메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: Implication of calcineurin as a downstream target

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALMODULIN; DUAL SPECIFICITY PHOSPHATASE 2; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MESSENGER RNA; TRANSCRIPTION FACTOR SOX9; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2; CALCINEURIN INHIBITOR; CYCLOSPORIN; HYDROGEN PEROXIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR 1; PEPTIDE;

EID: 84898603514     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091541     Document Type: Article
Times cited : (36)

References (75)
  • 2
  • 3
    • 79953804886 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating peptide (PACAP) immunoreactivity distribution in the small intestine of the adult New Hampshire chicken
    • Pirone A, Baoan D, Piano I, Santina LD, Baglini A, et al. (2011) Pituitary adenylate cyclase-activating peptide (PACAP) immunoreactivity distribution in the small intestine of the adult New Hampshire chicken. Acta Histochem 113: 477-483.
    • (2011) Acta Histochem , vol.113 , pp. 477-483
    • Pirone, A.1    Baoan, D.2    Piano, I.3    Santina, L.D.4    Baglini, A.5
  • 4
    • 84858295185 scopus 로고    scopus 로고
    • Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney
    • Reglodi D, Kiss P, Horvath G, Lubics A, Laszlo E, et al. (2011) Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney. Neuropeptides 46:61-70.
    • (2011) Neuropeptides , vol.46 , pp. 61-70
    • Reglodi, D.1    Kiss, P.2    Horvath, G.3    Lubics, A.4    Laszlo, E.5
  • 5
    • 77957259260 scopus 로고    scopus 로고
    • Alterations of pituitary adenylate cyclase-activating polypeptide-like immunoreactivity in the human plasma during pregnancy and after birth
    • Reglodi D, Gyarmati J, Ertl T, Borzsei R, Bodis J, et al. (2010) Alterations of pituitary adenylate cyclase-activating polypeptide-like immunoreactivity in the human plasma during pregnancy and after birth. J Endocrinol Invest 33: 443-445.
    • (2010) J Endocrinol Invest , vol.33 , pp. 443-445
    • Reglodi, D.1    Gyarmati, J.2    Ertl, T.3    Borzsei, R.4    Bodis, J.5
  • 6
    • 64549084141 scopus 로고    scopus 로고
    • Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk
    • Borzsei R, Mark L, Tamas A, Bagoly T, Bay C, et al. (2009) Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk. Eur J Endocrinol 160: 561-565.
    • (2009) Eur J Endocrinol , vol.160 , pp. 561-565
    • Borzsei, R.1    Mark, L.2    Tamas, A.3    Bagoly, T.4    Bay, C.5
  • 7
    • 69249234736 scopus 로고    scopus 로고
    • CAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells
    • Nagata A, Tanaka T, Minezawa A, Poyurovsky M, Mayama T, et al. (2009) cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells. J Cell Physiol 221: 75-83.
    • (2009) J Cell Physiol , vol.221 , pp. 75-83
    • Nagata, A.1    Tanaka, T.2    Minezawa, A.3    Poyurovsky, M.4    Mayama, T.5
  • 8
    • 80055000834 scopus 로고    scopus 로고
    • The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts
    • Persson E, Lerner UH (2011) The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts. J Cell Biochem 112: 3732-3741.
    • (2011) J Cell Biochem , vol.112 , pp. 3732-3741
    • Persson, E.1    Lerner, U.H.2
  • 9
    • 0030944068 scopus 로고    scopus 로고
    • Immunocytochemical demonstration of pituitary adenylate cyclase activating polypeptide (PACAP) in the porcine epiphyseal cartilage canals
    • DOI 10.1016/S0143-4179(97)90082-2
    • Strange-Vognsen HH, Arnbjerg J, Hannibal J (1997) Immunocytochemical demonstration of pituitary adenylate cyclase activating polypeptide (PACAP) in the porcine epiphyseal cartilage canals. Neuropeptides 31: 137-141. (Pubitemid 27240054)
    • (1997) Neuropeptides , vol.31 , Issue.2 , pp. 137-141
    • Strange-Vognsen, H.H.1    Arnbjerg, J.2    Hannibal, J.3
  • 11
    • 58149091897 scopus 로고    scopus 로고
    • Effects of PACAP on the circadian changes of signaling pathways in chicken pinealocytes
    • Racz B, Horvath G, Faluhelyi N, Nagy AD, Tamas A, et al. (2008) Effects of PACAP on the circadian changes of signaling pathways in chicken pinealocytes. J Mol Neurosci 36: 220-226.
