Thiopental is a competitive inhibitor at the human nicotinic acetylcholine receptor α7 nicotinic acetylcholine receptor

Anesthesia and Analgesia

Volumn 92, Issue 4, 2001, Pages 930-933

  Coates, Kristen Marie ^a   Mather, Lawrence Edward ^a   Johnson, Raymond ^a   Flood, Pamela ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINIC RECEPTOR; THIOPENTAL;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENANTIOMER; HUMAN; MEMBRANE POTENTIAL; PRIORITY JOURNAL; RIGHTING REFLEX;

EID: 0035087117     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200104000-00026     Document Type: Article

References (18)

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7. Anesthetic potency and acute toxicity of optically active disubstituted barbituric acids
8. Pharmacological comparison of R(+), S(-) and racemic thiopentone in mice
9. Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure
10. pA, a new scale for the measurement of drug antagonism
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14. Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected
15. Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics
16. Electroencephalographic effects of thiopentone and its enantiomers in the rat: Correlation with drug tissue distribution
17. Pentobarbital: Stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neurons
18. Stereoselective interaction of thiopentone enantiomers with the GABA(A) receptor