Sex hormones and age: A cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men

American Journal of Epidemiology

Volumn 147, Issue 8, 1998, Pages 750-754

  Ferrini, Rebecca L ^a   Barrett Connor, Elizabeth ^b,c  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Estradiol; Hormones; Men; Testosterone

Indexed keywords

ESTRADIOL; SEX HORMONE; TESTOSTERONE;

ADULT; AGE; AGED; AGING; ARTICLE; DISEASE ASSOCIATION; ELDERLY CARE; ESTRADIOL BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; RADIOIMMUNOASSAY; STATISTICAL ANALYSIS; TESTOSTERONE BLOOD LEVEL; UNITED STATES;

EID: 0032522860     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.aje.a009519     Document Type: Article

References (34)

1. Phillips GB, Pinkernell BH, Jing TY. The association of hyperestrogenemia with coronary thrombosis in men. Arterioscler Thromb Vase Biol 1996;16:1383-7.
2. Winkler UH. Effects of androgens on haemostasis. Maturitas 1996;24:147-55.
3. Phillips GB, Jing TY, Resnick LM, et al. Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension. J Hypertens 1993;11:699-702.
4. Henderson BE, Ross RK, Pike MC, et al. Endogenous hormones as a major factor in human cancer. Cancer Res 1982: 42:3232-9.
5. Wilding G. The importance of steroid hormones in prostate cancer. Cancer Surv 1992;14:113-30.
6. Thomas DB. Breast cancer in men. Epidemiol Rev 1993;15:220-31.
7. Holmes SJ, Shalet SM. Role of growth hormone and sex steroids in achieving and maintaining normal bone mass. Horm Res 1996;45:86-93.
8. Jeppesen LL, Jorgensen HS, Nakayama H, et al. Decreased serum testosterone in men with acute ischemic stroke. Arterioscler Thromb Vase Biol 1996;16:749-54.
9. Barrett-Connor E, Khaw K-T, Yen SS. Endogenous sex hormone levels in older adult men with diabetes mellitus. Am J Epidemiol 1990;132:895-901.
10. Haffner SM. Sex hormone-binding protein, hyperinsulinemia, insulin resistance and noninsulin-dependent diabetes. Horm Res 1996;45:233-7.
11. Simon D, Preziosi P, Barrett-Connor E, et al. The influence of aging on plasma sex hormones in men: The Telecom Study. Am J Epidemiol 1992;135:783-91.
12. Zumoff B, Strain GW, Kream J, et al. Age variation of the 24-hour mean plasma concentrations of androgens, estrogens, and gonadotropins in normal adult men. J Clin Endocrinol Metab 1982;54:534-8.
13. Tietz NW, Shuey DF, Wekstein DR. Laboratory values in fit aging individuals - sexagenarians through centenarians. Clin Chem 1992;38:1167-85.
14. Gray A, Feldman HA, McKinlay JB, et al. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991;73:1016-25.
15. Gray A, Berlin JA, McKinlay JB, et al. An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. J Clin Epidemiol 1991;44:671-84.
16. Field AE, Colditz GA, Willett WC, et al. The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. J Clin Endocrinol Metab 1994;79:1310-16.
17. Moss AJ, Parsons VL. Current estimates from the National Health Interview Survey, United States, 1985. (Vital and health statistics, series 10, no. 160). Hyattsville, MD: National Center for Health Statistics, 1986. (DHHS publication no. (PHS) 86-1588).
18. McPhillips JB, Pellettera KM, Barrett-Connor E, et al. Exercise patterns in a population of older adults. Am J Prev Med 1989;5:65-72.
19. Taylor HL, Jacobs DR Jr, Schucker B, et al. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis 1978;31:741-55.
20. World Health Organization Expert Committee on Diabetes. Diabetes mellitus: report of a WHO study group. World Health Organ Tech Rep Ser 1985;727:1-313.
21. Anderson DC, Hopper BR, Lasley BL, et al. A simple method for the assay of eight steroids in small volumes of plasma. Steroids 1976;28:179-96.
22. Tremblay RR, Dube JY. Plasma concentrations of free and non-TeBG bound testosterone in women on oral contraceptives. Contraception 1974;10:599-605.
23. Rubens R, Dhont M, Vermeulen A. Further studies on Leydig cell function in old age. J Clin Endocrinol Metab 1974;39:40-5.
24. Bartsch W. Interrelationships between sex hormone-binding globulin and testosterone, 5-alpha-dihydrotestosterone and oestradiol-17-beta in blood of normal men. Maturitas 1980;2:109-18.
25. Davidson JM, Chen JJ, Crapo L, et al. Hormonal changes and sexual function in aging men. J Clin Endocrinol Metab 1983;57:71-7.
26. Greenblatt RB, Oettinger M, Bohler CS. Estrogen-androgen levels in aging men and women: therapeutic considerations. J Am Geriatr Soc 1976;24:173-8.
27. Sparrow D, Bosse R, Rowe JW. The influence of age, alcohol consumption, and body build on gonadal function in men. J Clin Endocrinol Metab 1980;51:508-12.
28. Nieschlag E, Lammers U, Freischem CW, et al. Reproductive functions in young fathers and grandfathers. J Clin Endocrinol Metab 1982;55:676-81.
29. Tsitouras PD, Martin CE, Harman SM. Relationship of serum testosterone to sexual activity in healthy elderly men. J Gerontol 1982;37:288-93.
30. Dai WS, Kuller LH, LaPorte RE, et al. The epidemiology of plasma testosterone levels in middle-aged men. Am J Epidemiol 1981;114:804-16.
31. Baker HW, Burger HG, de Kretser DM, et al. Changes in the pituitary-testicular system with age. Clin Endocrinol 1976;5:349-72.
32. Pirke KM, Doerr P. Age related changes and interrelationships between plasma testosterone, oestradiol and testosterone-binding globulin in normal adult males. Acta Endocrinol (Copenh) 1973;74:792-800.
33. Phillips GB, Yano K, Stemmermann GN. Serum sex hormone levels and myocardial infarction in the Honolulu Heart Program: pitfalls in prospective studies on sex hormones. J Clin Epidemiol 1988;41:1151-6.
34. Bolelli G, Muti P, Micheli A, et al. Validity for epidemiological studies of long-term cryoconservation of steroid and protein hormones in serum and plasma. Cancer Epidemiol Biomarkers Prev 1995;4:509-13.