H2O2 inhibits proliferation and mediates suppression of migration via DLC1/RhoA signaling in cancer cells

Asian Pacific Journal of Cancer Prevention

Volumn 16, Issue 4, 2015, Pages 1637-1642

  Ma, Long ^a   Zhu, Wen Zhen ^a   Liu, Ting Ting ^a   Fu, Hui Ling ^a   Liu, Zhao Jun ^a   Yang, Bing Wu ^a   Song, Tai Yu ^a   Li, Guo Rong ^a  

^a SHANDONG NORMAL UNIVERSITY   (China)

Author keywords

Deleted in liver cancer 1; H2O2; Migration; Proliferation; RhoA

Indexed keywords

DLC1 PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYDROGEN PEROXIDE; MESSENGER RNA; OXIDIZING AGENT; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; BREAST; BREAST NEOPLASMS; CELL CULTURE; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WOUND HEALING;

APOPTOSIS; BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; GTPASE-ACTIVATING PROTEINS; HUMANS; HYDROGEN PEROXIDE; LUNG NEOPLASMS; OXIDANTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS; WOUND HEALING;

EID: 84926194833     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2015.16.4.1637     Document Type: Article

References (33)

1. Aghajanian A, Wittchen ES, Campbell SL, et al (2009). Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif. PLoS One, 4, 8045.
2. 2 Induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression. J Biol Chem, 277, 13761-70.
3. Chrzanowska-Wodnicka M, Burridge K (1996). Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol, 133, 1403-15.
4. Chua PJ, Yip GW, Bay BH (2009). Cell cycle arrest induced by hydrogen peroxide is associated with modulation of oxidative stress related genes in breast cancer cells. Exp Biol Med, 234, 1086-94.
5. Davies KJA (1999). The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life, 48, 41-7.
6. Fattahi S, Ardekani AM, Zabihi E, et al (2013). Antioxidant and apoptotic effects of an aqueous extract of Urtica dioica on the MCF-7 human breast cancer cell line. Asian Pac J Cancer Prev, 14, 5317-23.
7. Friberg H, Wieloch T (2002). Mitochondrial permeability transition in acute neurodegeneration. Biochimie, 84, 241-50.
8. Gupta SC, Hevia D, Patchva S, et al (2012). Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Signal, 16, 1295-322.
9. 2-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. Intern J Biol Sci, 7, 869.
10. Jung EM, Choi KC, Jeung EB (2011). Expression of calbindin-D28k is inversely correlated with proapototic gene expression in hydrogen peroxide-induced cell death in endometrial cancer cells. Int J Oncol, 38, 1059-66.
11. Kang YK, Kim WH, Jang JJ (2002). Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma. Human Pathol, 33, 877-83.
12. Kaverina I, Krylyshkina O, Small JV (2002). Regulation of substrate adhesion dynamics during cell motility. Intern J Biochem Cell Biol, 34, 746-61.
13. Keyomarsi K, Tucker SL, Buchholz TA, et al (2002). Cyclin E and survival in patients with breast cancer. New England J Med, 347, 1566-75.
14. Kimura K, Ito M, Amano M, et al (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science, 273, 245-8.
15. Li G, Du X, Vass WC, et al (2011). Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK). Proc Natl Acad Sci U S A, 108, 17129-34.
16. Li QF, Spinelli AM, Tang DD (2009). Cdc42GAP, reactive oxygen species, and the vimentin network. Am J Physiol Cell Physiol, 297, 299-309.
17. Liu S-L, Lin X, Shi D-Y, et al (2002). Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways. Arch Biochem Biophys, 406, 173-82.
18. Liu S-Z, Zhang F, Chang Y-X, et al (2013). Prognostic impact of cyclin d1, cyclin e and p53 on gastroenteropancreatic neuroendocrine tumours. Asian Pac J Cancer Prev, 14, 419-22.
19. Luanpitpong S, Talbott SJ, Rojanasakul Y, et al (2010). Regulation of lung cancer cell migration and invasion by reactive oxygen species and caveolin-1. J Biol Chem, 285, 38832-40.
20. Nayak RC, Chang KH, Vaitinadin NS, et al (2013). Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunological Rev, 256, 255-68.
21. 2-induced apoptosis. J Biol Chem, 283, 15359-69.
22. Nimnual AS, Taylor LJ, Bar-Sagi D (2003). Redox-dependent downregulation of Rho by Rac. Nat Cell Biol, 5, 236-41.
23. Park IJ, Hwang JT, Kim YM, et al (2006). Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. Ann N Y Acad Sci, 1091, 102-9.
24. Pyo CW, Choi JH, Oh SM, et al (2013). Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing. Biochim Biophys Acta, 1830, 5316-25.
25. Qian X, Li G, Asmussen HK, et al (2007). Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci USA, 104, 9012-7.
26. Rengarajan T, Nandakumar N, Rajendran P, et al (2014). D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pac J Cancer Prev, 15, 1757-62.
27. Tanaka KI, Asanuma M, Ogawa N (2004). Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells. Neurochem Res, 29, 1529-36.
28. 2-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases. FEBS Letters, 581, 248-52.
29. Veal EA, Day AM, Morgan BA (2007). Hydrogen peroxide sensing and signaling. Molecular Cell, 26, 1-14.
30. Winterbourn CC (2008). Reconciling the chemistry and biology of reactive oxygen species. Nature Chem Biol, 4, 278-86.
31. Wong CM, Lee JM-F, Ching Y-P, et al (2003). Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Cancer Res, 63, 7646-51.
32. Yuan BZ, Miller MJ, Keck CL, et al (1998). Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res, 58, 2196-9.
33. Zhang L, Yu H, Sun Y, et al (2007). Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol, 564, 18-25.