J (2014) mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metab Brain Dis 29:729–736
    • (2014) Metab Brain Dis , vol.29 , pp. 729-736
    • Wang, S.1    Zhou, S.L.2    Min, F.Y.3    Ma, J.J.4    Shi, X.J.5    Bereczki, E.6    Wu, J.7
  • 56
    • 40449087334 scopus 로고    scopus 로고
    • Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    • COI: 1:CAS:528:DC%2BD1cXjt1GgsL8%3D, PID: 18322105
    • Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28:2624–2632
    • (2008) J Neurosci , vol.28 , pp. 2624-2632
    • Wen, Y.1    Planel, E.2    Herman, M.3    Figueroa, H.Y.4    Wang, L.5    Liu, L.6    Lau, L.F.7    Yu, W.H.8    Duff, K.E.9
  • 57
    • 84901268554 scopus 로고    scopus 로고
    • Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats
    • PID: 24337945
    • Yang W, Ma J, Liu Z, Lu Y, Hu B, Yu H (2014) Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats. Neurol Sci 35:741–751
    • (2014) Neurol Sci , vol.35 , pp. 741-751
    • Yang, W.1    Ma, J.2    Liu, Z.3    Lu, Y.4    Hu, B.5    Yu, H.6
  • 58
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • COI: 1:CAS:528:DC%2BD3MXjslSktLc%3D, PID: 11377828
    • Zhao WQ, Alkon DL (2001) Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 177:125–134
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2
  • 59
    • 10944228564 scopus 로고    scopus 로고
    • Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer’s disease intervention
    • COI: 1:CAS:528:DC%2BD2cXhtFagurfP, PID: 15590928
    • Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM (2004a) Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer’s disease intervention. J Neurosci 24:11120–11126
    • (2004) J Neurosci , vol.24 , pp. 11120-11126
    • Zhao, L.1    Teter, B.2    Morihara, T.3    Lim, G.P.4    Ambegaokar, S.S.5    Ubeda, O.J.6    Frautschy, S.A.7    Cole, G.M.8
  • 60
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • COI: 1:CAS:528:DC%2BD2cXjt1Shsb8%3D, PID: 15094074
    • Zhao WQ, Chen H, Quon MJ, Alkon DL (2004b) Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 490:71–81
    • (2004) Eur J Pharmacol , vol.490 , pp. 71-81
    • Zhao, W.Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4


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