Aging and circadian rhythms: General trends

Principles and Practice of Geriatric Sleep Medicine

Volumn , Issue , 2009, Pages 3-21

  Pandi Perumal, Seithikurippu R ^a   Spence, D Warren ^b   Sharma, Vijay Kumar ^c  

^a Somnogen Inc   (United States)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84926106491     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511770661.004     Document Type: Chapter

References (225)

1. Pandi-Perumal SR, Seils LK, Kayumov L, et al. Senescence, sleep, and circadian rhythms. Ageing Res Rev 2002; 1: 559-604.
2. Turek FW, Penev P, Zhang Y, Van Reeth O, Zee P. Effects of age on circadian system. Neurosci Biobehav Rev 1995; 19: 53-58.
3. Turek FW, Penev P, Zhang Y, et al. Alterations in the circadian system in advanced age. Ciba Found Symp 1995; 183: 212-26.
4. Weinert D. Age-dependent changes of the circadian system. Chronobiol Int 2000; 17: 261-83.
5. Pittendrigh CS, Minis DH. Circadian systems: longevity as a function of circadian resonance in Drosophila melanogaster. Proc Natl Acad Sci USA 1972; 69: 1537-9.
6. Davis FC. Ontogeny of circadian rhythms. In AschoffJ, ed. Biological Rhythms: Handbook of Behavioral Neurobiology, vol. 4. 1981: pp. 257-74.
7. Samis HV Jr. Aging: the loss of temporal organization. Perspect Biol Med 1968; 12: 95-102.
8. Ingram DK, London ED, Reynolds MA. Circadian rhythmicity and sleep: effects of aging in laboratory animals. N eurobiol Aging 1982; 3: 287-97.
9. Van Gool WA, Mirmiran M. Effects of aging and housing in an enriched environment on sleep-wake patterns in rats. Sleep 1986; 9: 335-47.
10. Van Gool WA, Mirmiran M. Aging and circadian rhythms. Prog Brain Res 1986; 70: 255-77.
11. Welsh DK, Richardson GS, Dement WC. Effect of age on the circadian pattern of sleep and wakefulness in the mouse. J Gerontol 1986; 41: 579-86.
12. Brock MA. Chronobiology of aging. J Am Geriatr Soc 1991; 39: 74-91.
13. Stone WS, Rudd RJ, Parsons MW, Gold PE. Memory scores in middle aged rats predict later deficits in memory, paradoxical sleep, and blood glucose regulation in old age. Exp Aging Res 1997; 23: 287-300.
14. Morin LP. Age-related changes in hamster circadian period, entrainment and rhythm splitting. J Biol Rhythms 1988; 3: 237-48.
15. Swaab DF, Fliers E, Partiman TS. The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res 1985; 342: 37-44.
16. Roozendaal B, Van Gool WA, Swaab DF, Hoogendijk JE, Mirmiran M. Changes in vasopressin cells of the rat suprachiasmatic nucleus with aging. Brain Res 1987; 409: 259-64. 1 7. Chee CA, Roozendaal AB, Swaab DF, Goudsmit E, Mirmiran M. Vasoactive intestinal polypeptide neuron changes in the senile rat suprachiasmatic nucleus. Neurobiol Aging 1988; 9: 307-12.
17. Wise PM, Cohen IR, Weiland NG, London DE. Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus. Proc Natl Acad Sci USA 1988; 85: 5305-09.
18. Satinoff E, Li H, Tcheng TK, et al. Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones? Am J Physiol 1993; 265: R1216-22.
19. Sutin EL, Dement WC, Heller HC, Kilduff TS. Light-induced gene expression in the suprachiasmatic nucleus of young and aged rats. Neurobiol Aging 1993; 14: 441-6.
20. Hofman MA, Swaab DF. Alterations in circadian rhythmicity of the vasopressin-producing neurons of the suprachiasmatic nucleus (SCN) with aging. Brain Res 1994; 651: 134-42.
21. Hofman MA, Swaab DF. Influence of aging on the seasonal rhythm of the vasopressin-expressing neurons in the human suprachiasmatic nucleus. Neurobiol Aging 1995; 16: 965-71.
22. Reiter RJ, Richardson B, Johnson L, Ferguson B, Dinh D. Pineal melatonin rhythm: reduction in aging Syrian hamsters. Science 1980; 210: 1372-74.
23. Reiter RJ, Craft CM, Johnson JE Jr, et al. Age associated reduction in nocturnal pineal melatonin levels in female rats. Endocrinology 1981; 109: 1295-97.
24. Yunis EJ, Fernandes G, Nelson W, Halberg F. Circadian temperature rhythms and aging in rodents. In Sheving LE, Halberg F, Pauly JE, eds. Chronobiology. Great Britain: William Heinemann; 1974: pp. 54-65.
25. McDonald RB, Hoban-Higgins TM, Ruhe RC, Fuller CA, Horwitz BA. Alterations in endogenous circadian rhythm of core temperature in senescent Fischer 344 rats. Am J Physiol 1999; 276: R824-30.
26. Rosenberg RS, Zepelin H, Rechtschaffen A. Sleep in young and old rats. J Gerontol 1979; 34: 525-32.
27. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev 1995; 19: 553-71.
28. Davis FC, Menaker M. Hamsters through time's window: temporal structure of hamster locomotor rhythmicity. Am J Physiol 1980; 239: R149-R155.
