Loss of MicroRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release

Circulation: Arrhythmia and Electrophysiology

Volumn 7, Issue 6, 2014, Pages 1214-1222

  Chiang, David Y ^a   Kongchan, Natee ^a   Beavers, David L ^a   Alsina, Katherina M ^a   Voigt, Niels ^c   Neilson, Joel R ^a   Jakob, Heinz ^d   Martin, James F ^a,b   Dobrev, Dobromir ^c   Wehrens, Xander H T ^a   Li, Na ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS HEART INSTITUTE   (United States)

^c UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Atrial fibrillation; MicroRNA; Ryanodine receptor calcium release channel

Indexed keywords

K201; MICRORNA; MICRORNA 106B; MICRORNA 106B 25; MICRORNA 25; MICRORNA 93; RECEPTOR BLOCKING AGENT; RYANODINE RECEPTOR 2; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; CALCIUM; MIRN106 MICRORNA, HUMAN; MIRN106 MICRORNA, MOUSE; RYANODINE RECEPTOR; RYANODINE RECEPTOR 2. MOUSE;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; ELECTROCARDIOGRAM; HEART ATRIUM; HEART ATRIUM CONDUCTION; HEART ATRIUM FIBRILLATION; HEART ATRIUM PACING; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SARCOPLASMIC RETICULUM; SINUS RHYTHM; TELEMETRY; WILD TYPE; ACTION POTENTIAL; ANIMAL; ATRIAL FIBRILLATION; CARDIAC MUSCLE; CASE CONTROL STUDY; DISEASE MODEL; DOWN REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; TIME FACTOR; UPREGULATION;

3' UNTRANSLATED REGIONS; ACTION POTENTIALS; ANIMALS; ATRIAL FIBRILLATION; CALCIUM; CALCIUM SIGNALING; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE, KNOCKOUT; MICRORNAS; MYOCARDIUM; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84925811392     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.114.001973     Document Type: Article

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