Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Yamada, Atsushi ^a   Aki, Toshihiko ^a   Unuma, Kana ^a   Funakoshi, Takeshi ^a   Uemura, Koichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ALPHA SMOOTH MUSCLE ACTIN; CASPASE 9; FIBRONECTIN; PARAQUAT; SCLEROPROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; CADHERIN; COLLAGEN; TRANSCRIPTION FACTOR;

ADENOCARCINOMA CELL LINE; ANOIKIS; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CELL ADHESION; CELL DEATH; CELL SURVIVAL; CELLULAR DISTRIBUTION; COLLAGEN SYNTHESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; FIBROGENESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM CELL; LUNG FIBROSIS; MESENCHYME CELL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; BRONCHUS; CELL NUCLEUS; CHEMICALLY INDUCED; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; LUNG; METABOLISM; PATHOLOGY; SECRETION (PROCESS); TIME FACTOR; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; BRONCHI; CADHERINS; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBRONECTINS; HUMANS; LUNG; PARAQUAT; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84925862433     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120192     Document Type: Article

References (36)

1. Suntres ZE. Role of antioxidants in paraquat toxicity. Toxicology. 2002; 180(1):65-77. Epub 2002/09/ 27. S0300483X02003827 [pii]. PubMed PMID: 12324200.
2. Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011; 72(5):745-57. Epub 2011/05/28. doi: 10.1111/j.1365-2125.2011.04026.x. PubMed PMID: 21615775; PubMed Central PMCID: PMC3243009.
3. Smith P, Heath D. The pathology of the lung in paraquat poisoning. J Clin Pathol Suppl (R Coll Pathol). 1975; 9:81-93. Epub 1975/01/01. PubMed PMID: 783217; PubMed Central PMCID: PMC1347187.
4. Ishii G, Sangai T, Sugiyama K., Ito T, Hasebe T, Endoh Y., et al. In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions. Stem Cells. 2005; 23(5):699-706. Epub 2005/04/26. 23/5/699 [pii]doi: 10.1634/stemcells.2004-0183. PubMed PMID: 15849177.
5. Ishii G, Ito TK, Aoyagi K, Fujimoto H., Chiba H, Hasebe T, et al. Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients. Stem Cells. 2007; 25 (6):1469-77. Epub 2007/03/24. 2006-0449 [pii]doi: 10.1634/stemcells.2006-0449. PubMed PMID: 17379768.
6. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014; 15(3):178-96. Epub 2014/02/22. doi: 10.1038/nrm3758nrm3758 [pii]. PubMed PMID: 24556840.
7. Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol. 2011; 73:413-35. Epub 2010/11/09. doi: 10.1146/annurev-physiol-012110-142225. PubMed PMID: 21054168.
8. Kage H, Borok Z. EMT and interstitial lung disease: a mysterious relationship. CurrOpin PulmMed. 2012; 18(5):517-23. Epub 2012/08/03. doi: 10.1097/MCP.0b013e328356672100063198-201209000-00021 [pii]. PubMed PMID: 22854509; PubMed Central PMCID: PMC3914631.
9. Nieto MA. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol. 2011; 27:347-76. Epub 2011/07/12. doi: 10.1146/annurev-cellbio-092910-154036. PubMed PMID: 21740232.
10. Chiarugi P, Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol. 2008; 76(11):1352-64. Epub 2008/08/19. doi: 10.1016/j.bcp.2008.07.023S0006-2952(08)00511-X [pii]. PubMed PMID: 18708031.
11. Reddig PJ, Juliano RL. Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev. 2005; 24(3):425-39. Epub 2005/11/01. doi: 10.1007/s10555-005-5134-3. PubMed PMID: 16258730.
12. Tsai JH, Yang J. Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev. 2013; 27 (20):2192-206. Epub 2013/10/22. doi: 10.1101/gad.225334.11327/20/2192 [pii]. PubMed PMID: 24142872; PubMed Central PMCID: PMC3814640.
