The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors

British Journal of Pharmacology

Volumn 171, Issue 23, 2014, Pages 5446-5457

  Li, P ^a   Bracamontes, J R ^a   Manion, B D ^a   Mennerick, S ^a   Steinbach, J H ^a   Evers, A S ^a   Akk, G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1BETA2GAMMA2L; ELTANOLONE; ETOMIDATE; HYDROCORTISONE; PENTOBARBITAL; PROPOFOL; UNCLASSIFIED DRUG; HYPNOTIC SEDATIVE AGENT;

ADRENAL CORTEX CELL; ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; EC50; ELECTROPHYSIOLOGY; GABAERGIC SYSTEM; HEK293 CELL LINE; HORMONE INHIBITION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; RIGHTING REFLEX; SEDATION; STEROIDOGENESIS; TADPOLE; WHOLE CELL; XENOPUS; ANIMAL; ANIMAL BEHAVIOR; BAGG ALBINO MOUSE; CELL LINE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; XENOPUS LAEVIS;

ANIMALS; BEHAVIOR, ANIMAL; CELL LINE; DRUG SYNERGISM; ETOMIDATE; HEK293 CELLS; HUMANS; HYDROCORTISONE; HYPNOTICS AND SEDATIVES; MICE, INBRED BALB C; PREGNANOLONE; RATS; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 84925938748     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12861     Document Type: Article

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