29. Pittendrigh CS, Daan S. Circadian oscillation in rodents: a systematic increase of their frequency with age. Science 1974; 186: 548-50.
30. Wever R. The meaning of circadian rhythmicity with regard to aging. Verhandlungen der Deutschen Gesellschaft fur Pathologie 1975; 59: 160-80.
31. Simpkins JW, Millard WJ. Influence of age on neurotransmitter function. Endocrinol Metab Clin North Am 1987; 16: 893-917.
32. Waterhouse JM, Minors DS. Circadian rhythms in the neonate and in old age: what do they tell us about the development and decay of the body clock in humans? Braz J Med Biol Res 1996; 29: 87-94.
33. Halberg F, Nelson W. Chronobiologic optimization of aging. In Samis HV, Jr, Capobianco S, eds. Aging and Biological Rhythms. New York and London: Plenum Press; 1978: pp. 5-56.
34. Hurd MW, Zimmer KA, Lehman MN, Ralph, MR. Circadian locomotor rhythms in aged hamsters following suprachiasmatic transplant. Am J Physiol 1995; 269: R958-68.
35. Scarbrough K, Losse-Olson S, Wallen EP, Turek FW. Aging and photoperiod affect entrainment and quantitative aspects of locomotor behavior in Syrian hamsters. Am J Physiol 1997; 272: R1219-25.
36. Valentinuzzi VS, Scarborough K, Takahashi JS, Turek FW. Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. Am J Physiol 1997; 273: R1957-64.
37. Davis FC, Viswanathan N. Stability of circadian timing with age in Syrian hamsters. Am J Physiol 1998; 275: R960-8.
38. Minors DS, Waterhouse JM. Endogenous and exogenous components of circadian rhythms when living on a 21-hour day. Int J Chronobiol 1981; 8: 31-48.
39. Peng MT, Jiang MJ, Hsu HK. Changes in wheel-running activity, eating and drinking and their day/night distributions throughout the life span of the rat. J Gerontol 1980; 35: 339-47.
40. Weitzman ED, Moline M, Czeisler C, Zimmerman JC. Chronobiology of aging: temperature, sleep-wake rhythms and entrainment. Neurobiol Aging 1982; 3: 299-309.
41. Renfrew JW, Pettigrew KD, Rapport SI. Motor activity and sleep duration as a function of age in healthy men. Physiol Behav 1987; 41: 627-34.
42. Sacher GA, Duffy PH. Age changes in rhythms of energy metabolism, activity, and body temperature in Mus and Peromyscus. Adv Exp Med Biol 1978; 108: 105-24.
43. Refinetti R, Ma H, SatinoffE. Body temperature rhythms, cold tolerance, and fever in young and old rats of both genders. Exp Gerontol 1990; 25: 533-43.
44. Magri F, Terenzi F, Migliorati G, et al. Biochemical and cerebral morphometric correlates of physiological aging and senile dementia. Aging (Milano) 1997; 9 (Suppl. 4): 53-4.
45. Magri F, Locatelli M, Balza G, et al. Changes in endocrine circadian rhythms as markers o f physiological and pathological brain aging. Chronobiol Int 1997; 14: 385-96.
46. SatinoffE. Patterns of circadian body temperature rhythms in aged rats. Clin Exp Pharmacol Physiol 1998; 25: 135-40.
47. Halberg F. Biological rhythms, hormones, and aging. In Vernadakis A, Timiras PS, eds. Hormones in Development and Aging. SP Medical & Scientific Books; 1982: pp. 451-76.
48. Wise PM, Walovitch RC, Cohen IR, Weiland NG, London ED. Diurnal rhythmicity and hypothalamic deficits in glucose utilization in aged ovariectomized rats. J Neurosci 1987; 7: 3469-73.
49. Kawakami F, Okamura H, Tamada Y, et al. Loss of day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats. Neurosci Lett 1997; 222: 99-102.
50. Duncan MJ, Herron JM, Hill SA. Aging selectively suppresses vasoactive intestinal peptide messenger RNA expression in the suprachiasmatic nucleus of the Syrian hamster. Mol Brain Res 2001; 87: 196-203.
51. Krajnak K, Kashon ML, Rosewell KL, Wise PM. Aging alters the rhythmic expression of vasoactive intestinal polypeptide mRNA but not arginine vasopressin mRNA in the suprachiasmatic nuclei of female rats. J Neurosci 1998; 18: 4767-74.
52. Li H, SatinoffE. Fetal tissue containing the suprachiasmatic nucleus restores multiple circadian rhythms in old rats. Am J Physiol 1998; 275: R1735-44.
53. Hurd MW, Ralph MR. The significance of circadian organization for longevity in the golden hamster. J Biol Rhythms 1998; 13: 430-6.
54. Lobban MC, Tredre BE. Diurnal rhythms of renal excretion and of body temperature in aged subjects. J Physiol 1967; 188: 48P-49P.
55. Cahn AA, Folk GE, Huston PE. Age comparison of human day-night physiological differences. Aerospace Med 1968; 39: 608-10.
56. Amir S, Stewart J. Conditioning in the circadian system. Chronobiol Int 1998; 15: 447-56.
57. Mrosovsky N, Biello SM. Nonphotic phase shift ing in the old and the cold. Chronobiol Int 1994; 11: 232-52.
58. Mrosovsky N. Locomotor activity and non-photic influences on circadian clocks. Biol Rev Camb Philos Soc 1996; 71: 343-72.
