Antioxidant and apoptotic effects of an aqueous extract of Urtica dioica on the MCF-7 human breast cancer cell line

Asian Pacific Journal of Cancer Prevention

Volumn 14, Issue 9, 2013, Pages 5317-5323

  Fattahi, Sadegh ^a   Ardekani, Ali Motevalizadeh ^b   Zabihi, Ebrahim ^a   Abedian, Zeinab ^a   Mostafazadeh, Amrollah ^a   Pourbagher, Roghayeh ^a   Akhavan Niaki, Haleh ^a  

^a BABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

Author keywords

Anti oxidant; Apoptosis; Breast cancer; MCF 7; Urtica dioica

Indexed keywords

ANTIOXIDANT; PLANT EXTRACT;

APOPTOSIS; ARTICLE; BREAST TUMOR; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; MCF 7 CELL LINE; PATHOLOGY; PHYTOTHERAPY; URTICA DIOICA;

ANTIOXIDANTS; APOPTOSIS; BREAST NEOPLASMS; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; MCF-7 CELLS; PHYTOTHERAPY; PLANT EXTRACTS; URTICA DIOICA;

EID: 84887569045     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.9.5317     Document Type: Article

References (44)

1. Abu-Dahab Rand Afifi F (2007). Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7). Scientia Pharmaceutica, 75, 121-36.
2. Apak R, Guclu K, Demirata B, et al (2007). Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay. Molecules, 12, 1496-547.
3. Benzie IF, Strain JJ (1996). The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem, 239, 70-6.
4. Bnouham M, Merhfour FZ, Ziyyat A, et al (2010). Antidiabetic effect of some medicinal plants of Oriental Morocco in neonatal non-insulin-dependent diabetes mellitus rats. Hum Exp Toxicol, 29, 865-71.
5. Bosetti C, Spertini L, Parpinel M, et al (2005). Flavonoids and breast cancer risk in Italy. Cancer Epidemiol Biomarkers Prev, 14, 805-8.
6. Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-54.
7. Bray F, Jemal A, Grey N, et al (2012). Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol, 13, 790-801.
8. Campbell MK, Carr C, Devellis B, et al (2009). A randomized trial of tailoring and motivational interviewing to promote fruit and vegetable consumption for cancer prevention and control. Ann Behav Med, 38, 71-85.
9. Chen J, Grant ME, Schor AM, et al (1989). Differences between adult and foetal fibroblasts in the regulation of hyaluronate synthesis: correlation with migratory activity. J Cell Sci, 94, 577-89.
10. Cheng EH, Kirsch DG, Clem RJ, et al (1997). Conversion of Bcl-2 to a Bax-like death effector by caspases. Science, 278, 1966-8.
11. Cui Q, Yu JH, Wu JN, et al (2007). P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. Acta Pharmacol Sin, 28, 1057-66.
12. DeSantis C, Siegel R, Bandi P, et al (2011). Breast cancer statistics, 2011. CA Cancer J Clin, 61, 409-18.
13. Devarajan E, Sahin AA, Chen JS, et al (2002). Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene, 21, 8843-51.
14. El Haouari M, Bnouham M, Bendahou M, et al (2006). Inhibition of rat platelet aggregation by Urtica dioica leaves extracts. Phytother Res, 20, 568-72.
15. Guler ER (2013). Investigation of Chemopreventif Properties of Urtica dioica L., in MCF-7 and MDA 231 Breast Cancer Cell Lines. The New J Med, 30, 50-3.
16. Harris MH, Thompson CB (2000). The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ, 7, 1182-91.
17. Herrmann M, Lorenz HM, Voll R, et al (1994). A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res, 22, 5506-7.
18. Huang XJ, Ren W, Li J, et al (2013). Anti-inflammatory and anticancer activities of ethanol extract of pendulous monkshood root in vitro. Asian Pac J Cancer Prev, 14, 3569-73.
19. Jänicke RU (2009). MCF-7 breast carcinoma cells do not express caspase-3. Breast Cancer Res Treat, 117, 219-21.
