Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats

Journal of Medicinal Food

Volumn 16, Issue 7, 2013, Pages 577-586

  Liu, Jiping ^a,b   Wang, Shuyuan ^a   Feng, Liang ^c   Ma, Dongying ^a   Fu, Qiang ^a   Song, Yu ^a   Jia, Xiaobin ^c   Ma, Shiping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

^c KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

Author keywords

AGEs; cognitive deficit; diabetic encephalopathy; NF jB; oxidative stress; paeonol; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; AMINOGUANIDINE; DONEPEZIL; GLUCOSE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; PEONOL; PLASMA PROTEIN; ROSIGLITAZONE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CELL; BRAIN DISEASE; BRAIN LEVEL; BRAIN PROTECTION; BRAIN TISSUE; CONTROLLED STUDY; DIABETIC ENCEPHALOPATHY; DRUG MEGADOSE; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES; WEIGHT GAIN; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BRAIN DISEASES, METABOLIC; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; HYPOGLYCEMIC AGENTS; MALE; NF-KAPPA B; OXIDATIVE STRESS; PAEONIA; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN;

EID: 84880825303     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.2654     Document Type: Article

References (41)

1. Rajashree R, Kholkute SD, Goudar SS: Effects of duration of diabetes on behavioural and cognitive parameters in streptozotocin-induced juvenile diabetic rats. Malays J Med Sci 2011; 18:26-31
2. Manschot SM, Biessels GJ, de Valk H, Algra A, Rutten GE, Van Der Grond J, Kappelle LJ; Utrecht Diabetic Encephalopathy Study Group: Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia 2007;50:2388-2397
3. Margineanu DG, Niespodziany I, Wü lfert E: Hippocampal slices from long-Term streptozotocin-injected rats are prone to epileptiform responses. Neurosci Lett 1998;252:183-186
4. Sima AA: Encephalopathies: The emerging diabetic complications. Acta Diabetol 2010;47:279-293
5. Yaffe K, Lindquist K, Schwartz AV, Vitartas C, Vittinghoff E, Satterfield S, Simonsick EM, Launer L, Rosano C, Cauley JA, Harris T: Advanced glycation end product level, diabetes, and accelerated cognitive aging. Neurology 2011;77:1351-1356
6. Timaru-Kast R, Luh C, Gotthardt P, Huang C, Schäfer MK, Engelhard K, Thal SC: Influence of age on brain edema formation, secondary brain damage and inflammatory response after brain trauma in mice. PLoS One 2012;7:e43829
7. Coker LH, Wagenknecht LE: Advanced glycation end products, diabetes, and the brain. Neurology 2011;77:1326-1327
8. Hsieh CL, Cheng CY, Tsai TH, Lin IH, Liu CH, Chiang SY, Lin JG, Lao CJ, Tang NY: Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol 2006;106: 208-215
9. Tseng YT, Hsu YY, Shih YT, Lo YC: Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons. Shock 2012;37:312-318
10. Wu JB, Song NN, Wei XB, Guan HS, Zhang XM: Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation-induced injury. J Neurol Sci 2008; 264:50-55
11. Zhong SZ, Ge QH, Qu R, Li Q, Ma SP: Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. J Neurol Sci 2009;277:58-64
12. Lau CH, Chan CM, Chan YW, Lau KM, Lau TW, Lam FC, Law WT, Che CT, Leung PC, Fung KP, Ho YY, Lau CB: Pharmacological investigations of the anti-Diabetic effect of Cortex moutan and its active component paeonol. Phytomedicine 2007;14:778-784
13. Luo D, Fan Y, Xu X: The effects of aminoguanidine on retinopathy in STZ-induced diabetic rats. Bioorg Med Chem Lett 2012;22:4386-4390
14. Burrin JM, Price CP: Performance of three enzymic methods for filter paper glucose determination. Ann Clin Biochem 1984;21: 411-416
15. Tahara N, Yamagishi SI, Takeuchi M, Honda A, Tahara A, Nitta Y, Kodama N, Mizoguchi M, Kaida H, Ishibashi M, Hayabuchi N, Matsui T, Imaizumi T: Positive association between serum level of glyceraldehyde-Derived advanced glycation end products and vascular inflammation evaluated by [18F]fluorodeoxyglucose positron emission tomography. Diabetes Care 2012;35: 2618-2625
16. Griffith OW: Determination of glutathione and glutathione disulfide using glutathione reductase and 2-Vinylpyridine. Anal Biochem 1980;106:207-212
17. Lan Z, Liu J, Chen L, Fu Q, Luo J, Qu R, Kong L, Ma S: Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactoseinduced senescent mice. J Ethnopharmacol 2012;141:386-395
18. Vosse BA, Seelentag W, Bachmann A, Bosman FT, Yan P: Background staining of visualization systems in immunohistochemistry: Comparison of the Avidin-Biotin Complex system and the EnVision + system. Appl Immunohistochem Mol Morphol 2007;15:103-107