59. Zee PC, Rosenberg RS, Turek FW. Effects of aging on entrainment and rate of resynchronization of circadian locomotor activity. Am J Physiol 1992; 263: R1099-103.
60. Rosenberg RS, Zee PC, Turek FW. Phase response curves to light in young and old hamsters. Am J Physiol 1991; 261: R491-5. 62a. Benloucif S, Masana MI, Dubocovich ML. Responsiveness to melatonin and its receptor expression in the aging circadian clock of mice. Am J Physiol 1997; 273: R1855-60. 62b. Benloucif S, Masana MI, Dubocovich ML. Light-induced phase-shift s of circadian activity rhythms and immediate early gene expression in the suprachiasmatic nucleus are attenuated in old C3H/HeN mice. Brain Res 1997; 747: 34-42.
61. Zhang Y, Kornhauser JM, Zee PC, et al. Effects of aging on light-induced phase-shift ing of circadian behavioral rhythms, fos expression and CREB phosphorylation in the hamster suprachiasmatic nucleus. Neuroscience 1996; 70: 951-61.
62. Antoniadis EA, Ko CH, Ralph MR, McDonald RJ. Circadian rhythms, aging and memory. Behav Brain Res 2000; 114: 221-33.
63. Ralph MR, Mrosovsky N. Behavioral inhibition of circadian responses to light. J Biol Rhythms 1992; 7: 353-9.
64. Penev PD, Zee PC, Wallen EP, Turek FW. Aging alters the phase-resetting properties of a serotonin agonist on hamster circadian rhythmicity. Am J Physiol 1995; 268: R293-8.
65. Van Reeth O, Zhang Y, Reddy A, Zee P, Turek FW. Aging alters the entraining effects of an activity-inducing stimulus on the circadian clock. Brain Res 1992; 607: 286-92.
66. Van Reeth O, Zhang Y, Zee PC, Turek FW. Graft ing fetal suprachiasmatic nuclei in the hypothalamus of old hamsters restores responsiveness of the circadian clock to a phase shift ing stimulus. Brain Res 1994; 643: 338-42.
67. Van Reeth O, Weibel L, Olivares E, et al. Melatonin or a melatonin agonist corrects age-related changes in circadian response to environmental stimulus. Am J Physiol 2001; 280: R1582-91.
68. Weibel L, Turek FW, Mocaer E, Van Reeth O. A melatonin agonist facilitates circadian resynchronization in old hamsters aft er abrupt shift s in the light-dark cycle. Brain Res 2000; 880: 207-11.
69. Monk TH. Circadian rhythm. Clin Geriatric Med 1989; 5: 331-46.
70. Aschoff, J. On the aging of circadian systems. In Hiroshige T, Honma K, eds. Evolution of Circadian Clock. Sapporo: Hokkaido University Press; 1994: pp. 23-45.
71. Aujard F, Dkhissi-Benyahya O, Fournier I, et al. Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus. Neuroscience 2001; 105: 403-12. 7 4. Possidente B, McEldowney S, Pabon A. Aging lengthens circadian period for wheel-running activity C57BL mice. Physiol Behav 1995; 57: 575-9.
72. Sharma VK, Chandrashekaran MK. Age-dependent modulation of circadian parameters in the field mouse Mus booduga. J Exp Zool 1998; 280: 321-6.
73. Czeisler CA, Duffy JF, Shanahan TL, et al. Stability, precision, and near 24 h period of human circadian pacemaker. Science 1999; 284: 2177-81.
74. Asai M, Ikeda M, Akiyama M, Ohima I, Shibata S. Administration of melatonin in drinking water promotes the phase-advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8. Brain Res 2000; 876: 220-4.
75. Duffy JF, Viswanathan N, Davis FC. Free-running circadian period does not shorten with age in female Syrian hamsters. Neurosci Lett 1999; 271: 77-80.
76. Witting W, Mirmiran M, Bos NP, Swaab DF. The effect of old age on the free-running period of circadian rhythms in rat. Chronobiol Int 1994; 11: 103-12.
77. Kendall AR, Lewy AJ, Sack RL. Effects of aging on the intrinsic circadian period of totally blind humans. J Biol Rhythms 2001; 16: 87-95.
78. Van Someren EJW, Hagebeuk EEO, Lijzenga C, et al. Circadian rest-activity rhythm disturbances in Alzheimer's disease. Biol Psychiatry 1996; 40: 259-70.
79. Van Someren EJW, Swaab DF, Colenda CC, et al. Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods. Chronobiol Int 1999; 16: 505-18.
80. Monk TH, Reynolds CF 3rd, Machen MA, Kupfer DJ. Daily social rhythms in the elderly and their relation to objectively recorded sleep. Sleep 1992; 15: 322-9.
81. Minors DS, Waterhouse JM. The role of naps in alleviating sleepiness during an irregular sleep-wake schedule. Ergonomics 1987; 30: 1261-73.
82. Manber R, Bootzin RR, Acebo C, Carskadon MA. The effects of regularizing sleep-wake schedules on daytime sleepiness. Sleep 1996; 19: 432-41.
83. Cho K. Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits. Nat Neurosci 2001; 4: 567-8.
84. Van Someren EJW. Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits. Sleep Med 2002; 3: 81-2.
85. Van Someren EJW, Riemersma RF, Swaab DF. Functional plasticity of the circadian timing system in old age: light exposure. Prog Brain Res 2002; 138: 205-31.
