The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia

Neuropharmacology

Volumn 45, Issue 1, 2003, Pages 57-71

  Belelli, Delia ^a   Muntoni, Anna Lisa ^a   Merrywest, Simon D ^b   Gentet, Luc J ^a   Casula, Anna ^a   Callachan, Helen ^a   Madau, Paola ^a   Gemmell, David K ^c   Hamilton, Niall M ^c   Lambert, Jeremy J ^a   Sillar, Keith T ^b   Peters, John A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Etomidate; GABAA receptor; GABAergic inhibitory synaptic transmission; General anaesthesia

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ETOMIDATE; GLUTAMATE RECEPTOR; ISOPROTEIN; NICOTINIC RECEPTOR; RADIOLIGAND; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG TARGETING; ELECTROPHYSIOLOGY; ENANTIOMER; ENANTIOSELECTIVITY; EVOKED RESPONSE; EXPERIMENTAL MODEL; FEMALE; GABAERGIC SYSTEM; GENERAL ANESTHESIA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LOCOMOTION; MALE; MOUSE; NERVE CELL; NERVE POTENTIAL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUALITATIVE ANALYSIS; RAT; REGULATORY MECHANISM; RIGHTING REFLEX; SWIMMING; TADPOLE; XENOPUS LAEVIS;

EID: 0038178877     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00144-8     Document Type: Article

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