Quality of ulcer healing in gastrointestinal tract: Its pathophysiology and clinical relevance

World Journal of Gastroenterology

Volumn 18, Issue 35, 2012, Pages 4811-4822

  Arakawa, Tetsuo ^a   Watanabe, Toshio ^a   Tanigawa, Tetsuya ^a   Tominaga, Kazunari ^a   Fujiwara, Yasuhiro ^a   Morimoto, Ken'ichi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytokines; Growth factors; Peptic ulcer disease; Prostaglandin; Quality of ulcer healing; Recurrence

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CIMETIDINE; FAMOTIDINE; HYDROTALCITE; INFLIXIMAB; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LAFUTIDINE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEPRAZOLE; PLACEBO; PROSTACYCLIN; PROSTAGLANDIN E2; RANITIDINE; REBAMIPIDE; SUCRALFATE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; CELL INFILTRATION; CELL PROTECTION; CHROMOENDOSCOPY; CONFOCAL MICROSCOPY; CROHN DISEASE; CYTOKINE PRODUCTION; DIGESTIVE TRACT ENDOSCOPY; DRUG EFFICACY; DUODENUM ULCER; GENE EXPRESSION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MACROPHAGE ACTIVATION; MAGNIFYING ENDOSCOPY; MOLECULAR IMAGING; NARROW BAND IMAGING; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PEPTIC ULCER; QUALITY OF ULCER HEALING; RECURRENT DISEASE; REMISSION; REVIEW; STOMACH ULCER; TH1 TH2 BALANCE; ULCER HEALING; ULCERATIVE COLITIS;

EID: 84867794583     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i35.4811     Document Type: Review

References (48)