86. Van Someren EJW, Kessler A, Mirmiran M, Swaab DF. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol Psychiatry 1997; 41: 955-963. 9 0. A bbott A. R estless nights, listless days. N ature 2003; 425: 896-8.
87. Vitiello MV, Smallwood RG, Avery DH, et al. Circadian temperature rhythms in young adult and aged men. Neurobiol Aging 1986; 7 (2): 97-100.
88. van Gool WA, Witting W, Mirmiran M. Age-related changes in circadian sleep-wakefulness rhythms in male rats isolated from time cues. Brain Res 1987; 413: 384-7.
89. Sloan EP, Flint AJ, Reinish L, Shapiro CM. Circadian rhythms and psychiatric disorders in the elderly. J Geriatr Psychiatry Neurol 1996; 9: 164-70.
90. Monk TH, Buysse DJ, Rose LR, Hall JA, Kupfer DJ. The sleep of healthy people- a diary study. Chronobiol Int 2000; 17: 49-60.
91. Van Hoof J, Aarts MPJ, Rense CG, Schoutens AMC. Ambient bright light in dementia: effects on behaviour and circadian rhythmicity. Building Environment 2009; 44: 146-55.
92. Carvalho-Bos SS, Riemersma RF, Waterhouse J, Reilly T, Van Someran EJW. Strong association of the rest-activity rhythm with well-being in demented elderly women. Am J Geriatr Psychiatry 2007; 15: 92-100.
93. Weinert D, Weinert H. The relative Zeitgeber strength of lights-on and lights-offis changed in old mice. Chronobiol Int 2003; 20: 405-16.
94. Miyamoto M. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10. Exp Gerontol 1997; 32: 139-48.
95. Driver C. The circadian clock in old Drosophila melanogaster. Biogerontology 2000; 1: 157-62.
96. Oster H, Baeriswyl S, Van Der Horst GT, Albrecht U. Loss of circadian rhythmicity in aging mPer1-/- mCry2-/- mutant mice. Genes Dev 2003; 17: 1366-79.
97. Jagota A, Kalyani D. Daily serotonin rhythms in rat brain during postnatal development and aging. Biogerontology 2008; 9: 229-34.
98. Kunieda T, Minamino T, Miura K, et al. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res 2008; 102: 607-14.
99. Pang KC, Miller JP, McAuley JD. Circadian rhythms in SAMP8: a longitudinal study of the effects of age and experience. Neurobiol Aging 2004; 25: 111-23.
100. Harper DG, Volicer L, Stopa EG, et al. Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry 2005; 13: 359-68. 1 05. Martin JR, Fuchs A, Bender R, Harting J. Altered light/dark activity difference with aging in two rat strains. J Gerontol 1986; 41: 2-7.
101. Dawson KA, Crowne DP, Richardson CM, Anderson E. Effects of age on nocturnal activity rhythms in rats. Prog Clin Biol Res 1987; 227B: 107-10.
102. Duffy PH, Feuers RJ, Pipkin JL, Turturro A, Hart RW. Age and temperature related changes in behavioral and physiological performance in the Peromyscus leucopus mouse. Mech Ageing Dev 1997; 95: 43-61.
103. Huang YL, Liu RY, Wang QS, et al. Age-associated difference in circadian sleep-wake and rest-activity rhythms. Physiol Behav 2002; 76: 597-603.
104. Huitron-Resendiz S, Sanchez-Alavez M, Gallegos R, et al. Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice. Brain Res 2002; 928: 126-37.
105. Perret M, Aujard F. Aging and biological rhythms in primates. Med Sci (Paris) 2006; 22: 279-83.
106. Sanchez-Barcelo EJ, Megias M, Verduga R, Crespo D. Differences between the circadian system of two strains of senescence-accelerated mice (SAM). Physiol Behav 1997; 62: 1225-9.
107. Kopp C, Ressel V, Wigger E, Tobler I. Influence of estrus cycle and ageing on activity patterns in two inbred mouse strains. Behav Brain Res 2006; 167: 165-74.
108. Buresova M, Benesova O, Illnerova H. Aging alters resynchronization of the circadian system in rats aft er a shift of the light-dark cycle. Experientia 1990; 46: 75-7.
109. Duffy JF, Czeisler CA. Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans. Neurosci Lett 2002; 318: 117-20.
110. Mayeda AR, Hofstetter JR, Possidente B. Aging lengthens TauDD in C57BL/6J, DBA/2J, and outbred SWR male mice (Mus musculus). Chronobiol Int 1997; 14: 19-23.
111. Yoon IY, Kripke DF, Elliott JA, et al. Age-related changes of circadian rhythms and sleep-wake cycles. J Am Geriatr Soc 2003; 51: 1085-91.
112. Kripke DF, Elliott JA, Youngstedt SD, Rex KM. Circadian phase response curves to light in older and young women and men. J Circadian Rhythms 2007; 5: 4.
113. Janvier B, Testu F. Age-related differences in daily attention patterns in preschool, kindergarten, first-grade, and fift h-grade pupils. Chronobiol Int 2007; 24: 327-43.
114. Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Circadian phase resetting in older people by ocular bright light exposure. J Investig Med 2001; 49: 30-40.
