-
1
-
-
0033540056
-
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
-
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
-
(1999)
Nature
, vol.402
, pp. 656-660
-
-
Kojima, M.1
Hosoda, H.2
Date, Y.3
Nakazato, M.4
Matsuo, H.5
Kangawa, K.6
-
2
-
-
44049094269
-
Ghrelin octanoylation mediated by an orphan lipid transferase
-
Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE: Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA 2008; 105:6320-6325.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6320-6325
-
-
Gutierrez, J.A.1
Solenberg, P.J.2
Perkins, D.R.3
Willency, J.A.4
Knierman, M.D.5
Jin, Z.6
Witcher, D.R.7
Luo, S.8
Onyia, J.E.9
Hale, J.E.10
-
3
-
-
38849090670
-
Identification of the acyltransferase that oc-tanoylates ghrelin, an appetite-stimulating peptide hormone
-
Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL: Identification of the acyltransferase that oc-tanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008; 132:387-396.
-
(2008)
Cell
, vol.132
, pp. 387-396
-
-
Yang, J.1
Brown, M.S.2
Liang, G.3
Grishin, N.V.4
Goldstein, J.L.5
-
4
-
-
84855369905
-
Mouse ghre-lin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption
-
Kang K, Schmahl J, Lee JM, Garcia K, Patil K, Chen A, Keene M, Murphy A, Sleeman MW: Mouse ghre-lin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption. FASEB J 2012; 26:259-271.
-
(2012)
FASEB J
, vol.26
, pp. 259-271
-
-
Kang, K.1
Schmahl, J.2
Lee, J.M.3
Garcia, K.4
Patil, K.5
Chen, A.6
Keene, M.7
Murphy, A.8
Sleeman, M.W.9
-
5
-
-
2942666142
-
Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans
-
Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, Abribat T, van der Lely AJ, Ghigo E: Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab 2004; 89:3062-3065.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3062-3065
-
-
Broglio, F.1
Gottero, C.2
Prodam, F.3
Gauna, C.4
Muccioli, G.5
Papotti, M.6
Abribat, T.7
Van Der Lely, A.J.8
Ghigo, E.9
-
6
-
-
6344291317
-
Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity
-
Gauna C, Meyler FM, Janssen J, Delhanty PJD, Abribat T, Van Koetsveld P, Hofland LJ, Broglio F, Ghigo E, van der Lely AJ: Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity. J Clin Endocrinol Metab 2004; 89:5035-5042.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5035-5042
-
-
Gauna, C.1
Meyler, F.M.2
Janssen, J.3
Delhanty, P.J.D.4
Abribat, T.5
Van Koetsveld, P.6
Hofland, L.J.7
Broglio, F.8
Ghigo, E.9
Van Der Lely, A.J.10
-
7
-
-
77957374080
-
Unraveling the role of the ghrelin gene peptides in the endocrine pancreas
-
Granata R, Baragli A, Settanni F, Scarlatti F, Ghigo E: Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 2010; 45: 107-118.
-
(2010)
J Mol Endocrinol
, vol.45
, pp. 107-118
-
-
Granata, R.1
Baragli, A.2
Settanni, F.3
Scarlatti, F.4
Ghigo, E.5
-
8
-
-
79960333463
-
Ghrelin and glucose homeostasis
-
Delhanty PJ, van der Lely AJ: Ghrelin and glucose homeostasis. Peptides 2011; 32:2309-2318.
-
(2011)
Peptides
, vol.32
, pp. 2309-2318
-
-
Delhanty, P.J.1
Van Der Lely, A.J.2
-
9
-
-
33846435771
-
Acylated and unacylated ghre-lin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: Involvement of 3 ′, 5′-cyclic adenosine monophosphate/protein ki-nase A, extracellular signal-regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling
-
Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Marti-netti M, Catapano F, Ghe C, Isgaard J, Papotti M, Ghigo E, Muccioli G: Acylated and unacylated ghre-lin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3 ′, 5′-cyclic adenosine monophosphate/protein ki-nase A, extracellular signal-regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling. Endocrinology 2007; 148:512-529.
