메뉴 건너뛰기




Volumn 45, Issue 12, 2013, Pages 969-977

Definition and evaluation of mucosal healing in clinical practice

Author keywords

Anti TNF ; CD; CDEIS; Endoscopic index of severity; IBD; Inflammation; Inflammatory bowel disease; MH; Mucosal healing; Pathology; SES CD; The Lemann score; UC; UCEIS

Indexed keywords

CLINICAL PRACTICE; CROHN DISEASE; ENDOSCOPY; HEALING; HISTOPATHOLOGY; HOSPITALIZATION; HUMAN; INTESTINE MUCOSA; PRIORITY JOURNAL; QUALITATIVE DIAGNOSIS; QUANTITATIVE DIAGNOSIS; REMISSION; REVIEW; ULCERATIVE COLITIS;

EID: 84887208189     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2013.06.010     Document Type: Review
Times cited : (112)

References (90)
  • 1
    • 34147209958 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target
    • Rutgeerts P., Vermiere S., Assche G.V. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target. Gut 2007, 56:453-455.
    • (2007) Gut , vol.56 , pp. 453-455
    • Rutgeerts, P.1    Vermiere, S.2    Assche, G.V.3
  • 2
    • 79951671131 scopus 로고    scopus 로고
    • Randomised clinical trial: delayed-release oral mesalazine 4.8g/day vs. 2.4g/day in endoscopic mucosal healing-ASCEND I and II combined analysis
    • Lichtenstein G.R., Ramsey D., Rubin D.T. Randomised clinical trial: delayed-release oral mesalazine 4.8g/day vs. 2.4g/day in endoscopic mucosal healing-ASCEND I and II combined analysis. Alimentary Pharmacology and Therapeutics 2011, 33:672-678.
    • (2011) Alimentary Pharmacology and Therapeutics , vol.33 , pp. 672-678
    • Lichtenstein, G.R.1    Ramsey, D.2    Rubin, D.T.3
  • 3
    • 0025219580 scopus 로고
    • Clinical, biological, and endoscopic picture of Latest studies show that images taken with the CLE might offer information equivalent to conventional histology with a good correlation between CLE and histological results attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
    • Modigliani R., Mary J.Y., Simon J.F., et al. Clinical, biological, and endoscopic picture of Latest studies show that images taken with the CLE might offer information equivalent to conventional histology with a good correlation between CLE and histological results attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives. Gastroenterology 1990, 98:811-818.
    • (1990) Gastroenterology , vol.98 , pp. 811-818
    • Modigliani, R.1    Mary, J.Y.2    Simon, J.F.3
  • 4
    • 0032723990 scopus 로고    scopus 로고
    • Endoscopic and histologic healing of Crohn's ileo-colitis with azathioprine
    • D'Haens G., Geboes K., Rutgeerts P. Endoscopic and histologic healing of Crohn's ileo-colitis with azathioprine. Gastrointestinal Endoscopy 1999, 50:667-671.
    • (1999) Gastrointestinal Endoscopy , vol.50 , pp. 667-671
    • D'Haens, G.1    Geboes, K.2    Rutgeerts, P.3
  • 5
    • 34250883817 scopus 로고    scopus 로고
    • MMX Multi Matrix System mesalazine for the induction of remission in patients with mild-to-moderate ulcerative colitis: a combined analysis of two randomized, double-blind, placebo-controlled trials
    • Sandborn W.J., Kamm M.A., Lichtenstein G.R., et al. MMX Multi Matrix System mesalazine for the induction of remission in patients with mild-to-moderate ulcerative colitis: a combined analysis of two randomized, double-blind, placebo-controlled trials. Alimentary Pharmacology and Therapeutics 2007, 26:205-211.
    • (2007) Alimentary Pharmacology and Therapeutics , vol.26 , pp. 205-211
    • Sandborn, W.J.1    Kamm, M.A.2    Lichtenstein, G.R.3
  • 6
    • 79957452795 scopus 로고    scopus 로고
    • Mucosal healing predicts late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitis
    • Ardizzone S., Cassinotti A., Duca P., et al. Mucosal healing predicts late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitis. Clinical Gastroenterology and Hepatology 2011, 9:483-489.
    • (2011) Clinical Gastroenterology and Hepatology , vol.9 , pp. 483-489
    • Ardizzone, S.1    Cassinotti, A.2    Duca, P.3
  • 7
    • 29244457275 scopus 로고    scopus 로고
    • Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis
    • Ardizzone S., Maconi G., Russo A., et al. Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis. Gut 2006, 55:47-53.