115. Benloucif S, Green K, L'Hermite-Baleriaux M, et al. Responsiveness of the aging circadian clock to light. Neurobiol Aging 2006; 27: 1870-9.
116. Aujard F, Cayetanot F, Terrien J, Van Someren EJW. Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate. Exp Gerontol 2007; 42: 1079-87.
117. Davidson AJ, Yamazaki S, Arble DM, Menaker M, Block GD. Resetting of central and peripheral circadian oscillators in aged rats. Neurobiol Aging 2008; 29: 471-77.
118. Penev PD, Turek FW, Wallen EP, Zee PC. Aging alters the serotonergic modulation of light-induced phase advances in golden hamsters. Am J Physiol 1997; 272: R509-13.
119. Duffy JF, Zeitzer JM, Czeisler CA. Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects. Neurobiol Aging 2007; 28: 799-807.
120. Kowal M, Buda-Lewandowska D, Płytycz B, Styrna J. Day/night food consumption in mice is strain and age-dependent. Folia Biol (Krakow) 2002; 50: 1-3.
121. Kavaliers M, Hirst M. Aging and day-night rhythms in feeding in mice: effects of the putative sigma opiate agonist, N-allylnormetazocine (SKF-10,047). Neurobiol Aging 1986; 7: 179-83.
122. Baehr EK, Eastman CI, Revelle W, et al. Circadian phase-shift ing effects of nocturnal exercise in older compared with young adults. Am J Physiol Regul Integr Comp Physiol 2003; 284: R1542-50.
123. Stupfel M, Gourlet V, Court L. Effects of aging on circadian and ultradian respiratory rhythms of rats synchronized by an LD12:12 lighting (L=100 lx). Gerontology 1986; 32: 81-90.
124. Li H, SatinoffE. Changes in circadian rhythms of body temperature and sleep in old rats. Am J Physiol 1995; 269: R208-14.
125. Weinert D, Waterhouse J. Daily activity and body temperature rhythms do not change simultaneously with age in laboratory mice. Physiol Behav 1999; 66: 605-12.
126. Weinert D, Waterhouse J. The circadian rhythm of core temperature: effects of physical activity and aging. Physiol Behav 2007; 90: 246-56.
127. Zeitzer JM, Duffy JF, Lockley SW, Dijk DJ, Czeisler CA. Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake. Sleep 2007; 30: 1437-43.
128. Sletvold O, Laerum OD. Multipotent stem cell (CFU-S) numbers and circadian variations in aging mice. Eur J Haematol 1988; 41: 230-6. 1 34. Sletvold O, Laerum OD, Riise T. Age-related differences and circadian and seasonal variations of myelopoietic progenitor cell (CFU-GM) numbers in mice. Eur J Haematol 1988; 40: 42-9.
129. Barbeito CG, Surur JM, Badran AF. Mitotic activity of the pars intermedia in the female mouse: age-associated variations in proliferation rate and circadian periodicity. Chronobiol Int 2000; 17: 751-6.
130. Pav E, Bubna-Littiz H, Skalicky M, Hofecker G. Circadian studies with young and old rats. Aktuelle Gerontol 1981; 11: 12-6.
131. Sei H, Sano A, Ohno H, et al. Age-related changes in control of blood pressure and heart rate during sleep in the rat. Sleep 2002; 25: 279-85.
132. Shibata S, Minamoto Y, Ono M, Watanabe S. Age-related impairment of food anticipatory locomotor activity in rats. Physiol Behav 1994; 55: 875-8.
133. Mistlberger RE, Houpt TA, Moore-Ede MC. Effects of aging on food-entrained circadian rhythms in the rat. Neurobiol Aging 1990; 11: 619-24.
134. McAuley JD, Miller JP, Beck E, Nagy ZM, Pang KC. Age-related disruptions in circadian timing: evidence for "split" activity rhythms in the SAMP8. Neurobiol Aging 2002; 23: 625-32.
135. McAuley JD, Miller JP, Pang KC. Age-related changes in the spontaneous motor rhythms of the senescence-accelerated mouse (SAMP8). Exp Aging Res 2004; 30: 113-27.
136. Harma MI, Ilmarinen JE. Towards the 24-hour society-new approaches for aging shift workers? Scand J Work Environ Health 1999; 25: 610-5.
137. Chan G, Tan V, Koh D. Ageing and fitness to work. Occup Med (Lond) 2000; 50: 483-91.
138. Costa G. Work capacity and aging. Med Lav 2000; 91: 302-12.
139. Costa G, Sartori S. Ageing, working hours and work ability. Ergonomics 2007; 50: 1914-30.
140. Bohle P, Di Milia L, Fletcher A, Rajaratnam S. Introduction: aging and the multifaceted influences on adaptation to working time. Chronobiol Int 2008; 25: 155-64.
141. Costa G, Di Milia L. Aging and shift work: a complex problem to face. Chronobiol Int 2008; 25: 165-81.
142. Gander P, Signal L. Who is too old for shift work? Developing better criteria. Chronobiol Int 2008; 25: 199-213.
143. Kecklund G, Eriksen CA, Akerstedt T. Police officers attitude to different shift systems: association with age, present shift schedule, health and sleep/wake complaints. Appl Ergon 2008; 39: 565-71.
144. Asai M, Yoshinobu Y, Kaneko S, et al. Circadian profile of Per gene mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, and pineal body of aged rats. J Neurosci Res 2001; 66: 1133-9.
