Ameliorative effects of PACAP against cartilage degeneration. Morphological, immunohistochemical and biochemical evidence from in vivo and in vitro models of rat osteoarthritis

International Journal of Molecular Sciences

Volumn 16, Issue 3, 2015, Pages 5922-5944

  Giunta, Salvatore ^a   Castorina, Alessandro ^a   Marzagalli, Rubina ^a   Szychlinska, Marta Anna ^a   Pichler, Karin ^b   Mobasheri, Ali ^c,d,e   Musumeci, Giuseppe ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Anterior cruciate ligament transection (ACLT); BAX; Bcl 2; Caspase 3; Immunohistochemistry; Osteoarthritis; Pituitary adenylate cyclase activating polypeptide (PACAP)

Indexed keywords

CYCLOOXYGENASE 2; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; APOPTOSIS REGULATORY PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; BIOCHEMISTRY; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGY; MORPHOMETRICS; MTT ASSAY; NONHUMAN; OSTEOARTHRITIS; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; SYNOVIAL FLUID;

RATTUS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; MALE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; RATS, SPRAGUE-DAWLEY; SYNOVIAL FLUID;

EID: 84925845611     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16035922     Document Type: Article

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