    • (2006) Gut , vol.55 , pp. 47-53
    • Ardizzone, S.1    Maconi, G.2    Russo, A.3
  • 9
    • 84862777782 scopus 로고    scopus 로고
    • Adalimumab induces and maintains mucosal healing in patients with Crohn's disease: data from the EXTEND trial
    • 1102e11.e2
    • Rutgeerts P., Van Assche G., Sandborn W.J., et al. Adalimumab induces and maintains mucosal healing in patients with Crohn's disease: data from the EXTEND trial. Gastroenterology 2012, 142. 1102e11.e2.
    • (2012) Gastroenterology , vol.142
    • Rutgeerts, P.1    Van Assche, G.2    Sandborn, W.J.3
  • 10
  • 14
    • 33847179443 scopus 로고    scopus 로고
    • A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis
    • D'Haens G., Sandborn W.J., Feagan B.G., et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007, 132:763-786.
    • (2007) Gastroenterology , vol.132 , pp. 763-786
    • D'Haens, G.1    Sandborn, W.J.2    Feagan, B.G.3
  • 15
    • 0036161216 scopus 로고    scopus 로고
    • A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with Crohn's disease
    • William J., Sandborn W.J., Brian G., et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology 2002, 122:512-530.
    • (2002) Gastroenterology , vol.122 , pp. 512-530
    • William, J.1    Sandborn, W.J.2    Brian, G.3
  • 16
    • 70450164329 scopus 로고    scopus 로고
    • Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease
    • D'Haens G.R., Fedorak R., Lemann M., et al. Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease. Inflammatory Bowel Diseases 2009, 15:1599-1604.
    • (2009) Inflammatory Bowel Diseases , vol.15 , pp. 1599-1604
    • D'Haens, G.R.1    Fedorak, R.2    Lemann, M.3
  • 17
    • 75049083157 scopus 로고    scopus 로고
    • Mucosal healing after initial treatment may be a prognostic marker for long-term outcome in inflammatory bowel disease
    • Solberg I.C., Lygren I., Jahnsen J., Vatn M., Moum B. Mucosal healing after initial treatment may be a prognostic marker for long-term outcome in inflammatory bowel disease. Gut 2008, 57(Suppl. 2):A15.
    • (2008) Gut , vol.57 , Issue.SUPPL. 2
    • Solberg, I.C.1    Lygren, I.2    Jahnsen, J.3    Vatn, M.4    Moum, B.5
  • 18
    • 0003037738 scopus 로고    scopus 로고
    • Endoscopic healing after infliximab treatment for Crohn's disease provides a longer time to relapse
    • D'Haens G., Norman M., Baert F., Hiele M. Endoscopic healing after infliximab treatment for Crohn's disease provides a longer time to relapse. Gastroenterology 2002, 122:100A.
    • (2002) Gastroenterology , vol.122
    • D'Haens, G.1    Norman, M.2    Baert, F.3    Hiele, M.4
  • 19
    • 70350172248 scopus 로고    scopus 로고
    • Mucosal healing predicts long term outcome of maintenance therapy with infliximab in Crohn's disease
    • Schnitzler F., Fidder H., Ferrante M., et al. Mucosal healing predicts long term outcome of maintenance therapy with infliximab in Crohn's disease. Inflammatory Bowel Diseases 2009, 15:1295-1301.
    • (2009) Inflammatory Bowel Diseases , vol.15 , pp. 1295-1301
    • Schnitzler, F.1    Fidder, H.2    Ferrante, M.3
  • 20
    • 34547503869 scopus 로고    scopus 로고
    • Vatn Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort
    • Froslie K.F., Jahnsen J., Moum B.A. Vatn Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 2007, 33:412-422.
    • (2007) Gastroenterology , vol.33 , pp. 412-422
    • Froslie, K.F.1    Jahnsen, J.2    Moum, B.A.3
  • 21
  • 22
    • 77949372602 scopus 로고    scopus 로고
    • Azathioprine, mucosal healing in ulcerative colitis, and the chemoprevention of colitic cancer: a clinical-practice-based forecast
    • Actis G.C., Pellicano R., David E., et al. Azathioprine, mucosal healing in ulcerative colitis, and the chemoprevention of colitic cancer: a clinical-practice-based forecast. Inflammation & Allergy Drug Targets 2010, 9:6e9.
    • (2010) Inflammation & Allergy Drug Targets , vol.9
    • Actis, G.C.1    Pellicano, R.2    David, E.3
  • 23
    • 78650485624 scopus 로고    scopus 로고
    • Management of inflammatory bowel disease with infliximab and other anti-tumor necrosis factor alpha therapies
    • Magro F., Portella F. Management of inflammatory bowel disease with infliximab and other anti-tumor necrosis factor alpha therapies. Bio Drugs 2010, 24(Suppl 1):3-14.