-
(2007)
Endocrinology
, vol.148
, pp. 512-529
-
-
Granata, R.1
Settanni, F.2
Biancone, L.3
Trovato, L.4
Nano, R.5
Bertuzzi, F.6
Destefanis, S.7
Annunziata, M.8
Marti-Netti, M.9
Catapano, F.10
Ghe, C.11
Isgaard, J.12
Papotti, M.13
Ghigo, E.14
Muccioli, G.15
-
10
-
-
14044250280
-
Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes
-
Gauna C, Delhanty PJ, Hofland LJ, Janssen JA, Bro-glio F, Ross RJ, Ghigo E, van der Lely AJ: Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endo-crinol Metab 2005; 90:1055-1060.
-
(2005)
J Clin Endo-crinol Metab
, vol.90
, pp. 1055-1060
-
-
Gauna, C.1
Delhanty, P.J.2
Hofland, L.J.3
Janssen, J.A.4
Bro-Glio, F.5
Ross, R.J.6
Ghigo, E.7
Van Der Lely, A.J.8
-
11
-
-
77955842961
-
Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin. A study of pancreatic polypep-tide secretion from mouse islets
-
Kumar R, Salehi A, Rehfeld JF, Hoglund P, Lindstrom E, Hakanson R: Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin. A study of pancreatic polypep-tide secretion from mouse islets. Regul Pept 2010; 164:65-70.
-
(2010)
Regul Pept
, vol.164
, pp. 65-70
-
-
Kumar, R.1
Salehi, A.2
Rehfeld, J.F.3
Hoglund, P.4
Lindstrom, E.5
Hakanson, R.6
-
12
-
-
10844287775
-
Stomach regulates energy balance via acylated ghrelin and de-sacyl ghrelin
-
Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shin-fuku N, Ueta Y, Meguid MM, Kasuga M: Stomach regulates energy balance via acylated ghrelin and de-sacyl ghrelin. Gut 2005; 54:18-24.
-
(2005)
Gut
, vol.54
, pp. 18-24
-
-
Asakawa, A.1
Inui, A.2
Fujimiya, M.3
Sakamaki, R.4
Shin-Fuku, N.5
Ueta, Y.6
Meguid, M.M.7
Kasuga, M.8
-
13
-
-
56149100976
-
Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats
-
Inhoff T, Monnikes H, Noetzel S, Stengel A, Goebel M, Dinh QT, Riedl A, Bannert N, Wisser AS, Wie-denmann B, Klapp BF, Tache Y, Kobelt P: Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats. Peptides 2008; 29:2159-2168.
-
(2008)
Peptides
, vol.29
, pp. 2159-2168
-
-
Inhoff, T.1
Monnikes, H.2
Noetzel, S.3
Stengel, A.4
Goebel, M.5
Dinh, Q.T.6
Riedl, A.7
Bannert, N.8
Wisser, A.S.9
Wie-Denmann, B.10
Klapp, B.F.11
Tache, Y.12
Kobelt, P.13
-
14
-
-
50449085374
-
Effect of des-acyl ghrelin on adiposity and glucose metabolism
-
Zhang W, Chai B, Li JY, Wang H, Mulholland MW: Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology 2008; 149:4710-4716.
-
(2008)
Endocrinology
, vol.149
, pp. 4710-4716
-
-
Zhang, W.1
Chai, B.2
Li, J.Y.3
Wang, H.4
Mulholland, M.W.5
-
15
-
-
76749118930
-
Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: Implications for metabolism research
-
Martens K, Bottelbergs A, Baes M: Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research. FEBS Lett 2010; 584:1054-1058.
-
(2010)
FEBS Lett
, vol.584
, pp. 1054-1058
-
-
Martens, K.1
Bottelbergs, A.2
Baes, M.3
-
16
-
-
51249105332
-
Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice
-
Longo KA, Charoenthongtrakul S, Giuliana DJ, Gov-ek EK, McDonagh T, Qi Y, DiStefano PS, Geddes BJ: Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice. Regul Pept 2008; 150:55-61.
-
(2008)
Regul Pept
, vol.150
, pp. 55-61
-
-
Longo, K.A.1
Charoenthongtrakul, S.2
Giuliana, D.J.3
Gov-Ek, E.K.4
McDonagh, T.5
Qi, Y.6
Distefano, P.S.7
Geddes, B.J.8
-
17
-
-
33751506108
-
Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice
-
Nonogaki K, Nozue K, Oka Y: Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice. Endocrinology 2006; 147:5893-900.
