The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection

Osteoarthritis and Cartilage

Volumn 20, Issue 8, 2012, Pages 940-948

  Elsaid, K A ^a   Zhang, L ^b   Waller, K ^c   Tofte, J ^b   Teeple, E ^b   Fleming, B C ^b,c   Jay, G D ^b,c  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c Brown University   (United States)

Author keywords

ACL; Cartilage degeneration; Forced exercise; Lubricin

Indexed keywords

ANTIRHEUMATIC AGENT; CASPASE 3; LUBRICIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT INJURY; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; ENZYME ACTIVATION; EXERCISE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; HISTOLOGY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; CARTILAGE, ARTICULAR; CASPASE 3; CHONDROCYTES; DISEASE MODELS, ANIMAL; EXERCISE; GLYCOPROTEINS; HINDLIMB; HUMANS; MALE; RATS; RATS, INBRED LEW;

EID: 84862986675     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.04.021     Document Type: Article

References (41)

1. Gelber A.C., Hochberg M.C., Mead L.A., Wang N.Y., Wigley F.M., Klag M.J. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med 2000, 133:321-328.
2. Nelson F., Billinghurst R.C., Pidoux I., Reiner A., Langworthy M., McDermott M., et al. Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament. Osteoarthritis Cartilage 2006, 14:114-119.
3. Roos E., Adalberth T., Dahlberg L., Lohmander L.S. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage 1995, 3:261-267.
4. Elsaid K.A., Fleming B.C., Oksendahl H.L., Machan J.T., Fadale P.D., Hulstyn M.J., et al. Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 2008, 58:1707-1715.
5. Anderson D.D., Chubinskaya S., Guilak F., Martin J.A., Oegema T.R., Olson S.A., et al. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res 2011, 29:802-809.
6. Jay G.D., Britt D.E., Cha C.J. Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. J Rheumatol 2000, 27:594-600.
7. Flannery C.R., Hughes C.E., Schumacher B.L., Tudor D., Aydelotte M.B., Kuettner K.E., et al. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. Biochem Biophys Res Commun 1999, 254:535-541.
8. Jay G.D. Characterization of a bovine synovial fluid lubricating factor. I. Chemical, surface activity and lubricating properties. Connect Tissue Res 1992, 28:71-88.
9. Gleghorn J.P., Jones A.R., Flannery C.R., Bonassar L.J. Boundary mode lubrication of articular cartilage by recombinant human lubricin. J Orthop Res 2009, 27:771-777.
10. Rhee D.K., Marcelino J., Brown M., Gong Y., Smits P., Lefebvre V., et al. The secreted protein lubricin protects cartilage surfaces and inhibits synovial cell adhesion. J Clin Invest 2005, 115:622-631.
11. Jay G.D., Torres J.R., Rhee D.K., Helminen H.J., Cha C.J., Elsaid K.A., et al. Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum 2007, 56:3662-3669.
12. Elsaid K.A., Machan J.T., Waller K., Fleming B.C., Jay G.D. The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model. Arthritis Rheum 2009, 60:2997-3006.
13. Jay G.D., Fleming B.C., Watkins B.A., McHugh K.A., Anderson S.C., Zhang L.X., et al. Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum 2010, 62:2382-2391.
14. Teeple E., Elsaid K.A., Jay G.D., Zhang L., Badger G.J., Akelman M., et al. Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient knee. Am J Sports Med 2011, 39:164-172.
15. Elsaid K.A., Jay G.D., Chichester C.O. Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis. Arthritis Rheum 2007, 56:108-116.
16. Roche P.J. Preparation of template DNA and labeling techniques. In situ Hybridization Protocols 2006, 9-16. Humana Press, Totowa (NJ). 3rd edn. I.A. Darby, T.D. Hewitson (Eds.).
17. Tesch G.H., Lan H.Y., Nikolic-Paterson D.J. Treatment of tissue sections for in situ hybridization. In situ Hybridization Protocols 2006, 1-7. Humana Press, Totowa (NJ). 3rd edn. I.A. Darby, T.D. Hewitson (Eds.).
18. Ge N.L., Kocan K.M., Murphy G.L., Blouin E.F. Detection of Anaplasma marginale DNA in bovine erythrocytes by slot-blot and in situ hybridization with a PCR-mediated digoxigenin-labeled DNA probe. J Vet Diagn Invest 1995, 7:465-472.
19. Pritzker K.P., Gay S., Jimenez S.A., Ostergaard K., Pelletier J.P., Revell P.A., et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006, 14:13-29.