20. Jänicke RU, Sprengart ML, Wati MR, Porter AG (1998). Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem, 273, 9357-60.
21. Konrad L, Muller HH, Lenz C, et al (2000). Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med, 66, 44-7.
22. Lam L, Hu X, Aktary Z, et al (2009). Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha. Breast Cancer Res Treat, 118, 605-21.
23. Liang Y, Yan C, Schor NF (2001). Apoptosis in the absence of caspase 3. Oncogene, 20, 6570-8.
24. Lin B, Kolluri SK, Lin F, et al (2004). Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell, 116, 527-40.
25. Mc Geea M, Hyland E, Campiani G, et al (2002). Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1, 5-benzoxazepine, PBOX-6 Febs. Lett, 515, 66-70.
26. Muraina IA, Suleiman MM, Eloff JN (2009). Can MTT be used to quantify the antioxidant activity of plant extracts? Phytomedicine, 16, 665-8.
27. Nijveldt RJ, van Nood E, van Hoorn DE, et al (2001). Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr, 74, 418-25.
28. Nizamutdinova IT, Lee GW, Son KH et al (2008). Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. Int J Oncol, 33, 485-91.
29. O'Donovan N, Crown J, Stunell H, et al (2003). Caspase 3 in breast cancer. Clin Cancer Res, 9, 738-42.
30. Ofir R, Seidman R, Rabinski T, et al (2002). Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent. Cell Death Differ, 9, 636-42.
31. Olaku O,White JD (2011). Herbal therapy use by cancer patients: A literature review on case reports. Eur J Cancer, 47, 508-14.
32. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-19.
33. Pandamooz S, Hadipour A, Akhavan-Niaki H, et al (2012). Short exposure to collagenase and co-culture with mice embryonic pancreas improve the human dermal fibroblast culture. Biotechnol Appl Biochem, 59, 254-61.
34. Peterson J, Dwyer J (1998). Flavonoids: dietary occurrence and biochemical activity. Nutr Res, 18, 1995-2018.
35. Salehin D, Fromberg I, Haugk C, et al (2010). Immunhistochemical Analysis for Expression of Calpain 1, Calpain 2 and Calpastatin in Endometrial Cancer. Ant Can Res, 30, 2837-44.
36. Schor SL, Schor AM, Rushton G (1988a). Fibroblasts from cancer patients display a mixture of both foetal and adult-like phenotypic characteristics. J Cell Sci, 90, 401-7.
37. Schor SL, Schor AM, Howell A, et al (1987). Hypothesis: persistent expression of fetal phenotypic characteristics by fibroblasts is associated with an increased susceptibility to neoplastic disease. Exp Cell Biol, 55, 11-7.
38. Schor SL, Schor AM, Grey AM, et al (1988b). Foetal and cancer patient fibroblasts produce an autocrine migration-stimulating factor not made by normal adult cells. J Cell Sci, 90, 391-9.
39. Shim HY, Park JH, Paik HD, et al (2007). Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation. Mol Cells, 24, 95-104.
40. Suzuki N, Takimoto Y, Suzuki R, et al (2013). Effificacy of oral administration of lentinula eododes mycelia extract for breast cancer patients undergoing postoperative hormone therapy. Asian Pac J Cancer Prev, 14, 3469-72.
41. Terry P, Terry JB, Wolk A (2001). Fruit and vegetable consumption in the prevention of cancer: an update. J Intern Med, 250, 280-90.
42. Testai L, Chericoni S, Calderone V, et al (2002). Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies. J Ethnopharmacol, 81, 105-9.
43. Tophkhane C, Yang S, Bales W, et al (2007). Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanisms. Int J Oncol, 31, 867-74.
44. Yu MS, Lai CS, Ho YS, et al (2007). Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity. Int J Mol Med, 20, 261-8.