145. Antoch MP, Gorbacheva VY, Vykhovanets O, et al. Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 2008; 7: 1197-204.
146. Zhdanova IV, Yu L, Lopez-Patino M, et al. Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance. Brain Res Bull 2008; 75: 433-41.
147. Yamazaki S, Straume M, Tei H, et al. Effects of aging on central and peripheral mammalian clocks. Proc Natl Acad Sci USA 2002; 99: 10 801-6.
148. Weinert H, Weinert D, Schurov I, Maywood ES, Hastings MH. Impaired expression of the mPer2 circadian clock gene in the suprachiasmatic nuclei of aging mice. Chronbiol Int 2001; 18: 559-65.
149. Kolker DE, Fukuyama H, Huang DS, et al. Aging alters circadian and light-induced expression of clock genes in golden hamsters. J Biol Rhythms 2003; 18: 159-69.
150. Claustrat F, Fournier I, Geelen G, et al. Aging and circadian clock gene expression in peripheral tissues in rats. Pathol Biol (Paris) 2005; 53: 257-60.
151. Sitzmann BD, Lemos DR, Ottinger MA, Urbanski HF. Effects of age on clock gene expression in the rhesus macaque pituitary gland. Neurobiol Aging 7 July 2008 [Epub ahead of print].
152. Cai A, Wise PM. Age-related changes in light-induced Jun-B and Jun-D expression: effects of transplantation of fetal tissue containing the suprachiasmatic nucleus. J Biol Rhythms 1996; 11: 284-90.
153. Cai A, Wise PM. Age-related changes in the diurnal rhythm of CRH gene expression in the paraventricular nuclei. Am J Physiol 1996; 270: E238-43.
154. Servillo G, Della Fazia MA, Viola-Magni M. Tyrosine aminotransferase gene regulation during aging. Arch Gerontol Geriatr 1992; 15 (Suppl 1): 339-47.
155. Kolker DE, Vitaterna MH, Fruechte EM, Takahashi JS, Turek FW. Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice. Neurobiol Aging 2004; 25: 517-23.
156. Xue Q, Hou J. Age-related change of synaptic number in the suprachiasmatic nucleus of the rat hypothalamus. Hua Xi Yi Ke Da Xue Xue Bao 1992; 23: 160-3.
157. Xue Q, Hou J, Li Y. Age-related morphological changes in the suprachiasmatic nucleus of the rat hypothalamus. Hua Xi Yi Ke Da Xue Xue Bao 1992; 23: 314-7. 1 64. Watanabe A, Shibata S, Watanabe S. Circadian rhythm of spontaneous neuronal activity in the suprachiasmatic nucleus of old hamsters in vitro. Brain Res 1995; 695: 237-39.
158. Aujard F, Herzog ED, Block GD. Circadian rhythms in firing rate of individual suprachiasmatic nucleus neurons from adult and middle aged mice. Neuroscience 2001; 106: 255-61.
159. Nygard M, Hill RH, Wikstrom MA, Kristensson K. Age-related changes in electrophysiological properties of the mouse suprachiasmatic nucleus in vitro. Brain Res Bull 2005; 65: 149-54.
160. Von Gall C, Weaver DR. Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus. Neurobiol Aging 2008; 29: 464-70.
161. Kalamatianos T, Kallo I, Coen CW. Ageing and the diurnal expression of the mRNAs for vasopressin and for the V1a and V1b vasopressin receptors in the suprachiasmatic nucleus of male rats. J Neuroendocrinol 2004; 16: 493-501.
162. Kallo I, Kalamatianos T, Piggins HD, Coen CW. Ageing and the diurnal expression of mRNAs for vasoactive intestinal peptide and for the VPAC2 and PAC1 receptors in the suprachiasmatic nucleus of male rats. J Neuroendocrinol 2004; 16: 758-66.
163. Bentivoglio M, Deng XH, Nygard M, Sadki A, Kristensson K. The aging suprachiasmatic nucleus and cytokines: functional, molecular, and cellular changes in rodents. Chronobiol Int 2006; 23: 437-49.
164. Palomba M, Nygard M, Florenzano F, et al. Decline of the presynaptic network, including GABAergic terminals, in the aging suprachiasmatic nucleus of the mouse. J Biol Rhythms 2008; 23: 220-31.
165. Nygard M, Palomba M. The GABAergic network in the suprachiasmatic nucleus as a key regulator of the biological clock: does it change during senescence? Chronobiol Int 2006; 23: 427-35.
166. Semo M, Peirson S, Lupi D, et al. Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci 2003; 17: 1793-801.
167. Basso A, Piantanelli L. Influence of age on circadian rhythms of adrenoceptors in brain cortex, heart and submandibular glands of BALB/c mice: when circadian studies are not only useful but necessary. Exp Gerontol 2002; 37: 1441-50.
168. Jenni-Eiermann S, von Hahn HP, Honegger CG. Circadian variations of neurotransmitter binding in three age groups of rats. Gerontology 1985; 31: 138-49.
169. Richter V, Rassoul F, Rotzsch W. Circadian rhythm and aging. Z Gesamte Inn Med 1980; 35: 119-23.
170. Pazo D, Cardinali DP, Cano P, Reyes Toso CA, Esquifino AI. Age-related changes in 24-hour rhythms of norepinephrine content and serotonin turnover in rat pineal gland: effect of melatonin treatment. Neurosignals 2002; 11: 81-7.