    • (2008) J Mol Neurosci , vol.36 , pp. 220-226
    • Racz, B.1    Horvath, G.2    Faluhelyi, N.3    Nagy, A.D.4    Tamas, A.5
  • 12
    • 79958175258 scopus 로고    scopus 로고
    • Role of PACAP in neural stem/progenitor cell and astrocyte-from neural development to neural repair
    • Nakamachi T, Farkas J, Watanabe J, Ohtaki H, Dohi K, et al. (2011) Role of PACAP in neural stem/progenitor cell and astrocyte-from neural development to neural repair. Curr Pharm Des 17: 973-984.
    • (2011) Curr Pharm des , vol.17 , pp. 973-984
    • Nakamachi, T.1    Farkas, J.2    Watanabe, J.3    Ohtaki, H.4    Dohi, K.5
  • 13
    • 77956191559 scopus 로고    scopus 로고
    • The vasoactive intestinal peptide-receptor system is involved in human glioblastoma cell migration
    • Cochaud S, Chevrier L, Meunier AC, Brillet T, Chadeneau C, et al. (2010) The vasoactive intestinal peptide-receptor system is involved in human glioblastoma cell migration. Neuropeptides 44: 373-383.
    • (2010) Neuropeptides , vol.44 , pp. 373-383
    • Cochaud, S.1    Chevrier, L.2    Meunier, A.C.3    Brillet, T.4    Chadeneau, C.5
  • 14
    • 55549092391 scopus 로고    scopus 로고
    • Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury
    • Sanchez A, Chiriva-Internati M, Grammas P (2008) Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury. Neurosci Lett 448: 52-55.
    • (2008) Neurosci Lett , vol.448 , pp. 52-55
    • Sanchez, A.1    Chiriva-Internati, M.2    Grammas, P.3
  • 15
    • 57249094333 scopus 로고    scopus 로고
    • PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin
    • Sanchez A, Rao HV, Grammas P (2009) PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin. Regul Pept 152: 33-40.
    • (2009) Regul Pept , vol.152 , pp. 33-40
    • Sanchez, A.1    Rao, H.V.2    Grammas, P.3
  • 17
    • 77956876138 scopus 로고    scopus 로고
    • Effects of PACAP on the oxidative stress-induced cell death in chicken pinealocytes is influenced by the phase of the circadian clock
    • Horvath G, Reglodi D, Opper B, Brubel R, Tamas A, et al. (2010) Effects of PACAP on the oxidative stress-induced cell death in chicken pinealocytes is influenced by the phase of the circadian clock. Neurosci Lett 484: 148-152.
    • (2010) Neurosci Lett , vol.484 , pp. 148-152
    • Horvath, G.1    Reglodi, D.2    Opper, B.3    Brubel, R.4    Tamas, A.5
  • 18
    • 72649091911 scopus 로고    scopus 로고
    • Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro
    • Horvath G, Mark L, Brubel R, Szakaly P, Racz B, et al. (2010) Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro. Neurosci Lett 469: 70-74.
    • (2010) Neurosci Lett , vol.469 , pp. 70-74
    • Horvath, G.1    Mark, L.2    Brubel, R.3    Szakaly, P.4    Racz, B.5
  • 19
    • 79954424855 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis
    • Masmoudi-Kouki O, Douiri S, Hamdi Y, Kaddour H, Bahdoudi S, et al. (2011) Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis. J Neurochem 117: 403-411.
    • (2011) J Neurochem , vol.117 , pp. 403-411
    • Masmoudi-Kouki, O.1    Douiri, S.2    Hamdi, Y.3    Kaddour, H.4    Bahdoudi, S.5
  • 20
    • 64449088732 scopus 로고    scopus 로고
    • Distribution and functional characterization of pituitary adenylate cyclaseactivating polypeptide receptors in the brain of non-human primates
    • Jolivel V, Basille M, Aubert N, de JS, Ancian P, Le Bigot JF, et al. (2009) Distribution and functional characterization of pituitary adenylate cyclaseactivating polypeptide receptors in the brain of non-human primates. Neuroscience 160: 434-451.
