Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: The basis of its anti-inflammatory effect

Journal of Investigative Dermatology

Volumn 132, Issue 1, 2012, Pages 59-68

  Tsuji, Gaku ^a   Takahara, Masakazu ^a   Uchi, Hiroshi ^a,b   Matsuda, Tetsuo ^a   Chiba, Takahito ^a,b   Takeuchi, Satoshi ^a   Yasukawa, Fumiko ^a,b   Moroi, Yoichi ^a   Furue, Masutaka ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CYTOCHROME P450 1A1; INTERLEUKIN 8; KETOCONAZOLE; MESSENGER RNA; OXIDOREDUCTASE; QUINONE OXIDOREDUCTASE 1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROTECTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; KERATINOCYTE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 84856089401     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.194     Document Type: Article

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