171. Cano P, Cardinali DP, Spinedi E, Esquifino AI. Effect of aging on 24-hour pattern of stress hormones and leptin in rats. Life Sci 2008; 83: 142-8.
172. Jean-Faucher C, Berger M, de Turckheim M, Veyssiere G, Jean C. Circadian variations in plasma LH and FSH in juvenile and adult male mice. Horm Res 1986; 23: 185-92.
173. Feuers RJ, Delongchamp RR, Kramer S, Scheving LE, Casciano DA. The effect of age on the circadian rhythms of 23 liver or brain enzymes from C57BL/6J mice. Gerontology 1985; 31: 46-53.
174. Labunets IF. Age-related changes in circadian and circannual fluctuations of the immune response and the number of cells in lymphoid organs of animals: a possible connection to thymic factors. Fiziol Zh 2001; 47: 54-62.
175. Desarnaud F, Murillo-Rodriguez E, Lin L, et al. The diurnal rhythm of hypocretin in young and old F344 rats. Sleep 2004; 27: 851-6.
176. Murillo-Rodriguez E, Blanco-Centurion C, Gerashchenko D, Salin-Pascual RJ, Shiromani PJ. The diurnal rhythm of adenosine levels in the basal forebrain of young and old rats. Neuroscience 2004; 123: 361-70.
177. Duncan MJ, Grear KE, Hoskins MA. Aging and SB-269970-A, a selective 5-HT7 receptor antagonist, attenuate circadian phase advances induced by microinjections of serotonergic drugs in the hamster dorsal raphe nucleus. Brain Res 2004; 15: 40-8.
178. Cervenka S, Halldin C, Farde L. Age-related diurnal effect on D2 receptor binding: a preliminary PET study. Int J Neuropsychopharmacol 2008; 11: 671-8.
179. Duncan MJ, Davis FC. Developmental appearance and age related changes in specific 2-[125I] iodomelatonin binding sites in the suprachiasmatic nuclei of female Syrian hamsters. Brain Res Dev Brain Res 1993; 73: 205-12.
180. Cayetanot F, Deprez J, Aujard F. Calbindin D28K protein cells in a primate suprachiasmatic nucleus: localization, daily rhythm and age-related changes. Eur J Neurosci 2007; 26: 2025-32.
181. Iwahana E, Hamada T, Uchida A, Shibata S. Differential effect of lithium on the circadian oscillator in young and old hamsters. Biochem Biophys Res Commun 2007; 354: 752-6.
182. Yoshimura A, Masui A, Jinde S, et al. Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus aft er corticosterone exposure. Brain Res Bull 2007; 73: 254-8. 1 90. Ferrari E, Mirani M, Barili L, et al. Cognitive and affective disorders in the elderly: a neuroendocrine study. Arch Gerontol Geriatr Suppl 2004; 9: 171-82.
183. Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA 2000; 284: 861-8.
184. Copinschi G, Van Cauter E. Effects of aging on modulation of hormonal secretions by sleep and circadian rhythmicity. Horm Res 1995; 43: 20-4.
185. Copinschi G, Leproult R, Van Cauter E. Sleep and hormonal rhythms in humans. In Hof PR, Mobbs CV, eds. Functional Neurobiology of Aging. San Diego, CA: Academic Press; 2001: pp. 855-68.
186. Pierpaoli W, Regelson W. Pineal control of aging: effect of melatonin and pineal graft ing on aging mice. Proc Natl Acad Sci USA 1994; 91: 787-91.
187. Lesnikov VA, Pierpaoli W. Pineal cross-transplantation (old-to-young and vice versa) as evidence for an endogenous " aging clock". Ann N Y Acad Sci 1994; 719: 456-60.
188. Humbert W, Pevet P. The pineal gland of the aging rat: calcium localization and variation in the number of pinealocytes. J Pineal Res 1995; 18: 32-40.
189. Reuss S, Spies C, Schroder H, Vollrath L. The aged pineal gland: reduction in pinealocyte number and adrenergic innervation in male rats. Exp Gerontol 1990; 25: 183-8.
190. Schmidt RE, Dorsey DA, Parvin CA, Beaudet LN. Sympathetic neuroaxonal dystrophy in the aged rat pineal gland. Neurobiol Aging 2006; 27: 1514-23.
191. Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP. Melatonin and sleep in aging populations. Exp Gerontol 2005; 40: 911-25.
192. Garau C, Aparicio S, Rial RV, Nicolau MC, Esteban S. Age-related changes in circadian rhythm of serotonin synthesis in ring doves: effects of increased tryptophan ingestion. Exp Gerontol 2006; 41: 40-8.
193. Hauger RL, Th rivikraman KV, Plotsky PM. Agerelated alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats. Endocrinology 1994; 134: 1528-36.
194. Dalm S, Enthoven L, Meijer OC, et al. Age-related changes in hypothalamic-pituitary-adrenal axis activity of male C57BL/6J mice. Neuroendocrinology 2005; 81: 372-80.
195. Pivina SG, Akulova VK, Ordyan NE. Changed activity of the hypothalamic-pituitary-adrenocortical system in prenatally stressed female rat during aging. Bull Exp Biol Med 2007; 143: 740-3.