13. Barth K, Reh J, Sturrock A., Kasper M. Epithelial vs myofibroblast differentiation in immortal rat lung cell lines-modulating effects of bleomycin. HistochemCell Biol. 2005; 124(6):453-64. Epub 2005/09/28. doi: 10.1007/s00418-005-0048-2. PubMed PMID: 16187068.
14. Gorowiec MR, Borthwick LA, Parker S.M., Kirby JA, Saretzki GC, Fisher AJ. Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta1-dependent mechanism. Free Radic Biol Med. 2012; 52(6):1024-32. Epub 2012/01/14. doi: 10.1016/j.freeradbiomed.2011.12.020S0891-5849(11)01279-2 [pii]. PubMed PMID: 22240154.
15. Chen T, Nie H, Gao X., Yang J, Pu J, Chen Z., et al. Epithelial-mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway. Toxicol Lett. 2014; 226(2):150-62. Epub 2014/02/18. doi: 10.1016/j.toxlet.2014.02.004S0378-4274(14)00073-3 [pii]. PubMed PMID: 24530353.
16. Kan B, Jian X, Zhou Q., Wang J, Yu G, Sun J., et al. Effect of transforming growth factor-beta1 on acute lung injury caused by paraquat. Mol Med Rep. 2014; 9(4):1232-6. Epub 2014/02/19. doi: 10.3892/mmr.2014.1938. PubMed PMID: 24535699.
17. Xie H, Tan JT, Wang R.L., Meng XX, Tang X, Gao S. Expression and significance of HIF-1alpha in pulmonary fibrosis induced by paraquat. Exp Biol Med (Maywood). 2013; 238(9):1062-8. Epub 2013/09/ 21. doi: 10.1177/1535370213498978238/9/1062 [pii]. PubMed PMID: 24048193.
18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. Epub 1976/05/07. S0003269776699996 [pii]. PubMed PMID: 942051.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. Epub 1970/08/15. PubMed PMID: 5432063.
20. Cappelletti G, Maggioni MG, Maci R. Apoptosis in human lung epithelial cells: triggering by paraquat and modulation by antioxidants. Cell Biol Int. 1998; 22(9-10):671-8. Epub 1999/08/24. S1065-6995 (98)90305-5 [pii]doi: 10.1006/cbir.1998.0305. PubMed PMID: 10452837.
21. Omura T, Asari M, Yamamoto J., Oka K, Hoshina C, Maseda C., et al. Sodiumtauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells. Biochem Biophys Res Commun. 2013; 432(4):689-94. Epub 2013/ 02/19. doi: 10.1016/j.bbrc.2013.01.131S0006-291X(13)00260-X [pii]. PubMed PMID: 23416354.
22. Frisch SM, Schaller M, Cieply B. Mechanisms that linkthe oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci. 2013; 126(Pt 1):21-9. Epub 2013/03/22. doi: 10.1242/jcs.120907126/1/21 [pii]. PubMed PMID: 23516327; PubMed Central PMCID: PMC3603508.
23. Nakazono-Kusaba A, Takahashi-Yanaga F, Morimoto S., Furue M, Sasaguri T. Staurosporine-induced cleavage of alpha-smooth muscle actin during myofibroblast apoptosis. J Invest Dermatol. 2002; 119 (5):1008-13. Epub 2002/11/26.19525 [pii]doi: 10.1046/j.1523-1747.2002.19525.x. PubMed PMID: 12445185.
24. Ishiguro S, Akasaka Y, Kiguchi H., Suzuki T, Imaizumi R, Ishikawa Y., et al. Basic fibroblast growth factor induces down-regulation of alpha-smooth muscle actin and reduction of myofibroblast areas in open skin wounds. Wound Repair Regen. 2009; 17(4):617-25. Epub 2009/07/21. doi: 10.1111/j.1524-475X.2009.00511.xWRR511 [pii]. PubMed PMID: 19614927.