    • (2009) Neuroscience , vol.160 , pp. 434-451
    • Jolivel, V.1    Basille, M.2    Aubert, N.3    De Js Ancian, P.4    Le Bigot, J.F.5
  • 22
    • 0026759537 scopus 로고
    • Antagonistic properties are shifted back to agonistic properties by further Nterminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes
    • Vandermeers A, Vandenborre S, Hou X, De NP, Robberecht P, et al. (1992) Antagonistic properties are shifted back to agonistic properties by further Nterminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes. Eur J Biochem 208: 815-819.
    • (1992) Eur J Biochem , vol.208 , pp. 815-819
    • Vandermeers, A.1    Vandenborre, S.2    Hou, X.3    De Np Robberecht, P.4
  • 23
    • 34548480168 scopus 로고    scopus 로고
    • Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology
    • DOI 10.1016/j.peptides.2007.04.026, PII S0196978107001568
    • Laburthe M, Couvineau A, Tan V (2007) Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology. Peptides 28: 1631-1639. (Pubitemid 47371033)
    • (2007) Peptides , vol.28 , Issue.9 , pp. 1631-1639
    • Laburthe, M.1    Couvineau, A.2    Tan, V.3
  • 24
    • 70349922918 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery
    • Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, et al. (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 61: 283-357.
    • (2009) Pharmacol Rev , vol.61 , pp. 283-357
    • Vaudry, D.1    Falluel-Morel, A.2    Bourgault, S.3    Basille, M.4    Burel, D.5
  • 25
    • 33644948464 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating peptide (PACAP) induces differentiation in the neuronal F11 cell line through a PKA-dependent pathway
    • McIlvain HB, Baudy A, Sullivan K, Liu D, Pong K, et al. (2006) Pituitary adenylate cyclase-activating peptide (PACAP) induces differentiation in the neuronal F11 cell line through a PKA-dependent pathway. Brain Res 1077: 16-23.
    • (2006) Brain Res , vol.1077 , pp. 16-23
    • McIlvain, H.B.1    Baudy, A.2    Sullivan, K.3    Liu, D.4    Pong, K.5
  • 26
    • 0141504018 scopus 로고    scopus 로고
    • The role of reactive oxygen species in homeostasis and degradation of cartilage
    • DOI 10.1016/S1063-4584(03)00150-X
    • Henrotin YE, Bruckner P, Pujol JP (2003) The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 11: 747-755. (Pubitemid 37184493)
    • (2003) Osteoarthritis and Cartilage , vol.11 , Issue.10 , pp. 747-755
    • Henrotin, Y.E.1    Bruckner, P.2    Pujol, J.-P.L.3
  • 28
    • 0024996225 scopus 로고
    • Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines
    • Tiku ML, Liesch JB, Robertson FM (1990) Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines. J Immunol 145: 690-696. (Pubitemid 20252381)
    • (1990) Journal of Immunology , vol.145 , Issue.2 , pp. 690-696
    • Tiku, M.L.1    Liesch, J.B.2    Robertson, F.M.3
  • 29
    • 0036171665 scopus 로고    scopus 로고
    • Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species
    • DOI 10.1002/art.10056
    • Del CM, Jr., Loeser RF (2002) Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum 46: 394-403. (Pubitemid 34136577)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.2 , pp. 394-403
    • Del Carlo Jr., M.1    Loeser, R.F.2
  • 30
    • 79955893457 scopus 로고    scopus 로고
    • Oxidative stress induces senescence in chondrocytes
    • Brandl A, Hartmann A, Bechmann V, Graf B, et al. (2011) Oxidative stress induces senescence in chondrocytes. J Orthop Res 29: 1114-1120.