1. Arakawa T, Higuchi K, Fujiwara Y, Tominaga K, Watanabe T, Shiba M, Uchida T, Kuroki T. Helicobacter pylori: criminal or innocent bystander? J Gastroenterol 2000; 35 Suppl 12: 42-46
2. Jang HJ, Choi MH, Shin WG, Kim KH, Chung YW, Kim KO, Park CH, Baek IH, Baik KH, Kae SH, Kim HY. Has peptic ulcer disease changed during the past ten years in Korea? A prospective multi-center study. Dig Dis Sci 2008; 53: 1527-1531
3. Musumba C, Jorgensen A, Sutton L, Van Eker D, Moorcroft J, Hopkins M, Pritchard DM, Pirmohamed M. The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. Aliment Pharmacol Ther 2012; 36: 48-56
4. Sbrozzi-Vanni A, Zullo A, Di Giulio E, Hassan C, Corleto VD, Lahner E, Annibale B. Low prevalence of idiopathic peptic ulcer disease: an Italian endoscopic survey. Dig Liver Dis 2010; 42: 773-776
5. Kang JM, Seo PJ, Kim N, Lee BH, Kwon J, Lee DH, Jung HC. Analysis of direct medical care costs of peptic ulcer disease in a Korean tertiary medical center. Scand J Gastroenterol 2012; 47: 36-42
6. Oi M, Oshida K, Sugimura S. The location of gastric ulcer. Gastroenterology 1959; 36: 45-56
7. Pan S, Liao CH. The histological maturity of regenerating mucosa of healed duodenal ulcer and ulcer recurrence after treatment with H2-antagonist. Am J Gastroenterol 1990; 85: 949-952
8. Takagi K, Okabe S, Saziki R. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jpn J Pharmacol 1969; 19: 418-426
9. Tarnawski A, Hollander D, Krause WJ, Dabros W, Stachura J, Gergely H. "Healed" experimental gastric ulcers remain histologically and ultrastructurally abnormal. J Clin Gastroenterol 1990; 12 Suppl 1: S139-S147
10. Tarnawski A, Douglass TG, Stachura J, Krause WJ. Quality of gastric ulcer healing: histological and ultrastructural assessment. Aliment Pharmacol Ther 1991; 5 Suppl 1: 79-90
11. Tarnawski A, Stachura J, Krause WJ, Douglass TG, Gergely H. Quality of gastric ulcer healing: a new, emerging concept. J Clin Gastroenterol 1991; 13 Suppl 1: S42-S47
12. Arakawa T, Kobayashi K. Quality of ulcer healing--a new concept to rank healed peptic ulcers. Gastroenterol Jpn 1993; 28 Suppl 5: 158-162
13. Arakawa T, Nebiki H, Uchida T, Kimura S, Higuchi K, Kobayashi K. Clinical assessment of quality of ulcer healing-a new approach of endoscopic evaluation. Eur J Gastroenterol Hepatol 1993; 5 Suppl 3: S87-S92
14. Nebiki H, Arakawa T, Higuchi K, Kobayashi K. Quality of ulcer healing influences the relapse of gastric ulcers in humans. J Gastroenterol Hepatol 1997; 12: 109-114
15. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979; 77: 433-443
16. Kobayashi K, Arakawa T, Nakamura H, Chono S, Yamada H, Satoh H, Kamata T, Ono T. Protective action of endogenous prostacyclin (PGI2) and prostaglandin E2 (PGE2) in endoscopic polypectomy-induced human ulcers. Gastroenterol Jpn 1982; 17: 430-433
17. Kobayashi K, Arakawa T, Nakamura H, Chono S, Yamada H, Kamata T, Ono T. Role of prostaglandin E2 on human gastric ulcers. Gastroenterol Jpn 1982; 17: 21-24
18. Arakawa T, Watanabe T, Fukuda T, Higuchi K, Takaishi O, Yamasaki K, Kobayashi K, Tarnawski A. Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. Dig Dis Sci 1996; 41: 2055-2061
19. Kobayashi K, Arakawa T. Arachidonic acid cascade and gastric mucosal injury, protection, and healing: topics of this decade. J Clin Gastroenterol 1995; 21 Suppl 1: S12-S17
20. Arakawa T, Higuchi K, Fukuda T, Fujiwara Y, Kobayashi K, Kuroki T. Prostaglandins in the stomach: an update. J Clin Gastroenterol 1998; 27 Suppl 1: S1-11
21. Jones MK, Kawanaka H, Baatar D, Szabó IL, Tsugawa K, Pai R, Koh GY, Kim I, Sarfeh IJ, Tarnawski AS. Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Gastroenterology 2001; 121: 1040-1047
22. Watanabe T, Arakawa T, Fukuda T, Higuchi K, Kobayashi K. Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin-1 beta. Am J Pathol 1997; 150: 971-979
23. Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Matsumoto T, Arakawa T. Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factoralpha. Am J Physiol Gastrointest Liver Physiol 2004; 287: G919-G928
24. Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T. Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1beta. Gut 2001; 48: 774-781
25. Arakawa T, Watanabe T, Fukuda T, Higuchi K, Fujiwara Y, Kobayashi K, Tarnawski A. Ulcer recurrence: cytokines and inflammatory response-dependent process. Dig Dis Sci 1998; 43: 61S-66S
26. Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K. Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. Dig Dis Sci 1995; 40: 2469-2472
27. Arakawa T, Satoh H, Fukuda T, Sakuma H, Nakamura H, Kobayashi K. Gastric mucosal resistance and prostanoid levels after cimetidine treatment in rats. Digestion 1988; 41: 1-8
