Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity

Journal of Controlled Release

Volumn 141, Issue 2, 2010, Pages 234-240

  van den Berg, Joost H ^a,b,c   Oosterhuis, Koen ^c   Hennink, Wim E ^b   Storm, Gert ^b   van der Aa, Leonardus J ^d   Engbersen, Johan F J ^d   Haanen, John B A G ^c   Beijnen, Jos H ^a,b   Schumacher, Ton N ^c   Nuijen, Bastiaan ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Dermal delivery; DNA tattooing; DNA vaccination; Nanoparticles; PEGylation

Indexed keywords

ANTIGEN EXPRESSION; CATIONIC CHARGES; CATIONIC LIPOSOMES; CATIONIC NANOPARTICLES; CELL TYPES; CHARGE SHIELDING; DETRIMENTAL EFFECTS; DNA CARRIER; DNA VACCINATION; DNA VACCINE; ELECTROSTATIC INTERACTIONS; EX-VIVO; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX COMPONENTS; HUMAN SKIN; IMMUNOGENICITY; IN-VITRO ASSAYS; IN-VIVO; NAKED DNA; NANOPARTICLE FORMULATION; PEGYLATION; POLYPLEXES; T-CELL RESPONSE; TARGETED NANOPARTICLE; TRANSFECTION EFFICIENCY;

ANTIGENS; CHARGED PARTICLES; DNA; GENES; LIPOSOMES; NANOPARTICLES; PHOSPHOLIPIDS; POLYMERS; SHIELDING; SKIN; STRATEGIC PLANNING; SURFACE CHARGE; VACCINES;

NUCLEIC ACIDS;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CATION; CYTOKERATIN ANTIBODY; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DNA VACCINE; GREEN FLUORESCENT PROTEIN; LIPOPLEX; NANOPARTICLE; POLYAMIDOAMINE; POLYPLEX; T6 ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA IMMUNIZATION; DNA TRANSFECTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; EX VIVO STUDY; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANIMALS; CATIONS; FEMALE; HUMANS; INFLUENZA VACCINES; INJECTIONS, INTRADERMAL; LIPIDS; LIPOSOMES; MICE; MICE, INBRED C57BL; MIDDLE AGED; NANOPARTICLES; PEPTIDE FRAGMENTS; POLYAMINES; POLYETHYLENE GLYCOLS; SKIN; SURFACE PROPERTIES; T-LYMPHOCYTES; TIME FACTORS; TRANSFECTION; VACCINES, DNA; VIRAL CORE PROTEINS;

EID: 72149108423     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.09.005     Document Type: Article

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