    • (2011) J Orthop Res , vol.29 , pp. 1114-1120
    • Brandl, A.1    Hartmann, A.2    Bechmann, V.3    Graf, B.4
  • 31
    • 20144375217 scopus 로고    scopus 로고
    • Hydrogen peroxide inhibits formation of cartilage in chicken micromass cultures and decreases the activity of calcineurin: Implication of ERK1/2 and Sox9 pathways
    • DOI 10.1016/j.yexcr.2004.12.016
    • Zakany R, Szijgyarto Z, Matta C, Juhasz T, Csortos C, et al. (2005) Hydrogen peroxide inhibits formation of cartilage in chicken micromass cultures and decreases the activity of calcineurin: implication of ERK1/2 and Sox9 pathways. Exp Cell Res 305: 190-199. (Pubitemid 40380665)
    • (2005) Experimental Cell Research , vol.305 , Issue.1 , pp. 190-199
    • Zakany, R.1    Szijgyarto, Z.2    Matta, C.3    Juhasz, T.4    Csortos, C.5    Szucs, K.6    Czifra, G.7    Biro, T.8    Modis, L.9    Gergely, P.10
  • 32
    • 0036789798 scopus 로고    scopus 로고
    • Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation
    • Jovanovic DV, Mineau F, Notoya K, Reboul P, Martel-Pelletier J, et al. (2002) Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation. J Rheumatol 29: 2165-2175.
    • (2002) J Rheumatol , vol.29 , pp. 2165-2175
    • Jovanovic, D.V.1    Mineau, F.2    Notoya, K.3    Reboul, P.4    Martel-Pelletier, J.5
  • 33
    • 33646133405 scopus 로고    scopus 로고
    • Thioredoxin protects against joint destruction in a murine arthritis model
    • Tsuji G, Koshiba M, Nakamura H, Kosaka H, Hatachi S, et al. (2006) Thioredoxin protects against joint destruction in a murine arthritis model. Free Radic Biol Med 40: 1721-1731.
    • (2006) Free Radic Biol Med , vol.40 , pp. 1721-1731
    • Tsuji, G.1    Koshiba, M.2    Nakamura, H.3    Kosaka, H.4    Hatachi, S.5
  • 34
    • 0017739437 scopus 로고
    • Stage-related capacity for limb chondrogenesis in cell culture
    • DOI 10.1016/0012-1606(77)90110-5
    • Ahrens PB, Solursh M, Reiter RS (1977) Stage-related capacity for limb chondrogenesis in cell culture. Dev Biol 60: 69-82. (Pubitemid 8185563)
    • (1977) Developmental Biology , vol.60 , Issue.1 , pp. 69-82
    • Ahrens, P.B.1    Solursh, M.2    Reiter, R.S.3
  • 35
    • 0020316624 scopus 로고
    • Cartilage differentiation in micro-mass cultures of chicken limb buds
    • Hadhazy C, Lazlo MB, Kostenszky KS (1982) Cartilage differentiation in micromass cultures of chicken limb buds. Acta Morphol Acad Sci Hung 30: 65-78. (Pubitemid 12059393)
    • (1982) Acta Morphologica , vol.30 , Issue.1 , pp. 65-78
    • Hadhazy, Cs.1    Laszlo, M.B.2    Kostenszky, K.S.3
  • 36
    • 0036346580 scopus 로고    scopus 로고
    • Protein phosphatase 2A is involved in the regulation of protein kinase A signaling pathway during in vitro chondrogenesis
    • Zakany R, Szucs K, Bako E, Felszeghy S, Czifra G, et al. (2002) Protein phosphatase 2A is involved in the regulation of protein kinase A signaling pathway during in vitro chondrogenesis. Exp Cell Res 275: 1-8.
    • (2002) Exp Cell Res , vol.275 , pp. 1-8
    • Zakany, R.1    Szucs, K.2    Bako, E.3    Felszeghy, S.4    Czifra, G.5
  • 37
    • 0033813919 scopus 로고    scopus 로고
    • Transcriptional mechanisms of chondrocyte differentiation
    • de CB, Lefebvre V, Behringer RR, Bi W, Murakami S, et al. (2000) Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol 19: 389-394.
    • (2000) Matrix Biol , vol.19 , pp. 389-394
    • De Cb Lefebvre, V.1    Behringer, R.R.2    Bi, W.3    Murakami, S.4
  • 38
    • 78651281189 scopus 로고    scopus 로고
    • PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures
    • Matta C, Juhasz T, Szijgyarto Z, Kolozsvari B, Somogyi C, et al. (2011) PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures. Biochimie 93: 149-159.
