Confocal laser endomicroscopy: A new gold standard for the assessment of mucosal healing in ulcerative colitis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 30, Issue S1, 2015, Pages 85-92

  Macé, Vincent ^a   Ahluwalia, Amrita ^b   Coron, Emmanuel ^a   Le Rhun, Marc ^a   Boureille, Arnaud ^a   Bossard, Céline ^a   Mosnier, Jean François ^a   Matysiak Budnik, Tamara ^a   Tarnawski, Andrzej S ^b  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; Confocal laser endomicroscopy (CLE); COX2; Mitochondrial DNA (mtDNA) mutation; Mucosal healing; Ulcerative colitis

Indexed keywords

CYCLOOXYGENASE 2; FLUORESCEIN; MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; BLOOD; BLOOD VESSEL PERMEABILITY; CLINICAL ARTICLE; COLON MUCOSA; COLONOSCOPY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FEMALE; GOLD STANDARD; HEALING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; INFLAMMATION; INTESTINE BIOPSY; MALE; MICROVASCULATURE; MUCOSAL HEALING; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGENERATION; REMISSION; ULCERATIVE COLITIS; CONFOCAL MICROSCOPY; GASTROINTESTINAL ENDOSCOPY; GENETICS; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; MOLECULAR IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; STANDARDS; WOUND HEALING;

ADULT; AGED; COLITIS, ULCERATIVE; CYCLOOXYGENASE 2; DNA, MITOCHONDRIAL; ENDOSCOPY, GASTROINTESTINAL; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MOLECULAR IMAGING; MUTATION; WOUND HEALING;

EID: 84925936401     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12748     Document Type: Article

References (41)