28. Qi Z, Jie L, Haixia C, Xiaoying Z. Effect of rebamipide on quality of peptic ulcer healing in rat. Dig Dis Sci 2009; 54: 1876-1883
29. Higuchi K, Arakawa T, Nebiki H, Uchida T, Fujiwara Y, Ando K, Yamasaki K, Takaishi O, Fukuda T, Kobayashi K, Kuroki T. Rebamipide prevents recurrence of gastric ulcers without affecting Helicobacter pylori status. Dig Dis Sci 1998; 43: 99S-106S
30. Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig Dis Sci 1998; 43: 5S-13S
31. Arakawa T, Higuchi K, Fujiwara Y, Watanabe T, Tominaga K, Sasaki E, Oshitani N, Yoshikawa T, Tarnawski AS. 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. Dig Dis Sci 2005; 50 Suppl 1: S3-S11
32. Schmassmann A, Tarnawski A, Gerber HA, Flogerzi B, Sanner M, Varga L, Halter F. Antacid provides better restoration of glandular structures within the gastric ulcer scar than omeprazole. Gut 1994; 35: 896-904
33. Tovey FI, Husband EM, Yiu YC, Baker L, McPhail G, Jayaraj AP, Lewin MR, Clark CG. Differences in mucosal appearances and in relapse rates in duodenal ulceration treated with sucralfate or cimetidine. Am J Med 1989; 86: 141-144
34. Higuchi K, Watanabe T, Tominaga K, Shiba M, Nakagawa K, Uno H, Kitada K, Satoh H, Chono S, Oshitani N, Fujiwara Y, Arakawa T. Lafutidine can improve the quality of gastric ulcer healing in humans: a randomized, controlled, multicenter trial. Inflammopharmacology 2006; 14: 226-230
35. Higuchi K, Watanabe T, Tominaga K, Shiba M, Nakagawa K, Uno H, Kitada K, Satoh H, Chono S, Uchida T, Fujiwara Y, Arakawa T. Effects of ranitidine on quality of gastric ulcer healing compared with famotidine: a randomized, controlled, multicenter trial. Int J Clin Pharmacol Res 2005; 25: 187-194
36. Leite MR, Santos SS, Lyra AC, Mota J, Santana GO. Thalidomide induces mucosal healing in Crohn's disease: case report. World J Gastroenterol 2011; 17: 5028-5031
37. Hara J, Ohtani H, Matsumoto T, Nakamura S, Kitano A, Arakawa T, Nagura H, Kobayashi K. Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease: demonstration of cell-to-cell contact with T lymphocytes. Lab Invest 1997; 77: 175-184
38. Kakazu T, Hara J, Matsumoto T, Nakamura S, Oshitani N, Arakawa T, Kitano A, Nakatani K, Kinjo F, Kuroki T. Type T-helper cell predominance in granulomas of Crohn's disease. Am J Gastroenterol 1999; 94: 2149-2155
39. Morimoto K, Hosomi S, Yamagami H, Watanabe K, Kamata N, Sogawa M, Machida H, Okazaki H, Tanigawa T, Nagahara H, Noda E, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T. Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease. Scand J Gastroenterol 2011; 46: 701-709
40. Kawashima D, Oshitani N, Jinno Y, Watanabe K, Nakamura S, Higuchi K, Arakawa T. Augmented expression of secondary lymphoid tissue chemokine and EBI1 ligand chemokine in Crohn's disease. J Clin Pathol 2005; 58: 1057-1063
41. Monteleone I, Sarra M, Pallone F, Monteleone G. Th17-related cytokines in inflammatory bowel diseases: friends or foes? Curr Mol Med 2012; 12: 592-597
42. Hitzler I, Kohler E, Engler DB, Yazgan AS, Müller A. The role of Th cell subsets in the control of Helicobacter infections and in T cell-driven gastric immunopathology. Front Immunol 2012; 3: 142
43. Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. Biochem Biophys Res Commun 2009; 382: 252-258
44. Hosomi S, Oshitani N, Kamata N, Sogawa M, Yamagami H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T. Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease. Inflamm Bowel Dis 2008; 14: 1205-1213
45. Ochi M, Tominaga K, Tanaka F, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T. Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats. Life Sci 2008; 82: 862-868
46. Suekane T, Ikura Y, Watanabe K, Arimoto J, Iwasa Y, Sugama Y, Kayo S, Sugioka K, Naruko T, Maeda K, Hirakawa K, Arakawa T, Ueda M. Phenotypic change and accumulation of smooth muscle cells in strictures in Crohn's disease: relevance to local angiotensin II system. J Gastroenterol 2010; 45: 821-830
47. Oshitani N, Hato F, Suzuki K, Sawa Y, Matsumoto T, Maeda K, Higuchi K, Kitagawa S, Arakawa T. Cross-reactivity of yeast antigens in human colon and peripheral leukocytes. J Pathol 2003; 199: 361-367
48. Tarnawski AS, Coron E, Sandor Z, Mosnier JF, Ahluwalia A, Rhun ML, Galmiche JP, Matysiak-Budnik T. Confocal endomicroscopy and molecular imaging demonstrates in colonic mucosa of patients with IBD in remission impaired crypt regeneration, persistent inflammation and pathological angiogenesis. Underlying mechanisms include dysregulation of survivin and aberrant activation of VEGF gene. Gastroenterology 2010; 138 Suppl 1: S-75