    • (2010) Bio Drugs , vol.24 , Issue.SUPPL 1 , pp. 3-14
    • Magro, F.1    Portella, F.2
  • 24
    • 80053133374 scopus 로고    scopus 로고
    • Results from the 2nd Scientific Workshop of the ECCO (I): impact of mucosal healing on the course of inflammatory bowel disease
    • Peyrin-Biroulet L., Ferrante M., Magro F., et al. Results from the 2nd Scientific Workshop of the ECCO (I): impact of mucosal healing on the course of inflammatory bowel disease. Journal of Crohn's and Colitis 2011, 5:477-483.
    • (2011) Journal of Crohn's and Colitis , vol.5 , pp. 477-483
    • Peyrin-Biroulet, L.1    Ferrante, M.2    Magro, F.3
  • 25
    • 11844282828 scopus 로고    scopus 로고
    • Endoscopy in inflammatory bowel disease: indications, surveillance, and use in clinical practice
    • David S., Fefferman, Farrell Richard J. Endoscopy in inflammatory bowel disease: indications, surveillance, and use in clinical practice. Clinical Gastroenterology and Hepatology 2005, 3:11-24.
    • (2005) Clinical Gastroenterology and Hepatology , vol.3 , pp. 11-24
    • David, S.1    Fefferman, M.D.2    Farrell, R.J.3
  • 26
    • 0024469432 scopus 로고
    • Ultrastructural abnormalities in endoscopically and histologically normal and involved colon in ulcerative colitis
    • Delpre G., Avidor I., Steinherz R., Kadish U., Ben-Bassat M. Ultrastructural abnormalities in endoscopically and histologically normal and involved colon in ulcerative colitis. American Journal of Gastroenterology 1989, 84:1038-1046.
    • (1989) American Journal of Gastroenterology , vol.84 , pp. 1038-1046
    • Delpre, G.1    Avidor, I.2    Steinherz, R.3    Kadish, U.4    Ben-Bassat, M.5
  • 27
    • 79960685513 scopus 로고    scopus 로고
    • Prospective evaluation of the learning curve of confocal laser endomicroscopy in patients with IBD
    • Neumann H., Vieth M., Atreya R., et al. Prospective evaluation of the learning curve of confocal laser endomicroscopy in patients with IBD. Histology and Histopathology 2011, 26:867e72.
    • (2011) Histology and Histopathology , vol.26
    • Neumann, H.1    Vieth, M.2    Atreya, R.3
  • 29
    • 33947317600 scopus 로고    scopus 로고
    • Chromoscopyguided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis
    • Kiesslich R., Goetz M., Lammersdorf K., et al. Chromoscopyguided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology 2007, 132:874e82.
    • (2007) Gastroenterology , vol.132
    • Kiesslich, R.1    Goetz, M.2    Lammersdorf, K.3
  • 30
    • 77953233104 scopus 로고    scopus 로고
    • Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy
    • Li C.Q., Xie X.J., Yu T., et al. Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy. American Journal of Gastroenterology 2010, 105(6):1391-1396.
    • (2010) American Journal of Gastroenterology , vol.105 , Issue.6 , pp. 1391-1396
    • Li, C.Q.1    Xie, X.J.2    Yu, T.3
  • 32
    • 63649130839 scopus 로고    scopus 로고
    • Mucosal vascular pattern in ulcerative colitis: observations using narrow band imaging colonoscopy with special reference to histologic inflammation
    • Kudo T., Matsumoto T., Esaki M., Yao T., Iida M. Mucosal vascular pattern in ulcerative colitis: observations using narrow band imaging colonoscopy with special reference to histologic inflammation. International Journal of Colorectal Disease 2009, 24:495-501.
    • (2009) International Journal of Colorectal Disease , vol.24 , pp. 495-501
    • Kudo, T.1    Matsumoto, T.2    Esaki, M.3    Yao, T.4    Iida, M.5
  • 33
    • 84859773929 scopus 로고    scopus 로고
    • Confocal laser endomicroscopy in the Study of Colonic Mucosa in IBD Patients: a review
    • Salvatori F., Siciliano S., Maione F., et al. Confocal laser endomicroscopy in the Study of Colonic Mucosa in IBD Patients: a review. Gastroenterology Research and Practice 2012, 2012:525098.
    • (2012) Gastroenterology Research and Practice , vol.2012 , pp. 525098
    • Salvatori, F.1    Siciliano, S.2    Maione, F.3
  • 34
    • 33845463326 scopus 로고    scopus 로고
    • Pit patterns in rectal mucosa assessed by magnifying colonoscope are predictive of relapse in patients with quiescent ulcerative colitis
    • Nishio Y., Ando T., Maeda O., et al. Pit patterns in rectal mucosa assessed by magnifying colonoscope are predictive of relapse in patients with quiescent ulcerative colitis. Gut 2006, 55:1768-1773.
