Time for international action on treating testosterone deficiency syndrome

Aging Male

Volumn 12, Issue 1, 2009, Pages 21-28

  Carruthers, Malcolm ^a  

^a Centre for Men's Health   (United Kingdom)

Author keywords

Education; Expert; Opinion; Prevalence; TDS; Testosterone deficiency syndrome; Treatment

Indexed keywords

ANTIANDROGEN; TESTOSTERONE; ANDROGEN;

ADULT; AGE DISTRIBUTION; AGING; ANDROGEN DEFICIENCY; AUSTRALIA; CONTROLLED STUDY; DIABETES MELLITUS; DRUG SAFETY; DRUG TREATMENT FAILURE; ENVIRONMENTAL STRESS; FRANCE; GEOGRAPHIC DISTRIBUTION; GERMANY; GROUPS BY AGE; HEALTH CARE COST; HORMONE SUBSTITUTION; HUMAN; ITALY; MALE; MEN'S HEALTH; METABOLIC SYNDROME X; OBESITY; PHYSICIAN ATTITUDE; PRACTICE GUIDELINE; PREVALENCE; PRIORITY JOURNAL; REVIEW; RUSSIAN FEDERATION; UNITED KINGDOM; UNITED STATES; AGED; ARTICLE; CLINICAL PRACTICE; ENDOCRINE DISEASE; HEALTH; METABOLISM; MIDDLE AGED; SYNDROME;

AGED; AGED, 80 AND OVER; AGING; ANDROGENS; ENDOCRINE SYSTEM DISEASES; HUMANS; MALE; MEN'S HEALTH; MIDDLE AGED; PHYSICIAN'S PRACTICE PATTERNS; PREVALENCE; SYNDROME; TESTOSTERONE; WORLD HEALTH;

EID: 66149143224     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.1080/13685530802699067     Document Type: Review

References (52)