19. Lu M, Xu L, Li B, Zhang W, Zhang C, Feng H, Cui X, Gao H: Protective effects of grape seed proanthocyanidin extracts on cerebral cortex of streptozotocin-induced diabetic rats through modulating AGEs/RAGE/NF-kappaB pathway. J Nutr Sci Vitaminol (Tokyo) 2010;56:87-97
20. Reitman S, Frankel A: A colorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic transaminases. Am J Clin Pathol 1975;28:56-62
21. Tikoo K, Meena RL, Kabra DG, Gaikwad AB: Change in posttranslational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocininduced type I diabetic nephropathy. Br J Pharmacol 2008;153: 1225-1231
22. Hoffman WH, Artlett CM, Zhang W, Kreipke CW, Passmore GG, Rafols JA, Sima AA: Receptor for advanced glycation end products and neuronal deficit in the fatal brain edema of diabetic ketoacidosis. Brain Res 2008;1238:154-162
23. Gökcek-Sarac C, Karakurt S, Adali O, Jakubowska-Doǧru E: Correlation between hippocampal levels of neural, epithelial and inducible NOS and spatial learning skills in rats. Behav Brain Res 2012;235:326-333
24. Liu X, Luo D, Zheng M, Hao Y, Hou L, Zhang S: Effect of pioglitazone on insulin resistance in fructose-Drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation. Eur J Pharmacol 2010;629: 153-158
25. Xu L, Li B, Cheng M, Zhang W, Pan J, Zhang C, Gao H: Oral administration of grape seed proanthocyanidin extracts downregulate RAGE dependant nuclear factor-kappa B P65 expression in the hippocampus of streptozotocin induced diabetic rats. Exp Clin Endocrinol Diabetes 2008;116:215-224
26. Cully JA, Armento ME, Mott J, Nadorff MR, Naik AD, Stanley MA, Sorocco KH, Kunik ME, Petersen NJ, Kauth MR: Brief cognitive behavioral therapy in primary care: A hybrid type 2 patient-randomized effectiveness implementation design. Implement Sci 2012;7:64
27. Chang PC, Chien LY, Chong LY, Kuo YP, Hsiao JK: Glycated matrix up-regulates inflammatory signaling similarly to Porphyromonas gingivalis lipopolysaccharide. J Periodontal Res 2013;48:184-193
28. Greco R, Amantea D, Mangione AS, Petrelli F, Gentile R, Nappi G, Blandini F, Corasaniti MT, Tassorelli C: Modulation of RAGE isoforms expression in the brain and plasma of rats exposed to transient focal cerebral ischemia. Neurochem Res 2012;37:1508-1516
29. Perrone L, Sbai O, Nawroth PP, Bierhaus A: The complexity of sporadic Alzheimer's disease pathogenesis: The role of RAGE as therapeutic target to promote neuroprotection by inhibiting neurovascular dysfunction. Int J Alzheimers Dis 2012;2012: 734956
30. Kamboj SS, Sandhir R: Protective effect of N-Acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-Treated diabetic rats. Mitochondrion 2011;11:214-222
31. Mastrocola R, Restivo F, Vercellinatto I, Danni O, Brignardello E, Aragno M, Boccuzzi G: Oxidative and nitrosative stress in brain mitochondria of diabetic rats. J Endocrinol 2005;187: 37-44
32. Cai ZY, Yan Y, Sun SQ, Zhang J, Huang LG, Yan N, Wu F, Li JY: Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion. Neurosci Bull 2008;24:305-313
33. Sachdeva R, Babbar R, Puri V, Agarwal S, Krishana B: Correlation between cognitive functions and nitric oxide levels in patients with dementia. Clin EEG Neurosci 2011;42:190-194
34. Xue HY, Jin L, Jin LJ, Li XY, Zhang P, Ma YS, Lu YN, Xia YQ, Xu YP: Aucubin prevents loss of hippocampal neurons and regulates antioxidative activity in diabetic encephalopathy rats. Phytother Res 2009;23:980-986
35. Radak Z, Zhao Z, Koltai E, Ohno H, Atalay M: Oxygen consumption and usage during physical exercise: The balance between oxidative stress and ROS-Dependent adaptive signaling. Antioxid Redox Signal 2013;18:1208-1246
36. Chaudhary S, Parvez S: An in vitro approach to assess the neurotoxicity of valproic acid-induced oxidative stress in cerebellum and cerebral cortex of young rats. Neuroscience 2012;225: 258-268
37. Yu N, Di Q, Liu H, Hu Y, Jiang Y, Yan YK, Zhang YF, Zhang YD: Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats. Mediators Inflamm 2011;2011:670613
38. Su SY, Cheng CY, Tsai TH, Hsieh CL: Paeonol protects memory after ischemic stroke via inhibiting b-secretase and apoptosis. Evid Based Complement Alternat Med 2012;2012: 932823
39. Zhou J, Zhou L, Hou D, Tang J, Sun J, Bondy SC: Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease. Brain Res 2011;1388:141-147
40. Valente T, Gella A, Fernandez-Busquets X, Unzeta M, Durany N: Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiol Dis 2010;37:67-76
41. Huttunen HJ, Fages C, Kuja-Panula J, Ridley AJ, Rauvala H: Receptor for advanced glycation end products-binding COOHterminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res 2002;62:4805-4811 students in Jiangsu General Colleges