    • (2006) Gut , vol.55 , pp. 1768-1773
    • Nishio, Y.1    Ando, T.2    Maeda, O.3
  • 35
    • 0036781083 scopus 로고    scopus 로고
    • Minute findings by magnifying colonoscopy are useful for the evaluation of ulcerative colitis
    • Fujiya M., Saitoh Y., Nomura M., et al. Minute findings by magnifying colonoscopy are useful for the evaluation of ulcerative colitis. Gastrointestinal Endoscopy 2002, 56(4):535-542.
    • (2002) Gastrointestinal Endoscopy , vol.56 , Issue.4 , pp. 535-542
    • Fujiya, M.1    Saitoh, Y.2    Nomura, M.3
  • 36
    • 35348966194 scopus 로고    scopus 로고
    • Magnifying colonoscopy with narrow band imaging system for the diagnosis of dysplasia in ulcerative colitis: a pilot study
    • Matsumoto T., Kudo T., Jo Y., Esaki M., Yao T., Iida M. Magnifying colonoscopy with narrow band imaging system for the diagnosis of dysplasia in ulcerative colitis: a pilot study. Gastrointestinal Endoscopy 2007, 66:957-965.
    • (2007) Gastrointestinal Endoscopy , vol.66 , pp. 957-965
    • Matsumoto, T.1    Kudo, T.2    Jo, Y.3    Esaki, M.4    Yao, T.5    Iida, M.6
  • 37
    • 79960699887 scopus 로고    scopus 로고
    • Colorectal cancer screening in patients with ulcerative and Crohn's colitis with use of colonoscopy, chromoendoscopy and confocal endomicroscopy
    • Hlavaty T., Huorka M., Koller T., et al. Colorectal cancer screening in patients with ulcerative and Crohn's colitis with use of colonoscopy, chromoendoscopy and confocal endomicroscopy. European Journal of Gastroenterology & Hepatology 2011, 23:680-689.
    • (2011) European Journal of Gastroenterology & Hepatology , vol.23 , pp. 680-689
    • Hlavaty, T.1    Huorka, M.2    Koller, T.3
  • 38
    • 48249117836 scopus 로고    scopus 로고
    • Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomized comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions
    • van den Broek F.J., Fockens P., van Eeden S., et al. Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomized comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions. Gut 2008, 57:1083-1089.
    • (2008) Gut , vol.57 , pp. 1083-1089
    • van den Broek, F.J.1    Fockens, P.2    van Eeden, S.3
  • 39
    • 84869224255 scopus 로고    scopus 로고
    • Assessment of Crohn's disease activity by confocal laser endomicroscopy
    • [Published Online First: 16 February 2012]
    • Neumann H., Vieth M., Atreya R., et al. Assessment of Crohn's disease activity by confocal laser endomicroscopy. Inflammatory Bowel Diseases 2012, [Published Online First: 16 February 2012]. 10.1002/ibd.22907.
    • (2012) Inflammatory Bowel Diseases
    • Neumann, H.1    Vieth, M.2    Atreya, R.3
  • 40
    • 84862880940 scopus 로고    scopus 로고
    • Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    • Kiesslich R., Duckworth C.A., Moussata D., et al. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut 2012, 61:114653.
    • (2012) Gut , vol.61 , pp. 114653
    • Kiesslich, R.1    Duckworth, C.A.2    Moussata, D.3
  • 41
    • 84887178348 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCTO1417728.
  • 42
    • 70249118593 scopus 로고    scopus 로고
    • Role of small bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus
    • Bourreille A., Ignjatovic A., Aabakken L., et al. Role of small bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Endoscopy 2009, 41:618-637.
    • (2009) Endoscopy , vol.41 , pp. 618-637
    • Bourreille, A.1    Ignjatovic, A.2    Aabakken, L.3
  • 43
    • 0001607738 scopus 로고
    • Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicenter study. Groupe d'Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID)
    • Mary J.Y., Modigliani R. Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicenter study. Groupe d'Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID). Gut 1989, 30:983-989.
    • (1989) Gut , vol.30 , pp. 983-989
    • Mary, J.Y.1    Modigliani, R.2
  • 44
    • 4744375545 scopus 로고    scopus 로고
    • Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD
    • Daperno M., D'Haens G., Assche G.V., et al. Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointestinal Endoscopy 2004, 60:505-512.
    • (2004) Gastrointestinal Endoscopy , vol.60 , pp. 505-512
    • Daperno, M.1    D'Haens, G.2    Assche, G.V.3
  • 45
    • 33748334337 scopus 로고    scopus 로고
    • Review article: recurrence of Crohn's disease after surgery-the need for treatment of new lesions
    • Rutgeerts P. Review article: recurrence of Crohn's disease after surgery-the need for treatment of new lesions. Alimentary Pharmacology and Therapeutics 2006, 24:29-32.