1. Carruthers M. The paradox dividing testosterone deficiency symptoms and androgen assays: A closer look at the cellular and molecular mechanisms of androgen action. J Sex Med 2008;5:998-1012.
2. Andersson AM, Jensen TK, Juul A, Petersen JH, Jorgensen T, Skakkebaek NE. Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys. J Clin Endocrinol Metab 2007;92:4696-4705.
3. Araujo AB, Esche GR, Kupelian V, O'donnell AB, Travison TG, Williams RE, Clark RV, McKinlay JB. Prevalence of symptomatic androgen deficiency in Men. J Clin Endocrinol Metab 2007;93:4241-4247.
4. Andersson AM, Bay K, Grigor KM, Toppari J, Skakkabaek NE. Proceedings of the 4th Copenhagen workshop on endocrine disruptors. Int J Androl 2008;31:73-293.
5. Jones RD, Malkin CJ, Channer KS, Jones TH. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: Further supportive data. J Clin Endocrinol Metab 2003;88:1403-1404.
6. Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) prospective population study. Circulation 2007;116:2694-2701.
7. Kapoor D, Jones T. Androgen deficiency as a predictor of metabolic syndrome in aging men: An opportunity for intervention? Drugs Aging 2008;25:357-369.
8. Guay AT, Jacobson J. The relationship between testosterone levels, the metabolic syndrome (by two criteria), and insulinresistance in a population of men with organic erectile dysfunction. J Sex Med 2007;4:1046-1055.
9. Grossmann M, Thomas M, Panagiotopoulos S, Sharpe K, Macisaac R, Clarke S, Zajac J, Jerums G. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab 2008;93:1834-1840.
10. Fukui M, Soh J, Tanaka M, Kitagawa Y, Hasegawa G, Yoshikawa T, Miki T, Nakamura N. Low serum testosterone concentration in middle-aged men with type 2 diabetes. Endocr J 2007;54:871-877.
11. Meier C, Nguyen TV, Handelsman DJ, Schindler C, Kushnir MM, Rockwood AL, Meikle AW, Center JR, Eisman JA, Seibel MJ. Endogenous sex hormones and incident fracture risk in older men: The Dubbo osteoporosis epidemiology study. Arch Intern Med 2008;168:47-54.
12. Schubert M, Bullmann C, Minnemann T, Reiners C, Krone W, Jockenhovel F. Osteoporosis in male hypogonadism: Responses to androgen substitution differ among men with primary and secondary hypogonadism. Horm Res 2003;60: 21-28.
13. Mohr BA, Bhasin S, Kupelian V, Araujo AB, O'donnell AB, McKinlay JB. Testosterone, sex hormone-binding globulin, and frailty in older men. J Am Geriatr Soc 2007;55:548-555.
14. Morley JE, Haren MT, Rolland Y, Kim MJ. Frailty. Med Clin North Am 2006;90:837-847.
15. Bates KA, Harvey AR, Carruthers M, Martins RN. Androgens, andropause and neurodegeneration: Exploring the link between steroidogenesis, androgens and Alzheimer's disease. Cell Mol Life Sci 2005;62:281-292.
16. Tan RS, Culberson JW. An integrative review on current evidence of testosterone replacement therapy for the andropause. Maturitas 2003;45:15-27.
17. Hogervorst E, Lehmann DJ, Warden DR, McBroom J, Smith AD. Apolipoprotein E epsilon4 and testosterone interact in the risk of Alzheimer's disease in men. Int J Geriatr Psychiatry 2002;17:938-940.
18. Shores MM, Matsumoto AM, Sloan KL, Kivlahan DR. Low serum testosterone and mortality in male veterans. Arch Intern Med 2006;166:1660-1665.
19. Laughlin GA, Barrett C, Bergstrom J. Low serum testosterone and mortality in older men. J Clin Endocrinol Metab 2008;93:68-75.
20. Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren D. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: The European male aging study. J Clin Endocrinol Metab 2008;93:2737-2745.
21. Hameed A, Brothwood T, Bouloux P. Delivery of testosterone replacement therapy. Curr Opin Investig Drugs 2003;4:1213-1219.
22. Carruthers M, Trinick TR, Wheeler MJ. The validity of androgen assays. Aging Male 2007;10:165-172.
23. Heinemann LAJ, Zimmermann T, Vermeulen A, Thiel C, Hummel W. A new 'aging males' symptoms' (AMS) rating scale. Aging Male 1999;2:105-114.
24. Heinemann LA, Saad F, Heinemann K, Thai DM. Can results of the aging males' symptoms (AMS) scale predict those of screening scales for androgen deficiency? Aging Male 2004;7:211-218. (Pubitemid 39315125)
25. Heinemann LA. Aging males' symptoms scale: A standardized instrument for the practice. J Endocrinol Invest 2005;28: 34-38.
26. Heinemann LAJ, Saad F, Thiele K. The Aging males' symptoms rating scale: Cultural and linguistic validation into English. Aging Male 2001;4:14-22.