    • (2011) Biochimie , vol.93 , pp. 149-159
    • Matta, C.1    Juhasz, T.2    Szijgyarto, Z.3    Kolozsvari, B.4    Somogyi, C.5
  • 39
    • 0034067651 scopus 로고    scopus 로고
    • Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer
    • DOI 10.1128/MCB.20.11.4149-4158.2000
    • Huang W, Zhou X, Lefebvre V, de CB (2000) Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol 20: 4149-4158. (Pubitemid 30314512)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.11 , pp. 4149-4158
    • Huang, W.1    Zhou, X.2    Lefebvre, V.3    De Crombrugghe, B.4
  • 40
    • 35048875679 scopus 로고    scopus 로고
    • Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCα and p38 MAP kinase
    • Lee YA, Kang SS, Baek SH, Jung JC, Jin EJ, et al. (2007) Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase. Mol Cells 24: 9-15. (Pubitemid 47554787)
    • (2007) Molecules and Cells , vol.24 , Issue.1 , pp. 9-15
    • Lee, Y.A.1    Kang, S.-S.2    Baek, S.-H.3    Jung, J.-C.4    Jin, E.J.5    Tak, E.N.6    Sonn, J.K.7
  • 41
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: Form and function
    • Rusnak F, Mertz P (2000) Calcineurin: form and function. Physiol Rev 80: 1483-1521.
    • (2000) Physiol Rev , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 43
    • 49749153485 scopus 로고    scopus 로고
    • Cytosolic free Ca2+ concentration exhibits a characteristic temporal pattern during in vitro cartilage differentiation: A possible regulatory role of calcineurin in Ca-signalling of chondrogenic cells
    • Matta C, Fodor J, Szijgyarto Z, Juhasz T, Gergely P, et al. (2008) Cytosolic free Ca2+ concentration exhibits a characteristic temporal pattern during in vitro cartilage differentiation: a possible regulatory role of calcineurin in Ca-signalling of chondrogenic cells. Cell Calcium 44: 310-323.
    • (2008) Cell Calcium , vol.44 , pp. 310-323
    • Matta, C.1    Fodor, J.2    Szijgyarto, Z.3    Juhasz, T.4    Gergely, P.5
  • 45
    • 65949089831 scopus 로고    scopus 로고
    • SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation
    • Zhao L, Li G, Zhou GQ (2009) SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation. J Bone Miner Res 24: 826-836.
    • (2009) J Bone Miner Res , vol.24 , pp. 826-836
    • Zhao, L.1    Li, G.2    Zhou, G.Q.3
  • 46
    • 81855185313 scopus 로고    scopus 로고
    • Pituitary adenylatecyclase-activating polypeptide-immunoreactive nerve fibers in the rat epiglottis and pharynx
    • Kano M, Shimizu Y, Suzuki Y, Furukawa Y, Ishida H, et al. (2011) Pituitary adenylatecyclase-activating polypeptide-immunoreactive nerve fibers in the rat epiglottis and pharynx. Ann Anat 193: 494-499.
    • (2011) Ann Anat , vol.193 , pp. 494-499
    • Kano, M.1    Shimizu, Y.2    Suzuki, Y.3    Furukawa, Y.4    Ishida, H.5
  • 47
    • 79951576697 scopus 로고    scopus 로고
    • Effects of PACAP on oxidative stress-induced cell death in rat kidney and human hepatocyte cells
    • Horvath G, Brubel R, Kovacs K, Reglodi D, Opper B, et al. (2011) Effects of PACAP on oxidative stress-induced cell death in rat kidney and human hepatocyte cells. J Mol Neurosci 43: 67-75.
    • (2011) J Mol Neurosci , vol.43 , pp. 67-75
    • Horvath, G.1    Brubel, R.2    Kovacs, K.3    Reglodi, D.4    Opper, B.5
  • 49
    • 62949120743 scopus 로고    scopus 로고
    • Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis
    • Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, et al. (2009) Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 4: 324-335.