    • (2006) Alimentary Pharmacology and Therapeutics , vol.24 , pp. 29-32
    • Rutgeerts, P.1
  • 47
    • 0021266269 scopus 로고    scopus 로고
    • Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery
    • Rutgeerts P., Geboes K., Vantrappen G., Kerremans R., Coenegrachts J.L., Coremans G. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut 2004, 25:665-672.
    • (2004) Gut , vol.25 , pp. 665-672
    • Rutgeerts, P.1    Geboes, K.2    Vantrappen, G.3    Kerremans, R.4    Coenegrachts, J.L.5    Coremans, G.6
  • 48
    • 33144463875 scopus 로고    scopus 로고
    • European evidence based consensus on the diagnosis and management of Crohn's disease: special situation
    • Caprilli R. European evidence based consensus on the diagnosis and management of Crohn's disease: special situation. Gut 2006, 55(Suppl. 1):i36-i58.
    • (2006) Gut , vol.55 , Issue.SUPPL. 1
    • Caprilli, R.1
  • 49
    • 77953505500 scopus 로고    scopus 로고
    • What is the role of endoscopy in the postoperative management of Crohn's disease?
    • Rutgeerts P., Van Assche G. What is the role of endoscopy in the postoperative management of Crohn's disease?. Inflammatory Bowel Diseases 2008, 14(Suppl. 2):S179-S180.
    • (2008) Inflammatory Bowel Diseases , vol.14 , Issue.SUPPL. 2
    • Rutgeerts, P.1    Van Assche, G.2
  • 50
    • 79955844087 scopus 로고    scopus 로고
    • Development of the Crohn's disease digestive damage score, the Lémann score
    • Pariente B., Cosnes J., Danese S., et al. Development of the Crohn's disease digestive damage score, the Lémann score. Inflammatory Bowel Diseases 2011, 17:1415-1422.
    • (2011) Inflammatory Bowel Diseases , vol.17 , pp. 1415-1422
    • Pariente, B.1    Cosnes, J.2    Danese, S.3
  • 51
    • 0008690916 scopus 로고
    • Cortisone in ulcerative colitis; final report on a therapeutic trial
    • Truelove S.C., Witts L.J. Cortisone in ulcerative colitis; final report on a therapeutic trial. British Medical Journal 1955, 2:1041-1048.
    • (1955) British Medical Journal , vol.2 , pp. 1041-1048
    • Truelove, S.C.1    Witts, L.J.2
  • 52
    • 75549096111 scopus 로고
    • Variation between observers in describing mucosal appearances in proctocolitis
    • Baron J.H., Connell A.M., Lennard-Jones J.E. Variation between observers in describing mucosal appearances in proctocolitis. British Medical Journal 1964, 1:89-92.
    • (1964) British Medical Journal , vol.1 , pp. 89-92
    • Baron, J.H.1    Connell, A.M.2    Lennard-Jones, J.E.3
  • 53
    • 0018170964 scopus 로고
    • A comparison of oral prednisolone given as single or multiple daily doses for active proctocolitis
    • Powell-Tuck J., Bown R.L., Lennard-Jones J.E. A comparison of oral prednisolone given as single or multiple daily doses for active proctocolitis. Scandinavian Journal of Gastroenterology 1978, 13:971-976.
    • (1978) Scandinavian Journal of Gastroenterology , vol.13 , pp. 971-976
    • Powell-Tuck, J.1    Bown, R.L.2    Lennard-Jones, J.E.3
  • 54
    • 0023221030 scopus 로고
    • 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis and proctitis
    • Sutherland L.R., Martin F., Greer S., et al. 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis and proctitis. Gastroenterology 1987, 92:1894-1898.
    • (1987) Gastroenterology , vol.92 , pp. 1894-1898
    • Sutherland, L.R.1    Martin, F.2    Greer, S.3
  • 55
    • 0024587677 scopus 로고
    • Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of ulcerative colitis: randomized trials
    • Rachmilewitz D. Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of ulcerative colitis: randomized trials. British Medical Journal 1989, 298:82-86.
    • (1989) British Medical Journal , vol.298 , pp. 82-86
    • Rachmilewitz, D.1
  • 56
    • 72549104759 scopus 로고    scopus 로고
    • Ulcerative Colitis: correlation of the Rachmilewitz Endoscopic Activity Index with fecal calprotectin, clinical activity, C-reactive protein and blood leukocytes
    • Schoepfer A.M., Beglinger C., Straumann A., Trummler M., Renzulli P., Seilbond F. Ulcerative Colitis: correlation of the Rachmilewitz Endoscopic Activity Index with fecal calprotectin, clinical activity, C-reactive protein and blood leukocytes. Inflammatory Bowel Diseases 2009, 15:1851-1858.