1. Tarnawski A, Hollander D, Krause WJ, Dabros W, Stachura J, Gergely H. "Healed" experimental gastric ulcers remain histologically and ultrastructurally abnormal. J. Clin. Gastroenterol. 1990; 12 (Suppl. 1): S139-147.
2. Tarnawski A, Stachura J, Krause WJ, Douglass TG, Gergely H. Quality of gastric ulcer healing: a new, emerging concept. J. Clin. Gastroenterol. 1991; 13 (Suppl. 1): S42-47.
3. Arakawa T, Kobayashi K. Quality of ulcer healing-a new concept to rank healed peptic ulcers. Gastroenterol. Jpn. 1993; 28 (Suppl. 5): 158-162.
4. Arakawa T, Watanabe T, Tanigawa T, Tominaga K, Fujiwara Y, Morimoto K. Quality of ulcer healing in gastrointestinal tract: Its pathophysiology and clinical relevance. World J. Gastroenterol. 2012; 18: 4811-4822.
5. Lichtenstein GR, Rutgeerts P. Importance of mucosal healing in ulcerative colitis. Inflamm. Bowel Dis. 2010; 16: 338-346.
6. Mazzuoli S, Guglielmi FW, Antonelli E, Salemme M, Bassotti G, Villanacci V. Definition and evaluation of mucosal healing in clinical practice. Dig. Liver Dis. 2013; 45: 969-977.
7. Peyrin-Biroulet L, Bressenot A, Kampman W. Histologic Remission: The Ultimate Therapeutic Goal in Ulcerative Colitis? Clin. Gastroenterol. Hepatol. 2014; 12: 929-34.e2.
8. Yokoyama K, Kobayashi K, Mukae M, Sada M, Koizumi W. Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis. Gastroenterol. Res. Pract. 2013; doi: 10.1155/2013/192794.
9. Seidelin JB, Coskun M, Nielsen OH. Mucosal healing in ulcerative colitis: pathophysiology and pharmacology. Adv. Clin. Chem. 2013; 59: 101-123.
10. Dave M, Loftus EV Jr. Mucosal healing in inflammatory bowel disease-a true paradigm of success? Gastroenterol. Hepatol. (N Y) 2012; 8: 29-38.
11. Pineton de Chambrun G, Peyrin-Biroulet L, Lémann M, Colombel JF. Clinical implications of mucosal healing for the management of IBD. Nat. Rev. Gastroenterol. Hepatol. 2010; 7: 15-29.
12. Neurath MF, Travis SP. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut 2012; 61: 1619-1635.
13. Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J etal. Infliximab for induction and maintenance therapy for ulcerative colitis. N. Engl. J. Med. 2005; 353: 2462-2476.
14. Colombel JF, Rutgeerts P, Reinisch W, Esser D, Wang Y, Lang Y etal. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011; 141: 1194-1201.
15. Kiesslich R, Goetz M, Lammersdorf K, Schneider C, Burg J, Stolte M etal. Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology 2007; 132: 874-882.
16. Watanabe O, Ando T, Maeda O, Hasegawa M, Ishikawa D, Ishiguro K etal. Confocal endomicroscopy in patients with ulcerative colitis. J. Gastroenterol. Hepatol. 2008; 23 (Suppl 2): S286-290.
17. Li CQ, Xie XJ, Yu T, Gu XM, Zuo XL, Zhou CJ etal. Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy. Am. J. Gastroenterol. 2010; 105: 1391-1396.
18. Neumann H, Vieth M, Atreya R, Grauer M, Siebler J, Bernatik T etal. Assessment of Crohn's disease activity by confocal laser endomicroscopy. Inflamm. Bowel. Dis. 2012; 18: 2261-2269.
19. Kiesslich R, Duckworth CA, Moussata D, Gloeckner A, Lim LG, Goetz M etal. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut 2012; 61: 1146-1153.
20. Kiesslich R, Burg J, Vieth M, Gnaendiger J, Enders M, Delaney P etal. Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo. Gastroenterology 2004; 127: 706-713.
21. Gheonea DI, Cârţână T, Ciurea T, Popescu C, Bădărău A, Săftoiu A. Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies. World J. Gastroenterol. 2011; 17: 21-27.
22. Gheorghe C, Cotruta B, Iacob R, Becheanu G, Dumbrava M, Gheorghe L. Endomicroscopy for assessing mucosal healing in patients with ulcerative colitis. J. Gastrointestin. Liver Dis. 2011; 20: 423-426.
23. Pai R, Soreghan B, Szabo IL, Pavelka M, Baatar D, Tarnawski AS. Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat. Med. 2002; 8: 289-293.
24. Pai R, Nakamura T, Moon WS, Tarnawski AS. Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. FASEB J. 2003; 17: 1640-1647.
25. Ussakli CH, Ebaee A, Binkley J, Brentnall TA, Emond MJ, Rabinovitch PS etal. Mitochondria and tumor progression in ulcerative colitis. J. Natl. Cancer Inst. 2013; 105: 1239-1248.
26. Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D etal. Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proc. Natl. Acad. Sci. U.S.A. 2006; 103: 714-719.
27. Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC etal. Mitochondrial DNA mutations in human colonic crypt stem cells. J. Clin. Invest. 2003; 112: 1351-1360.
28. Musquer N, Coquenlorge S, Bourreille A, Aubert P, Matysiak-Budnik T, des Varannes SB etal. Probe-based confocal laser endomicroscopy: a new method for quantitative analysis of pit structure in healthy and Crohn's disease patients. Dig. Liver Dis. 2013; 45: 487-492.
29. Geboes K, Riddell R, Ost A, Jensfelt B, Persson T, Löfberg R. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut 2000; 47: 404-409.
30. Wright NA, Pike C, Elia G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 1990; 343: 82-85.
31. Tarnawski A, Stachura J, Durbin T, Sarfeh IJ, Gergely H. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats. Gastroenterology 1992; 102: 695-698.
32. Harada S, Nagy JA, Sullivan KA, Thomas KA, Endo N, Rodan GA etal. Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J. Clin. Invest. 1994; 93: 2490-2496.
33. Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q etal. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J. Exp. Med. 2006; 203: 941-951.
34. Pai R, Szabo IL, Soreghan BA, Atay S, Kawanaka H, Tarnawski AS. PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways. Biochem. Biophys. Res. Commun. 2001; 286: 923-928.
35. Capaldi RA. Structure and function of cytochrome c oxidase. Annu. Rev. Biochem. 1990; 59: 569-596.
36. Danese S. Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow. Curr. Opin. Gastroenterol. 2007; 23: 384-389.
37. Dvorak HF, Detmar M, Claffey KP, Nagy JA, van de Water L, Senger DR. Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. Int. Arch. Allergy Immunol. 1995; 107: 233-235.
38. Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E etal. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogen-esis. Gastroenterology 2009; 136: 585-595.
39. Coron E, Mosnier JF, Ahluwalia A, Le Rhun M, Galmiche JP, Tarnawski AS, Matysiak-Budnik T. Colonic mucosal biopsies obtained during confocal endomicroscopy are pre-stained with fluorescein in vivo and are suitable for histologic evaluation. Endoscopy 2012; 44: 148-153.
40. Munjal C, Tyagi N, Lominadze D, Tyagi SC. Matrix metalloproteinase-9 in homocysteine-induced intestinal microvascular endothelial paracellular and transcellular permeability. J. Cell. Biochem. 2012; 113: 1159-1169.
41. Bardin N, Reumaux D, Geboes K, Colombel JF, Blot-Chabaud M, Sampol J etal. Increased expression of CD146, a new marker of the endothelial junction in active inflammatory bowel disease. Inflamm. Bowel Dis. 2006; 12: 16-21.