    • (2009) Cell Stem Cell , vol.4 , pp. 324-335
    • Koelling, S.1    Kruegel, J.2    Irmer, M.3    Path, J.R.4    Sadowski, B.5
  • 50
    • 0343907213 scopus 로고    scopus 로고
    • Expression of mRNAs for neuropeptide receptors and β-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells
    • DOI 10.1016/S0304-3940(97)00649-6, PII S0304394097006496
    • Togari A, Arai M, Mizutani S, Mizutani S, Koshihara Y, et al. (1997) Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells. Neurosci Lett 233: 125-128. (Pubitemid 27418180)
    • (1997) Neuroscience Letters , vol.233 , Issue.2-3 , pp. 125-128
    • Togari, A.1    Arai, M.2    Mizutani, S.3    Mizutani, S.4    Koshihara, Y.5    Nagatsu, T.6
  • 51
    • 0029975290 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating peptide stimulates cyclic AMP accumulation in UMR 106 osteoblast-like cells
    • Kovacs CS, Chik CL, Li B, Karpinski E, Ho AK (1996) Pituitary adenylate cyclase-activating peptide stimulates cyclic AMP accumulation in UMR 106 osteoblast-like cells. J Endocrinol 149: 287-295. (Pubitemid 26174824)
    • (1996) Journal of Endocrinology , vol.149 , Issue.2 , pp. 287-295
    • Kovacs, C.S.1    Chik, C.L.2    Li, B.3    Karpinski, E.4    Ho, A.K.5
  • 52
    • 67349283365 scopus 로고    scopus 로고
    • Ionotropic purinergic receptor P2X4 is involved in the regulation of chondrogenesis in chicken micromass cell cultures
    • Fodor J, Matta C, Juhasz T, Olah T, Gonczi M, et al. (2009) Ionotropic purinergic receptor P2X4 is involved in the regulation of chondrogenesis in chicken micromass cell cultures. Cell Calcium 45: 421-430.
    • (2009) Cell Calcium , vol.45 , pp. 421-430
    • Fodor, J.1    Matta, C.2    Juhasz, T.3    Olah, T.4    Gonczi, M.5
  • 53
    • 81455133427 scopus 로고    scopus 로고
    • Switch of voltagegated K+ channel expression in the plasma membrane of chondrogenic cells affects cytosolic Ca2+-oscillations and cartilage formation
    • Varga Z, Juhasz T, Matta C, Fodor J, Katona E, et al. (2011) Switch of voltagegated K+ channel expression in the plasma membrane of chondrogenic cells affects cytosolic Ca2+-oscillations and cartilage formation. PLoS One 6: e27957.
    • (2011) PLoS One , vol.6
    • Varga, Z.1    Juhasz, T.2    Matta, C.3    Fodor, J.4    Katona, E.5
  • 54
    • 80455164687 scopus 로고    scopus 로고
    • Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: Lessons from PACAP-deficient mice
    • Vincze A, Reglodi D, Helyes Z, Hashimoto H, Shintani N, et al. (2011) Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: lessons from PACAP-deficient mice. Int J Dev Neurosci 29: 923-935.
    • (2011) Int J Dev Neurosci , vol.29 , pp. 923-935
    • Vincze, A.1    Reglodi, D.2    Helyes, Z.3    Hashimoto, H.4    Shintani, N.5
  • 55
    • 34548400224 scopus 로고    scopus 로고
    • Knocked down and out: PACAP in development, reproduction and feeding
    • DOI 10.1016/j.peptides.2007.03.008, PII S0196978107001027
    • Sherwood NM, Adams BA, Isaac ER, Wu S, Fradinger EA (2007) Knocked down and out: PACAP in development, reproduction and feeding. Peptides 28: 1680-1687. (Pubitemid 47361410)
    • (2007) Peptides , vol.28 , Issue.9 , pp. 1680-1687
    • Sherwood, N.M.1    Adams, B.A.2    Isaac, E.R.3    Wu, S.4    Fradinger, E.A.5
  • 56
    • 0344442730 scopus 로고    scopus 로고
    • Light-induced phase shift in the Syrian hamster (Mesocricetus auratus) is attenuated by the PACAP receptor antagonist PACAP6-38 or PACAP immunoneutralization
    • DOI 10.1046/j.1460-9568.2003.03000.x
    • Bergstrom AL, Hannibal J, Hindersson P, Fahrenkrug J (2003) Light-induced phase shift in the Syrian hamster (Mesocricetus auratus) is attenuated by the PACAP receptor antagonist PACAP6-38 or PACAP immunoneutralization. Eur J Neurosci 18: 2552-2562. (Pubitemid 37452671)
    • (2003) European Journal of Neuroscience , vol.18 , Issue.9 , pp. 2552-2562
    • Bergstrom, A.L.1    Hannibal, J.2    Hindersson, P.3    Fahrenkrug, J.4
  • 57
    • 58149103069 scopus 로고    scopus 로고
    • Agonistic behavior of PACAP6-38 on sensory nerve terminals and cytotrophoblast cells
    • Reglodi D, Borzsei R, Bagoly T, Boronkai A, Racz B, et al. (2008) Agonistic behavior of PACAP6-38 on sensory nerve terminals and cytotrophoblast cells. J Mol Neurosci 36: 270-278.