196. Cizza G, Gold PW, Chrousos GP. Aging is associated in the 344/N Fischer rat with decreased stress responsivity of central and peripheral catecholaminergic systems and impairment of the hypothalamic-pituitary-adrenal axis. Ann N Y Acad Sci 1995; 771: 491-511.
197. Ferrari E, Arcaini A, Gornati R, et al. Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. Exp Gerontol 2000; 35: 1239-50.
198. Goncharova ND, Oganyan TE, Smelkova SA. Effect of aging on stress reactivity of the adrenal cortex in laboratory primates: dependence on the time of day. Bull Exp Biol Med 2006; 141: 368-71.
199. Goncharova ND, Shmaliy AV, Marenin VY, Smelkova SA. Hypothalamic-pituitary-adrenal system and enzymes of the glutathione-dependent antioxidant system during stress and aging. Bull Exp Biol Med 2007; 144: 730-3.
200. Goncharova ND, Shmaliy AV, Marenin VY, Smelkova SA, Lapin BA. Circadian and age-related changes in stress responsiveness of the adrenal cortex and erythrocyte antioxidant enzymes in female rhesus monkeys. J Med Primatol 2008; 37: 229-38.
201. Fowler CG, Torre P 3rd, Kemnitz JW. Effects of caloric restriction and aging on the auditory function of rhesus monkeys (Macaca mulatta): The University of Wisconsin Study. Hear Res 2002; 169:24-35.
202. Urbanski HF, Downs JL, Garyfallou VT, et al. Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaques. Ann N Y Acad Sci 2004; 1019: 443-7.
203. Mattison JA, Black A, Huck J, et al. Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiol Aging 2005; 26: 1117-27.
204. Downs JL, Mattison JA, Ingram DK, Urbanski HF. Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol Aging 2008; 29: 1412-22.
205. Froy O, Miskin R. The interrelations among feeding, circadian rhythms and ageing. Prog Neurobiol 2007; 82: 142-50.
206. Jimenez AJ, Garcia-Fernandez JM, Gonzalez B, Foster RG. The spatio-temporal pattern of photoreceptor degeneration in the aged rd/rd mouse retina. Cell Tissue Res 1996; 284: 193-202.
207. Mrosovsky N, Th ompson S. Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during aging. Vision Res 2008; 48: 1270-3.
208. Kida T, Liu JH, Weinreb RN. Effects of aging on corneal biomechanical properties and their impact on 24-hour measurement of intraocular pressure. Am J Ophthalmol 2008; 146: 567-72. 2 17. Daszuta A, Gambarelli F, Ternaux JP. Sleep variations in C57BL and BALBc mice from 3 weeks to 14 weeks of age. Brain Res 1983; 283: 87-96.
209. Van Gool WA, Witting W, Mirmiran M. Age-related changes in circadian sleep-wakefulness rhythms in male rats isolated from time cues. Brain Res 1987; 413: 384-87.
210. Naylor E, Buxton OM, Bergmann BM, et al. Effects of aging on sleep in the golden hamster. Sleep 1998; 21: 687-93.
211. Dijk DJ, Duffy JF. Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics. Ann Med 1999; 31: 130-40.
212. Mendelson WB, Bergmann BM. Age-related changes in sleep in the rat. Sleep 1999; 22: 145-50.
213. Dijk DJ, Duffy JF, Czeisler CA. Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep. Chronobiol Int 2000; 17: 285-311.
214. Dijk DJ, Duffy JF, Czeisler CA. Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phases. Sleep. 2001; 24: 565-77.
215. Colas D, Cespuglio R, Sarda N. Sleep wake profile and EEG spectral power in young or old senescence accelerated mice. Neurobiol Aging 2005; 26: 265-73.
216. Knoblauch V, Munch M, Blatter K, et al. Age-related changes in the circadian modulation of sleep-spindle frequency during nap sleep. Sleep 2005; 28: 1093-101.
217. Yang CK, Kim JK, Patel SR, Lee JH. Age-related changes in sleep/wake patterns among Korean teenagers. Pediatrics 2005; 115 (Suppl. 1): 250-6.
218. Ancoli-Israel S, Ayalon L. Diagnosis and treatment of sleep disorders in older adults. Am J Geriatr Psychiatry 2006; 14: 95-103.
219. Koh K, Evans JM, Hendricks JC, Sehgal A. A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci USA 2006; 103: 13 843-7.
220. Spencer RM, Gouw AM, Ivry RB. Age-related decline of sleep-dependent consolidation. Learn Mem 2007; 14: 480-4.
221. Misra S, Malow BA. Evaluation of sleep disturbances in older adults. Clin Geriatr Med 2008; 24: 15-26.
222. Kripke DF, Youngstedt SD, Elliott JA, et al. Circadian phase in adults of contrasting ages. Chronobiol Int 2005; 22: 695-709.
223. Walcott EC, Tate BA. Entrainment of aged, dysrhythmic rats to restricted feeding schedule. Physiol Behav 1996; 60: 1205-8.
224. Malatesta M, Baldelli B, Battistelli S, Fattoretti P, Bertoni-Freddari C. Aging affects the distribution of the circadian CLOCK protein in rat hepatocytes. Microsc Res Tech 2005; 68: 45-50.
225. Malatesta M, Fattoretti P, Baldelli B, et al. Effects of ageing on the find distribution of the circadian CLOCK protein in reticular formation neurons. Histochem Cell Biol 2007; 27: 641-7.