27. Daig I, Heinemann LA, Kim S, Leungwattanakij S, Badia X, Myon E, Moore C, Saad F, Potthoff P, Thai DM. The aging males' symptoms (AMS) scale: Review of its methodological characteristics. Health Qual Life Outcomes 2003;1:77.
28. Moore C, Huebler D, Zimmermann T, Heinemann LA, Saad F, Thai dM. The aging males' symptoms scale (AMS) as outcome measure for treatment of androgen deficiency. Eur Urol 2004;46:80-87. (Pubitemid 38748514)
29. Heinemann LA, Moore C, Dinger JC, Stoehr D. Sensitivity as outcome measure of androgen replacement: The AMS scale. Health Qual Life Outcomes 2006;4:23.
30. Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D, Perry HM. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism 2000;49:1239-1242.
31. Carruthers M. ADAM: Androgen deficiency in the adult male - causes, diagnosis and treatment. London, New York: Taylor & Francis; 2004.
32. Corona G, Mannucci E, Petrone L, Balercia G, Fisher AD, Chiarini V, Forti G, Maggi M. ANDROTEST: A structured interview for the screening of hypogonadism in patients with sexual dysfunction. J Sex Med 2006;3:706-715.
33. Abramsky L, Chapple J. 47,XXY (Klinefelter syndrome) and 47,XYY: Estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling. Prenat Diagn 1997;17:363-368.
34. Sijstermans K, Hack WW, Meijer RW, Van Der Voort- Doedens LM. The frequency of undescended testis from birth to adulthood: A review. Int J Androl 2008;31:1-11.
35. Allan CA, McLachlan RI. Age-related changes in testosterone and the role of replacement therapy in older men. Clin Endocrinol (Oxf) 2004;60:653-670.
36. Liverman CT, Blazer DG; Institute of Medicine Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy. Testosterone and aging: Clinical research directions, Washington, DC: The National Academies Press; 2004.
37. Hall SA, Araujo AB, Esche GR, Williams RE, Clark RV, Travison TG, McKinlay JB. Treatment of symptomatic androgen deficiency: Results from the Boston Area Community Health Survey. Arch Intern Med 2008;168:1070-1076.
38. Jungwirth A, Plas E, Geurts P. Clinical experience with andriol testocaps-the first Austrian surveillance study on the treatment of late-onset hypogonadism. Aging Male 2007;10: 183-187.
39. Handelsman DJ. Trends and regional differences in testosterone prescribing in Australia, 1991-2001. Med J Aust 2004; 181:419-422.
40. Spetz ACE, Palmefors L, Skobe RSP, Stroemstedt MT, Fredriksson M, Theodorsson E, Hammar ML. Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population. Menopause 2007;14:999-1005.
41. McKinlay JB, Travison TG, Araujo AB, Kupelian V. Male menopause: Time for a decent burial? Menopause 2007;14: 973-975.
42. Gooren LJ, Behre HM, Saad F, Frank A, Schwerdt S. Diagnosing and treating testosterone deficiency in different parts of the world. Results from global market research. Aging Male 2007;10:173-181.
43. Nieschlag E, Swerdloff R, Behre HM, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morley JE, Schulman C, Wang C, Weidner W, Wu FC. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. Int J Androl 2005;28: 125-127. (Pubitemid 40780337)
44. Traish A, Kim N. The physiological role of androgens in penile erection: Regulation of corpus cavernosum structure and function. J Sex Med 2005;2:759-770.
45. Hackett G, Kell P, Ralph D, Dean J, Price D, Speakman M, Wylie K. British society for sexual medicine guidelines on the management of erectile dysfunction. J Sex Med 2008;5:1841-1865.
46. Morgentaler A. Testosterone and prostate cancer: An historical perspective on a modern myth. Eur Urol 2006;50:935-939.
47. Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocrinol Metab 2006;91:4335-4343.
48. Travison TG, Shackelton R, Araujo AB, Hall SA, Williams RE, Clark RV, O'donnell AB, McKinlay JB. The natural history of symptomatic androgen deficiency in men: Onset, progression, and spontaneous remission. J Am Geriatr Soc 2008;56:831-839.
49. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in adult men with androgen deficiency syndromes: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2006;91:1995-2010.
50. Nieschlag E, Behre HM. Testosterone therapy. In: Neischlag E, Behre HM, editors. Andrology: Male reproductive health and dysfunction, Berlin: Springer; 1997. pp 295-309.
51. Maggi M, Schulman C, Quinton R, Langham S, Uhl- Hochgraeber K. The burden of testosterone deficiency syndrome in adult men: Economic and quality-of-life impact. J Sex Med 2007;4:1056-1069.
52. Cohen JT, Neumann PJ, Weinstein MC. Does preventive care save money? Health economics and the presidential candidates. N Engl J Med 2008;358:661-663.