    • (2008) J Mol Neurosci , vol.36 , pp. 270-278
    • Reglodi, D.1    Borzsei, R.2    Bagoly, T.3    Boronkai, A.4    Racz, B.5
  • 58
    • 84895739766 scopus 로고    scopus 로고
    • PACAP receptor pharmacology and agonist bias: Analysis in primary neurons and glia from the trigeminal ganglia and transfected cells
    • doi: 10.1111/bph.12541
    • Walker CS, Sundrum T, Hay DL (2013) PACAP receptor pharmacology and agonist bias: Analysis in primary neurons and glia from the trigeminal ganglia and transfected cells. Br J Pharmacol. doi: 10.1111/bph.12541
    • Br J Pharmacol , vol.2013
    • Walker, C.S.1    Sundrum, T.2    Hay, D.L.3
  • 59
    • 84858866010 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide causes increased tyrosine phosphorylation of focal adhesion kinase and paxillin
    • Moody TW, Leyton J, Jensen RT (2012) Pituitary adenylate cyclase-activating polypeptide causes increased tyrosine phosphorylation of focal adhesion kinase and paxillin. J Mol Neurosci 46:68-74.
    • (2012) J Mol Neurosci , vol.46 , pp. 68-74
    • Moody, T.W.1    Leyton, J.2    Jensen, R.T.3
  • 60
    • 84856076396 scopus 로고    scopus 로고
    • Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) impairs the regulation of apoptosis in megakaryocytes by activating NF-kB: A proteomic study
    • Di Michele M, Peeters K, Loyen S, Thys C, Waelkens E, et al. (2012) Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) impairs the regulation of apoptosis in megakaryocytes by activating NF-kB: a proteomic study. Mol Cell Proteomics 11(1):M111.007625.
    • (2012) Mol Cell Proteomics , vol.11 , Issue.1
    • Di Michele, M.1    Peeters, K.2    Loyen, S.3    Thys, C.4    Waelkens, E.5
  • 61
    • 78049468118 scopus 로고    scopus 로고
    • Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation
    • St Hilaire RC, Murthy SN, Kadowitz PJ, Jeter JR, Jr. (2010) Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation. Peptides 31: 1517-1522.
    • (2010) Peptides , vol.31 , pp. 1517-1522
    • St Hilaire, R.C.1    Murthy, S.N.2    Kadowitz, P.J.3    Jeter Jr., J.R.4
  • 62
    • 77955131077 scopus 로고    scopus 로고
    • Pituitary adenylyl cyclase-activating polypeptide controls the proliferation of retinal progenitor cells through downregulation of cyclin D1
    • Njaine B, Martins RA, Santiago MF, Linden R, Silveira MS (2010) Pituitary adenylyl cyclase-activating polypeptide controls the proliferation of retinal progenitor cells through downregulation of cyclin D1. Eur J Neurosci 32: 311-321.
    • (2010) Eur J Neurosci , vol.32 , pp. 311-321
    • Njaine, B.1    Martins, R.A.2    Santiago, M.F.3    Linden, R.4    Silveira, M.S.5
  • 63
    • 78649778509 scopus 로고    scopus 로고
    • Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures
    • Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, et al. (2010) Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures. BMC Cancer 10: 676.