    • (2009) Inflammatory Bowel Diseases , vol.15 , pp. 1851-1858
    • Schoepfer, A.M.1    Beglinger, C.2    Straumann, A.3    Trummler, M.4    Renzulli, P.5    Seilbond, F.6
  • 57
    • 0023521441 scopus 로고
    • Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomizes study
    • Schroeder K.W., Tremaine W.J., Ilstrup D.M. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomizes study. New England Journal of Medicine 1987, 317:1625-1629.
    • (1987) New England Journal of Medicine , vol.317 , pp. 1625-1629
    • Schroeder, K.W.1    Tremaine, W.J.2    Ilstrup, D.M.3
  • 58
    • 80053132087 scopus 로고    scopus 로고
    • Validation of the ulcerative colitis endoscopic index of severity (UCEIS) and its correlation with clinical indices and laboratory measures of disease activity
    • Samuel S., Loftus E.V., Bruining D.H., et al. Validation of the ulcerative colitis endoscopic index of severity (UCEIS) and its correlation with clinical indices and laboratory measures of disease activity. Gastroenterology 2011, 140:A851.
    • (2011) Gastroenterology , vol.140
    • Samuel, S.1    Loftus, E.V.2    Bruining, D.H.3
  • 59
    • 84870888253 scopus 로고    scopus 로고
    • Validation of the ulcerative colitis colonoscopic index of severity and its correlation with disease activity measures
    • Samuel S., Bruining D.H., Loftus E.V., et al. Validation of the ulcerative colitis colonoscopic index of severity and its correlation with disease activity measures. Clinical Gastroenterology and Hepatology 2013, 11:49-54.
    • (2013) Clinical Gastroenterology and Hepatology , vol.11 , pp. 49-54
    • Samuel, S.1    Bruining, D.H.2    Loftus, E.V.3
  • 61
    • 38749106156 scopus 로고    scopus 로고
    • Warren BF; for the European Crohn's and Colitis Organization (ECCO). European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis
    • Stange E.F., Travis S.P., Vermeire S., et al. Warren BF; for the European Crohn's and Colitis Organization (ECCO). European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis. Journal of Crohns and Colitis 2008, 2:1-23.
    • (2008) Journal of Crohns and Colitis , vol.2 , pp. 1-23
    • Stange, E.F.1    Travis, S.P.2    Vermeire, S.3
  • 62
    • 33144468326 scopus 로고    scopus 로고
    • European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis
    • Stange E.F., Travis S.P., Vermeire S., et al. European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. Gut 2006, 55(Suppl. 1):i1-i15.
    • (2006) Gut , vol.55 , Issue.SUPPL. 1
    • Stange, E.F.1    Travis, S.P.2    Vermeire, S.3
  • 63
    • 0036104086 scopus 로고    scopus 로고
    • Influence of treatment on morphological features of mucosal inflammation
    • III37-III42
    • Geboes K., Dalle I. Influence of treatment on morphological features of mucosal inflammation. Gut 2002, 50(Suppl. 3):III37-III42.
    • (2002) Gut , vol.50 , Issue.SUPPL. 3
    • Geboes, K.1    Dalle, I.2
  • 64
    • 0031043997 scopus 로고    scopus 로고
    • Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative
    • Jenkins D., Balsitis M., Gallivan S., et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. Journal of Clinical Pathology 1997, 50:93-105.
    • (1997) Journal of Clinical Pathology , vol.50 , pp. 93-105
    • Jenkins, D.1    Balsitis, M.2    Gallivan, S.3
  • 65
    • 0025889013 scopus 로고
    • Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications
    • Seldenrijk C.A., Morson B.C., Meuwissen S.G., Schipper N.W., Lindeman J., Meijer C.J. Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. Gut 1991, 32:1514-1520.
    • (1991) Gut , vol.32 , pp. 1514-1520
    • Seldenrijk, C.A.1    Morson, B.C.2    Meuwissen, S.G.3    Schipper, N.W.4    Lindeman, J.5    Meijer, C.J.6
  • 66
    • 0028351635 scopus 로고
    • A prospective study of first attacks of inflammatory bowel disease and infectious colitis
    • Schumacher G., Kollberg B., Sandstedt B. A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Scandinavian Journal of Gastroenterology 1994, 29:318-332.
    • (1994) Scandinavian Journal of Gastroenterology , vol.29 , pp. 318-332
    • Schumacher, G.1    Kollberg, B.2    Sandstedt, B.3
  • 67
    • 0035166741 scopus 로고    scopus 로고
    • Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis
    • Bitton A., Peppercorn M.A., Antonioli D.A., et al. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology 2001, 120:13-20.
