Polymer-mediated DNA vaccine delivery via bystander cells requires a proper balance between transfection efficiency and cytotoxicity

Journal of Controlled Release

Volumn 157, Issue 1, 2012, Pages 86-93

  Palumbo, R Noelle ^a   Zhong, Xiao ^a   Wang, Chun ^a  

^a University of Minnesota   (United States)

Author keywords

Cytotoxicity; DNA vaccine; Gene delivery; Immune response; Polyplex

Indexed keywords

ANTIGEN PRESENTING CELLS; COCULTURE; CROSS-PRIMING; DENDRITIC CELLS; DNA VACCINE; GENE DELIVERY; IMMUNE ACTIVATION; IMMUNE RESPONSE; IMMUNE SYSTEMS; NONVIRAL; POLYPLEXES; T CELLS; TRANSFECTION EFFICIENCY;

ANTIGENS; CYTOTOXICITY; DENDRIMERS; DNA; FIBROBLASTS; GENE THERAPY; GENE TRANSFER; IMMUNOLOGY; MOLECULAR BIOLOGY; VACCINES;

CELL CULTURE;

CD40 ANTIGEN; DNA VACCINE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POLYMER;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CD8+ T LYMPHOCYTE; CELL DEATH; CELL MATURATION; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; CYTOTOXICITY; DENDRITIC CELL; DNA DRUG COMPLEX; DRUG DELIVERY SYSTEM; FIBROBLAST; IMMUNE RESPONSE; IMMUNE SYSTEM; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; BYSTANDER EFFECT; CELL DEATH; COCULTURE TECHNIQUES; CYTOTOXINS; DRUG DELIVERY SYSTEMS; MICE; MICE, TRANSGENIC; NIH 3T3 CELLS; POLYMERS; TRANSFECTION; VACCINES, DNA;

EID: 84855853120     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.08.037     Document Type: Article

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