Ginseng improves cognitive deficit via the RAGE/NF-kB pathway in advanced glycation end product-induced rats

Journal of Ginseng Research

Volumn 39, Issue 2, 2015, Pages 116-124

  Tan, Xiaobin ^a   Gu, Junfei ^a,b   Zhao, Bingjie ^a,b   Wang, Shuyuan ^a,c   Yuan, Jiarui ^a,b   Wang, Chunfei ^a   Chen, Juan ^a,b   Liu, Jiping ^d   Feng, Liang ^a   Jia, Xiaobin ^a  

^a KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Advanced glycation end product; Alzheimer s disease; Antioxidation; Panax ginseng; Receptor for advanced glycation end product

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTIBODY; DONEPEZIL; GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RG 1; GINSENOSIDE RH 1; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN PROTECTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ESCAPE BEHAVIOR; GINSENG; HIPPOCAMPAL CA3 REGION; IMMUNOHISTOCHEMISTRY; LATENT PERIOD; LIPID PEROXIDATION; MALE; MEMORY; MORRIS WATER MAZE TEST; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE TEST; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPATIAL MEMORY;

PANAX GINSENG; RATTUS;

EID: 84926211656     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgr.2014.09.002     Document Type: Article

References (32)

1. Wang-Dietrich L, Funke SA, Kühbach K, Wang K, Besmehn A, Willbold S, Cinar Y, Bannach O, Birkmann E, Willbold D. The amyloid-b oligomer count in cerebrospinal fluid is a biomarker for Alzheimer’s disease. J Alzheimers Dis 2013;34:985-994.
2. Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Münch G. Advanced glycation endproducts and their receptor RAGE in Alzheimer’s disease. Neurobiol Aging 2011;32:763-7677.
3. Smith MA, Taneda S, Richey PL, Miyata S, Yan SD, Stern D, Sayre LM, Monnier VM, Perry G. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci USA 1994;91:5710-5714.
4. Sasaki N, Fukatsu R, Tsuzuki K, Hayashi Y, Yoshida T, Fujii N, Koike T, Wakayama I, Yanagihara R, Garruto R, et al. Advanced glycation end products in Alzheimer’s disease and other neurodegenerative diseases. Am J Pathol 1998;153:1149-1155.
5. Vicente MH, Outeiro TF. The sour side of neurodegenerative disorders: the effects of protein glycation. J Pathol 2010;221:13-25.
6. Pazdro R, Burgess JR. The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells. Exp Diabetes Res 2012;2012:137607.
7. Feng L, Zhu MM, Zhang MH, Wang RS, Tan XB, Song J, Ding SM, Jia XB, Hu SY. Protection of glycyrrhizic acid against AGEs-induced endothelial dysfunction through inhibiting RAGE/NF-kB pathway activation in human umbilical vein endothelial cells. J Ethnopharmacol 2013;148:27-36.
8. Wang CY, Xie JW, Xu Y, Wang T, Cai JH, Wang X, Zhao BL, An L, Wang ZY. Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/ RAGE/NF-kB pathway in a transgenic mouse model of Alzheimer’s disease. Antioxid Redox Signal 2013;19:2024-2039.
9. Yin DZ, Liu WF. Carbonyl stress, aging mechanisms, and the up-stream molecular etiology of Alzheimer’s disease. Prog Biochem Biophys 2012;39:747-755.
10. Nitta H, Matsumoto K, Shimizu M, Ni XH, Watanabe H. Panax ginseng extract improves the performance of aged Fischer 344 rats in radial maze task but not in operant brightness discrimination task. Biol Pharm Bull 1995;18:1286-1288.
11. Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 2003;75:687-700.
12. Lee ST, Chu K, Sim JY, Heo JH, Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22:222-226.
13. Kim HJ, Kim P, Shin CY. A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system. J Ginseng Res 2013;37:8-29.
14. Cho IH. Effects of Panax ginseng in neurodegenerative diseases. J Ginseng Res 2012;36:342-353.
15. Song XY, Hu JF, Chu SF, Zhang Z, Xu S, Yuan YH, Han N, Liu Y, Niu F, He X, et al. Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3b/tau signaling pathway and the Ab formation prevention in rats. Eur J Pharmacol 2013;710:29-38.
16. Quan HY, Kim do Y, Chung SH. Korean red ginseng extract alleviates advanced glycation end product-mediated renal injury. J Ginseng Res 2013;37:187-193.
17. Lan Z, Chen L, Fu Q, Ji W, Wang S, Liang Z, Qu R, Kong L, Ma S. Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats. Brain Res 2013;1498:9-19.
18. Li XH, Lv BL, Xie JZ, Liu J, Zhou XW, Wang JZ. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging 2012;33:1400-1410.
19. Shaw KE, Bondi CO, Light SH, Massimino LA, McAloon RL, Monaco CM, Kline AE. Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats. J Neurotrauma 2013;30: 557-564.
20. Lan Z, Liu J, Chen L, Fu Q, Luo J, Qu R, Kong L, Ma S. Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice. J Ethnopharmacol 2012;141:386-395.
21. Liu J, Wang S, Feng L, Ma D, Fu Q, Song Y, Jia X, Ma S. Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. J Med Food 2013;16: 577-586.
22. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
23. Lue LF, Walker DG, Jacobson S, Sabbagh M. Receptor for advanced glycation end products: its role in Alzheimer’s disease and other neurological diseases. Future Neurol 2009;4:167-177.
24. Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Inflammation in Alzheimer’s disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol 2009;87:181-194.
25. Lüth HJ, Ogunlade V, Kuhla B, Kientsch-Engel R, Stahl P, Webster J, Arendt T, Münch G. Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer’s disease brains. Cereb Cortex 2005;15:211-220.
26. Wong A, Lüth HJ, Deuther-Conrad W, Dukic-Stefanovic S, Gasic-Milenkovic J, Arendt T, Münch G. Advanced glycation end products co-localize with inducible nitric oxide synthase in Alzheimer’s disease. Brain Res 2001;920: 32-40.
27. Neumann A, Schinzel R, Palm D, Riederer P, Münch G. High molecular weight hyaluronic acid inhibits advanced glycation endproduct-induced NF-kappaB activation and cytokine expression. FEBS Lett 1999;453:283-287.
28. Win MT, Yamamoto Y, Munesue S, Saito H, Han D, Motoyoshi S, Kamal T, Ohara T, Watanabe T, Yamamoto H. Regulation of RAGE for attenuating progression of diabetic vascular complications. Exp Diabetes Res 2012;2012: 894605.
29. Nunomura A. Oxidative stress hypothesis for Alzheimer’s disease and its potential therapeutic implications. Rinsho Shinkeigaku 2013;53:1043-1045.
30. Edrey YH, Oddo S, Cornelius C, Caccamo A, Calabrese V, Buffenstein R. Oxidative damage and amyloid-b metabolism in brain regions of the longestlived rodents. J Neurosci Res 2014;92:195-205.
31. Perrone L, Sbai O, Nawroth PP, Bierhaus A. The complexity of sporadic Alzheimer’s disease pathogenesis: the role of RAGE as therapeutic target to promote neuroprotection by inhibiting neurovascular dysfunction. Int J Alzheimers Dis 2012;2012:734956.
32. Lü JM, Weakley SM, Yang Z, Hu M, Yao Q, Chen C. Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid. Curr Pharm Des 2012;18: 6339-6347.