    • (2001) Gastroenterology , vol.120 , pp. 13-20
    • Bitton, A.1    Peppercorn, M.A.2    Antonioli, D.A.3
  • 68
    • 84879225829 scopus 로고    scopus 로고
    • Histologic markers of inflammation in patients with ulcerative colitis in clinical remission
    • Rosenberg L., Nanda K.S., Zenlea T., et al. Histologic markers of inflammation in patients with ulcerative colitis in clinical remission. Clinical Gastroenterology and Hepatology 2013, 11(8):991-996.
    • (2013) Clinical Gastroenterology and Hepatology , vol.11 , Issue.8 , pp. 991-996
    • Rosenberg, L.1    Nanda, K.S.2    Zenlea, T.3
  • 69
    • 10744222222 scopus 로고    scopus 로고
    • The optimal dose of 5-aminosalicylic acid in active ulcerative colitis: a dose-finding study with newly developed mesalamine
    • Kruis W., Bar-Meir S., Feher J., et al. The optimal dose of 5-aminosalicylic acid in active ulcerative colitis: a dose-finding study with newly developed mesalamine. Clinical Gastroenterology and Hepatology 2003, 1:36-43.
    • (2003) Clinical Gastroenterology and Hepatology , vol.1 , pp. 36-43
    • Kruis, W.1    Bar-Meir, S.2    Feher, J.3
  • 71
    • 58849136710 scopus 로고    scopus 로고
    • International Salofalk OD Study Group Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomized, non-inferiority trial
    • Kruis W., Kiudelis G., Rácz I., et al. International Salofalk OD Study Group Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomized, non-inferiority trial. Gut 2009, 58:233-240.
    • (2009) Gut , vol.58 , pp. 233-240
    • Kruis, W.1    Kiudelis, G.2    Rácz, I.3
  • 73
    • 0023226091 scopus 로고
    • Histologic and colonoscopic assessment of disease extension in ulcerative colitis
    • Floren C.H., Benoni C., Willen R. Histologic and colonoscopic assessment of disease extension in ulcerative colitis. Scandinavian Journal of Gastroenterology 1987, 22:459-462.
    • (1987) Scandinavian Journal of Gastroenterology , vol.22 , pp. 459-462
    • Floren, C.H.1    Benoni, C.2    Willen, R.3
  • 74
    • 0036191611 scopus 로고    scopus 로고
    • A new mesalazine foam enema (Claversal Foam) compared with a standard liquid enema in patients with active distal ulcerative colitis
    • CLAFOAM Study group
    • Malchow H., Gertz B. A new mesalazine foam enema (Claversal Foam) compared with a standard liquid enema in patients with active distal ulcerative colitis. Alimentary Pharmacology and Therapeutics 2002, 16:415-423. CLAFOAM Study group.
    • (2002) Alimentary Pharmacology and Therapeutics , vol.16 , pp. 415-423
    • Malchow, H.1    Gertz, B.2
  • 75
    • 9044244136 scopus 로고    scopus 로고
    • A randomized trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis
    • Lee F.I., Jewell D.P., Mani V., et al. A randomized trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis. Gut 1996, 38:229-233.
    • (1996) Gut , vol.38 , pp. 229-233
    • Lee, F.I.1    Jewell, D.P.2    Mani, V.3
  • 76
    • 33749370428 scopus 로고    scopus 로고
    • Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials
    • Regueiro M., Loftus E.V., Steinhart A.H., Cohen R.D. Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials. Inflammatory Bowel Diseases 2006, 12:979-994.
    • (2006) Inflammatory Bowel Diseases , vol.12 , pp. 979-994
    • Regueiro, M.1    Loftus, E.V.2    Steinhart, A.H.3    Cohen, R.D.4
  • 77
    • 0001099179 scopus 로고
    • Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium. A report on a controlled therapeutic trial
    • Truelove S.C. Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium. A report on a controlled therapeutic trial. British Medical Journal 1958, 2:1072-1077.
    • (1958) British Medical Journal , vol.2 , pp. 1072-1077
    • Truelove, S.C.1
  • 78
    • 0028881322 scopus 로고
    • An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease
    • Sandborn W.J., Van O.E.C., Zins B.J., Tremaine W.J., Mays D.C., Lipsky J.J. An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease. Gastroenterology 1995, 109:1808-1817.
    • (1995) Gastroenterology , vol.109 , pp. 1808-1817
    • Sandborn, W.J.1    Van, O.E.C.2    Zins, B.J.3    Tremaine, W.J.4    Mays, D.C.5    Lipsky, J.J.6
  • 79
    • 0030888894 scopus 로고    scopus 로고
    • Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease
    • D'Haens G., Geboes K., Ponette E., Penninckx F., Rutgeerts P. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease. Gastroenterology 1997, 112:1475-1481.