25. Vega S, Morales AV, Ocana O.H., Valdes F., Fabregat I, Nieto MA. Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 2004; 18(10):1131-43. Epub 2004/05/25. doi: 10.1101/gad. 29410418/10/1131 [pii].PubMed PMID: 15155580; PubMed Central PMCID: PMC415638.
26. Mejlvang J, Kriajevska M, Vandewalle C., Chernova T, Sayan AE, Berx G, et al. Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition. Mol Biol Cell. 2007; 18(11):4615-24. Epub 2007/09/15. E07-05-0406 [pii]doi: 10.1091/mbc.E07-05-0406. PubMed PMID: 17855508; PubMed Central PMCID: PMC2043563.
27. Halder SK, Beauchamp RD, Datta PK. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia. 2005; 7(5):509-21. Epub 2005/06/22. PubMed PMID: 15967103; PubMed Central PMCID: PMC1501161.
28. Inman GJ, Nicolas FJ, Callahan J.F., Harling JD, Gaster LM, Reith AD, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002; 62(1):65-74. Epub 2002/06/18. PubMed PMID: 12065756.
29. Chen YW, Yang YT, Hung D.Z., Su CC, Chen KL. Paraquat induces lung alveolar epithelial cell apopto-sis via Nrf-2-regulated mitochondrial dysfunction and ER stress. Arch Toxicol. 2012; 86(10):1547-58. Epub 2012/06/09. doi: 10.1007/s00204-012-0873-8. PubMed PMID: 22678742.
30. Yang W, Tiffany-Castiglioni E, Koh H.C., Son IH. Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosisin human neuroblastoma SH-SY5Ycells. Toxicol Lett. 2009; 191(2-3):203-10. Epub 2009/09/09. doi: 10.1016/j.toxlet.2009.08.024S0378-4274(09)01422-2 [pii].PubMed PMID: 19735704.
31. Hong SY, Yang JO, Lee E.Y., Kim SH. Effect of haemoperfusion on plasma paraquat concentration in vitro and in vivo. Toxicol Ind Health. 2003; 19(1):17-23. Epub 2004/10/07. PubMed PMID: 15462533.
32. Seifirad S, Keshavarz A, Taslimi S., Aran S, Abbasi H, Ghaffari A. Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats. Clin Toxicol. 2012; 50(8):754-8. doi: 10.3109/15563650.2012.718783. PubMed PMID: ISI:000307996400006. PMID: 22924653
33. Yu N, Kozlowski JM, Park I.I., Chen L., Zhang Q, Xu D, et al. Overexpression of transforming growth factor beta1 in malignant prostate cells is partly caused by a runaway of TGF-beta1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-beta type I receptor. Urology. 2010; 76(6):1519e8-13. Epub 2010/10/30. doi: 10.1016/j.urology.2010.03.061S0090-4295(10)00480-2 [pii]. PubMed PMID: 21030067; PubMed Central PMCID: PMC2997920.
34. Grooteclaes ML, Frisch SM. Evidence for a function of CtBP in epithelial gene regulation and anoikis. Oncogene. 2000; 19(33):3823-8. Epub 2000/08/19. doi: 10.1038/sj.onc.1203721. PubMed PMID: 10949939.
35. Yang Y, Ahn YH, Chen Y, Tan X., Guo L, Gibbons DL, et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest. 2014; 124(6):2696-708. Epub 2014/04/26. doi: 10.1172/JCI7217172171 [pii].PubMed PMID: 24762440; PubMed Central PMCID: PMC4038569.
36. Oku H, Shimizu T, Kawabata T., Nagira M, Hikita I, Ueyama A., et al. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Eur J Pharmacol. 2008; 590(1-3):400-8. Epub 2008/07/05. doi: 10.1016/j.ejphar.2008.06.046S0014-2999(08)00638-9 [pii].PubMed PMID: 18598692.