    • (2010) BMC Cancer , vol.10 , pp. 676
    • Cohen, J.R.1    Resnick, D.Z.2    Niewiadomski, P.3    Dong, H.4    Liau, L.M.5
  • 65
    • 34347207562 scopus 로고    scopus 로고
    • Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop
    • DOI 10.1124/mol.107.035477
    • Ushiyama M, Ikeda R, Sugawara H, Yoshida M, Mori K, Kangawa K, et al. (2007) Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop. Mol Pharmacol 72: 103-111. (Pubitemid 46998529)
    • (2007) Molecular Pharmacology , vol.72 , Issue.1 , pp. 103-111
    • Ushiyama, M.1    Ikeda, R.2    Sugawara, H.3    Yoshida, M.4    Mori, K.5    Kangawa, K.6    Inoue, K.7    Yamada, K.8    Miyata, A.9
  • 67
    • 0034048147 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide and its receptors: From structure to functions
    • Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, et al. (2000) Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol Rev 52: 269-324. (Pubitemid 30368434)
    • (2000) Pharmacological Reviews , vol.52 , Issue.2 , pp. 269-324
    • Vaudry, D.1    Gonzalez, B.J.2    Basille, M.3    Yon, L.4    Fournier, A.5    Vaudry, H.6
  • 68
    • 33747662969 scopus 로고    scopus 로고
    • Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes
    • DOI 10.1074/jbc.M512362200
    • Hinoi E, Ueshima T, Hojo H, Iemata M, Takarada T, et al. (2006) Upregulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes. J Biol Chem 281: 23632-23642. (Pubitemid 44274138)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.33 , pp. 23632-23642
    • Hinoi, E.1    Ueshima, T.2    Hojo, H.3    Iemata, M.4    Takarada, T.5    Yoneda, Y.6
  • 69
    • 84870452811 scopus 로고    scopus 로고
    • Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia
    • Lam SY, Liu Y, Liong EC, Tipoe GL, Fung ML (2012) Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia. Adv Exp Med Biol 758:301-306.
    • (2012) Adv Exp Med Biol , vol.758 , pp. 301-306
    • Lam, S.Y.1    Liu, Y.2    Liong, E.C.3    Tipoe, G.L.4    Fung, M.L.5
  • 70
    • 84868203425 scopus 로고    scopus 로고
    • IL-6 and PACAP receptor expression and localization after global brain ischemia in mice
    • Nakamachi T, Tsuchida M, Kagami N, Yofu S, Wada Y, et al. (2012) IL-6 and PACAP receptor expression and localization after global brain ischemia in mice. J Mol Neurosci 48(3):518-525.
    • (2012) J Mol Neurosci , vol.48 , Issue.3 , pp. 518-525
    • Nakamachi, T.1    Tsuchida, M.2    Kagami, N.3    Yofu, S.4    Wada, Y.5
  • 71
    • 77955852397 scopus 로고    scopus 로고
    • Optimalized transient transfection of chondrogenic primary cell cultures
    • Juhasz T, Matta C, Mészár Z, Nagy G, Szijgyarto Z, et al. (2010). Optimalized transient transfection of chondrogenic primary cell cultures. CEJB 5: 572-584.
    • (2010) CEJB , vol.5 , pp. 572-584
    • Juhasz, T.1    Matta, C.2    Mészár, Z.3    Nagy, G.4    Szijgyarto, Z.5
  • 72
    • 80051548899 scopus 로고    scopus 로고
    • PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells
    • Holighaus Y, Mustafa T, Eiden LE (2011) PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells. Peptides 32: 1647-1655.
    • (2011) Peptides , vol.32 , pp. 1647-1655
    • Holighaus, Y.1    Mustafa, T.2    Eiden, L.E.3
  • 74
    • 85047687526 scopus 로고    scopus 로고
    • Renoprotection with pituitary adenylate cyclase-activating polypeptide in cyclosporine A-induced nephrotoxicity
    • Khan AM, Li M, Brant E, Maderdrut JL, Majid DS, et al. (2011) Renoprotection with pituitary adenylate cyclase-activating polypeptide in cyclosporine A-induced nephrotoxicity. J Investig Med 59:793-802.
    • (2011) J Investig Med , vol.59 , pp. 793-802
    • Khan, A.M.1    Li, M.2    Brant, E.3    Maderdrut, J.L.4    Majid, D.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.