    • (1997) Gastroenterology , vol.112 , pp. 1475-1481
    • D'Haens, G.1    Geboes, K.2    Ponette, E.3    Penninckx, F.4    Rutgeerts, P.5
  • 80
    • 0032723990 scopus 로고    scopus 로고
    • Endoscopic and histologic healing of Crohn's (ileo-) colitis with azathioprine
    • D'Haens G., Geboes K., Rutgeerts P. Endoscopic and histologic healing of Crohn's (ileo-) colitis with azathioprine. Gastrointestinal Endoscopy 1999, 50:667-671.
    • (1999) Gastrointestinal Endoscopy , vol.50 , pp. 667-671
    • D'Haens, G.1    Geboes, K.2    Rutgeerts, P.3
  • 81
    • 0031915148 scopus 로고    scopus 로고
    • Early lesions caused by infusion of intestinal contents in excluded ileum in Crohn's disease
    • D'Haens G., Geboes K., Peeters M., Baert F., Penninckx F., Rutgeerts P. Early lesions caused by infusion of intestinal contents in excluded ileum in Crohn's disease. Gastroenterology 1998, 114:262-267.
    • (1998) Gastroenterology , vol.114 , pp. 262-267
    • D'Haens, G.1    Geboes, K.2    Peeters, M.3    Baert, F.4    Penninckx, F.5    Rutgeerts, P.6
  • 82
    • 66149148366 scopus 로고    scopus 로고
    • Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn's disease
    • Mantzaris G.J., Christidou A., Sfakianakis M., et al. Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn's disease. Inflammatory Bowel Diseases 2009, 15:375-382.
    • (2009) Inflammatory Bowel Diseases , vol.15 , pp. 375-382
    • Mantzaris, G.J.1    Christidou, A.2    Sfakianakis, M.3
  • 84
    • 79951674459 scopus 로고    scopus 로고
    • Mucosal healing with methotrexate in Crohn's disease: a prospective comparative study with azathioprine and infliximab
    • Laharie D., Reffet A., Belleannée G., et al. Mucosal healing with methotrexate in Crohn's disease: a prospective comparative study with azathioprine and infliximab. Alimentary Pharmacology and Therapeutics 2011, 33:714-721.
    • (2011) Alimentary Pharmacology and Therapeutics , vol.33 , pp. 714-721
    • Laharie, D.1    Reffet, A.2    Belleannée, G.3
  • 85
    • 0032913394 scopus 로고    scopus 로고
    • Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial
    • D'Haens G., Van Deventer S., Van Hogezand R., et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial. Gastroenterology 1999, 116:1029-1034.
    • (1999) Gastroenterology , vol.116 , pp. 1029-1034
    • D'Haens, G.1    Van Deventer, S.2    Van Hogezand, R.3
  • 86
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
    • Baert F.J., D'Haens G.R., Peeters M., et al. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 1999, 116:22-28.
    • (1999) Gastroenterology , vol.116 , pp. 22-28
    • Baert, F.J.1    D'Haens, G.R.2    Peeters, M.3
  • 87
    • 0034827790 scopus 로고    scopus 로고
    • Etanercept in the treatment of active refractory Crohn's disease: a single-center pilot trial
    • D'Haens G., Swijsen C., Noman M., et al. Etanercept in the treatment of active refractory Crohn's disease: a single-center pilot trial. American Journal of Gastroenterology 2001, 96:2564-2568.
    • (2001) American Journal of Gastroenterology , vol.96 , pp. 2564-2568
    • D'Haens, G.1    Swijsen, C.2    Noman, M.3
  • 88
    • 34547691199 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha down-regulation parallels inflammatory regression in ulcerative colitis patients treated with infliximab
    • Hassan C., Ierardi E., Burattini O., et al. Tumour necrosis factor alpha down-regulation parallels inflammatory regression in ulcerative colitis patients treated with infliximab. Digestive and Liver Disease 2007, 39:811-817.
    • (2007) Digestive and Liver Disease , vol.39 , pp. 811-817
    • Hassan, C.1    Ierardi, E.2    Burattini, O.3
  • 89
    • 77954662897 scopus 로고    scopus 로고
    • Ultrastructural evidence of mucosal healing after infliximab in patients with ulcerative colitis
    • Fratila O.C., Craciun C. Ultrastructural evidence of mucosal healing after infliximab in patients with ulcerative colitis. Journal of Gastrointestinal and Liver Diseases 2010, 19:147-153.
    • (2010) Journal of Gastrointestinal and Liver Diseases , vol.19 , pp. 147-153
    • Fratila, O.C.1    Craciun, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.