-
(2006)
Endocrinology
, vol.147
, pp. 5893-5900
-
-
Nonogaki, K.1
Nozue, K.2
Oka, Y.3
-
18
-
-
72949115929
-
Acylated and non-acylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome
-
Pacifico L, Poggiogalle E, Costantino F, Anania C, Ferraro F, Chiarelli F, Chiesa C: Acylated and non-acylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome. Eur J Endocrinol 2009; 161:861-870.
-
(2009)
Eur J Endocrinol
, vol.161
, pp. 861-870
-
-
Pacifico, L.1
Poggiogalle, E.2
Costantino, F.3
Anania, C.4
Ferraro, F.5
Chiarelli, F.6
Chiesa, C.7
-
19
-
-
33846034095
-
Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women
-
St-Pierre DH, Karelis AD, Coderre L, Malita F, Fontaine J, Mignault D, Brochu M, Bastard JP, Cianflone K, Doucet E, Imbeault P, Rabasa-Lhoret R: Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women. J Clin Endocrinol Metab 2007; 92:264-269.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 264-269
-
-
St-Pierre, D.H.1
Karelis, A.D.2
Coderre, L.3
Malita, F.4
Fontaine, J.5
Mignault, D.6
Brochu, M.7
Bastard, J.P.8
Cianflone, K.9
Doucet, E.10
Imbeault, P.11
Rabasa-Lhoret, R.12
-
20
-
-
35348979155
-
Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome
-
Barazzoni R, Zanetti M, Ferreira C, Vinci P, Pirulli A, Mucci M, Dore F, Fonda M, Ciocchi B, Cattin L, Guarnieri G: Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome. J Clin Endocrinol Metab 2007; 92: 3935-3940.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 3935-3940
-
-
Barazzoni, R.1
Zanetti, M.2
Ferreira, C.3
Vinci, P.4
Pirulli, A.5
Mucci, M.6
Dore, F.7
Fonda, M.8
Ciocchi, B.9
Cattin, L.10
Guarnieri, G.11
-
21
-
-
59149103238
-
Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader-Willi syndrome
-
Prodam F, Bellone S, Grugni G, Crino A, Ragusa L, Franzese A, Di Battista E, Corrias A, Walker G, Rapa A, Aimaretti G, Bona G: Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader-Willi syndrome. Clin Nutr 2009; 28:94-99.
-
(2009)
Clin Nutr
, vol.28
, pp. 94-99
-
-
Prodam, F.1
Bellone, S.2
Grugni, G.3
Crino, A.4
Ragusa, L.5
Franzese, A.6
Di Battista, E.7
Corrias, A.8
Walker, G.9
Rapa, A.10
Aimaretti, G.11
Bona, G.12
-
23
-
-
79251634954
-
Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes
-
Miegueu P, St Pierre D, Broglio F, Cianflone K: Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes. J Cell Biochem 2011; 112: 704-714.
-
(2011)
J Cell Biochem
, vol.112
, pp. 704-714
-
-
Miegueu, P.1
St Pierre, D.2
Broglio, F.3
Cianflone, K.4
-
24
-
-
33846985961
-
Regulation of appetite in lean and obese adolescents after exercise: Role of acylated and desacyl ghrelin
-
Mackelvie KJ, Meneilly GS, Elahi D, Wong AC, Barr SI, Chanoine JP: Regulation of appetite in lean and obese adolescents after exercise: role of acylated and desacyl ghrelin. J Clin Endocrinol Metab 2007; 92: 648-654.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 648-654
-
-
MacKelvie, K.J.1
Meneilly, G.S.2
Elahi, D.3
Wong, A.C.4
Barr, S.I.5
Chanoine, J.P.6
-
25
-
-
39149122215
-
Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children
-
Kim HJ, Lee S, Kim TW, Kim HH, Jeon TY, Yoon YS, Oh SW, Kwak H, Lee JG: Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children. Clin Endocrinol (Oxf) 2008; 68:416-422.
-
(2008)
Clin Endocrinol (Oxf)
, vol.68
, pp. 416-422
-
-
Kim, H.J.1
Lee, S.2
Kim, T.W.3
Kim, H.H.4
Jeon, T.Y.5
Yoon, Y.S.6
Oh, S.W.7
Kwak, H.8
Lee, J.G.9
-
26
-
-
78650304822
-
Glucose and weight control in mice with a designed ghrelin O-acyltrans-ferase inhibitor
-
Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukher-jee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschop MH, Boeke JD, Cole PA: Glucose and weight control in mice with a designed ghrelin O-acyltrans-ferase inhibitor. Science 2010; 330:1689-1692.