20. Young A.A., McLennan S., Smith S.M., Cake M.A., Read R.A., Melrose J., et al. Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Res Ther 2006, 8:R41.
21. Elsaid K.A., Jay G.D., Warman M.L., Rhee D.K., Chichester C.O. Association of articular cartilage degeneration and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum 2005, 52:1746-1755.
22. Jones A.R., Flannery C.R. Bioregulation of lubricin expression by growth factors and cytokines. Eur Cell Mater 2007, 13:40-45.
23. Niikura T., Reddi A.H. Differential regulation of lubricin/superficial zone protein by transforming growth factor beta/bone morphogenetic protein superfamily members in articular chondrocytes and synoviocytes. Arthritis Rheum 2007, 56:2312-2321.
24. Jones A.R., Chen S., Chai D.H., Stevens A.L., Gleghorn J.P., Bonassar L.J., et al. Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum 2009, 60:133-142.
25. Nugent G.E., Aneloski N.M., Schmidt T.A., Schumacher B.L., Voegtline M.S., Sah R. Dynamic shear stimulation of bovine cartilage biosynthesis of proteoglycans 4. Arthritis Rheum 2006, 54:1888-1896.
26. Nugent G.E., Schmidt T.A., Schumacher B.L., Voegtline M.S., Bae W.C., Jardin K.D., et al. Static and dynamic compression regulate cartilage metabolism of proteoglycans 4 (PRG4). Biorheology 2006, 43:191-200.
27. Nugent-Derfus G.E., Takara T., O'Neil J.K., Cahill S.B., Görtz S., Pong T., et al. Continuous passive motion applied to whole joints stimulates chondrocyte biosynthesis of PRG4. Osteoarthritis Cartilage 2007, 15:566-574.
28. Otterness I.G., Eskra J.D., Bliven M.L., Shay A.K., Pelletier J.P., Milici A.J. Exercise protects against articular cartilage degeneration. Arthritis Rheum 1998, 41:2068-2076.
29. Appelton C.T., McErlain D.D., Pitelka V., Schwartz N., Bernier S.M., Henry J.L., et al. Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis. Arthritis Res Ther 2007, 9:R13.
30. Pap G., Eberhardt R., Sturmer I., Machner A., Schwarzberg H., Roessner A., et al. Development of osteoarthritis in the knee joints of Wistar rats after strenuous running exercise in a running wheel by intracranial self-stimulation. Pathol Res Pract 1998, 194:41-47.
31. Galois L., Etienne S., Grossin L., Watrin-Pinzano A., Cournil-Henrionnet C., Loeuille D., et al. Dose-response relationship for exercise on severity of experimental osteoarthritis in rats; a pilot study. Osteoarthritis Cartilage 2004, 12:779-786.
32. Almonte-Becerril M., Navarro-Garcia F., Gonzalez-Robles A., Vega-Lopez M.A., Lavalle C., Kouri J.B. Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of osteoarthritis within an experimental model. Apoptosis 2010, 15:631-638.
33. Thomas C.M., Fuller C.J., Whittles C.E., Sharif M. Chondrocyte death by apoptosis is associated with the initiation and severity of articular cartilage degradation. Int J Rheum Dis 2011, 14:191-198.
34. Musumeci G., Loreto C., Carnazza M.L., Martinez G. Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis. Knee Surg Sports Traumatol Arthrosc 2011, 19:307-313.
35. Colwell C.W., D'Lima D.D., Hoenecke H.R., Fronek J., Pulido P., Morris B.A., et al. In vivo changes after mechanical injury. Clin Orthop Relat Res 2001, 391:S116-S123.
36. D'Lima D., Hermida J., Hashimoto S., Colwell C., Lotz M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 2006, 54:1814-1821.
37. Zhu F., Wang P., Lee N.H., Goldring M.B., Konstantopoulos K. Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PLoS One 2010, 5:e15174.
38. Hashimoto S., Nishiyama T., Hayashi S., Fukishiro T., Takebe K., Kanzaki N., et al. Role of p53 in human chondrocyte apoptosis in response to shear strain. Arthritis Rheum 2009, 60:2340-2349.
39. D'lima D.D., Hashimoto S., Chen P.C., Colwell C.W., Lotz M.K. Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 2001, 9:712-719.
40. Flannery C.R., Zollner R., Corcoran C., Jones A.R., Root A., Rivera-Bermúdez M.A., et al. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum 2009, 60:840-847.
41. Vugmeyester Y., Wang Q., Xu X., Harrold J., Daugusta D., Li J., et al. Disposition of human recombinant lubricin in naïve rats and in a rat model of post-traumatic arthritis after intra-articular or intravenous administration. AAPS J 2012, 14:97-104.