-
(2010)
Science
, vol.330
, pp. 1689-1692
-
-
Barnett, B.P.1
Hwang, Y.2
Taylor, M.S.3
Kirchner, H.4
Pfluger, P.T.5
Bernard, V.6
Lin, Y.Y.7
Bowers, E.M.8
Mukher-Jee, C.9
Song, W.J.10
Longo, P.A.11
Leahy, D.J.12
Hussain, M.A.13
Tschop, M.H.14
Boeke, J.D.15
Cole, P.A.16
-
27
-
-
80051570581
-
The Peptidic GHS-R antagonist [ D-Lys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity
-
Maletinska L, Matyskova R, Maixnerova J, Sykora D, Pychova M, Spolcova A, Blechova M, Drapalova J, Lacinova Z, Haluzik M, Zelezna B: The Peptidic GHS-R antagonist [ D-Lys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity. Mol Cell Endocrinol 2011; 343:55-62.
-
(2011)
Mol Cell Endocrinol
, vol.343
, pp. 55-62
-
-
Maletinska, L.1
Matyskova, R.2
Maixnerova, J.3
Sykora, D.4
Pychova, M.5
Spolcova, A.6
Blechova, M.7
Drapalova, J.8
Lacinova, Z.9
Haluzik, M.10
Zelezna, B.11
-
28
-
-
79960182458
-
Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention
-
Cederberg H, Rajala U, Koivisto VM, Jokelainen J, Surcel HM, Keinanen-Kiukaanniemi S, Laakso M: Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention. Eur J Endocrinol. 2011; 165:243-248.
-
(2011)
Eur J Endocrinol.
, vol.165
, pp. 243-248
-
-
Cederberg, H.1
Rajala, U.2
Koivisto, V.M.3
Jokelainen, J.4
Surcel, H.M.5
Keinanen-Kiukaanniemi, S.6
Laakso, M.7
-
29
-
-
84862104269
-
Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans
-
Benso A, St-Pierre D, Prodam F, Gramaglia E, Granata R, Van der Lely AJ, Ghigo E, Broglio F: Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans. Eur J Endocrinol 2012; 166:911-916.
-
(2012)
Eur J Endocrinol
, vol.166
, pp. 911-916
-
-
Benso, A.1
St-Pierre, D.2
Prodam, F.3
Gramaglia, E.4
Granata, R.5
Van Der Lely, A.J.6
Ghigo, E.7
Broglio, F.8
-
30
-
-
34547157499
-
Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)
-
Gauna C, van de ZB, van KA, Themmen AP, van der Lely AJ, Delhanty PJ: Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R). Mol Cell Endocrinol 2007; 274:30-34.
-
(2007)
Mol Cell Endocrinol
, vol.274
, pp. 30-34
-
-
Gauna, C.1
Van De, Z.B.2
Van, K.A.3
Themmen, A.P.4
Van Der Lely, A.J.5
Delhanty, P.J.6
-
31
-
-
33646582986
-
Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
-
Gauna C, Delhanty PJ, van Aken MO, Janssen JA, Themmen AP, Hofland LJ, Culler M, Broglio F, Ghigo E, van der Lely AJ: Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol Cell Endocrinol 2006; 251:103-111.
-
(2006)
Mol Cell Endocrinol
, vol.251
, pp. 103-111
-
-
Gauna, C.1
Delhanty, P.J.2
Van Aken, M.O.3
Janssen, J.A.4
Themmen, A.P.5
Hofland, L.J.6
Culler, M.7
Broglio, F.8
Ghigo, E.9
Van Der Lely, A.J.10
-
32
-
-
27344437877
-
A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
-
Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, Diano S, Horvath TL, Culler MD: A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology 2005; 81:339-349.
-
(2005)
Neuroendocrinology
, vol.81
, pp. 339-349
-
-
Halem, H.A.1
Taylor, J.E.2
Dong, J.Z.3
Shen, Y.4
Datta, R.5
Abizaid, A.6
Diano, S.7
Horvath, T.L.8
Culler, M.D.9
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